LOCUS       NM_003950               3334 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.
ACCESSION   NM_003950
VERSION     NM_003950.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Andrianova,I., Kowalczyk,M. and Denorme,F.
  TITLE     Protease activated receptor-4: ready to be part of the
            antithrombosis spectrum
  JOURNAL   Curr Opin Hematol 31 (5), 238-244 (2024)
   PUBMED   38814792
  REMARK    GeneRIF: Protease activated receptor-4: ready to be part of the
            antithrombosis spectrum.
            Review article
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Deng,L., Cao,C., Cai,Z., Wang,Z., Leng,B., Chen,Z., Kong,F.,
            Zhou,Z., He,J., Nie,X. and Bian,J.S.
  TITLE     STING Contributes to Pulmonary Hypertension by Targeting IFN and
            BMPR2 Signaling through Regulating of F2RL3
  JOURNAL   Am J Respir Cell Mol Biol 71 (3), 356-371 (2024)
   PUBMED   38864771
  REMARK    GeneRIF: STING Contributes to Pulmonary Hypertension by Targeting
            IFN and BMPR2 Signaling through Regulating of F2RL3.
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Pelland-St-Pierre,L., Pham,M.C., Nguyen,A.Q.H., Pasquet,R.,
            Taylor,S.A., Bosson-Rieutort,D., Koushik,A. and Ho,V.
  TITLE     The Influence of Smoking and Occupational Risk Factors on DNA
            Methylation in the AHRR and F2RL3 Genes
  JOURNAL   Cancer Epidemiol Biomarkers Prev 33 (2), 224-233 (2024)
   PUBMED   38051301
  REMARK    GeneRIF: The Influence of Smoking and Occupational Risk Factors on
            DNA Methylation in the AHRR and F2RL3 Genes.
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Denorme,F., Armstrong,N.D., Stoller,M.L., Portier,I.,
            Tugolukova,E.A., Tanner,R.M., Montenont,E., Bhatlekar,S., Cody,M.,
            Rustad,J.L., Ajanel,A., Tolley,N.D., Murray,D.C., Boyle,J.L.,
            Nieman,M.T., McKenzie,S.E., Yost,C.C., Lange,L.A., Cushman,M.,
            Irvin,M.R., Bray,P.F. and Campbell,R.A.
  TITLE     The predominant PAR4 variant in individuals of African ancestry
            worsens murine and human stroke outcomes
  JOURNAL   J Clin Invest 133 (18), e169608 (2023)
   PUBMED   37471144
  REMARK    GeneRIF: The predominant PAR4 variant in individuals of African
            ancestry worsens murine and human stroke outcomes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Su,Q., Shen,G. and Xu,G.
  TITLE     Strong correlation between F2RL3 in the blood and osteoarthritis
            based on a retrospective cohort study
  JOURNAL   Medicine (Baltimore) 102 (21), e33657 (2023)
   PUBMED   37233402
  REMARK    GeneRIF: Strong correlation between F2RL3 in the blood and
            osteoarthritis based on a retrospective cohort study.
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Kahn,M.L., Zheng,Y.W., Huang,W., Bigornia,V., Zeng,D., Moff,S.,
            Farese,R.V. Jr., Tam,C. and Coughlin,S.R.
  TITLE     A dual thrombin receptor system for platelet activation
  JOURNAL   Nature 394 (6694), 690-694 (1998)
   PUBMED   9716134
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Xu,W.F., Andersen,H., Whitmore,T.E., Presnell,S.R., Yee,D.P.,
            Ching,A., Gilbert,T., Davie,E.W. and Foster,D.C.
  TITLE     Cloning and characterization of human protease-activated receptor 4
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6642-6646 (1998)
   PUBMED   9618465
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Ogino,Y., Tanaka,K. and Shimizu,N.
  TITLE     Direct evidence for two distinct G proteins coupling with thrombin
            receptors in human neuroblastoma SH-EP cells
  JOURNAL   Eur J Pharmacol 316 (1), 105-109 (1996)
   PUBMED   8982657
REFERENCE   9  (bases 1 to 3334)
  AUTHORS   Offermanns,S., Laugwitz,K.L., Spicher,K. and Schultz,G.
  TITLE     G proteins of the G12 family are activated via thromboxane A2 and
            thrombin receptors in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 504-508 (1994)
   PUBMED   8290554
REFERENCE   10 (bases 1 to 3334)
  AUTHORS   Shenker,A., Goldsmith,P., Unson,C.G. and Spiegel,A.M.
  TITLE     The G protein coupled to the thromboxane A2 receptor in human
            platelets is a member of the novel Gq family
  JOURNAL   J Biol Chem 266 (14), 9309-9313 (1991)
   PUBMED   1851174
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP281855.1, AC008737.11,
            BQ269855.1 and AF055917.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003950.3.
            
            Summary: This gene encodes a member of the protease-activated
            receptor subfamily, part of the G-protein coupled receptor 1 family
            of proteins. The encoded receptor is proteolytically processed to
            reveal an extracellular N-terminal tethered ligand that binds to
            and activates the receptor. This receptor plays a role in blood
            coagulation, inflammation and response to pain. Hypomethylation at
            this gene may be associated with lung cancer in human patients.
            [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138516.858413.1, AF080214.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248076.4/ ENSP00000248076.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BP281855.1         139-225
            88-88               AC008737.11        204821-204821
            89-623              BQ269855.1         79-613
            624-3328            AF055917.1         608-3312
            3329-3334           AC008737.11        208336-208341
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3334
                     /gene="F2RL3"
                     /gene_synonym="PAR4"
                     /note="F2R like thrombin or trypsin receptor 3"
                     /db_xref="GeneID:9002"
                     /db_xref="HGNC:HGNC:3540"
                     /db_xref="MIM:602779"
     exon            1..300
                     /gene="F2RL3"
                     /gene_synonym="PAR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1349
                     /gene="F2RL3"
                     /gene_synonym="PAR4"
                     /note="protease-activated receptor-4; proteinase-activated
                     receptor 4; PAR-4; thrombin receptor-like 3; coagulation
                     factor II (thrombin) receptor-like 3; F2R like
                     thrombin/trypsin receptor 3"
                     /codon_start=1
                     /product="proteinase-activated receptor 4 preproprotein"
                     /protein_id="NP_003941.2"
                     /db_xref="CCDS:CCDS12350.1"
                     /db_xref="GeneID:9002"
                     /db_xref="HGNC:HGNC:3540"
                     /db_xref="MIM:602779"
                     /translation="MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILP
                     APRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVL
                     ATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHM
                     YGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTF
                     RLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGR
                     RYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSC
                     VDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ"
     exon            301..3334
                     /gene="F2RL3"
                     /gene_synonym="PAR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2727..2732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2RL3"
                     /gene_synonym="PAR4"
                     /note="hexamer: AATAAA"
     polyA_site      2747
                     /gene="F2RL3"
                     /gene_synonym="PAR4"
                     /note="major polyA site"
ORIGIN      
        1 aacccacact ccagtcctcc cacgggctgg ctggcaagcg gccctggtgg gtctgcgggg
       61 gcaggggcag ccttcctggt ttatctctac cggcgcgatc tgctcgtccg cctcggctcc
      121 agaagctggg gctcagggtc cggcgaggca ggaagcctga ggccacagcc cagagcagcc
      181 tgagtgcagt catgtggggg cgactgctcc tgtggcccct ggtgctgggg ttcagcctgt
      241 ctggcggcac ccagaccccc agcgtctacg acgagagcgg gagcaccgga ggtggtgatg
      301 acagcacgcc ctcaatcctg cctgcccccc gcggctaccc aggccaagtc tgtgccaatg
      361 acagtgacac cctggagctc ccggacagct cacgggcact gcttctgggc tgggtgccca
      421 ccaggctggt gcccgccctc tatgggctgg tcctggtggt ggggctgccg gccaatgggc
      481 tggcgctgtg ggtgctggcc acgcaggcac ctcggctgcc ctccaccatg ctgctgatga
      541 acctcgcggc tgctgacctc ctgctggccc tggcgctgcc cccgcggatc gcctaccacc
      601 tgcgtggcca gcgctggccc ttcggggagg ccgcctgccg cctggccacg gccgcactct
      661 atggtcacat gtatggctca gtgctgctgc tggccgccgt cagcctggat cgctacctgg
      721 ccctggtgca cccgctgcgg gcccgcgccc tgcgtggccg gcgcctggcc cttggactct
      781 gcatggctgc ttggctcatg gcggccgccc tggcactgcc cctgacactg cagcggcaga
      841 ccttccggct ggcgcgctcc gatcgcgtgc tctgccatga cgcgctgccc ctggacgcac
      901 aggcctccca ctggcaaccg gccttcacct gcctggcgct gttgggctgt ttcctgcccc
      961 tgctggccat gctgctgtgc tacggggcca ccctgcacac gctggcggcc agcggccggc
     1021 gctacggcca cgcgctgagg ctgaccgcag tggtgctggc ctccgccgtg gccttcttcg
     1081 tgcccagcaa cctgctgctg ctgctgcatt actcggaccc gagccccagc gcctggggca
     1141 acctctatgg tgcctacgtg cccagcctgg cgctgagcac cctcaacagc tgcgtggatc
     1201 ccttcatcta ctactacgtg tcggccgagt tcagggacaa ggtgcgggca gggctcttcc
     1261 aacggtcgcc gggggacacc gtggcctcca aggcctctgc ggaagggggc agccggggca
     1321 tgggcaccca ctcctctttg ctccagtgac acaaagtggg gaaggctgta ctgggtcgaa
     1381 cagggtccct tcccccactt cacgtccttc ctgggacctc agaatgtgac cttatttgga
     1441 aatagggttg ttacaactgt cactagcgga ggtcactttg gagaagggtg ggccttacat
     1501 ccagtgtggg tggtgtcctc ataagataag gagaggccag gcctggtggc tcacgcctgt
     1561 aatcccagca ctttaagagg ccaaggcgga tggatcactt gagcccagga gttcaacacc
     1621 agcctgagca acatggtaaa accccatctc taccaaaaat acaaaaatta gctgggcttg
     1681 gtggctggcg cctgtaatcc cagctactca ggagactgag gcagaaggat cgcttgaacc
     1741 tgggaggcag aggttgcagt gagccgagat tgcgccactg gactccagcc tgcgtgacag
     1801 agagcctgtc tctaaattaa ttaattaatt aatttaattc aattttaaaa agacgaaaag
     1861 tgacggccag gtgcagtggc tcacgcctat aatctcagca ctctgggagg ccaagatgga
     1921 ggattgcttg aagccaggag tttgggacca gcctgggcaa cataggggga tcccatctct
     1981 acacacaaaa aaatttttta atgaaccagg cattgtggca tgcgcctata gtcccagcca
     2041 ctcaagaggc acaggcggga ggatcacttg agcctgggag gttgtggttg cagtgagcta
     2101 tgattgtacc actgcactcc agcctgggca acagagcaag accttgtctc aaaaataaac
     2161 aaactaaaat taaaaaaaga agacgagaga tagtgggtgt ggtggctcac acctgcaatc
     2221 ccagcacttt ggaaggccga ggtgggcaga tcatctgagg ccaggagttc aagaccagcc
     2281 tggctaacat ggtgaaatcc tatctctacc aaaaatacaa aaattagcca ggcgtggtgg
     2341 tgggcacctg tactggggag gtgcccaccc agctactggg gaggctgagt caggagaatc
     2401 gcttgaacct gggaggcgga ggttgcggtc agctgagatg gtgccactgc actccagcct
     2461 gggcgaaaga gcgactctgt ctccaaaaaa aagagaagag gagaggacac agagacacac
     2521 agagaagaaa gccatgtggc ggcagaggca gagatgggag tgatgcggac ggacacaaac
     2581 taagggatgc cacgatgcca agcacagcca acagccacca gcagccagga gacaggcctg
     2641 ggacgggctc tccctcacag cctccagagg gaaccagccc tgccaccacc ttgaccctgg
     2701 acttctggcc tgcagaactg tgagacaata aactctcatt gttttaagct gcctggcatg
     2761 tggcactttg tcagggcagc ccaggaatct gaaacaggat caaactctgc ttcctgggcc
     2821 ctgccagcat ctctggctcg gctttctggg ctggatgcag cccacgacgc actggtgtct
     2881 gagatggggc tggagctggg gctggggctg cattccctgg agactcactg caagttcctg
     2941 cccaggaggc tgagggcacc ccatcctcag tgcccaatgc tgtggcccca ccaggcccag
     3001 agcctggttg gccattctca tgcccaccag cttctggctt tgggatgtct cttgagcaac
     3061 cagaatagca cccccaactc tgctccccaa aacccatcac tagcacggct cagcctcctg
     3121 ctatcccctg actgctgggg accctcgcct tccctcctct cacctgcagg ctgatccttc
     3181 ttttcacttt ctgtcaatgt caccagggat aaggtgggac aatggggggt gggggtggac
     3241 agtgtgtgct ggggggttcg ggtgctgcag acctggaact cccttctgcc aggatgttgg
     3301 cagccggttg taagccttgc acgggacaga ccac
//
