LOCUS       NM_005242               2861 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens F2R like trypsin receptor 1 (F2RL1), mRNA.
ACCESSION   NM_005242
VERSION     NM_005242.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Perico,L.L., Vegso,A.J., Baggio,C.H. and MacNaughton,W.K.
  TITLE     Protease-activated receptor 2 drives migration in a colon cancer
            cell line but not in noncancerous human epithelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (5), G525-G542 (2024)
   PUBMED   38440826
  REMARK    GeneRIF: Protease-activated receptor 2 drives migration in a colon
            cancer cell line but not in noncancerous human epithelial cells.
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Han,L.L., Lu,Q.Q., Zheng,W.W., Li,Y.L., Song,Y.Y., Zhang,X.Z.,
            Long,S.R., Liu,R.D., Wang,Z.Q. and Cui,J.
  TITLE     A novel trypsin of Trichinella spiralis mediates larval invasion of
            gut epithelium via binding to PAR2 and activating ERK1/2 pathway
  JOURNAL   PLoS Negl Trop Dis 18 (1), e0011874 (2024)
   PUBMED   38166153
  REMARK    GeneRIF: A novel trypsin of Trichinella spiralis mediates larval
            invasion of gut epithelium via binding to PAR2 and activating
            ERK1/2 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Ma,J., Liu,Y., Yuan,J., Ma,Y., Zhao,X., Chen,K., Zhang,X., Zhang,F.
            and Wang,H.
  TITLE     Bcl-xL mediates interferon-beta secretion by protease-activated
            receptor 2 deficiency through the mitochondrial permeability
            transition pore in colorectal cancer metastasis
  JOURNAL   Cancer Lett 580, 216483 (2024)
   PUBMED   37972702
  REMARK    GeneRIF: Bcl-xL mediates interferon-beta secretion by
            protease-activated receptor 2 deficiency through the mitochondrial
            permeability transition pore in colorectal cancer metastasis.
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Soeda,M., Ohka,S., Nishizawa,D., Iseki,M., Yamaguchi,K., Arita,H.,
            Hanaoka,K., Kato,J., Ogawa,S., Hiranuma,A., Hasegawa,J.,
            Nakayama,K., Ebata,Y., Hayashida,M., Ichinohe,T., Fukuda,K.I. and
            Ikeda,K.
  TITLE     Single-Nucleotide Polymorphisms of the PAR2 and IL-17A Genes Are
            Significantly Associated with Chronic Pain
  JOURNAL   Int J Mol Sci 24 (24), 17627 (2023)
   PUBMED   38139455
  REMARK    GeneRIF: Single-Nucleotide Polymorphisms of the PAR2 and IL-17A
            Genes Are Significantly Associated with Chronic Pain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Fu,X., Li,J., Wu,Y., Mao,C. and Jiang,Y.
  TITLE     PAR2 deficiency tunes inflammatory microenvironment to magnify
            STING signalling for mitigating cancer metastasis via anionic
            CRISPR/Cas9 nanoparticles
  JOURNAL   J Control Release 363, 733-746 (2023)
   PUBMED   37827223
  REMARK    GeneRIF: PAR2 deficiency tunes inflammatory microenvironment to
            magnify STING signalling for mitigating cancer metastasis via
            anionic CRISPR/Cas9 nanoparticles.
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Kagota,S., Maruyama,K. and McGuire,J.J.
  TITLE     Characterization and Functions of Protease-Activated Receptor 2 in
            Obesity, Diabetes, and Metabolic Syndrome: A Systematic Review
  JOURNAL   Biomed Res Int 2016, 3130496 (2016)
   PUBMED   27006943
  REMARK    GeneRIF: PAR2 activation promoted obesity.
            Review article
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Mirza,H., Yatsula,V. and Bahou,W.F.
  TITLE     The proteinase activated receptor-2 (PAR-2) mediates mitogenic
            responses in human vascular endothelial cells
  JOURNAL   J Clin Invest 97 (7), 1705-1714 (1996)
   PUBMED   8601636
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Santulli,R.J., Derian,C.K., Darrow,A.L., Tomko,K.A., Eckardt,A.J.,
            Seiberg,M., Scarborough,R.M. and Andrade-Gordon,P.
  TITLE     Evidence for the presence of a protease-activated receptor distinct
            from the thrombin receptor in human keratinocytes
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9151-9155 (1995)
   PUBMED   7568091
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Nystedt,S., Emilsson,K., Larsson,A.K., Strombeck,B. and Sundelin,J.
  TITLE     Molecular cloning and functional expression of the gene encoding
            the human proteinase-activated receptor 2
  JOURNAL   Eur J Biochem 232 (1), 84-89 (1995)
   PUBMED   7556175
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Nystedt,S., Emilsson,K., Wahlestedt,C. and Sundelin,J.
  TITLE     Molecular cloning of a potential proteinase activated receptor
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9208-9212 (1994)
   PUBMED   7937743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010621.7.
            
            On Nov 23, 2018 this sequence version replaced NM_005242.5.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family of proteins. The encoded cell surface receptor is
            activated through proteolytic cleavage of its extracellular amino
            terminus, resulting in a new amino terminus that acts as a tethered
            ligand that binds to an extracellular loop domain. Activation of
            the receptor has been shown to stimulate vascular smooth muscle
            relaxation, dilate blood vessels, increase blood flow, and lower
            blood pressure. This protein is also important in the inflammatory
            response, as well as innate and adaptive immunity. [provided by
            RefSeq, Jun 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018130.1, SRR1660805.44147.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296677.5/ ENSP00000296677.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC010621.7         29878-30112
            236-2861            AC010621.7         43538-46163
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..2861
                     /gene="F2RL1"
                     /gene_synonym="GPR11; PAR2"
                     /note="F2R like trypsin receptor 1"
                     /db_xref="GeneID:2150"
                     /db_xref="HGNC:HGNC:3538"
                     /db_xref="MIM:600933"
     exon            1..235
                     /gene="F2RL1"
                     /gene_synonym="GPR11; PAR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1347
                     /gene="F2RL1"
                     /gene_synonym="GPR11; PAR2"
                     /note="proteinase-activated receptor 2; thrombin
                     receptor-like 1; G-protein coupled receptor 11;
                     coagulation factor II (thrombin) receptor-like 1;
                     protease-activated receptor 2"
                     /codon_start=1
                     /product="proteinase-activated receptor 2 preproprotein"
                     /protein_id="NP_005233.4"
                     /db_xref="CCDS:CCDS4033.1"
                     /db_xref="GeneID:2150"
                     /db_xref="HGNC:HGNC:3538"
                     /db_xref="MIM:600933"
                     /translation="MRSPSAAWLLGAAILLAASLSCSGTIQGTSRSSKGRSLIGKVDG
                     TSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLF
                     RTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMY
                     CSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFI
                     PALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDE
                     NSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLST
                     LNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTT
                     VKTSY"
     exon            236..2861
                     /gene="F2RL1"
                     /gene_synonym="GPR11; PAR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2RL1"
                     /gene_synonym="GPR11; PAR2"
                     /note="hexamer: AACAAA"
     polyA_site      2861
                     /gene="F2RL1"
                     /gene_synonym="GPR11; PAR2"
                     /note="major polyA site"
ORIGIN      
        1 gaaacctaac ccgccctggg gaggcgcgca gcagaggctc cgattcgggg caggtgagag
       61 gctgactttc tctcggtgcg tccagtggag ctctgagttt cgaatcggcg gcggcggatt
      121 ccccgcgcgc ccggcgtcgg ggcttccagg aggatgcgga gccccagcgc ggcgtggctg
      181 ctgggggccg ccatcctgct agcagcctct ctctcctgca gtggcaccat ccaaggaacc
      241 agtagatcct ctaaaggaag aagccttatt ggtaaggttg atggcacatc ccacgtcact
      301 ggaaaaggag ttacagttga aacagtcttt tctgtggatg agttttctgc atctgtcctc
      361 actggaaaac tgaccactgt cttccttcca attgtctaca caattgtgtt tgtggtgggt
      421 ttgccaagta acggcatggc cctgtgggtc tttcttttcc gaactaagaa gaagcaccct
      481 gctgtgattt acatggccaa tctggccttg gctgacctcc tctctgtcat ctggttcccc
      541 ttgaagattg cctatcacat acatggcaac aactggattt atggggaagc tctttgtaat
      601 gtgcttattg gctttttcta tggcaacatg tactgttcca ttctcttcat gacctgcctc
      661 agtgtgcaga ggtattgggt catcgtgaac cccatggggc actccaggaa gaaggcaaac
      721 attgccattg gcatctccct ggcaatatgg ctgctgattc tgctggtcac cattcctttg
      781 tatgtcgtga agcagaccat cttcattcct gccctgaaca tcacgacctg tcatgatgtt
      841 ttgcctgagc agctcttggt gggagacatg ttcaattact tcctctctct ggccattggg
      901 gtctttctgt tcccagcctt cctcacagcc tctgcctatg tgctgatgat cagaatgctg
      961 cgatcttctg ccatggatga aaactcagag aagaaaagga agagggccat caaactcatt
     1021 gtcactgtcc tggccatgta cctgatctgc ttcactccta gtaaccttct gcttgtggtg
     1081 cattattttc tgattaagag ccagggccag agccatgtct atgccctgta cattgtagcc
     1141 ctctgcctct ctacccttaa cagctgcatc gacccctttg tctattactt tgtttcacat
     1201 gatttcaggg atcatgcaaa gaacgctctc ctttgccgaa gtgtccgcac tgtaaagcag
     1261 atgcaagtat ccctcacctc aaagaaacac tccaggaaat ccagctctta ctcttcaagt
     1321 tcaaccactg ttaagacctc ctattgagtt ttccaggtcc tcagatggga attgcacagt
     1381 aggatgtgga acctgtttaa tgttatgagg acgtgtctgt tatttcctaa tcaaaaaggt
     1441 ctcaccacat accatgtgga tgcagcacct ctcaggattg ctaggagctc ccctgtttgc
     1501 atgagaaaag tagtccccca aattaacatc agtgtctgtt tcagaatctc tctactcaga
     1561 tgaccccaga aactgaacca acagaagcag acttttcaga agatggtgaa gacagaaacc
     1621 cagtaacttg caaaaagtag acttggtgtg aagactcact tctcagctga aattatatat
     1681 atacacatat atatatttta catctgggat catgatagac ttgttagggc ttcaaggccc
     1741 tcagagatga tcagtccaac tgaacgacct tacaaatgag gaaaccaaga taaatgagct
     1801 gccagaatca ggtttccaat caacagcagt gagttgggat tggacagtag aatttcaatg
     1861 tccagtgagt gaggttcttg taccacttca tcaaaatcat ggatcttggc tgggtgcggt
     1921 gcctcatgcc tgtaatccta gcactttggg aggctgaggc aggcaatcac ttgaggtcag
     1981 gagttcgaga ccagcctggc catcatggcg aaacctcatc tctactaaaa atacaaaagt
     2041 taaccaggtg tgtggtgcac gtttgtaatc ccagttactc aggaggctga ggcacaagaa
     2101 ttgagtatca ctttaactca ggaggcagag gttgcagtga gccgagattg caccactgca
     2161 ctccagcttg ggtgataaaa taaaataaaa tagtcgtgaa tcttgttcaa aatgcagatt
     2221 cctcagattc aataatgaga gctcagactg ggaacagggc ccaggaatct gtgtggtaca
     2281 aacctgcatg gtgtttatgc acacagagat ttgagaacca ttgttctgaa tgctgcttcc
     2341 atttgacaaa gtgccgtgat aatttttgaa aagagaagca aacaatggtg tctcttttat
     2401 gttcagctta taatgaaatc tgtttgttga cttattagga ctttgaatta tttctttatt
     2461 aaccctctga gtttttgtat gtattattat taaagaaaaa tgcaatcagg attttaaaca
     2521 tgtaaataca aattttgtat aacttttgat gacttcagtg aaattttcag gtagtctgag
     2581 taatagattg ttttgccact tagaatagca tttgccactt agtattttaa aaaataattg
     2641 ttggagtatt tattgtcagt tttgttcact tgttatctaa tacaaaatta taaagccttc
     2701 agagggtttg gaccacatct ctttggaaaa tagtttgcaa catatttaag agatacttga
     2761 tgccaaaatg actttataca acgattgtat ttgtgacttt taaaaataat tattttattg
     2821 tgtaattgat ttataaataa caaaattttt tttacaactt a
//
