LOCUS       NM_001443                501 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.
ACCESSION   NM_001443
VERSION     NM_001443.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Qiu,S., Liu,Z., Hu,J., Wang,Z., Yue,Z., Jia,Z., Zhang,W., Xue,Z.,
            Liu,Z. and Liu,Y.
  TITLE     Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker
            for Gallbladder Cancer with Direct Hepatic Invasion
  JOURNAL   Int J Med Sci 21 (5), 862-873 (2024)
   PUBMED   38617005
  REMARK    GeneRIF: Fatty Acid Binding Protein 1 is an Independent Prognostic
            Biomarker for Gallbladder Cancer with Direct Hepatic Invasion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Lin,L.C. and Wu,V.C.
  TITLE     Unravelling the role of urinary liver-type fatty acid binding
            protein in histone-induced AKI
  JOURNAL   Nephrology (Carlton) 29 (3), 115-116 (2024)
   PUBMED   38246168
  REMARK    GeneRIF: Unravelling the role of urinary liver-type fatty acid
            binding protein in histone-induced AKI.
REFERENCE   3  (bases 1 to 501)
  AUTHORS   You,H., Wen,X., Wang,X., Zhu,C., Chen,H., Bu,L., Zhang,J. and Qu,S.
  TITLE     Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting
            ubiquitylation and degradation of FABP1
  JOURNAL   Free Radic Biol Med 207, 260-271 (2023)
   PUBMED   37499886
  REMARK    GeneRIF: Derlin-1 ameliorates nonalcoholic hepatic steatosis by
            promoting ubiquitylation and degradation of FABP1.
REFERENCE   4  (bases 1 to 501)
  AUTHORS   Valizadeh,M., Aghasizadeh,M., Shaghi,F., Moradi,A., Afshari,H.S.T.,
            Zare-Feyzabadi,R., Saberi-Karimian,M., Hashemi,M., Doust,F.N.S.,
            Nematy,M., Bahre,E.A., Aghaei-Bakhtiari,S.H., Ghazizadeh,H.,
            Safarian-Bana,H., Shabani,N., Esmaily,H., Ferns,G.A., Pasdar,A. and
            Ghayour-Mobarhan,M.
  TITLE     Association between the rs2241883 polymorphism of the fatty
            acid-binding protein-1 (FABP1) gene and obesity in a population of
            MASHAD study cohort
  JOURNAL   Mol Genet Genomic Med 11 (7), e2173 (2023)
   PUBMED   37026586
  REMARK    GeneRIF: Association between the rs2241883 polymorphism of the
            fatty acid-binding protein-1 (FABP1) gene and obesity in a
            population of MASHAD study cohort.
REFERENCE   5  (bases 1 to 501)
  AUTHORS   Abo El-Asrar,M., Ismail,E.A.R., Elnhrawy,A.M. and Thabet,R.A.
  TITLE     Fatty acid binding protein 1 (FABP1) and fatty acid binding protein
            2 (FABP2) as a link between diabetic nephropathy and subclinical
            atherosclerosis in children and adolescents with type 1 diabetes
  JOURNAL   J Diabetes Complications 37 (3), 108414 (2023)
   PUBMED   36758511
  REMARK    GeneRIF: Fatty acid binding protein 1 (FABP1) and fatty acid
            binding protein 2 (FABP2) as a link between diabetic nephropathy
            and subclinical atherosclerosis in children and adolescents with
            type 1 diabetes.
REFERENCE   6  (bases 1 to 501)
  AUTHORS   Carroll,S.L., Roth,K.A. and Gordon,J.I.
  TITLE     Liver fatty acid-binding protein: a marker for studying cellular
            differentiation in gut epithelial neoplasms
  JOURNAL   Gastroenterology 99 (6), 1727-1735 (1990)
   PUBMED   1699834
REFERENCE   7  (bases 1 to 501)
  AUTHORS   Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
            Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
REFERENCE   8  (bases 1 to 501)
  AUTHORS   Chen,S.H., Van Tuinen,P., Ledbetter,D.H., Smith,L.C. and Chan,L.
  TITLE     Human liver fatty acid binding protein gene is located on
            chromosome 2
  JOURNAL   Somat Cell Mol Genet 12 (3), 303-306 (1986)
   PUBMED   3012800
REFERENCE   9  (bases 1 to 501)
  AUTHORS   Lowe,J.B., Boguski,M.S., Sweetser,D.A., Elshourbagy,N.A.,
            Taylor,J.M. and Gordon,J.I.
  TITLE     Human liver fatty acid binding protein. Isolation of a full length
            cDNA and comparative sequence analyses of orthologous and
            paralogous proteins
  JOURNAL   J Biol Chem 260 (6), 3413-3417 (1985)
   PUBMED   3838313
REFERENCE   10 (bases 1 to 501)
  AUTHORS   Chan,L., Wei,C.F., Li,W.H., Yang,C.Y., Ratner,P., Pownall,H.,
            Gotto,A.M. Jr. and Smith,L.C.
  TITLE     Human liver fatty acid binding protein cDNA and amino acid
            sequence. Functional and evolutionary implications
  JOURNAL   J Biol Chem 260 (5), 2629-2632 (1985)
   PUBMED   3838309
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022287.1, M10617.1 and
            BP263155.1.
            
            On May 17, 2019 this sequence version replaced NM_001443.2.
            
            Summary: This gene encodes the fatty acid binding protein found in
            liver. Fatty acid binding proteins are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands. This protein and FABP6 (the ileal
            fatty acid binding protein) are also able to bind bile acids. It is
            thought that FABPs roles include fatty acid uptake, transport, and
            metabolism. [provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP328913.1, BM768288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295834.8/ ENSP00000295834.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BC022287.1         55-84
            31-492              M10617.1           1-462
            493-501             BP263155.1         406-414
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..501
                     /gene="FABP1"
                     /gene_synonym="FABPL; L-FABP"
                     /note="fatty acid binding protein 1"
                     /db_xref="GeneID:2168"
                     /db_xref="HGNC:HGNC:3555"
                     /db_xref="MIM:134650"
     exon            1..112
                     /gene="FABP1"
                     /gene_synonym="FABPL; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..429
                     /gene="FABP1"
                     /gene_synonym="FABPL; L-FABP"
                     /note="liver-type fatty acid-binding protein; fatty acid
                     binding protein 1, liver"
                     /codon_start=1
                     /product="fatty acid-binding protein, liver"
                     /protein_id="NP_001434.1"
                     /db_xref="CCDS:CCDS2001.1"
                     /db_xref="GeneID:2168"
                     /db_xref="HGNC:HGNC:3555"
                     /db_xref="MIM:134650"
                     /translation="MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQN
                     GKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVT
                     ELNGDIITNTMTLGDIVFKRISKRI"
     exon            113..285
                     /gene="FABP1"
                     /gene_synonym="FABPL; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            286..378
                     /gene="FABP1"
                     /gene_synonym="FABPL; L-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..501
                     /gene="FABP1"
                     /gene_synonym="FABPL; L-FABP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagagccg caggtcagtc gtgaagaggg agctctattg ccaccatgag tttctccggc
       61 aagtaccaac tgcagagcca ggaaaacttt gaagccttca tgaaggcaat cggtctgccg
      121 gaagagctca tccagaaggg gaaggatatc aagggggtgt cggaaatcgt gcagaatggg
      181 aagcacttca agttcaccat caccgctggg tccaaagtga tccaaaacga attcacggtg
      241 ggggaggaat gtgagctgga gacaatgaca ggggagaaag tcaagacagt ggttcagttg
      301 gaaggtgaca ataaactggt gacaactttc aaaaacatca agtctgtgac cgaactcaac
      361 ggcgacataa tcaccaatac catgacattg ggtgacattg tcttcaagag aatcagcaag
      421 agaatttaaa caagtctgca tttcatatta ttttagtgtg taaaattaat gtaataaagt
      481 gaactttgtt ttaaaaaaaa a
//
