LOCUS       NM_001105281             629 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fatty acid binding protein 12 (FABP12), transcript
            variant 1, mRNA.
ACCESSION   NM_001105281 XM_005251285 XM_929407
VERSION     NM_001105281.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 629)
  AUTHORS   Liu,R.Z., Choi,W.S., Jain,S., Dinakaran,D., Xu,X., Han,W.H.,
            Yang,X.H., Glubrecht,D.D., Moore,R.B., Lemieux,H. and Godbout,R.
  TITLE     The FABP12/PPARgamma pathway promotes metastatic transformation by
            inducing epithelial-to-mesenchymal transition and lipid-derived
            energy production in prostate cancer cells
  JOURNAL   Mol Oncol 14 (12), 3100-3120 (2020)
   PUBMED   33031638
  REMARK    GeneRIF: The FABP12/PPARgamma pathway promotes metastatic
            transformation by inducing epithelial-to-mesenchymal transition and
            lipid-derived energy production in prostate cancer cells.
REFERENCE   2  (bases 1 to 629)
  AUTHORS   Huang,Y., Cai,C., Ren,L., Cui,C., Zhang,X. and Liu,W.
  TITLE     Marie Unna hereditary hypotrichosis accompanied by multiple
            familial trichoepithelioma in a Chinese family
  JOURNAL   J Dermatol 46 (5), 413-417 (2019)
   PUBMED   30809827
  REMARK    GeneRIF: Study in a large, five-generation Han Chinese family with
            several patients presenting with Marie Unna hereditary
            hypotrichosis (MUHH) and multiple familial trichoepithelioma (MFT)
            revealed that the c.1A>G mutation in HR (U2HR) was present in all
            MUHH patients. No pathogenic variants were found in EPS8L3 or CYLD
            in any family members but FABP12 (rs536105592 G>A) was identified
            in the patients with both MUHH and MFT.
REFERENCE   3  (bases 1 to 629)
  AUTHORS   Liu,R.Z., Li,X. and Godbout,R.
  TITLE     A novel fatty acid-binding protein (FABP) gene resulting from
            tandem gene duplication in mammals: transcription in rat retina and
            testis
  JOURNAL   Genomics 92 (6), 436-445 (2008)
   PUBMED   18786628
  REMARK    GeneRIF: FABP12 arose as the result of tandem gene duplication, a
            mechanism that may have been instrumental to the expansion of the
            FABP family.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023644.6.
            
            On Mar 1, 2023 this sequence version replaced NM_001105281.5.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: EU733650.1, BC146981.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000360464.6/ ENSP00000353650.4
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC023644.6         31381-31446
            67-214              AC023644.6         33858-34005
            215-387             AC023644.6         35638-35810
            388-489             AC023644.6         38127-38228
            490-629             AC023644.6         40128-40267
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..629
                     /gene="FABP12"
                     /note="fatty acid binding protein 12"
                     /db_xref="GeneID:646486"
                     /db_xref="HGNC:HGNC:34524"
                     /db_xref="MIM:618923"
     exon            1..66
                     /gene="FABP12"
                     /inference="alignment:Splign:2.1.0"
     exon            67..214
                     /gene="FABP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..564
                     /gene="FABP12"
                     /note="intracellular fatty acid-binding protein FABP12;
                     fatty acid binding protein ORF; Probable fatty
                     acid-binding protein ENSP00000353650"
                     /codon_start=1
                     /product="fatty acid-binding protein 12"
                     /protein_id="NP_001098751.1"
                     /db_xref="CCDS:CCDS47882.1"
                     /db_xref="GeneID:646486"
                     /db_xref="HGNC:HGNC:34524"
                     /db_xref="MIM:618923"
                     /translation="MIDQLQGTWKSISCENSEDYMKELGIGRASRKLGRLAKPTVTIS
                     TDGDVITIKTKSIFKNNEISFKLGEEFEEITPGGHKTKSKVTLDKESLIQVQDWDGKE
                     TTITRKLVDGKMVVESTVNSVICTRTYEKVSSNSVSNS"
     exon            215..387
                     /gene="FABP12"
                     /inference="alignment:Splign:2.1.0"
     exon            388..489
                     /gene="FABP12"
                     /inference="alignment:Splign:2.1.0"
     exon            490..629
                     /gene="FABP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      605..610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FABP12"
                     /note="hexamer: AATAAA"
     polyA_site      629
                     /gene="FABP12"
                     /note="major polyA site"
ORIGIN      
        1 agaagtccat cgtgagatca gattgtgcat ctggggtcaa gcctaaacaa gaccagaagt
       61 cctaagttcc catactactt cagggaaaac cagcatacac atgaaactac tgttctttga
      121 gatcaactta tctcagacag aatgattgac cagctccaag gaacatggaa gtccatttct
      181 tgtgaaaatt ccgaagacta catgaaggag ctgggtatag gaagagccag caggaaactg
      241 ggccgtttgg caaaacccac tgtgaccatc agtacagatg gagatgtcat cacaataaaa
      301 accaaaagca tctttaaaaa taatgagatc tcctttaagc tgggagaaga gtttgaggaa
      361 atcacgccag gtggccacaa aacaaagagt aaagtaacct tagataagga gtccctgatt
      421 caagttcagg actgggatgg caaagaaacc accataacga gaaagctggt ggatgggaaa
      481 atggtggtgg aaagtactgt gaacagtgtt atctgtacac gaacatacga gaaagtatca
      541 tcaaactcag tctcaaactc ttaaggcttt ctcaagctgt catccaaact actgaggttg
      601 tttaaataaa actccaaagt aaaatatta
//
