LOCUS       NM_001992               3727 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens coagulation factor II thrombin receptor (F2R),
            transcript variant 1, mRNA.
ACCESSION   NM_001992
VERSION     NM_001992.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Stefanenko,M., Fedoriuk,M., Mamenko,M., Semenikhina,M.,
            Nowling,T.K., Lipschutz,J.H., Maximyuk,O., Staruschenko,A. and
            Palygin,O.
  TITLE     PAR1-mediated Non-periodical Synchronized Calcium Oscillations in
            Human Mesangial Cells
  JOURNAL   Function (Oxf) 5 (5) (2024)
   PUBMED   38984988
  REMARK    GeneRIF: PAR1-mediated Non-periodical Synchronized Calcium
            Oscillations in Human Mesangial Cells.
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Xia,L., Yang,Z. and Hu,C.
  TITLE     PAR1 Activation, via LMBR1/BMP Axis, Promotes the Osteogenesis of
            Periodontal Ligament Stem Cells (PDLSCs) and Alleviates the
            Inhibitory Effect of Sodium Butyrate on PDLSCs Osteogenesis
  JOURNAL   Discov Med 36 (187), 1657-1671 (2024)
   PUBMED   39190381
  REMARK    GeneRIF: PAR1 Activation, via LMBR1/BMP Axis, Promotes the
            Osteogenesis of Periodontal Ligament Stem Cells (PDLSCs) and
            Alleviates the Inhibitory Effect of Sodium Butyrate on PDLSCs
            Osteogenesis.
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Wu,K., Wu,B., Yan,K., Ding,Q. and Miao,Z.
  TITLE     KLK10 promotes the progression of KRAS mutant colorectal cancer via
            PAR1-PDK1-AKT signaling pathway
  JOURNAL   Cell Biol Int 48 (4), 440-449 (2024)
   PUBMED   38115179
  REMARK    GeneRIF: KLK10 promotes the progression of KRAS mutant colorectal
            cancer via PAR1-PDK1-AKT signaling pathway.
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Biswas,I., Giri,H., Panicker,S.R. and Rezaie,A.R.
  TITLE     Thrombomodulin Switches Signaling and Protease-Activated Receptor 1
            Cleavage Specificity of Thrombin
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (3), 603-616 (2024)
   PUBMED   38174561
  REMARK    GeneRIF: Thrombomodulin Switches Signaling and Protease-Activated
            Receptor 1 Cleavage Specificity of Thrombin.
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Zhao,L., Hu,J., Zheng,P., Mi,B., Chen,Z., Zhao,X., Wu,J. and
            Wang,Y.
  TITLE     PAR1 regulates sepsis-induced vascular endothelial barrier
            dysfunction by mediating ERM phosphorylation via the RhoA/ROCK
            signaling pathway
  JOURNAL   Int Immunopharmacol 124 (Pt B), 110992 (2023)
   PUBMED   37806106
  REMARK    GeneRIF: PAR1 regulates sepsis-induced vascular endothelial barrier
            dysfunction by mediating ERM phosphorylation via the RhoA/ROCK
            signaling pathway.
REFERENCE   6  (bases 1 to 3727)
  AUTHORS   Wojtukiewicz,M.Z., Tang,D.G., Ben-Josef,E., Renaud,C., Walz,D.A.
            and Honn,K.V.
  TITLE     Solid tumor cells express functional 'tethered ligand' thrombin
            receptor
  JOURNAL   Cancer Res 55 (3), 698-704 (1995)
   PUBMED   7834643
REFERENCE   7  (bases 1 to 3727)
  AUTHORS   Hein,L., Ishii,K., Coughlin,S.R. and Kobilka,B.K.
  TITLE     Intracellular targeting and trafficking of thrombin receptors. A
            novel mechanism for resensitization of a G protein-coupled receptor
  JOURNAL   J Biol Chem 269 (44), 27719-27726 (1994)
   PUBMED   7961693
REFERENCE   8  (bases 1 to 3727)
  AUTHORS   Coughlin,S.R., Vu,T.K., Hung,D.T. and Wheaton,V.I.
  TITLE     Characterization of a functional thrombin receptor. Issues and
            opportunities
  JOURNAL   J Clin Invest 89 (2), 351-355 (1992)
   PUBMED   1310691
  REMARK    Review article
REFERENCE   9  (bases 1 to 3727)
  AUTHORS   Shenker,A., Goldsmith,P., Unson,C.G. and Spiegel,A.M.
  TITLE     The G protein coupled to the thromboxane A2 receptor in human
            platelets is a member of the novel Gq family
  JOURNAL   J Biol Chem 266 (14), 9309-9313 (1991)
   PUBMED   1851174
REFERENCE   10 (bases 1 to 3727)
  AUTHORS   Vu,T.K., Hung,D.T., Wheaton,V.I. and Coughlin,S.R.
  TITLE     Molecular cloning of a functional thrombin receptor reveals a novel
            proteolytic mechanism of receptor activation
  JOURNAL   Cell 64 (6), 1057-1068 (1991)
   PUBMED   1672265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051909.1 and BM994328.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001992.4.
            
            Summary: Coagulation factor II receptor is a 7-transmembrane
            receptor involved in the regulation of thrombotic response.
            Proteolytic cleavage leads to the activation of the receptor. F2R
            is a G-protein coupled receptor family member. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA405909.1, SRR1803613.270776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319211.5/ ENSP00000321326.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3280              BC051909.1         5-3284
            3281-3727           BM994328.1         18-464              c
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..3727
                     /gene="F2R"
                     /gene_synonym="CF2R; HTR; PAR-1; PAR1; TR"
                     /note="coagulation factor II thrombin receptor"
                     /db_xref="GeneID:2149"
                     /db_xref="HGNC:HGNC:3537"
                     /db_xref="MIM:187930"
     exon            1..270
                     /gene="F2R"
                     /gene_synonym="CF2R; HTR; PAR-1; PAR1; TR"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1460
                     /gene="F2R"
                     /gene_synonym="CF2R; HTR; PAR-1; PAR1; TR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; proteinase-activated receptor 1;
                     protease-activated receptor 1"
                     /codon_start=1
                     /product="proteinase-activated receptor 1 isoform 1
                     precursor"
                     /protein_id="NP_001983.2"
                     /db_xref="CCDS:CCDS4032.1"
                     /db_xref="GeneID:2149"
                     /db_xref="HGNC:HGNC:3537"
                     /db_xref="MIM:187930"
                     /translation="MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFL
                     LRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLT
                     LFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKIS
                     YYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGR
                     ASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSA
                     VFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLI
                     AHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESS
                     DPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT"
     exon            271..3727
                     /gene="F2R"
                     /gene_synonym="CF2R; HTR; PAR-1; PAR1; TR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3703..3708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F2R"
                     /gene_synonym="CF2R; HTR; PAR-1; PAR1; TR"
                     /note="hexamer: AATAAA"
     polyA_site      3727
                     /gene="F2R"
                     /gene_synonym="CF2R; HTR; PAR-1; PAR1; TR"
                     /note="major polyA site"
ORIGIN      
        1 aaccgcccca gacacagcgc tcgccgaggg tcgcttggac cctgatctta cccgtgggca
       61 ccctgcgctc tgcctgccgc gaagaccggc tccccgaccc gcagaagtca ggagagaggg
      121 tgaagcggag cagcccgagg cggggcagcc tcccggagca gcgccgcgca gagcccggga
      181 caatggggcc gcggcggctg ctgctggtgg ccgcctgctt cagtctgtgc ggcccgctgt
      241 tgtctgcccg cacccgggcc cgcaggccag aatcaaaagc aacaaatgcc accttagatc
      301 cccggtcatt tcttctcagg aaccccaatg ataaatatga accattttgg gaggatgagg
      361 agaaaaatga aagtgggtta actgaataca gattagtctc catcaataaa agcagtcctc
      421 ttcaaaaaca acttcctgca ttcatctcag aagatgcctc cggatatttg accagctcct
      481 ggctgacact ctttgtccca tctgtgtaca ccggagtgtt tgtagtcagc ctcccactaa
      541 acatcatggc catcgttgtg ttcatcctga aaatgaaggt caagaagccg gcggtggtgt
      601 acatgctgca cctggccacg gcagatgtgc tgtttgtgtc tgtgctcccc tttaagatca
      661 gctattactt ttccggcagt gattggcagt ttgggtctga attgtgtcgc ttcgtcactg
      721 cagcatttta ctgtaacatg tacgcctcta tcttgctcat gacagtcata agcattgacc
      781 ggtttctggc tgtggtgtat cccatgcagt ccctctcctg gcgtactctg ggaagggctt
      841 ccttcacttg tctggccatc tgggctttgg ccatcgcagg ggtagtgcct ctgctcctca
      901 aggagcaaac catccaggtg cccgggctca acatcactac ctgtcatgat gtgctcaatg
      961 aaaccctgct cgaaggctac tatgcctact acttctcagc cttctctgct gtcttctttt
     1021 ttgtgccgct gatcatttcc acggtctgtt atgtgtctat cattcgatgt cttagctctt
     1081 ccgcagttgc caaccgcagc aagaagtccc gggctttgtt cctgtcagct gctgttttct
     1141 gcatcttcat catttgcttc ggacccacaa acgtcctcct gattgcgcat tactcattcc
     1201 tttctcacac ttccaccaca gaggctgcct actttgccta cctcctctgt gtctgtgtca
     1261 gcagcataag ctgctgcatc gaccccctaa tttactatta cgcttcctct gagtgccaga
     1321 ggtacgtcta cagtatctta tgctgcaaag aaagttccga tcccagcagt tataacagca
     1381 gtgggcagtt gatggcaagt aaaatggata cctgctctag taacctgaat aacagcatat
     1441 acaaaaagct gttaacttag gaaaagggac tgctgggagg ttaaaaagaa aagtttataa
     1501 aagtgaataa cctgaggatt ctattagtcc ccacccaaac tttattgatt cacctcctaa
     1561 aacaacagat gtacgacttg catacctgct ttttatggga gctgtcaagc atgtattttt
     1621 gtcaattacc agaaagataa caggacgaga tgacggtgtt attccaaggg aatattgcca
     1681 atgctacagt aataaatgaa tgtcacttct ggatatagct aggtgacata tacatactta
     1741 catgtgtgta tatgtagatg tatgcacaca catatattat ttgcagtgca gtatagaata
     1801 ggcactttaa aacactcttt ccccgcaccc cagcaattat gaaaataatc tctgattccc
     1861 tgatttaata tgcaaagtct aggttggtag agtttagccc tgaacatttc atggtgttca
     1921 tcaacagtga gagactccat agtttgggct tgtaccactt ttgcaaataa gtgtattttg
     1981 aaattgtttg acggcaaggt ttaagttatt aagaggtaag acttagtact atctgtgcgt
     2041 agaagttcta gtgttttcaa ttttaaacat atccaagttt gaattcctaa aattatggaa
     2101 acagatgaaa agcctctgtt ttgatatggg tagtattttt tacattttac acactgtaca
     2161 cataagccaa aactgagcat aagtcctcta gtgaatgtag gctggctttc agagtaggct
     2221 attcctgaga gctgcatgtg tccgcccccg atggaggact ccaggcagca gacacatgcc
     2281 agggccatgt cagacacaga ttggccagaa accttcctgc tgagcctcac agcagtgaga
     2341 ctggggccac tacatttgct ccatcctcct gggattggct gtgaactgat catgtttatg
     2401 agaaactggc aaagcagaat gtgatatcct aggaggtaat gaccatgaaa gacttctcta
     2461 cccatcttaa aaacaacgaa agaaggcatg gacttctgga tgcccatcca ctgggtgtaa
     2521 acacatctag tagttgttct gaaatgtcag ttctgatatg gaagcaccca ttatgcgctg
     2581 tggccactcc aataggtgct gagtgtacag agtggaataa gacagagacc tgccctcaag
     2641 agcaaagtag atcatgcata gagtgtgatg tatgtgtaat aaatatgttt cacacaaaca
     2701 aggcctgtca gctaaagaag tttgaacatt tgggttacta tttcttgtgg ttataactta
     2761 atgaaaacaa tgcagtacag gacatatatt ttttaaaata agtctgattt aattgggcac
     2821 tatttattta caaatgtttt gctcaataga ttgctcaaat caggttttct tttaagaatc
     2881 aatcatgtca gtctgcttag aaataacaga agaaaataga attgacattg aaatctagga
     2941 aaattattct ataatttcca tttacttaag acttaatgag actttaaaag cattttttaa
     3001 cctcctaagt atcaagtata gaaaatcttc atggaattca caaagtaatt tggaaattag
     3061 gttgaaacat atctcttatc ttacgaaaaa atggtagcat tttaaacaaa atagaaagtt
     3121 gcaaggcaaa tgtttattta aaagagcagg ccaggcgcgg tggctcacgc ctgtaatccc
     3181 agcactttgg gaggctgagg cgggtggatc acgaggtcag gagatcgaga ccatcctggc
     3241 taacacggtg aaacccgtct ctactaaaaa tgcaaaaaaa attagccggg cgtggtggca
     3301 ggcacctgta gtcccagcta ctcgggaggc tgaggcagga gactggcgtg aacccaggag
     3361 gcggaccttg tagtgagccg agatcgcgcc actgtgctcc agcctgggca acagagcaag
     3421 actccatctc aaaaaataaa aataaataaa aaataaaaaa ataaaagagc aaactatttc
     3481 caaataccat agaataactt acataaaagt aatataactg tattgtaagt agaagctagc
     3541 actggtttta ttaatttagt gactattcat tttatctaaa tcagtgaaga tttactgtca
     3601 ttgtttatta gtctgtatat attaaaatat gatatcatta atgtacttac aaaatagtat
     3661 gtcactgttt ttatgttcat tcttaaaaac ataacctgta ttaataaatg tgaacatttg
     3721 cttggta
//
