LOCUS       NM_001142800           10590 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens eyes shut homolog (EYS), transcript variant 1, mRNA.
ACCESSION   NM_001142800
VERSION     NM_001142800.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10590)
  AUTHORS   Otsuka,Y., Imamura,K., Oishi,A., Asakawa,K., Kondo,T., Nakai,R.,
            Suga,M., Inoue,I., Sagara,Y., Tsukita,K., Teranaka,K.,
            Nishimura,Y., Watanabe,A., Umeyama,K., Okushima,N., Mitani,K.,
            Nagashima,H., Kawakami,K., Muguruma,K., Tsujikawa,A. and Inoue,H.
  TITLE     Phototoxicity avoidance is a potential therapeutic approach for
            retinal dystrophy caused by EYS dysfunction
  JOURNAL   JCI Insight 9 (8), e174179 (2024)
   PUBMED   38646933
  REMARK    GeneRIF: Phototoxicity avoidance is a potential therapeutic
            approach for retinal dystrophy caused by EYS dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10590)
  AUTHORS   Chan,C.M., Tan,T.E., Jain,K., Bylstra,Y., Mathur,R.S., Tang,R.W.C.,
            Lee,B.J.H., Jamuar,S.S., Kam,S., Vithana,E.N., Lim,W.K. and
            Fenner,B.J.
  TITLE     RETINITIS PIGMENTOSA ASSOCIATED WITH THE EYS C2139Y VARIANT : An
            Important Cause of Blindness in East Asian Populations
  JOURNAL   Retina 43 (10), 1788-1796 (2023)
   PUBMED   37418643
  REMARK    GeneRIF: RETINITIS PIGMENTOSA ASSOCIATED WITH THE EYS C2139Y
            VARIANT : An Important Cause of Blindness in East Asian
            Populations.
REFERENCE   3  (bases 1 to 10590)
  AUTHORS   Suvannaboon,R., Pawestri,A.R., Jinda,W., Tuekprakhon,A.,
            Trinavarat,A. and Atchaneeyasakul,L.O.
  TITLE     Genotypic and phenotypic profiles of EYS gene-related retinitis
            pigmentosa: a retrospective study
  JOURNAL   Sci Rep 12 (1), 21494 (2022)
   PUBMED   36513702
  REMARK    GeneRIF: Genotypic and phenotypic profiles of EYS gene-related
            retinitis pigmentosa: a retrospective study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10590)
  AUTHORS   Sano,Y., Koyanagi,Y., Wong,J.H., Murakami,Y., Fujiwara,K., Endo,M.,
            Aoi,T., Hashimoto,K., Nakazawa,T., Wada,Y., Ueno,S., Gao,D.,
            Murakami,A., Hotta,Y., Ikeda,Y., Nishiguchi,K.M., Momozawa,Y.,
            Sonoda,K.H., Akiyama,M. and Fujimoto,A.
  TITLE     Likely pathogenic structural variants in genetically unsolved
            patients with retinitis pigmentosa revealed by long-read sequencing
  JOURNAL   J Med Genet 59 (11), 1133-1138 (2022)
   PUBMED   35710107
  REMARK    GeneRIF: Likely pathogenic structural variants in genetically
            unsolved patients with retinitis pigmentosa revealed by long-read
            sequencing.
REFERENCE   5  (bases 1 to 10590)
  AUTHORS   Collin,R.W., Littink,K.W., Klevering,B.J., van den Born,L.I.,
            Koenekoop,R.K., Zonneveld,M.N., Blokland,E.A., Strom,T.M.,
            Hoyng,C.B., den Hollander,A.I. and Cremers,F.P.
  TITLE     Identification of a 2 Mb human ortholog of Drosophila eyes
            shut/spacemaker that is mutated in patients with retinitis
            pigmentosa
  JOURNAL   Am J Hum Genet 83 (5), 594-603 (2008)
   PUBMED   18976725
  REMARK    GeneRIF: EYS is identified as a human ortholog of Drosopbhila eys,
            which is mutated in patients with retinitis pigmentosa.
REFERENCE   6  (bases 1 to 10590)
  AUTHORS   Barragan,I., Abd El-Aziz,M.M., Borrego,S., El-Ashry,M.F.,
            O'Driscoll,C., Bhattacharya,S.S. and Antinolo,G.
  TITLE     Linkage validation of RP25 Using the 10K genechip array and further
            refinement of the locus by new linked families
  JOURNAL   Ann Hum Genet 72 (Pt 4), 454-462 (2008)
   PUBMED   18510647
  REMARK    GeneRIF: In order to validate the original linkage of RP25, study
            undertook a total genome scan using the 10K GeneChip mapping array
            on 3 of the previously linked families; data obtained supported the
            initial findings of linkage.
REFERENCE   7  (bases 1 to 10590)
  AUTHORS   Abd El-Aziz,M.M., Barragan,I., O'Driscoll,C., Borrego,S.,
            Abu-Safieh,L., Pieras,J.I., El-Ashry,M.F., Prigmore,E., Carter,N.,
            Antinolo,G. and Bhattacharya,S.S.
  TITLE     Large-scale molecular analysis of a 34 Mb interval on chromosome
            6q: major refinement of the RP25 interval
  JOURNAL   Ann Hum Genet 72 (Pt 4), 463-477 (2008)
   PUBMED   18510646
  REMARK    GeneRIF: To study if copy number variation exists within RP25,
            comparative genomic hybridization analysis on a consanguineous
            family revealed a clone, chr6tp-19C7, spanning 100-Kb was deleted
            in all affected members of the family.
            Erratum:[Ann Hum Genet. 2015 Jan;79(1):83]
REFERENCE   8  (bases 1 to 10590)
  AUTHORS   Khaliq,S., Hameed,A., Ismail,M., Mehdi,S.Q., Bessant,D.A.,
            Payne,A.M. and Bhattacharya,S.S.
  TITLE     Refinement of the locus for autosomal recessive Retinitis
            pigmentosa (RP25) linked to chromosome 6q in a family of Pakistani
            origin
  JOURNAL   Am J Hum Genet 65 (2), 571-574 (1999)
   PUBMED   10417302
REFERENCE   9  (bases 1 to 10590)
  AUTHORS   Ruiz,A., Borrego,S., Marcos,I. and Antinolo,G.
  TITLE     A major locus for autosomal recessive retinitis pigmentosa on 6q,
            determined by homozygosity mapping of chromosomal regions that
            contain gamma-aminobutyric acid-receptor clusters
  JOURNAL   Am J Hum Genet 62 (6), 1452-1459 (1998)
   PUBMED   9585594
REFERENCE   10 (bases 1 to 10590)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450319.4, FJ416331.1 and
            BX537914.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001142800.1.
            
            Summary: The product of this gene contains multiple epidermal
            growth factor (EGF)-like and LamG domains. The protein is expressed
            in the photoreceptor layer of the retina, and the gene is mutated
            in autosomal recessive retinitis pigmentosa. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA1970526
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503581.6/ ENSP00000424243.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL450319.4         80971-80971         c
            2-84                FJ416331.1         1-83
            85-444              BX537914.1         84-443
            445-10590           FJ416331.1         452-10597
FEATURES             Location/Qualifiers
     source          1..10590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q12"
     gene            1..10590
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /note="eyes shut homolog"
                     /db_xref="GeneID:346007"
                     /db_xref="HGNC:HGNC:21555"
                     /db_xref="MIM:612424"
     exon            1..92
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            93..207
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            208..342
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1287
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..9974
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EGF-like-domain, multiple 11; EGF-like-domain,
                     multiple 10; protein spacemaker homolog; epidermal growth
                     factor-like protein 10; epidermal growth factor-like
                     protein 11"
                     /codon_start=1
                     /product="protein eyes shut homolog isoform 1 precursor"
                     /protein_id="NP_001136272.1"
                     /db_xref="CCDS:CCDS47445.1"
                     /db_xref="GeneID:346007"
                     /db_xref="HGNC:HGNC:21555"
                     /db_xref="MIM:612424"
                     /translation="MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWT
                     LTENICLDFYRDCWFLGVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEIN
                     LMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCP
                     LGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACS
                     FKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN
                     SFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVS
                     EFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY
                     PCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKN
                     VYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCT
                     EDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLEN
                     TTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALS
                     HNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDI
                     DECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILN
                     ACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECT
                     SGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLL
                     HNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRC
                     ICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKI
                     SPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDC
                     KSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPC
                     MNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFD
                     CRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIP
                     NSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYT
                     IPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLE
                     SYLLQELIVTRELSAKHSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAA
                     TLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADI
                     ELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPI
                     FPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITEASSNQRLTNIKSQAADSLREL
                     SQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHS
                     FSSATEITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSI
                     VPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQYGITMGPTEVLNQESLLDME
                     KSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDF
                     SEVTTNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWEL
                     QPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCVRYYGDSYLEFQNVA
                     LNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKS
                     INTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIG
                     GFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSPTA
                     SFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPL
                     HFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILY
                     SNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVG
                     SPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFR
                     GCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRL
                     YSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTD
                     AFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAV
                     GLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAP
                     GRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNP
                     EGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDP
                     EHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASF
                     HVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIIL
                     ETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSS
                     LNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRN
                     GGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWV
                     GRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQ
                     NEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYI
                     NNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFF
                     QEPKNIELIKLEGYNVYDGDEQNEVT"
     exon            1288..1401
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1595
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1723
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1838
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1998
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2138
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2305
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2562
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2676
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2798
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2920
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3180
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3277
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3385
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3531
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3703
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3782
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3982
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4107
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4223
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4416
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4417..6183
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            6184..6374
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            6375..6466
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            6467..6617
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            6618..6730
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            6731..6963
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            6964..7110
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            7111..7264
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            7265..7373
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            7374..7594
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            7595..7767
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            7768..7950
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            7951..8117
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            8118..8262
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            8263..8437
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            8438..8610
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            8611..8772
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            8773..10590
                     /gene="EYS"
                     /gene_synonym="bA166P24.2; bA307F22.3; bA74E24.1;
                     C6orf178; C6orf179; C6orf180; dJ1018A4.2; dJ22I17.2;
                     dJ303F19.1; EGFL10; EGFL11; RP25; SPAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaacaaa gtgatacacg ctaggcatgt ccagacatta accgtaatca gaagcctcct
       61 agggttgcaa gcctccttgg ctaatggttg ggctttgtgc ctcactcttc tcttacacct
      121 ggggagtcaa gtctggatcc tctgctccat atttatttag caaataaaac actgatctca
      181 aacagcaacg gaacctgtgt acttgaggtg ttttttgaaa actaatcaga agaggaatgc
      241 ttatctccca agaaaattga aaccatctgt aaaagaatct tggctgtgct gtgttttgat
      301 tagattgaag cttggtgtaa agagaaaaca caaaagaccg cagaatattt acaacatttg
      361 aattcctgtt tctccatcaa agcacattgt catcaaagct actttgggta tagaaaaaag
      421 gtcaattcca attcccagga atccttaacc acaactttac ttggaaattt ccggtaatac
      481 ttaaaacacc attttgcagc aattctttat gataaactgt aaaatacagc tacccgaaaa
      541 tgactgacaa atcaatcgtc attctgagcc tgatggtttt tcacagctct ttcataaatg
      601 gaaaaacatg tagacggcaa ttggtggaag aatggcatcc acaaccctca tcatatgtgg
      661 taaattggac actaacagaa aacatctgct tggacttcta cagagattgc tggtttttgg
      721 gtgtaaacac taaaatagat acttcaggca atcaagctgt tccccagatt tgccctttgc
      781 aaattcaatt aggagatatc cttgtaattt cttctgaacc atctcttcaa tttccagaaa
      841 taaatttgat gaatgtttct gaaacatctt tcgttggctg tgtgcaaaat accacaacgg
      901 aagatcagtt actttttggc tgcagactaa aaggaatgca cactgttaat tctaagtggc
      961 tgagtgttgg gacacattat tttatcacag ttatggcaag tggtccatca ccttgtccac
     1021 tgggacttcg actaaatgtg acagtgaaac agcagttctg ccaggaatct ctgagttcag
     1081 aattttgctc tggtcatggt aaatgtctta gtgaagcttg gagcaagaca tatagctgcc
     1141 attgccagcc tccattttct ggaaaatact gccaggaact tgatgcatgt tcttttaaac
     1201 catgtaaaaa taatggcagt tgcattaata aaagagaaaa ttgggatgag caagcatatg
     1261 aatgtgtctg tcacccacca tttacaggaa agaattgctc agaaataatt ggccagtgtc
     1321 aaccacatgt ctgtttccat ggaaactgca gcaatattac ttcaaatagt ttcatttgtg
     1381 aatgtgatga gcaattttca ggtccattct gtgaggtgtc agcaaaacct tgtgtttctc
     1441 tgcttttttg gaaaagagga atttgcccaa atagcagttc tgcttatact tatgaatgcc
     1501 caaaaggatc ttccagccaa aatggtgaaa ctgatgtcag tgagttttca ttagtaccat
     1561 gtcagaatgg tactgactgc atcaaaatat caaatgatgt tatgtgcatc tgttcaccaa
     1621 tatttacaga tttgctttgt aagagcattc aaacatcatg tgagtcattt cctttgagga
     1681 ataatgctac atgtaagaaa tgtgagaaag attatccttg cagctgtata tcaggattta
     1741 ctgaaaaaaa ctgtgagaaa gcaattgacc actgtaaact gctcagcatc aactgtctga
     1801 atgaagaatg gtgtttcaat ataattggaa gattcaaata tgtatgcatt ccagggtgca
     1861 caaaaaatcc atgttggttt ttgaagaatg tttacctaat tcatcaacac ctctgctact
     1921 gtggagtcac cttccatggt atttgccaag ataaaggtcc tgctcaattt gaatatgtgt
     1981 ggcaattggg atttgcagga tctgaaggcg aaaagtgcca aggggttatt gatgcctatt
     2041 tctttctggc tgcaaactgc actgaagatg caacctatgt gaacgatcct gaagataata
     2101 attcttcatg ttggttccca catgaaggca caaaagagat ttgtgcaaat ggatgcagtt
     2161 gtttgagtga agaagacagt caggaatatc ggtatctatg ttttctcaga tgggctggca
     2221 acatgtatct ggaaaataca actgatgatc aagaaaatga gtgtcaacat gaagctgttt
     2281 gtaaagatga aattaataga cccagatgca gctgttctct tagttacatt ggcagattgt
     2341 gtgttgtcaa tgttgactat tgcttaggga accacagtat atcagtgcat ggcctctgcc
     2401 tggccctttc gcacaattgt aactgtagcg gtctgcaaag atatgaaagg aacatctgtg
     2461 agatagatac tgaagactgc aaatctgcgt cctgcaaaaa tggaacaact agtacacatt
     2521 taaggggata tttcttccgc aagtgtgtcc caggatttaa aggtacgcaa tgtgaaattg
     2581 atatagatga gtgtgcttca catccctgca aaaatggagc cacctgcatt gaccaacctg
     2641 gtaattactt ctgccagtgt gtgcctccat ttaaagtggt tgatggcttt tcctgcttat
     2701 gcaatccagg ctatgttggg ataagatgtg aacaggacat tgatgactgc atcctgaatg
     2761 cctgtgagca caattctacc tgcaaagacc tgcatctcag ctaccagtgt gtgtgcctat
     2821 ctgattggga aggaaatttt tgtgaacaag aatccaatga gtgtaaaatg aatccttgca
     2881 agaacaattc cacctgtact gacctttaca aaagctatcg atgtgagtgt acatctggat
     2941 ggactggaca gaactgtagt gaagaaataa atgaatgcga ctctgatcca tgcatgaatg
     3001 gaggtctttg tcatgaatct accatccctg gacaatttgt atgtctgtgc ccaccccttt
     3061 atactggaca attttgccac caacgctata acctttgtga cctacttcat aacccttgca
     3121 gaaacaactc aacatgctta gctttggtag acgcaaatca gcattgtatt tgtagagaag
     3181 aatttgaagg taaaaactgt gaaattgatg tgaaagactg cctcttcctt tcctgccagg
     3241 attatggtga ctgtgaagat atggtcaaca atttcaggtg tatttgcaga cctgggtttt
     3301 ctggatctct gtgtgaaatt gaaattaatg aatgttcctc tgaaccttgc aaaaataatg
     3361 gaacatgtgt ggatctgaca aacagatttt tttgtaattg tgaacctgag taccatgggc
     3421 ccttctgtga acttgatgta aataaatgta aaatctcacc ttgtctagat gaagaaaatt
     3481 gtgtctacag gactgatgga tacaactgcc tctgtgcccc tggttataca ggcatcaact
     3541 gtgaaataaa tctagatgaa tgcctatcag agccctgtct ccatgatgga gtttgtatcg
     3601 atggcatcaa tcattatacc tgtgactgca agagtgggtt ttttggaaca cactgtgaaa
     3661 caaacgccaa tgattgcctt tcaaatcctt gtctacatgg aaggtgcaca gaacttatta
     3721 atgaatatcc atgttcatgt gatgcagatg ggactagcac acaatgtaag atcaaaatta
     3781 atgactgcac atcaatccct tgtatgaatg aaggcttctg tcagaagtca gcacatggat
     3841 ttacttgcat ttgcccacgt ggatacactg gtgcatactg tgaaaaaagc attgataatt
     3901 gtgctgagcc tgaacttaat tcagtcatct gtcttaatgg agggatctgt gttgatgggc
     3961 ctggacatac ttttgactgc agatgtcttc ctggattttc tggtcaattt tgtgaaatta
     4021 atataaatga atgctcttca tcaccatgtc tacatggtgc agactgtgaa gatcacatca
     4081 atggatatgt ttgcaaatgc caaccaggat ggtctggaca ccactgtgag aatgagcttg
     4141 agtgcattcc caactcatgt gttcatgaac tctgcatgga gaatgaacct ggctcgacat
     4201 gtttatgcac acctggattt atgacctgct ccattgggct tctttgtggt gatgaaataa
     4261 ggagaattac ctgtttaact cccatctttc aaagaacaga tcccatttcc acacagacat
     4321 atacaattcc cccttctgag actttggtca gcagctttcc atctataaag gctactagaa
     4381 taccagccat aatggacact tacccagttg atcaaggtcc aaaacagaca ggcattgtca
     4441 agcacgacat tctcccaacc actggtttgg caacattaag aattagcaca cccttggaaa
     4501 gctacttact ccaagaactg attgtcacta gagagctttc agcaaaacac agtcttcttt
     4561 cttccgcaga tgtttcctct tctcgattcc tgaattttgg tattcgtgac ccagcacaaa
     4621 ttgtccagga caaaacatcg gtatcacata tgcctattcg aacttcagca gccacactag
     4681 gtttcttttt tcctgatagg agagcaagga ccccatttat catgtcttcc ttaatgtcag
     4741 attttatttt tcctacacaa tctttattat ttgagaactg tcagactgtt gctttatctg
     4801 ctaccccaac gacttcagta attagaagca ttccaggggc tgatattgag ctaaacaggc
     4861 agtcattact ctcccgtgga ttcctgctta tagctgcctc cataagtgca actccagttg
     4921 tctctagggg ggctcaagag gatattgaag aatattcagc tgattcttta atttcaagaa
     4981 gagagcactg gagattgctc agcccctcga tgtctcccat ttttcctgct aaggtaatta
     5041 tatctaaaca ggtaaccatc ttaaactcat cagctctgca ccggttcagt acaaaagcct
     5101 tcaatcccag tgaatatcag gctattactg aggcttcaag caaccagaga ctcacaaaca
     5161 tcaaatcaca ggctgctgat tctttaagag aattaagcca aacatgtgca acatgttcta
     5221 tgactgaaat aaaatcctct cgtgaattct cagatcaagt tttgcatagc aaacagtccc
     5281 acttttatga gacattctgg atgaactcag cgatattagc cagctggtat gcactaatgg
     5341 gagctcaaac tatcacttct gggcattcat tttcttctgc tactgaaata acaccatcag
     5401 tggcattcac agaagtgcca tctttatttc cttctaaaaa gagtgcaaaa agaacaattt
     5461 tatcctcatc cttggaagaa tccattaccc tatcaagtaa tttggatgtt aatttatgtt
     5521 tggataagac ttgtttatcc attgtccctt cacaaactat ctcttcagac ttgatgaatt
     5581 ctgatttgac ttcaaaaatg actactgatg aactgtcagt atcagaaaac attttaaaac
     5641 tattgaaaat aagacaatat ggcataacta tgggacccac tgaggtacta aatcaagaga
     5701 gcttattgga catggaaaaa agtaaaggat ctcatacact gttcaaactt cacccaagtg
     5761 atagttctct ggattttgag ttaaacttac aaatttatcc ggatgttact ttaaagacat
     5821 attcagaaat tacacatgca aatgacttca aaaataatct gccaccattg acaggctcag
     5881 tgcctgattt ttcagaagtc accaccaatg ttgcatttta tacagtttca gcaactccag
     5941 cactttcaat acagacgtct tcctccatgt ctgtaattag gccagattgg ccatatttta
     6001 cagattatat gacctctctt aaaaaagagg tcaagacttc ttcagaatgg tccaaatggg
     6061 aacttcagcc tagtgtgcaa tatcaggaat ttcccactgc aagccggcat cttcccttca
     6121 ctagatctct tactttgtct tcactggaat ccattctggc acctcaacgg ctgatgattt
     6181 ctgatttcag ttgtgttcgt tattatggag attcttatct agaatttcag aatgtggctt
     6241 taaatccaca aaataacatc tccctagaat ttcagacctt cagctcctat ggacttctgc
     6301 tgtatgtcaa gcaagactca aatttagtag atggattttt tattcaattg tttattgaaa
     6361 atggtacttt aaagtaccac ttttactgtc ctggtgaagc aaaatttaaa agcattaata
     6421 ctactgttag agtggacaac gggcaaaagt atacactgct tatcaggcaa gaattggatc
     6481 catgtaacgc tgagctgact attttaggga ggaatacaca aatatgcgaa tctatcaatc
     6541 atgtactcgg aaaacccctg ccaaaatcag gatctgtctt cattggtgga tttccagacc
     6601 ttcatgggaa aatccagatg cctgtaccag tcaagaattt tactggctgc atagaagtta
     6661 tagaaataaa taactggaga tctttcattc catccaaggc agtgaaaaac tatcacatta
     6721 acaattgcag atcccaggga tttatgctgt ctccaacagc ctcctttgtt gatgcttctg
     6781 atgtgacaca aggggttgat accatgtgga cttctgtcag cccctctgtt gcagcaccct
     6841 ctgtgtgcca gcaggatgta tgccacaatg gaggcacatg ccatgccatc ttcctctcca
     6901 gtggcatagt gtcattccaa tgtgactgtc cactacattt cactggccgc ttctgtgaaa
     6961 aagatgcagg tttattcttt ccatctttca atgggaattc ctatttagaa ctgccctttt
     7021 tgaagtttgt cctggagaag gaacataaca gaactgttac catctacttg actataaaaa
     7081 caaacagttt aaatggaact attctttaca gtaatgggaa taattgtgga aagcagtttc
     7141 ttcatttatt tcttgtggaa ggaaggccat cagttaaata tgggtgtgga aattctcaaa
     7201 atattttgac tgtttctgct aattacagca ttaacacaaa tgcattcacc cctatcacaa
     7261 tacgctacac aacgcctgtt ggcagccctg gagttgtttg tatgattgaa atgactgcag
     7321 atggaaaacc tccagtacag aagaaagaca cagagatttc ccatgcctct caggcatatt
     7381 ttgaatcaat gttccttggc catattcctg caaatgttca aattcataag aaagcaggtc
     7441 ctgtttatgg gttcaggggc tgcattctag accttcaagt aaacaacaaa gaattcttca
     7501 tcatcgatga agcacgacat ggaaagaata ttgagaactg ccacgtccct tggtgtgctc
     7561 atcatctgtg ccgcaacaat ggcacctgca tcagtgataa tgaaaatctg ttttgtgagt
     7621 gtccaaggct gtattcaggc aagctgtgcc agtttgcaag ttgtgaaaac aacccatgtg
     7681 gaaatggtgc cacctgtgtt ccaaaatccg gaacagatat tgtctgcctc tgcccatatg
     7741 ggaggtctgg acccctctgc actgatgcta ttaatattac tcagccaagg ttcagtggca
     7801 cagatgcctt tggatacacc tcattcctgg cttattcacg gatctcagac atcagcttcc
     7861 attatgaatt ccacctgaag tttcagctgg caaacaacca ctcagcactg caaaataact
     7921 tgatattttt tactggacag aaaggccatg ggttgaatgg cgatgacttc ctggctgtgg
     7981 gcctgctcaa tggcagtgtg gtttatagtt ataacctggg gtctggcata gcaagcatca
     8041 ggagcgagcc cctcaatctg agccttggag tccacactgt tcatctgggc aagttcttcc
     8101 aagagggctg gctgaaggta gatgatcata aaaataaatc cattatcgcc ccaggaagac
     8161 tggttggtct caatgtcttc agtcagtttt atgtaggtgg ctacagtgaa tacactccag
     8221 atctcttacc aaatggagca gattttaaaa atggttttca aggctgtatt ttcactcttc
     8281 aagttcgcac tgagaaggat ggccatttca gaggactggg aaatcctgag ggccacccaa
     8341 atgctggacg cagtgttggc cagtgtcatg cttctccctg cagtttaatg aaatgtggca
     8401 atggtgggac atgcatagag agtggaacta gtgtttactg caattgtacc actgggtgga
     8461 aaggatcatt ctgcacagag acagtttcta cctgtgatcc tgaacatgac cctccacacc
     8521 actgtagcag aggagcaacc tgcatttcat tacctcatgg atacacctgt ttctgtcctc
     8581 taggaaccac tggaatctac tgtgaacaag ctttatccat aagtgatcca tctttcagaa
     8641 gcaatgagtt atcctggatg tcttttgctt cctttcatgt tcgaaaaaag acacatattc
     8701 aattgcagtt tcagcctctc gctgcagatg gtatcctatt ttatgctgca caacacttaa
     8761 aagcccaatc aggtgatttt ttatgcatct ctttagtaaa tagttccgtt caacttcgct
     8821 acaaccttgg cgacagaact atcattctag aaactctcca aaaagtaact ataaacggaa
     8881 gtacttggca tataataaaa gcaggaagag ttggtgcaga aggctacctg gatctagatg
     8941 ggataaatgt aacagaaaag gcctccacta aaatgagttc tctggacaca aatacagact
     9001 tctatattgg aggagtatct tctttaaatc ttgtaaatcc catggcaata gaaaatgaac
     9061 ctgtaggttt tcaaggctgt atccgacaag ttatcataaa taatcaagaa ttacaattaa
     9121 ctgaatttgg agcaaaaggt ggctcaaatg taggtgactg tgatgggaca gcctgtgggt
     9181 acaacacatg cagaaatgga ggtgaatgta cagtaaatgg cacaactttt tcttgcagat
     9241 gtttgccaga ttgggctgga aatacatgta accagtctgt gtcctgtttg aataatcttt
     9301 gcctccacca atctttatgt atacctgacc aatcattttc ttacagttgc ctgtgtactt
     9361 tgggttgggt gggaaggtat tgtgaaaaca aaacttcatt ttcaactgca aaatttatgg
     9421 gtaattctta cattaaatac attgatccaa attatagaat gagaaacctc cagttcacta
     9481 ctatatcctt aaatttcagt accactaaaa cagaaggtct aattgtatgg atgggaatag
     9541 ctcaaaatga agaaaatgat tttctggcaa ttggtctcca taatcagacc ttgaaaatag
     9601 cagttaactt gggagaaaga atctctgtgc ctatgagcta taacaatggc acattctgtt
     9661 gtaataaatg gcaccatgta gttgtaattc aaaatcagac tcttatcaag gcctacataa
     9721 ataacagtct aattctttcc gaggatattg atccacataa aaactttgtg gctctaaact
     9781 atgatggcat ttgttatcta gggggctttg aatatggtag aaaggtaaat atcgttactc
     9841 aagagatttt taaaaccaat tttgttggca aaattaaaga tgttgtattt tttcaggaac
     9901 caaaaaacat tgaactaatt aaattagaag gatacaatgt ttatgatgga gatgaacaaa
     9961 atgaggttac ataagttaac actagagatt ttagtacaca ctatacataa atgcagttat
    10021 tttgatagtt atttctttga tacattgctt acggggaatc aactgtttac tatattacct
    10081 gaaatagtct aaatgctaac atatcttttt gataagattg taaaatgtca ctgaaggttc
    10141 tgattgtttt tcctacatct aatttatctg tatatatttt gattcatgtt ttaactccat
    10201 tagttcagtg cttattcaca gaatgtgctt attcactttg cttattcact ttttacctat
    10261 ccctaatgct tacattttaa aatcaacgtg taaacacaat tttaaaaatc aatgtgtaag
    10321 ctgaacttta aaatgtttaa aattcagttg ggaatgaatt agggataggt acaaataaga
    10381 aaaaaatcaa gttattaatc aaaggaaaaa taaaaattat acaaagcaat gtaaccatat
    10441 tgtattacat ggcttagcta caacttattt atatgattca acaatgtaaa acttgaacat
    10501 agatttaaac caaaaattat tgcatgaatg tagaaagaga aggtgagagg agaggagaac
    10561 aggctggtaa gagctaaatc cttatctttt
//
