LOCUS       NM_004100               5701 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens EYA transcriptional coactivator and phosphatase 4
            (EYA4), transcript variant 1, mRNA.
ACCESSION   NM_004100
VERSION     NM_004100.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5701)
  AUTHORS   de la Pena Avalos,B., Tropee,R., Duijf,P.H.G. and Dray,E.
  TITLE     EYA4 promotes breast cancer progression and metastasis through its
            role in replication stress avoidance
  JOURNAL   Mol Cancer 22 (1), 158 (2023)
   PUBMED   37777742
  REMARK    GeneRIF: EYA4 promotes breast cancer progression and metastasis
            through its role in replication stress avoidance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5701)
  AUTHORS   Li,C., Liu,Z., Xu,G., Wu,S., Peng,Y., Wu,R., Zhao,S., Liao,X. and
            Lin,R.
  TITLE     Aberrant DNA methylation and expression of EYA4 in gastric cardia
            intestinal metaplasia
  JOURNAL   Saudi J Gastroenterol 28 (6), 456-465 (2022)
   PUBMED   36453428
  REMARK    GeneRIF: Aberrant DNA methylation and expression of EYA4 in gastric
            cardia intestinal metaplasia.
REFERENCE   3  (bases 1 to 5701)
  AUTHORS   Zhang,W., Song,J., Tong,B., Ma,M., Guo,L., Yuan,Y. and Yang,J.
  TITLE     Identification of a novel CNV at the EYA4 gene in a Chinese family
            with autosomal dominant nonsyndromic hearing loss
  JOURNAL   BMC Med Genomics 15 (1), 113 (2022)
   PUBMED   35578334
  REMARK    GeneRIF: Identification of a novel CNV at the EYA4 gene in a
            Chinese family with autosomal dominant nonsyndromic hearing loss.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5701)
  AUTHORS   Ishino,T., Ogawa,Y., Sonoyama,T., Taruya,T., Kono,T., Hamamoto,T.,
            Ueda,T., Takeno,S., Moteki,H., Nishio,S.Y., Usami,S.I., Nagano,Y.,
            Yoshimura,A., Yoshikawa,K., Kato,M., Ichimoto,M. and Watanabe,R.
  TITLE     Identification of a Novel Copy Number Variation of EYA4 Causing
            Autosomal Dominant Non-syndromic Hearing Loss
  JOURNAL   Otol Neurotol 42 (7), e866-e874 (2021)
   PUBMED   33859130
  REMARK    GeneRIF: Identification of a Novel Copy Number Variation of EYA4
            Causing Autosomal Dominant Non-syndromic Hearing Loss.
REFERENCE   5  (bases 1 to 5701)
  AUTHORS   Wayne,S., Robertson,N.G., DeClau,F., Chen,N., Verhoeven,K.,
            Prasad,S., Tranebjarg,L., Morton,C.C., Ryan,A.F., Van Camp,G. and
            Smith,R.J.
  TITLE     Mutations in the transcriptional activator EYA4 cause late-onset
            deafness at the DFNA10 locus
  JOURNAL   Hum Mol Genet 10 (3), 195-200 (2001)
   PUBMED   11159937
REFERENCE   6  (bases 1 to 5701)
  AUTHORS   Schonberger,J., Levy,H., Grunig,E., Sangwatanaroj,S., Fatkin,D.,
            MacRae,C., Stacker,H., Halpin,C., Eavey,R., Philbin,E.F., Katus,H.,
            Seidman,J.G. and Seidman,C.E.
  TITLE     Dilated cardiomyopathy and sensorineural hearing loss: a heritable
            syndrome that maps to 6q23-24
  JOURNAL   Circulation 101 (15), 1812-1818 (2000)
   PUBMED   10769282
REFERENCE   7  (bases 1 to 5701)
  AUTHORS   Borsani,G., DeGrandi,A., Ballabio,A., Bulfone,A., Bernard,L.,
            Banfi,S., Gattuso,C., Mariani,M., Dixon,M., Donnai,D., Metcalfe,K.,
            Winter,R., Robertson,M., Axton,R., Brown,A., van Heyningen,V. and
            Hanson,I.
  TITLE     EYA4, a novel vertebrate gene related to Drosophila eyes absent
  JOURNAL   Hum Mol Genet 8 (1), 11-23 (1999)
   PUBMED   9887327
REFERENCE   8  (bases 1 to 5701)
  AUTHORS   O'Neill,M.E., Marietta,J., Nishimura,D., Wayne,S., Van Camp,G., Van
            Laer,L., Negrini,C., Wilcox,E.R., Chen,A., Fukushima,K., Ni,L.,
            Sheffield,V.C. and Smith,R.J.
  TITLE     A gene for autosomal dominant late-onset progressive non-syndromic
            hearing loss, DFNA10, maps to chromosome 6
  JOURNAL   Hum Mol Genet 5 (6), 853-856 (1996)
   PUBMED   8776603
REFERENCE   9  (bases 1 to 5701)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
REFERENCE   10 (bases 1 to 5701)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX490250.1, Y17114.1,
            DA760903.1, BC014193.2, AL450270.7 and AW613879.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004100.4.
            
            Summary: This gene encodes a member of the eyes absent (EYA) family
            of proteins. The encoded protein may act as a transcriptional
            activator through its protein phosphatase activity, and it may be
            important for eye development, and for continued function of the
            mature organ of Corti. Mutations in this gene are associated with
            postlingual, progressive, autosomal dominant hearing loss at the
            deafness, autosomal dominant non-syndromic sensorineural 10 locus.
            The encoded protein is also a putative oncogene that mediates DNA
            repair, apoptosis, and innate immunity following DNA damage,
            cellular damage, and viral attack. Defects in this gene are also
            associated with dilated cardiomyopathy 1J. Alternative splicing
            results in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes isoform a, which is
            more abundant in adult brain.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y17114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355286.12/ ENSP00000347434.7
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               BX490250.1         1-162
            163-690             Y17114.1           146-673
            691-714             DA760903.1         464-487
            715-1286            Y17114.1           698-1269
            1287-1428           BC014193.2         126-267
            1429-2400           Y17114.1           1412-2383
            2401-5297           AL450270.7         26324-29220
            5298-5693           AW613879.1         5-400               c
            5694-5701           AL450270.7         29617-29624
FEATURES             Location/Qualifiers
     source          1..5701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..5701
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /note="EYA transcriptional coactivator and phosphatase 4"
                     /db_xref="GeneID:2070"
                     /db_xref="HGNC:HGNC:3522"
                     /db_xref="MIM:603550"
     exon            1..393
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            394..491
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             459..2378
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1; eyes
                     absent homolog 4; dJ78N10.1 (eyes absent); eyes
                     absent-like protein 4; protein phosphatase EYA4"
                     /codon_start=1
                     /product="protein phosphatase EYA4 isoform a"
                     /protein_id="NP_004091.3"
                     /db_xref="CCDS:CCDS5165.1"
                     /db_xref="GeneID:2070"
                     /db_xref="HGNC:HGNC:3522"
                     /db_xref="MIM:603550"
                     /translation="MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGG
                     GDTPGSSKLEKSNLSSTSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEP
                     LNSSETTATTGDGALDTFTGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTM
                     SAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSG
                     CLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAF
                     GQNQYAQYYSASTYGAYMTSNNTADGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPST
                     PIKDLDERTCRSSGSKSRGRGRKNNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYA
                     QKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYS
                     FATDGFHAAASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKR
                     DAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYSLGG
                     AFPIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHNMPFWRISSH
                     SDLLALHQALELEYL"
     exon            492..541
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            542..666
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            667..735
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            736..828
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            829..895
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1038
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1182
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1262
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1428
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1565
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1649
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1739
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1798
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1959
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2074
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2196
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2297
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..5701
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3223..3228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /note="hexamer: AATAAA"
     polyA_site      3245
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /note="major polyA site"
     regulatory      4551..4556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /note="hexamer: AATAAA"
     polyA_site      4576
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
     regulatory      5659..5664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /note="hexamer: AATAAA"
     polyA_site      5701
                     /gene="EYA4"
                     /gene_synonym="CMD1J; DFNA10"
                     /note="major polyA site"
ORIGIN      
        1 gcaaaacttc catcctgtcc acgtgaagtt gtcgctgcct tagagagggg gaaagagctg
       61 cgggaaaagc cggggagtga cgactgcggc ggctgggcgc gctctctcat tttcttttct
      121 tctcctttcc cccctgtcgc agtccggagt tttggctcct ctcctttcct cctccccctc
      181 ggagccggct tctccctccg ccccgcttct cccccgcttg tgtacgctat ttgttgtggg
      241 gtggccgaag gggatgtcct gttttcacca gaggcacagc gcgaagggga aacttcgaca
      301 ctggaaggaa cgagaataaa tacttaatta cggacgcact gaaccgcggc tgggacagac
      361 acttcgggaa cccgaggcgg accgggcgac gagatagtca tttttacttg aaggaagctg
      421 cttctacttg ggagtggcag gagaagtgag aaaaccacat ggaagactcc caggatttaa
      481 atgaacaatc agtaaagaaa acgtgcacag aatcagatgt ttcacaatct cagaattcca
      541 ggtctatgga aatgcaggac ctagcaagtc ctcatactct tgttggaggt ggtgatactc
      601 caggtagctc caaactggaa aaatctaatc tcagcagcac atcagttact acaaatggga
      661 caggagggga aaacatgact gttttaaaca cagcagactg gttgctgagt tgcaacaccc
      721 cctcttctgc aacaatgtct cttcttgcag tcaaaacaga gcccttgaac agcagtgaaa
      781 ccacagccac gactggagat ggagcgcttg acacttttac tgggtcagta attacaagta
      841 gtggctacag ccccagatca gcacatcagt attccccaca gctgtatcct tccaagccct
      901 atccacacat tctttctaca ccagcagctc aaacaatgtc tgcctatgca ggccagactc
      961 agtattcggg gatgcagcag ccagccgtct acacagccta ctcacagaca ggacagccct
     1021 acagcttgcc cacttacgat ttgggtgtga tgttgccagc catcaagaca gagagtggac
     1081 tttcccaaac tcagtcccca ttacagagtg gctgcctcag ttacagccca gggttctcta
     1141 ccccacagcc aggccagaca ccttattctt accaaatgcc aggttctagt tttgcaccat
     1201 catctactat ttatgcaaat aattcagttt ccaattcaac gaatttcagt ggttcacaac
     1261 aggattatcc atcctataca gcctttggcc aaaaccagta tgcacagtat tattcagcat
     1321 caacgtatgg agcgtatatg acatcgaata acacagccga tggcacaccc tcttcaacct
     1381 ctacttatca gttgcaggaa tctctcccag gactgactaa ccaaccagga gagttcgata
     1441 ccatgcagag tccctccaca cccatcaaag atcttgatga gagaacctgt aggagttctg
     1501 ggtcaaagtc cagaggaaga ggccggaaaa ataatccctc cccgcctcct gatagtgacc
     1561 tggagcgtgt gtttgtctgg gatttggatg aaaccatcat tgtttttcac tcactgctca
     1621 ccgggtctta tgcacagaag tatggcaagg atccccccat ggctgtaacc cttggactcc
     1681 gcatggaaga aatgattttt aatcttgctg atactcattt gttttttaat gatttagagg
     1741 agtgtgatca agttcatata gatgatgttt cctctgatga taatgggcag gacttaagta
     1801 cctacagttt tgcaactgat ggcttccatg cagctgcaag tagtgcaaac ctttgtttgc
     1861 caacaggtgt aagaggaggg gttgactgga tgaggaagtt ggcttttcgt tacagaagag
     1921 taaaagaatt atataacacc tacaagaaca acgttggagg actccttggc cctgccaaga
     1981 gggatgcctg gctacagtta agggcagaga ttgaaggtct gacagattcc tggctaacaa
     2041 atgcacttaa gtctttatca attattagca ctaggagtaa ctgcataaat gtcttggtaa
     2101 cgacaactca actgatccca gcacttgcga aggttctact ctatagttta ggaggtgctt
     2161 tccccattga gaatatttac agtgcaacta aaataggaaa agaaagttgc tttgaacgaa
     2221 taatgcaaag gtttggcaga aaagtagtgt atgttgtaat tggggatggt gtagaagaag
     2281 aacaggcagc aaaaaagcac aacatgccct tctggaggat atccagtcac tcagacctcc
     2341 tggctctcca ccaagcactg gaattagagt atttgtaact gtgttcttta gccggagatc
     2401 cattttttat atttcaagta cactgaattt ttatgtgtga ttcaatgcct ctggctctac
     2461 acatataaat tgtcttaatg gatgaaatca tatttggaat aaaaattcca gaatgaagaa
     2521 ttcagattgc tgaatggagt taaactttag tgctacagaa aagaaactct atggtcttat
     2581 atttacaaca ctttaatggg ttttttaaaa atctgtggag gttgctggta cacaccaaat
     2641 gagtccaaac tggaatgagc agctttagca aagaactctt accctggcaa agcagcaaca
     2701 cacatgctcc gtctgacaag gtggtcaaca acattcctca aaatgggaga tcttctcagc
     2761 cctgaggttt gaatctgact ttagcctacc taacccagaa aatctgaatt ggaatgcact
     2821 cagactgtat aaggacagtc ctatttagac atgtaatttg tgtaaattat tgatgaaaat
     2881 aatttactgt gactttatta gcagctgact ttcaaagtgg atgcaatttt tctttctttt
     2941 gttggggagg ggaatgggag gggaaatggg aatataatat tgtctctttt ttaagtttgg
     3001 caaacagaat gttcatactg atgtgttgtg ccttaaagac aagacagcat ttgtgtgtta
     3061 caatgtaact ttggttaaaa tctctgtaga taatgaaaaa aaacaaaaaa aaaaaccttt
     3121 gtgatgattc ttaacatgac caaatttaaa agtcaagctc tcagagctta attaccgcat
     3181 cagcaagaaa ctgagtattt tttgcaataa gaaaacaaca ataataaagg aaagcttgtg
     3241 tttcatttgg gttcttaata attccaataa ttgtatgagg caactatttg cgcatccaac
     3301 catgagtgga aggtttggga aagactgtgg gacctttact tagaaagtga aatgtatgta
     3361 gaagtctcaa gtaccccttc tacagtttta ctggagaaaa ctaagagcca tattcatgac
     3421 aacttgcaca gttttgaggt tgagactttt gatatgtgta agttgcatag aggaggatat
     3481 tatcatgcaa atcatgagca attatcacat aaactttttt agaatgtgcc atgaacatgg
     3541 cataaaattc acattgagtg cacagggctt aaaataaagc taagtatgtt tattcccaat
     3601 gccatggcaa aaatgataat atcatcagaa atggaaggca gttctcccag atggtgtcta
     3661 atgaaagcaa tgagtctatg aaaattttac ctagaatatc atcataaatt aaattagcaa
     3721 gtgcgctgga tcttggcagc gctgctgaaa tgacaacagt aaaataatac ctggttctcc
     3781 atctgaatac atcaatgcag gttctcctcg taacagactt gcatatgttt gttagtttct
     3841 gcctgtattg tcactgcgca acggatggca ttcattacaa gaagagccca tcatcgttgt
     3901 gtttgcatgg tttttttcct tgtgtgtagc ccatgttggg aacacgatac aggttctcct
     3961 cttatttcct atgacacgat ttcccttgtg gaaatttaag actttaagaa ctagagtatt
     4021 tttatggtgt ctgcacctgc agttctgtgt ttaaaatgtc ataatgtgga tcctggagtc
     4081 aggctactag tcagtgcccc tagccagagg ctggttcatg agttcatcaa ctgaggcctc
     4141 tgtggcttca ataaagtcta cattttgctc acagatcaca acattcactg tggaaatatg
     4201 atttcatttc tttaggctac aaacctgtat ttctttactg aatgctaagg ccatgtttat
     4261 attgggtaga aagatattga gatcccaatt ttgtacaaga ttgtgatttc attatctaaa
     4321 ccttaaactt aatcctttaa attttgtagc ttttggctgc atctgcccca agtactattc
     4381 caggcaaatt aaagttggaa tacctttaat aatataaaaa taatgatagt aaatcttata
     4441 cttctgttgg cccttagctt gaaaatagca gttaaaaaaa tttaaatgtt gccttgatta
     4501 tcagtactta attatgttgt gcactaaaac cttaaatatt tattactgtg aataaaaaca
     4561 aattatcttt actgtatagc tggtttcttt aaatgttgat agaattgtgg cattacatct
     4621 aaatttgtaa gtcttttcat atcaaacaag caaggctttt tatgctgcta agtctgtggg
     4681 tgcagaaaga aacacccctt ggaagggcaa agagaagccg gctggttgca tcaccccgtg
     4741 cagtttctca cacacatctc tttttctgat tctgtgttca gaagaggctg ccggcataaa
     4801 acctaaatgc aaggttgacg gagaacagct tgtctggcac aacaatggtg caggcccacg
     4861 agccagcatc acagcttggc catgggacgt tgagtatgca caaactagaa ctcttccctt
     4921 cccaccttag gaatagaaaa tcctcttcct ttctaatctg aaaaacgaaa actgaacaaa
     4981 cacaaaacca accccttggc agttcccacc tcctattgac atatggaata ttgtgcctta
     5041 ttgtaaacca gtttgaaaaa tgttctgtaa ctaaagtggg ttttcggcta ttatgtatac
     5101 agcttggtat attactacga aagataacca ccttgtgttg caccttaaaa atatcaagac
     5161 catgtaattt ccataacaaa ataggtggcc tggctatggt attatagcat acaattagga
     5221 cactatgccc ctgcaaaatt ttgtaaatca aattcagagg caaaaacata ttttagaatc
     5281 atacagtttg cacacgacaa gtaggtaata actgtctcta aaaatgtttt ctccttagtc
     5341 cgcaatgagc taagattcag aatagtgtca acagcatgct cctatatgaa gttgtttttt
     5401 ttaaagcaca tttgtttatg acaagcctac attctcagtg aatatggcat ttagtatttc
     5461 ttttgaaaac aaacttaagc atcatgagcc aaagttgcac tttgactccc aactacggta
     5521 gcattatgga catctcacaa tgtcaagggt ttctgttatg tattagtaaa gtatagatta
     5581 ttggggccta cataatttaa aagaaatgta aattaatatt aaaagcttgt aaaaatatgt
     5641 atatctttac tatttctcaa taaatacctt tgcaattgtt ttcatttcct tcaccctccc
     5701 a
//
