LOCUS       NM_001441               2042 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fatty acid amide hydrolase (FAAH), mRNA.
ACCESSION   NM_001441
VERSION     NM_001441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Lopez-Cortes,O.D., Trujillo-Sanchez,F., Sierra-Ruelas,E.,
            Martinez-Lopez,E., Di Marzo,V. and Vizmanos,B.
  TITLE     Association between the FAAH C385A variant (rs324420) and
            obesity-related traits: a systematic review
  JOURNAL   Int J Obes (Lond) 48 (2), 188-201 (2024)
   PUBMED   38114812
  REMARK    GeneRIF: Association between the FAAH C385A variant (rs324420) and
            obesity-related traits: a systematic review.
            Review article
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Sierra-Ruelas,E., Torres-Castillo,N., Vizmanos,B., Campos-Perez,W.,
            Lopez-Cortes,O.D., Di Marzo,V. and Martinez-Lopez,E.
  TITLE     FAAH Pro129Thr Variant Is Associated with Increased Cholesterol
            Levels in Normal-Weight Metabolically Unhealthy Subjects
  JOURNAL   Metab Syndr Relat Disord 21 (8), 435-442 (2023)
   PUBMED   37433211
  REMARK    GeneRIF: FAAH Pro129Thr Variant Is Associated with Increased
            Cholesterol Levels in Normal-Weight Metabolically Unhealthy
            Subjects.
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Bornscheuer,L., Lundin,A., Forsell,Y., Lavebratt,C. and Melas,P.A.
  TITLE     Functional Variation in the FAAH Gene Is Directly Associated with
            Subjective Well-Being and Indirectly Associated with Problematic
            Alcohol Use
  JOURNAL   Genes (Basel) 14 (9), 1826 (2023)
   PUBMED   37761966
  REMARK    GeneRIF: Functional Variation in the FAAH Gene Is Directly
            Associated with Subjective Well-Being and Indirectly Associated
            with Problematic Alcohol Use.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Tundidor,I., Seijo-Vila,M., Blasco-Benito,S., Rubert-Hernandez,M.,
            Adamez,S., Andradas,C., Manzano,S., Alvarez-Lopez,I.,
            Sarasqueta,C., Villa-Morales,M., Gonzalez-Lois,C.,
            Ramirez-Medina,E., Almoguera,B., Sanchez-Lopez,A.J., Bindila,L.,
            Hamann,S., Arnold,N., Rocken,C., Heras-Murillo,I., Sancho,D.,
            Moreno-Bueno,G., Caffarel,M.M., Guzman,M., Sanchez,C. and
            Perez-Gomez,E.
  TITLE     Identification of fatty acid amide hydrolase as a metastasis
            suppressor in breast cancer
  JOURNAL   Nat Commun 14 (1), 3130 (2023)
   PUBMED   37253733
  REMARK    GeneRIF: Identification of fatty acid amide hydrolase as a
            metastasis suppressor in breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Silva,H.H., Tavares,V., Silva,M.G., Neto,B.V., Cerqueira,F. and
            Medeiros,R.
  TITLE     Association of FAAH rs324420 (C385A) Polymorphism with High-Level
            Performance in Volleyball Players
  JOURNAL   Genes (Basel) 14 (6), 1164 (2023)
   PUBMED   37372343
  REMARK    GeneRIF: Association of FAAH rs324420 (C385A) Polymorphism with
            High-Level Performance in Volleyball Players.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Wan,M., Cravatt,B.F., Ring,H.Z., Zhang,X. and Francke,U.
  TITLE     Conserved chromosomal location and genomic structure of human and
            mouse fatty-acid amide hydrolase genes and evaluation of clasper as
            a candidate neurological mutation
  JOURNAL   Genomics 54 (3), 408-414 (1998)
   PUBMED   9878243
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Maccarrone,M., van der Stelt,M., Rossi,A., Veldink,G.A.,
            Vliegenthart,J.F. and Agro,A.F.
  TITLE     Anandamide hydrolysis by human cells in culture and brain
  JOURNAL   J Biol Chem 273 (48), 32332-32339 (1998)
   PUBMED   9822713
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Patricelli,M.P., Lashuel,H.A., Giang,D.K., Kelly,J.W. and
            Cravatt,B.F.
  TITLE     Comparative characterization of a wild type and transmembrane
            domain-deleted fatty acid amide hydrolase: identification of the
            transmembrane domain as a site for oligomerization
  JOURNAL   Biochemistry 37 (43), 15177-15187 (1998)
   PUBMED   9790682
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Patricelli,M.P., Patterson,J.E., Boger,D.L. and Cravatt,B.F.
  TITLE     An endogenous sleep-inducing compound is a novel competitive
            inhibitor of fatty acid amide hydrolase
  JOURNAL   Bioorg Med Chem Lett 8 (6), 613-618 (1998)
   PUBMED   9871570
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Giang,D.K. and Cravatt,B.F.
  TITLE     Molecular characterization of human and mouse fatty acid amide
            hydrolases
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2238-2242 (1997)
   PUBMED   9122178
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL122001.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001441.2.
            
            Summary: This gene encodes a protein that is responsible for the
            hydrolysis of a number of primary and secondary fatty acid amides,
            including the neuromodulatory compounds anandamide and oleamide.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U82535.1, SRR1803614.46089.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243167.9/ ENSP00000243167.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AL122001.32        29406-29632         c
            228-341             AL122001.32        21745-21858         c
            342-476             AL122001.32        18801-18935         c
            477-610             AL122001.32        18444-18577         c
            611-817             AL122001.32        18155-18361         c
            818-858             AL122001.32        17871-17911         c
            859-983             AL122001.32        17581-17705         c
            984-1109            AL122001.32        15365-15490         c
            1110-1207           AL122001.32        14751-14848         c
            1208-1307           AL122001.32        13452-13551         c
            1308-1348           AL122001.32        13095-13135         c
            1349-1388           AL122001.32        12298-12337         c
            1389-1497           AL122001.32        11698-11806         c
            1498-1643           AL122001.32        10729-10874         c
            1644-2042           AL122001.32        10104-10502         c
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2042
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /note="fatty acid amide hydrolase"
                     /db_xref="GeneID:2166"
                     /db_xref="HGNC:HGNC:3553"
                     /db_xref="MIM:602935"
     exon            1..227
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1772
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /EC_number="3.5.1.99"
                     /note="oleamide hydrolase 1; anandamide amidohydrolase 1;
                     fatty acid ester hydrolase"
                     /codon_start=1
                     /product="fatty-acid amide hydrolase 1"
                     /protein_id="NP_001432.2"
                     /db_xref="CCDS:CCDS535.1"
                     /db_xref="GeneID:2166"
                     /db_xref="HGNC:HGNC:3553"
                     /db_xref="MIM:602935"
                     /translation="MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRA
                     RQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVG
                     KAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNE
                     GVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSS
                     GGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAV
                     RLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDN
                     YTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNF
                     KGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHE
                     IEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVP
                     VTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMR
                     EVERLMTPEKQSS"
     exon            228..341
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            342..476
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            477..610
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            611..817
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            818..858
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            859..983
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1109
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1207
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1307
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1348
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1388
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1497
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1643
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..2042
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2042
                     /gene="FAAH"
                     /gene_synonym="FAAH-1; FAAH1; PSAB"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcggtag gcagcagcag gctgaaggga tcatggtgca gtacgagctg tgggccgcgc
       61 tgcctggcgc ctccggggtc gccctggcct gctgcttcgt ggcggcggcc gtggccctgc
      121 gctggtccgg gcgccggacg gcgcggggcg cggtggtccg ggcgcgacag aggcagcgag
      181 cgggcctgga gaacatggac agggcggcgc agcgcttccg gctccagaac ccagacctgg
      241 actcagaggc gctgctagcc ctgcccctgc ctcagctggt gcagaagtta cacagtagag
      301 agctggcccc tgaggccgtg ctcttcacct atgtgggaaa ggcctgggaa gtgaacaaag
      361 ggaccaactg tgtgacctcc tatctggctg actgtgagac tcagctgtct caggccccaa
      421 ggcagggcct gctctatggc gtccctgtga gcctcaagga gtgcttcacc tacaagggcc
      481 aggactccac gctgggcttg agcctgaatg aaggggtgcc ggcggagtgc gacagcgtag
      541 tggtgcatgt gctgaagctg cagggtgccg tgcccttcgt gcacaccaat gttccacagt
      601 ccatgttcag ctatgactgc agtaaccccc tctttggcca gaccgtgaac ccatggaagt
      661 cctccaaaag cccagggggc tcctcagggg gtgaaggggc cctcatcggg tctggaggct
      721 cccccctggg cttaggcact gatatcggag gcagcatccg cttcccctcc tccttctgcg
      781 gcatctgcgg cctcaagccc acagggaacc gcctcagcaa gagtggcctg aagggctgtg
      841 tctatggaca ggaggcagtg cgtctctccg tgggccccat ggcccgggac gtggagagcc
      901 tggcactgtg cctgcgagcc ctgctgtgtg aggacatgtt ccgcttggac cccactgtgc
      961 ctcccttgcc cttcagagaa gaggtctaca ccagctctca gcccctgcgt gtggggtact
     1021 atgagactga caactatacc atgccctccc cggccatgag gcgggccgtg ctggagacca
     1081 aacagagcct tgaggctgcg gggcacacgc tggttccctt cttgccaagc aacatacccc
     1141 atgctctgga gaccctgtca acaggtgggc tcttcagtga tggtggccac accttcctac
     1201 agaacttcaa aggtgatttc gtggacccct gcctggggga cctggtctca attctgaagc
     1261 ttccccaatg gcttaaagga ctgctggcct tcctggtgaa gcctctgctg ccaaggctgt
     1321 cagctttcct cagcaacatg aagtctcgtt cggctggaaa actctgggaa ctgcagcacg
     1381 agatcgaggt gtaccgcaaa accgtgattg cccagtggag ggcgctggac ctggatgtgg
     1441 tgctgacccc catgctggcc cctgctctgg acttgaatgc cccaggcagg gccacagggg
     1501 ccgtcagcta cactatgctg tacaactgcc tggacttccc tgcaggggtg gtgcctgtca
     1561 ccacggtgac tgctgaggac gaggcccaga tggaacatta caggggctac tttggggata
     1621 tctgggacaa gatgctgcag aagggcatga agaagagtgt ggggctgccg gtggccgtgc
     1681 agtgtgtggc tctgccctgg caagaagagt tgtgtctgcg gttcatgcgg gaggtggagc
     1741 gactgatgac ccctgaaaag cagtcatcct gatggctctg gctccagagg acctgagact
     1801 cacactctct gcagcccagc ctagtcaggg cacagctgcc ctgctgccac agcaaggaaa
     1861 tgtcctgcat ggggcagagg cttccgtgtc ctctccccca accccctgca agaagcgccg
     1921 actccctgag tctggacctc catccctgct ctggtcccct ctcttcgtcc tgatccctcc
     1981 acccccatgt ggcagcccat gggtatgaca taggccaagg cccaactaac agtcaagaaa
     2041 ca
//
