LOCUS       NM_004102               1097 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens fatty acid binding protein 3 (FABP3), transcript
            variant 2, mRNA.
ACCESSION   NM_004102
VERSION     NM_004102.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Michler,S., Schoffmann,F.A., Robaa,D., Volmer,J. and
            Hinderberger,D.
  TITLE     Fatty acid binding to the human transport proteins FABP3, FABP4,
            and FABP5 from a Ligand's perspective
  JOURNAL   J Biol Chem 300 (6), 107396 (2024)
   PUBMED   38777142
  REMARK    GeneRIF: Fatty acid binding to the human transport proteins FABP3,
            FABP4, and FABP5 from a Ligand's perspective.
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Yeh,J.T., Huang,C.C., Leu,H.B., Yin,W.H., Tseng,W.K., Wu,Y.W.,
            Lin,T.H., Yeh,H.I., Chang,K.C., Wang,J.H., Wu,C.C. and Chen,J.W.
  TITLE     Fatty acid-binding protein-3 and renal function decline in patients
            with chronic coronary syndrome
  JOURNAL   Clin Cardiol 47 (1), e24210 (2024)
   PUBMED   38269633
  REMARK    GeneRIF: Fatty acid-binding protein-3 and renal function decline in
            patients with chronic coronary syndrome.
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Sabbatinelli,J., Di Rosa,M., Giuliani,A., Domenichelli,M.,
            Bonfigli,A.R., Sarzani,R., Cherubini,A., Antonicelli,R.,
            Burattini,M., Corsonello,A., Galeazzi,R., Babini,L., Moretti,M.,
            Procopio,A.D., Lattanzio,F. and Olivieri,F.
  TITLE     Serum levels of soluble suppression of tumorigenicity 2 (sST2) and
            heart-type fatty acid binding protein (H-FABP) independently
            predict in-hospital mortality in geriatric patients with COVID-19
  JOURNAL   Mech Ageing Dev 216, 111876 (2023)
   PUBMED   37802485
  REMARK    GeneRIF: Serum levels of soluble suppression of tumorigenicity 2
            (sST2) and heart-type fatty acid binding protein (H-FABP)
            independently predict in-hospital mortality in geriatric patients
            with COVID-19.
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Baru,A., Devi,C., Mukhopadhyay,T. and Dogra,N.
  TITLE     Anti bacterial function of secreted human FABP3
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (12), 130472 (2023)
   PUBMED   37788726
  REMARK    GeneRIF: Anti bacterial function of secreted human FABP3.
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Ahmad,F., Karim,A., Khan,J. and Qaisar,R.
  TITLE     Circulating H-FABP as a biomarker of frailty in patients with
            chronic heart failure
  JOURNAL   Exp Biol Med (Maywood) 248 (16), 1383-1392 (2023)
   PUBMED   37787063
  REMARK    GeneRIF: Circulating H-FABP as a biomarker of frailty in patients
            with chronic heart failure.
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Zanotti,G., Scapin,G., Spadon,P., Veerkamp,J.H. and
            Sacchettini,J.C.
  TITLE     Three-dimensional structure of recombinant human muscle fatty
            acid-binding protein
  JOURNAL   J Biol Chem 267 (26), 18541-18550 (1992)
   PUBMED   1526991
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Peeters,R.A., Veerkamp,J.H., Geurts van Kessel,A., Kanda,T. and
            Ono,T.
  TITLE     Cloning of the cDNA encoding human skeletal-muscle
            fatty-acid-binding protein, its peptide sequence and chromosomal
            localization
  JOURNAL   Biochem J 276 (Pt 1) (Pt 1), 203-207 (1991)
   PUBMED   1710107
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Tanaka,T., Hirota,Y., Sohmiya,K., Nishimura,S. and Kawamura,K.
  TITLE     Serum and urinary human heart fatty acid-binding protein in acute
            myocardial infarction
  JOURNAL   Clin Biochem 24 (2), 195-201 (1991)
   PUBMED   2040092
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Spener,F., Unterberg,C., Borchers,T. and Grosse,R.
  TITLE     Characteristics of fatty acid-binding proteins and their relation
            to mammary-derived growth inhibitor
  JOURNAL   Mol Cell Biochem 98 (1-2), 57-68 (1990)
   PUBMED   2266970
  REMARK    Review article
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Borchers,T., Hojrup,P., Nielsen,S.U., Roepstorff,P., Spener,F. and
            Knudsen,J.
  TITLE     Revision of the amino acid sequence of human heart fatty
            acid-binding protein
  JOURNAL   Mol Cell Biochem 98 (1-2), 127-133 (1990)
   PUBMED   2266954
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007021.1 and AL451070.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004102.4.
            
            Summary: The intracellular fatty acid-binding proteins (FABPs)
            belongs to a multigene family. FABPs are divided into at least
            three distinct types, namely the hepatic-, intestinal- and
            cardiac-type. They form 14-15 kDa proteins and are thought to
            participate in the uptake, intracellular metabolism and/or
            transport of long-chain fatty acids. They may also be responsible
            in the modulation of cell growth and proliferation. Fatty
            acid-binding protein 3 gene contains four exons and its function is
            to arrest growth of mammary epithelial cells. This gene is a
            candidate tumor suppressor gene for human breast cancer.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.53081.1,
                                           SRR5189655.26926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373713.7/ ENSP00000362817.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               BC007021.1         1-410
            411-1097            AL451070.18        98446-99132         c
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..1097
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /note="fatty acid binding protein 3"
                     /db_xref="GeneID:2170"
                     /db_xref="HGNC:HGNC:3557"
                     /db_xref="MIM:134651"
     exon            1..135
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            136..308
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            309..410
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1097
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      674..679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      694
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /note="major polyA site"
     polyA_site      725
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /note="major polyA site"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      890
                     /gene="FABP3"
                     /gene_synonym="FABP11; H-FABP; M-FABP; MDGI; O-FABP"
ORIGIN      
        1 gccgtcggag cccttgcacg cctgctctct tgtagcttct ctcagcctag cccagcatca
       61 ctatggtgga cgctttcctg ggcacctgga agctagtgga cagcaagaat ttcgatgact
      121 acatgaagtc actcggtgtg ggttttgcta ccaggcaggt ggccagcatg accaagccta
      181 ccacaatcat cgaaaagaat ggggacattc tcaccctaaa aacacacagc accttcaaga
      241 acacagagat cagctttaag ttgggggtgg agttcgatga gacaacagca gatgacagga
      301 aggtcaagtc cattgtgaca ctggatggag ggaaacttgt tcacctgcag aaatgggacg
      361 ggcaagagac cacacttgtg cgggagctaa ttgatggaaa actcatcctg acactcaccc
      421 acggcactgc agtttgcact cgcacttatg agaaagaggc atgacctgac tgcactgttg
      481 ctgactacta ctctgccaat cggctacccc tcgactcagc accacattgc ctcatttctt
      541 cctctgcatt ttgtacaaat ccacgaattc ttctggggtc aggtgccact gaccgggatc
      601 cagttccagt tcccatggtg tatgtggttt tttttttttt tttttaactg cactcatagg
      661 gtgctctgag gtcaataaag cagagccaag gccacccagt tgcctttttg cctttggtaa
      721 cataactctg ggagtcttgg tttatcctgt gtgtcagaga gtgggcagaa ataacggcct
      781 gaaggttact gaggaagaag cactggatgg gagactgaaa tggacagtct cggagcctgt
      841 taatcagctg atcaccttac acatttaata ataaaagagc tgtacctaca cgttgccttt
      901 acactgcccc ccctccatgg tcaaatgacc tagttcagtc agtgatgggg cttccccagg
      961 tttggctatt gaactgtcac ttcaggccca tcctacactg aaagctcttg ggtctggctg
     1021 ttctctgtga aatgctgtag tctctccctt tccagaattc aggttcaggg cacagaaccc
     1081 aggcttgtac catggtg
//
