LOCUS       NM_016946               4639 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens F11 receptor (F11R), transcript variant 1, mRNA.
ACCESSION   NM_016946
VERSION     NM_016946.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4639)
  AUTHORS   Shu,F., Lu,J., Zhang,W., Huang,H., Lin,J., Jiang,L., Liu,W.,
            Liu,T., Xiao,S., Zheng,Y. and Xia,Z.
  TITLE     JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal
            Stem Cells Accelerated the Angiogenesis of Diabetic Wound By
            Enhancing Both Paracrine Function and Survival of Mesenchymal Stem
            Cells
  JOURNAL   Stem Cell Rev Rep 19 (5), 1554-1575 (2023)
   PUBMED   37060532
  REMARK    GeneRIF: JAM-A Overexpression in Human Umbilical Cord-Derived
            Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic
            Wound By Enhancing Both Paracrine Function and Survival of
            Mesenchymal Stem Cells.
REFERENCE   2  (bases 1 to 4639)
  AUTHORS   Cruz,R.G.B., Madden,S.F., Brennan,K. and Hopkins,A.M.
  TITLE     A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast
            Cancer
  JOURNAL   Cells 11 (4), 735 (2022)
   PUBMED   35203384
  REMARK    GeneRIF: A Transcriptional Link between HER2, JAM-A and FOXA1 in
            Breast Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4639)
  AUTHORS   Lampis,A., Hahne,J.C., Gasparini,P., Cascione,L., Hedayat,S.,
            Vlachogiannis,G., Murgia,C., Fontana,E., Edwards,J., Horgan,P.G.,
            Terracciano,L., Sansom,O.J., Martins,C.D., Kramer-Marek,G.,
            Croce,C.M., Braconi,C., Fassan,M. and Valeri,N.
  TITLE     MIR21-induced loss of junctional adhesion molecule A promotes
            activation of oncogenic pathways, progression and metastasis in
            colorectal cancer
  JOURNAL   Cell Death Differ 28 (10), 2970-2982 (2021)
   PUBMED   34226680
  REMARK    GeneRIF: MIR21-induced loss of junctional adhesion molecule A
            promotes activation of oncogenic pathways, progression and
            metastasis in colorectal cancer.
REFERENCE   4  (bases 1 to 4639)
  AUTHORS   Garrido-Urbani,S., Bradfield,P.F. and Imhof,B.A.
  TITLE     Tight junction dynamics: the role of junctional adhesion molecules
            (JAMs)
  JOURNAL   Cell Tissue Res 355 (3), 701-715 (2014)
   PUBMED   24595739
  REMARK    Review article
REFERENCE   5  (bases 1 to 4639)
  AUTHORS   Martin,T.A., Mason,M.D. and Jiang,W.G.
  TITLE     Tight junctions in cancer metastasis
  JOURNAL   Front Biosci (Landmark Ed) 16 (3), 898-936 (2011)
   PUBMED   21196209
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4639)
  AUTHORS   Severson,E.A. and Parkos,C.A.
  TITLE     Mechanisms of outside-in signaling at the tight junction by
            junctional adhesion molecule A
  JOURNAL   Ann N Y Acad Sci 1165, 10-18 (2009)
   PUBMED   19538282
  REMARK    Review article
REFERENCE   7  (bases 1 to 4639)
  AUTHORS   Naik,T.U., Naik,M.U. and Naik,U.P.
  TITLE     Junctional adhesion molecules in angiogenesis
  JOURNAL   Front Biosci 13, 258-262 (2008)
   PUBMED   17981544
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4639)
  AUTHORS   Sobocka,M.B., Sobocki,T., Banerjee,P., Weiss,C., Rushbrook,J.I.,
            Norin,A.J., Hartwig,J., Salifu,M.O., Markell,M.S., Babinska,A.,
            Ehrlich,Y.H. and Kornecki,E.
  TITLE     Cloning of the human platelet F11 receptor: a cell adhesion
            molecule member of the immunoglobulin superfamily involved in
            platelet aggregation
  JOURNAL   Blood 95 (8), 2600-2609 (2000)
   PUBMED   10753840
  REMARK    GeneRIF: The F11 receptor (F11R) was discovered in 1990 (Kornecki
            et al.), partially sequenced (1995) and cloned (Sobocka, et al) by
            this group. A 100% homology exists between platelet F11R and JAM.
REFERENCE   9  (bases 1 to 4639)
  AUTHORS   Naik,U.P., Ehrlich,Y.H. and Kornecki,E.
  TITLE     Mechanisms of platelet activation by a stimulatory antibody:
            cross-linking of a novel platelet receptor for monoclonal antibody
            F11 with the Fc gamma RII receptor
  JOURNAL   Biochem J 310 (Pt 1) (Pt 1), 155-162 (1995)
   PUBMED   7646439
REFERENCE   10 (bases 1 to 4639)
  AUTHORS   Kornecki,E., Walkowiak,B., Naik,U.P. and Ehrlich,Y.H.
  TITLE     Activation of human platelets by a stimulatory monoclonal antibody
  JOURNAL   J Biol Chem 265 (17), 10042-10048 (1990)
   PUBMED   2351647
  REMARK    GeneRIF: F11 receptor (F11R) was discovered by Kornecki, 1990 (JBC,
            265:10042) on platelets.  A 100% homology exists between the
            platelet F11R and human JAM at the protein level.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA907460.1, AF172398.3 and
            AL591806.16.
            
            On Nov 23, 2018 this sequence version replaced NM_016946.5.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. The protein encoded by this immunoglobulin
            superfamily gene member is an important regulator of tight junction
            assembly in epithelia. In addition, the encoded protein can act as
            (1) a receptor for reovirus, (2) a ligand for the integrin LFA1,
            involved in leukocyte transmigration, and (3) a platelet receptor.
            Multiple 5' alternatively spliced variants, encoding the same
            protein, have been identified but their biological validity has not
            been established. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of this gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172398.3, AK075152.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368026.11/ ENSP00000357005.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA907460.1         192-210
            20-64               AF172398.3         1-45
            65-68               AL591806.16        75087-75090         c
            69-1740             AF172398.3         50-1721
            1741-4639           AL591806.16        49213-52111         c
FEATURES             Location/Qualifiers
     source          1..4639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..4639
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="F11 receptor"
                     /db_xref="GeneID:50848"
                     /db_xref="HGNC:HGNC:14685"
                     /db_xref="MIM:605721"
     exon            1..143
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..979
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; junctional adhesion molecule 1; platelet F11
                     receptor; junctional adhesion molecule A; platelet
                     adhesion molecule 1"
                     /codon_start=1
                     /product="junctional adhesion molecule A isoform 1
                     precursor"
                     /protein_id="NP_058642.1"
                     /db_xref="CCDS:CCDS1213.1"
                     /db_xref="GeneID:50848"
                     /db_xref="HGNC:HGNC:14685"
                     /db_xref="MIM:605721"
                     /translation="MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENN
                     PVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRE
                     DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSP
                     PSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY
                     GTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSK
                     KVIYSQPSARSEGEFKQTSSFLV"
     exon            144..212
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..320
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..467
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..670
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..773
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..881
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..894
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..943
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..4639
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3633..3638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="hexamer: AATAAA"
     polyA_site      3656
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="major polyA site"
     regulatory      3941..3946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="hexamer: GATAAA"
     polyA_site      3964
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
     regulatory      4581..4586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="hexamer: AATAAA"
     regulatory      4594..4599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="hexamer: AATGAA"
     regulatory      4598..4603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="hexamer: AAGAAA"
     polyA_site      4608
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
     polyA_site      4611
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
     regulatory      4617..4622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
                     /note="hexamer: ATTAAA"
     polyA_site      4625
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
     polyA_site      4639
                     /gene="F11R"
                     /gene_synonym="CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1"
ORIGIN      
        1 agtcccctcg ctgtagtcgc ggagctgtgt ctgttcccag gagtccttcg gcggctgttg
       61 tgtcgggagc ctgatcgcga tggggacaaa ggcgcaagtc gagaggaaac tgttgtgcct
      121 cttcatattg gcgatcctgt tgtgctccct ggcattgggc agtgttacag tgcactcttc
      181 tgaacctgaa gtcagaattc ctgagaataa tcctgtgaag ttgtcctgtg cctactcggg
      241 cttttcttct ccccgtgtgg agtggaagtt tgaccaagga gacaccacca gactcgtttg
      301 ctataataac aagatcacag cttcctatga ggaccgggtg accttcttgc caactggtat
      361 caccttcaag tccgtgacac gggaagacac tgggacatac acttgtatgg tctctgagga
      421 aggcggcaac agctatgggg aggtcaaggt caagctcatc gtgcttgtgc ctccatccaa
      481 gcctacagtt aacatcccct cctctgccac cattgggaac cgggcagtgc tgacatgctc
      541 agaacaagat ggttccccac cttctgaata cacctggttc aaagatggga tagtgatgcc
      601 tacgaatccc aaaagcaccc gtgccttcag caactcttcc tatgtcctga atcccacaac
      661 aggagagctg gtctttgatc ccctgtcagc ctctgatact ggagaataca gctgtgaggc
      721 acggaatggg tatgggacac ccatgacttc aaatgctgtg cgcatggaag ctgtggagcg
      781 gaatgtgggg gtcatcgtgg cagccgtcct tgtaaccctg attctcctgg gaatcttggt
      841 ttttggcatc tggtttgcct atagccgagg ccactttgac agaacaaaga aagggacttc
      901 gagtaagaag gtgatttaca gccagcctag tgcccgaagt gaaggagaat tcaaacagac
      961 ctcgtcattc ctggtgtgag cctggtcggc tcaccgccta tcatctgcat ttgccttact
     1021 caggtgctac cggactctgg cccctgatgt ctgtagtttc acaggatgcc ttatttgtct
     1081 tctacacccc acagggcccc ctacttcttc ggatgtgttt ttaataatgt cagctatgtg
     1141 ccccatcctc cttcatgccc tccctccctt tcctaccact gctgagtggc ctggaacttg
     1201 tttaaagtgt ttattcccca tttctttgag ggatcaggaa ggaatcctgg gtatgccatt
     1261 gacttccctt ctaagtagac agcaaaaatg gcgggggtcg caggaatctg cactcaactg
     1321 cccacctggc tggcagggat ctttgaatag gtatcttgag cttggttctg ggctctttcc
     1381 ttgtgtactg acgaccaggg ccagctgttc tagagcggga attagaggct agagcggctg
     1441 aaatggttgt ttggtgatga cactggggtc cttccatctc tggggcccac tctcttctgt
     1501 cttcccatgg gaagtgccac tgggatccct ctgccctgtc ctcctgaata caagctgact
     1561 gacattgact gtgtctgtgg aaaatgggag ctcttgttgt ggagagcata gtaaattttc
     1621 agagaacttg aagccaaaag gatttaaaac cgctgctcta aagaaaagaa aactggaggc
     1681 tgggcgcagt ggctcacgcc tataatccca gaggctgagg caggcggatc acctgaggtc
     1741 aggagttcaa gatcagcctg accaacatgg agaaacccta ctaaaaatac aaagttagcc
     1801 aggcatagtg gtgcatgcct gtaatcccag ctgctcagga gcctggcaac aagagcaaaa
     1861 ctccagctca aaaaaaaaaa gaaagaaaag aaagctggag ctggtggctt aggccatcac
     1921 ccttcccttg gctggaacta ctggacagac ccttttgaga tgtgcctgtg gtgctgtgga
     1981 gatgtgtgta gtggtcttag ctctttgttg agcttgtgtg tgtgttgtgt agtcttagct
     2041 gtatgctgaa attgggcgtg tgttggaggg cttcttagct ctttggtgag attgtatttc
     2101 tatgtgtttg tatcagctga atgttgctgg aaataaaacc ttggtttgtc aaggctcttt
     2161 tttgtgggaa gtaagtaggg gaaaaggtct ttgagggttc ctaggctcct ttgtacaaca
     2221 ggaaaatgcc tcaaagcctt gcttcccagc aacctggggc tggttcccag tgcctggtcc
     2281 tgccccttcc tggttcttat ctcaaggcag agcttctgaa tttcaggcct tcattccaga
     2341 gccctcttgt ggccaggcct tcctttgctg gaggaaggta cacagggtga agctgatgct
     2401 gtacttgggg gatctccttg gcctgttcca ccaagtgaga gaaggtactt actcttgtac
     2461 ctcctgttca gccaggtgca ttaacagacc tccctacagc tgtaggaact actgtcccag
     2521 agctgaggca aggggatttc tcaggtcatt tggagaacaa gtgctttagt agtagtttaa
     2581 agtagtaact gctactgtat ttagtggggt ggaattcaga agaaatttga agaccagatc
     2641 atgggtggtc tgcatgtgaa tgaacaggaa tgagccggac agcctggctg tcattgcttt
     2701 cttcctcccc atttggaccc ttctctgccc ttacattttt gtttctccat ctaccaccat
     2761 ccaccagtct atttattaac ttagcaagag gacaagtaaa gggccctctt ggcttgattt
     2821 tgcttctttc tttctgtgga ggatatacta agtgcgactt tgccctatcc tatttggaaa
     2881 tccctaacag aattgagttt tctattaagg atccaaaaag aaaaacaaaa tgctaatgaa
     2941 gccatcagtc aagggtcaca tgccaataaa caataaattt tccagaagaa atgaaatcca
     3001 actagacaaa taaagtagag cttatgaaat ggttcagtaa agatgagttt gttgtttttt
     3061 gttttgtttt gttttgtttt tttaaagacg gagtctcgct ctgtcaccca ggctggagtg
     3121 cagtggtatg atcttggctc actgtaacct ccgcctcccg ggttcaagcc attctcctgc
     3181 ctcagtctcc tgagtagctg ggattacggg tgcgtgccac catgcctggc taatttttgt
     3241 gtttttagta gagacagggt ttcaccatgt tggtcgggct ggtctcaaac tcctgacctc
     3301 ttgatccgcc tgccttggcc tcccaaagtg atgggattac agatgtgagc caccgtgcct
     3361 agccaaggat gagattttta aagtatgttt cagttctgtg tcatggttgg aagacagagt
     3421 aggaaggata tggaaaaggt catggggaag cagaggtgat tcatggctct gtgaatttga
     3481 ggtgaatggt tccttattgt ctaggccact tgtgaagaat atgagtcagt tattgccagc
     3541 cttggaattt acttctctag cttacaatgg accttttgaa ctggaaaaca ccttgtctgc
     3601 attcacttta aaatgtcaaa actaattttt ataataaatg tttattttca cattgagttt
     3661 gtttaaatcc tgaagttctt accttaagag aattgggact cctagagtga ttggacattc
     3721 aaaatattcc tgatagtctt gttaattaag agattaggat atctttccat taccttgata
     3781 attacgtttt aatttagctt ttttcattgg cctgtgttta aatgcaaata accccacaat
     3841 ggacatttcc tatgttaaag tgacatttag gggataaaaa atgagagcag ttccatggat
     3901 tttggtgttt cccctgagac atgaactcag cataatctgg gataaaatga ttgagtgtta
     3961 aggatgtgtt tgttgttcct gtcgtttttt tattttcttc aaagtataca acatggtttg
     4021 atatgcacat acatttgtgt aatgattgcc atggtcaatt aacacatcac catttttgtg
     4081 tgtgtgtgtg tgtgtgtgtg tgagggagtc ttgctccgtt gccaggctgg agtgcaatgg
     4141 tacaaccttg gctcactgca acctccacct cctgggttca agcaattctc ttgcctcagc
     4201 ctcctaagta gctgggacta taggcgtgtg ccaccatgcc cagctaattt ttgtattttt
     4261 agtagagacg gggtttcacc atgttggcca ggatgatctc gatcccttga cctcatgatc
     4321 cgcccacctc ggcctcccaa agtgctggga ttacaggcgt gagtcactgc acccggccac
     4381 atcacctccc atgttctatc ttacgtattc agaacttgtt catcttgtaa ctgaaagcgt
     4441 gtaccctttg accaacactg tttttcctgt cttaacagga tctacagatc aaggacaggg
     4501 gaggggatag tggaggaaaa cggagttagt ctgtttctaa atgaggggac agtatgtttc
     4561 ttggggcctg aggacagctt aataaagtag acaaatgaag aaaaacaaca atttgcatta
     4621 aaaaatatcc aattcttta
//
