LOCUS       NM_001442                911 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens fatty acid binding protein 4 (FABP4), mRNA.
ACCESSION   NM_001442
VERSION     NM_001442.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Couselo-Seijas,M., Vazquez-Abuin,X., Gomez-Lazaro,M., Pereira,L.,
            Gomez,A.M., Caballero,R., Delpon,E., Bravo,S.,
            Gonzalez-Juanatey,J.R. and Eiras,S.
  TITLE     FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca2+
            Dynamic Changes
  JOURNAL   Circ Arrhythm Electrophysiol 17 (9), e012683 (2024)
   PUBMED   39212041
  REMARK    GeneRIF: FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and
            Ca[2+] Dynamic Changes.
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Ohguro,H., Watanabe,M., Hikage,F., Sato,T., Nishikiori,N.,
            Umetsu,A., Higashide,M., Ogawa,T. and Furuhashi,M.
  TITLE     Fatty Acid-Binding Protein 4-Mediated Regulation Is Pivotally
            Involved in Retinal Pathophysiology: A Review
  JOURNAL   Int J Mol Sci 25 (14), 7717 (2024)
   PUBMED   39062961
  REMARK    GeneRIF: Fatty Acid-Binding Protein 4-Mediated Regulation Is
            Pivotally Involved in Retinal Pathophysiology: A Review.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Saizonou,I., Lascombe,I., Monnien,F., Bedgedjian,I.,
            Kleinclauss,F., Algros,M.P. and Fauconnet,S.
  TITLE     Concomitant decrease of E- and A-FABP expression predicts worse
            survival in urothelial bladder cancer patients
  JOURNAL   Sci Rep 14 (1), 15390 (2024)
   PUBMED   38965292
  REMARK    GeneRIF: Concomitant decrease of E- and A-FABP expression predicts
            worse survival in urothelial bladder cancer patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Michler,S., Schoffmann,F.A., Robaa,D., Volmer,J. and
            Hinderberger,D.
  TITLE     Fatty acid binding to the human transport proteins FABP3, FABP4,
            and FABP5 from a Ligand's perspective
  JOURNAL   J Biol Chem 300 (6), 107396 (2024)
   PUBMED   38777142
  REMARK    GeneRIF: Fatty acid binding to the human transport proteins FABP3,
            FABP4, and FABP5 from a Ligand's perspective.
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Xu,S., Luo,J., Wang,Y. and Chen,X.
  TITLE     Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to
            Alleviate Lipopolysaccharide-induced Injury of Renal Tubular
            Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and
            Activator of Transcription 3 Signaling
  JOURNAL   J Physiol Investig 67 (1), 47-56 (2024)
   PUBMED   38780272
  REMARK    GeneRIF: Fatty Acid Binding Protein-4 Silencing Inhibits
            Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal
            Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal
            Transducer and Activator of Transcription 3 Signaling.
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Glatz,J.F., Borchers,T., Spener,F. and van der Vusse,G.J.
  TITLE     Fatty acids in cell signalling: modulation by lipid binding
            proteins
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 52 (2-3), 121-127 (1995)
   PUBMED   7784447
  REMARK    Review article
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Xu,Z., Bernlohr,D.A. and Banaszak,L.J.
  TITLE     The adipocyte lipid-binding protein at 1.6-A resolution. Crystal
            structures of the apoprotein and with bound saturated and
            unsaturated fatty acids
  JOURNAL   J Biol Chem 268 (11), 7874-7884 (1993)
   PUBMED   8463311
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Shekels,L.L., Smith,A.J., Van Etten,R.L. and Bernlohr,D.A.
  TITLE     Identification of the adipocyte acid phosphatase as a PAO-sensitive
            tyrosyl phosphatase
  JOURNAL   Protein Sci 1 (6), 710-721 (1992)
   PUBMED   1304913
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Buelt,M.K., Shekels,L.L., Jarvis,B.W. and Bernlohr,D.A.
  TITLE     In vitro phosphorylation of the adipocyte lipid-binding protein
            (p15) by the insulin receptor. Effects of fatty acid on receptor
            kinase and substrate phosphorylation
  JOURNAL   J Biol Chem 266 (19), 12266-12271 (1991)
   PUBMED   1648089
REFERENCE   10 (bases 1 to 911)
  AUTHORS   Baxa,C.A., Sha,R.S., Buelt,M.K., Smith,A.J., Matarese,V.,
            Chinander,L.L., Boundy,K.L. and Bernlohr,D.A.
  TITLE     Human adipocyte lipid-binding protein: purification of the protein
            and cloning of its complementary DNA
  JOURNAL   Biochemistry 28 (22), 8683-8690 (1989)
   PUBMED   2481498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003672.1, BQ880795.1 and
            AC018616.5.
            
            On May 17, 2019 this sequence version replaced NM_001442.2.
            
            Summary: FABP4 encodes the fatty acid binding protein found in
            adipocytes.  Fatty acid binding proteins are a family of small,
            highly conserved, cytoplasmic proteins that bind long-chain fatty
            acids and other hydrophobic ligands. It is thought that FABPs roles
            include fatty acid uptake, transport, and metabolism. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.184392.1, BC003672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256104.5/ ENSP00000256104.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-636               BC003672.1         1-636
            637-833             BQ880795.1         574-770
            834-911             AC018616.5         28696-28773
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..911
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /note="fatty acid binding protein 4"
                     /db_xref="GeneID:2167"
                     /db_xref="HGNC:HGNC:3559"
                     /db_xref="MIM:600434"
     exon            1..139
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..465
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /note="adipocyte lipid-binding protein; adipocyte-type
                     fatty acid-binding protein; epididymis secretory protein
                     Li 104; fatty acid binding protein 4, adipocyte; adipocyte
                     fatty acid binding protein"
                     /codon_start=1
                     /product="fatty acid-binding protein, adipocyte"
                     /protein_id="NP_001433.1"
                     /db_xref="CCDS:CCDS6230.1"
                     /db_xref="GeneID:2167"
                     /db_xref="HGNC:HGNC:3559"
                     /db_xref="MIM:600434"
                     /translation="MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIIS
                     VNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKS
                     TTIKRKREDDKLVVECVMKGVTSTRVYERA"
     exon            140..312
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /inference="alignment:Splign:2.1.0"
     exon            313..414
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /inference="alignment:Splign:2.1.0"
     exon            415..911
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      618..623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /note="hexamer: AATAAA"
     polyA_site      638
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /note="major polyA site"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
                     /note="hexamer: ATTAAA"
     polyA_site      852
                     /gene="FABP4"
                     /gene_synonym="A-FABP; AFABP; ALBP; aP2; HEL-S-104"
ORIGIN      
        1 acagcaccct cctgaaaact gcagcttcct tctcaccttg aagaataatc ctagaaaact
       61 cacaaaatgt gtgatgcttt tgtaggtacc tggaaacttg tctccagtga aaactttgat
      121 gattatatga aagaagtagg agtgggcttt gccaccagga aagtggctgg catggccaaa
      181 cctaacatga tcatcagtgt gaatggggat gtgatcacca ttaaatctga aagtaccttt
      241 aaaaatactg agatttcctt catactgggc caggaatttg acgaagtcac tgcagatgac
      301 aggaaagtca agagcaccat aaccttagat gggggtgtcc tggtacatgt gcagaaatgg
      361 gatggaaaat caaccaccat aaagagaaaa cgagaggatg ataaactggt ggtggaatgc
      421 gtcatgaaag gcgtcacttc cacgagagtt tatgagagag cataagccaa gggacgttga
      481 cctggactga agttcgcatt gaactctaca acattctgtg ggatatattg ttcaaaaaga
      541 tattgttgtt ttccatgatt tagcaagcaa ctaattttct cccaagctga ttttattcaa
      601 tatggttacg ttggttaaat aaactttttt tagatttaga aggtgatgta atgatgtatt
      661 cattgtgctt atgatgtatt cttagtcata actgagtgaa ggaaatggga aatttgcatt
      721 atttctttgt tctgatatga ataataacat atttcataat aattcaaggt aaaaagggat
      781 atctatggat ttccctaggt aggagataac aagtatgtac cattactgaa tattaaatcc
      841 ttctttacca tagctacagt taagtaggtg tatctcagaa acctaaggta gttttaaatg
      901 tagtgaaatt g
//
