LOCUS       NM_000134               2226 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fatty acid binding protein 2 (FABP2), mRNA.
ACCESSION   NM_000134
VERSION     NM_000134.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Nendl,A., Andersen,G.O., Seljeflot,I., Troseid,M. and Awoyemi,A.
  TITLE     Intestinal fatty acid binding protein is associated with infarct
            size and cardiac function in acute heart failure following
            myocardial infarction
  JOURNAL   Open Heart 11 (2), e002868 (2024)
   PUBMED   39277188
  REMARK    GeneRIF: Intestinal fatty acid binding protein is associated with
            infarct size and cardiac function in acute heart failure following
            myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Ijaz,M., Chen,C.C., Iqbal,R.K., Farooq,H.A., Mehmood,R., Asif,M.,
            Akbar,A., Khan,A., Ijaz,W., Said,M.B., Wondmie,G.F., Ibenmoussa,S.,
            Okla,M.K. and Iqbal,F.
  TITLE     Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are
            potentially associated with colorectal cancer susceptibility
  JOURNAL   Sci Rep 14 (1), 20464 (2024)
   PUBMED   39242607
  REMARK    GeneRIF: Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are
            potentially associated with colorectal cancer susceptibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Sydykova,L.A., Pavlova,N.I., Bochurov,A.A., Alekseev,V.A.,
            Krylov,A.V., Kurtanov,K.A. and Shestakova,M.V.
  TITLE     [Ala54Thr polymorphism of the fatty acid transporter gene (FABP2)
            in patients with type 2 diabetes mellitus in Yakutia]
  JOURNAL   Ter Arkh 95 (10), 845-849 (2023)
   PUBMED   38159016
  REMARK    GeneRIF: [Ala54Thr polymorphism of the fatty acid transporter gene
            (FABP2) in patients with type 2 diabetes mellitus in Yakutia].
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Zhang,Z., Li,H., Weng,H., Zhou,G., Chen,H., Yang,G., Zhang,P.,
            Zhang,X., Ji,Y., Ying,K., Liu,B., Xu,Q., Tang,Y., Zhu,G., Liu,Z.,
            Xia,S., Yang,X., Dong,L., Zhu,L., Zeng,M., Yuan,Y., Yang,Y.,
            Zhang,N., Xu,X., Pang,W., Zhang,M., Zhang,Y., Zhen,K., Wang,D.,
            Lei,J., Wu,S., Shu,S., Zhang,Y., Zhang,S., Gao,Q., Huang,Q.,
            Deng,C., Fu,X., Chen,G., Duan,W., Wan,J., Xie,W., Zhang,P.,
            Wang,S., Yang,P., Zuo,X., Zhai,Z. and Wang,C.
  CONSRTM   China pUlmonary Thromboembolism REgistry Study (CURES)
            investigators
  TITLE     Genome-wide association analyses identified novel susceptibility
            loci for pulmonary embolism among Han Chinese population
  JOURNAL   BMC Med 21 (1), 153 (2023)
   PUBMED   37076872
  REMARK    GeneRIF: Genome-wide association analyses identified novel
            susceptibility loci for pulmonary embolism among Han Chinese
            population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Zaragoza-Garcia,O., Castro-Alarcon,N., Perez-Rubio,G.,
            Falfan-Valencia,R., Briceno,O., Navarro-Zarza,J.E., Parra-Rojas,I.,
            Tello,M. and Guzman-Guzman,I.P.
  TITLE     Serum Levels of IFABP2 and Differences in Lactobacillus and
            Porphyromonas gingivalis Abundance on Gut Microbiota Are Associated
            with Poor Therapeutic Response in Rheumatoid Arthritis: A Pilot
            Study
  JOURNAL   Int J Mol Sci 24 (3), 1958 (2023)
   PUBMED   36768285
  REMARK    GeneRIF: Serum Levels of IFABP2 and Differences in Lactobacillus
            and Porphyromonas gingivalis Abundance on Gut Microbiota Are
            Associated with Poor Therapeutic Response in Rheumatoid Arthritis:
            A Pilot Study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Edwards,A., Hammond,H.A., Jin,L., Caskey,C.T. and Chakraborty,R.
  TITLE     Genetic variation at five trimeric and tetrameric tandem repeat
            loci in four human population groups
  JOURNAL   Genomics 12 (2), 241-253 (1992)
   PUBMED   1740333
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Polymeropoulos,M.H., Rath,D.S., Xiao,H. and Merril,C.R.
  TITLE     Trinucleotide repeat polymorphism at the human intestinal fatty
            acid binding protein gene (FABP2)
  JOURNAL   Nucleic Acids Res 18 (23), 7198 (1990)
   PUBMED   2263509
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Kaikaus,R.M., Bass,N.M. and Ockner,R.K.
  TITLE     Functions of fatty acid binding proteins
  JOURNAL   Experientia 46 (6), 617-630 (1990)
   PUBMED   2193826
  REMARK    Review article
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
            Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Lowe,J.B., Boguski,M.S., Sweetser,D.A., Elshourbagy,N.A.,
            Taylor,J.M. and Gordon,J.I.
  TITLE     Human liver fatty acid binding protein. Isolation of a full length
            cDNA and comparative sequence analyses of orthologous and
            paralogous proteins
  JOURNAL   J Biol Chem 260 (6), 3413-3417 (1985)
   PUBMED   3838313
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC111791.1, BC069466.1 and
            AK025079.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000134.3.
            
            Summary: The protein encoded by this gene is an intracellular fatty
            acid-binding protein that participates in the uptake, intracellular
            metabolism, and transport of long-chain fatty acids. The encoded
            protein is also involved in the modulation of cell growth and
            proliferation. This protein binds saturated long-chain fatty acids
            with high affinity, and may act as a lipid sensor to maintain
            energy homeostasis. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025079.1, BC069466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274024.4/ ENSP00000274024.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-942               BC111791.1         24-965
            943-2078            BC069466.1         957-2092
            2079-2226           AK025079.1         2074-2221
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..2226
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /note="fatty acid binding protein 2"
                     /db_xref="GeneID:2169"
                     /db_xref="HGNC:HGNC:3556"
                     /db_xref="MIM:134640"
     exon            1..103
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..435
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /note="intestinal-type fatty acid-binding protein; fatty
                     acid binding protein 2, intestinal"
                     /codon_start=1
                     /product="fatty acid-binding protein, intestinal"
                     /protein_id="NP_000125.2"
                     /db_xref="CCDS:CCDS3712.1"
                     /db_xref="GeneID:2169"
                     /db_xref="HGNC:HGNC:3556"
                     /db_xref="MIM:134640"
                     /translation="MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQE
                     GNKFTVKESSTFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNE
                     LNTVREIIGDELVQTYVYEGVEAKRIFKKD"
     exon            104..276
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            277..384
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            385..2226
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      675..680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /note="hexamer: AATAAA"
     polyA_site      701
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /note="major polyA site"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
                     /note="hexamer: TATAAA"
     polyA_site      2226
                     /gene="FABP2"
                     /gene_synonym="FABPI; I-FABP"
ORIGIN      
        1 atctctagct gcctagaggc tgactcaact gaaatcatgg cgtttgacag cacttggaag
       61 gtagaccgga gtgaaaacta tgacaagttc atggaaaaaa tgggtgttaa tatagtgaaa
      121 aggaagcttg cagctcatga caatttgaag ctgacaatta cacaagaagg aaataaattc
      181 acagtcaaag aatcaagcac ttttcgaaac attgaagttg tttttgaact tggtgtcacc
      241 tttaattaca atctagcaga cggaactgaa ctcaggggga cctggagcct tgagggaaat
      301 aaacttattg gaaaattcaa acggacagac aatggaaacg aactgaatac tgtccgagaa
      361 attataggtg atgaactagt ccagacttat gtatatgaag gagtagaagc caaaaggatc
      421 tttaaaaagg attgagcatt attcttggcg cacagtccaa aatacaaatt ggacagaaga
      481 tctatattgt accagaacta tttatttcac cccatcaagt ataaggttac tgattgattg
      541 gtccttttat aaacattggt atatttccat tcatgccaaa gcaaaagaag taaaagctaa
      601 ttaggattta atttgtttta tattctctaa gatatatatt tactaaaaga atttgtgaca
      661 ttttaaaaaa caaaaataaa tattgcgtcc atgttgcttt atatgtagcc ttgcctttta
      721 aaagaaaaag tatgtgaata tgaattgaca gactgttttc gtagagagag ggtcttactc
      781 tttcactcag gctggaatgt agtggagaga tcatagctca ctgtaacctc aaactcctgg
      841 actcatgcaa tcttcctgcc tcaggcttct gagtagctag gactatgggt acattccaca
      901 gtgcccagct aatttttgtt ttgttttctt tttatttttt ttagagatgg ggtcttgcta
      961 tattgcccag gctggtcttg aacccctggc ctcaagcaat cctcctgcct cagcctctca
     1021 agttgttttt tttctttaca tttgataaac taaaagcata ggctgcatat gagtctttaa
     1081 catcttgaac tggttgtgaa taattttctg gcactggttg taagtaatat ctattattat
     1141 aaaaataata tatgctcaac cagaaaactt agaaataaga aacacaaatg taaaataagt
     1201 atttccataa ctcataatcc agagataatt gccattctga ttttgataga tatcctctca
     1261 gctctcttcc ctgggggcag atatttccca atacatacca ctttgaatag gatgatagga
     1321 aataaatgat gtactacatt aaattaaatt attgtattac atttttgtac acatcagtca
     1381 ttcccacgct tggctgaaaa tcaggatcat ctgagaaact taaacaattt ctgcattctt
     1441 aatctccact gttattctat tatatcagaa tcgctaatag aaccaagaat tctagaaaat
     1501 ttcctggtga ttctgatgca gcctgtccac taacttgtct ttgagaacaa tggagatatc
     1561 agttatcaat gttattttta accaccccct tcttttttgt tgttgtgggt tttttcacat
     1621 aaacacatac attgccaatt ttccagggct caaaaagttt ccttttattc atattttcac
     1681 atgacgtaaa attttatgtg cttcacataa ttgtatttta gcagggtaca tattagggga
     1741 tggagagggg gtacaatttt taagcatttg cagctgcaac tctatagact tttgacaaat
     1801 tctttttcac actgatgtag ataacagctt aacatttaca tagttcttac tacttgccac
     1861 acactgttct aagtggtata tacatatgac atatatatta aaatgtagga agaaaaatgt
     1921 ttgagtacct gatgaaaatg aatagagagt atgtaatctt tgaaagctga atactgcgtg
     1981 ttctcactta taagtgggag ctaaataatg tatacacatg gacacaccag agtgtagaat
     2041 aatagacact ggagacttgg aagagttgga gggttggcag ggggcgatga taatttactt
     2101 aatgggtaca atgtacatta ttcagggggt gatggttaca gcccagactt taccactatg
     2161 caatatatca atgtaacaaa actatacttg tactccttaa atttatataa aaatacctta
     2221 aatcta
//
