LOCUS       NM_005244               2483 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens EYA transcriptional coactivator and phosphatase 2
            (EYA2), transcript variant 1, mRNA.
ACCESSION   NM_005244
VERSION     NM_005244.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Wolin,A.R., Vincent,M.Y., Hotz,T., Purdy,S.C., Rosenbaum,S.R.,
            Hughes,C.J., Hsu,J.Y., Oliphant,M.U.J., Armstrong,B., Wessells,V.,
            Varella-Garcia,M., Galbraith,M.D., Pierce,A., Wang,D.,
            Venkataraman,S., Danis,E., Veo,B., Serkova,N., Espinosa,J.M.,
            Gustafson,D.L., Vibhakar,R. and Ford,H.L.
  TITLE     EYA2 tyrosine phosphatase inhibition reduces MYC and prevents
            medulloblastoma progression
  JOURNAL   Neuro Oncol 25 (12), 2287-2301 (2023)
   PUBMED   37486991
  REMARK    GeneRIF: EYA2 tyrosine phosphatase inhibition reduces MYC and
            prevents medulloblastoma progression.
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Anantharajan,J., Baburajendran,N., Lin,G., Loh,Y.Y., Xu,W.,
            Ahmad,N.H.B., Liu,S., Jansson,A.E., Kuan,J.W.L., Ng,E.Y., Yeo,Y.K.,
            Hung,A.W., Joy,J., Hill,J., Ford,H.L., Zhao,R., Keller,T.H. and
            Kang,C.
  TITLE     Structure-activity relationship studies of allosteric inhibitors of
            EYA2 tyrosine phosphatase
  JOURNAL   Protein Sci 31 (2), 422-431 (2022)
   PUBMED   34761455
  REMARK    GeneRIF: Structure-activity relationship studies of allosteric
            inhibitors of EYA2 tyrosine phosphatase.
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Zhang,G., Dong,Z., Gimple,R.C., Wolin,A., Wu,Q., Qiu,Z., Wood,L.M.,
            Shen,J.Z., Jiang,L., Zhao,L., Lv,D., Prager,B.C., Kim,L.J.Y.,
            Wang,X., Zhang,L., Anderson,R.L., Moore,J.K., Bao,S., Keller,T.H.,
            Lin,G., Kang,C., Hamerlik,P., Zhao,R., Ford,H.L. and Rich,J.N.
  TITLE     Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem
            cells induces mitotic catastrophe
  JOURNAL   J Exp Med 218 (11) (2021)
   PUBMED   34617969
  REMARK    GeneRIF: Targeting EYA2 tyrosine phosphatase activity in
            glioblastoma stem cells induces mitotic catastrophe.
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Liu,Z.K., Li,C., Zhang,R.Y., Wei,D., Shang,Y.K., Yong,Y.L.,
            Kong,L.M., Zheng,N.S., Liu,K., Lu,M., Liu,M., Hu,C.X., Yang,X.Z.,
            Chen,Z.N. and Bian,H.
  TITLE     EYA2 suppresses the progression of hepatocellular carcinoma via
            SOCS3-mediated blockade of JAK/STAT signaling
  JOURNAL   Mol Cancer 20 (1), 79 (2021)
   PUBMED   34044846
  REMARK    GeneRIF: EYA2 suppresses the progression of hepatocellular
            carcinoma via SOCS3-mediated blockade of JAK/STAT signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Liu,H.M., Dong,A.B., Hua,H., Sun,Y.H., Wang,J.R., Yu,Q.Q.,
            Zhang,J.H. and Sun,W.H.
  TITLE     MicroRNA-219 inhibits cell viability and metastasis in papillary
            thyroid carcinoma by targeting EYA2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (18), 9556-9564 (2020)
   PUBMED   33015798
  REMARK    GeneRIF: MicroRNA-219 inhibits cell viability and metastasis in
            papillary thyroid carcinoma by targeting EYA2.
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Fee,B.E., Doyle,C.A. and Cleveland,J.L.
  TITLE     A novel Eyes Absent 2 protein is expressed in the human eye
  JOURNAL   Gene 285 (1-2), 221-228 (2002)
   PUBMED   12039049
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Borsani,G., DeGrandi,A., Ballabio,A., Bulfone,A., Bernard,L.,
            Banfi,S., Gattuso,C., Mariani,M., Dixon,M., Donnai,D., Metcalfe,K.,
            Winter,R., Robertson,M., Axton,R., Brown,A., van Heyningen,V. and
            Hanson,I.
  TITLE     EYA4, a novel vertebrate gene related to Drosophila eyes absent
  JOURNAL   Hum Mol Genet 8 (1), 11-23 (1999)
   PUBMED   9887327
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Duncan,M.K., Kos,L., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Tomarev,S.I.
  TITLE     Eyes absent: a gene family found in several metazoan phyla
  JOURNAL   Mamm Genome 8 (7), 479-485 (1997)
   PUBMED   9195991
  REMARK    Erratum:[Mamm Genome 1997;8(11):877]
REFERENCE   9  (bases 1 to 2483)
  AUTHORS   Zimmerman,J.E., Bui,Q.T., Steingrimsson,E., Nagle,D.L., Fu,W.,
            Genin,A., Spinner,N.B., Copeland,N.G., Jenkins,N.A., Bucan,M. and
            Bonini,N.M.
  TITLE     Cloning and characterization of two vertebrate homologs of the
            Drosophila eyes absent gene
  JOURNAL   Genome Res 7 (2), 128-141 (1997)
   PUBMED   9049631
REFERENCE   10 (bases 1 to 2483)
  AUTHORS   Abdelhak,S., Kalatzis,V., Heilig,R., Compain,S., Samson,D.,
            Vincent,C., Weil,D., Cruaud,C., Sahly,I., Leibovici,M.,
            Bitner-Glindzicz,M., Francis,M., Lacombe,D., Vigneron,J.,
            Charachon,R., Boven,K., Bedbeder,P., Van Regemorter,N.,
            Weissenbach,J. and Petit,C.
  TITLE     A human homologue of the Drosophila eyes absent gene underlies
            branchio-oto-renal (BOR) syndrome and identifies a novel gene
            family
  JOURNAL   Nat Genet 15 (2), 157-164 (1997)
   PUBMED   9020840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354766.17, AL121776.19,
            AL359434.15 and AL022342.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005244.4.
            
            Summary: This gene encodes a member of the eyes absent (EYA) family
            of proteins. The encoded protein may be post-translationally
            modified and may play a role in eye development. A similar protein
            in mice can act as a transcriptional activator. Alternative
            splicing results in multiple transcript variants, but the
            full-length natures of all of these variants have not yet been
            determined. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1), also known as EYA2I,
            represents the longer transcript and encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2770523.1, AK293032.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327619.10/ ENSP00000333640.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL354766.17        71110-71254
            146-264             AL121776.19        55198-55316
            265-310             AL121776.19        66625-66670
            311-453             AL121776.19        70139-70281
            454-570             AL121776.19        81378-81494
            571-638             AL121776.19        137382-137449
            639-816             AL121776.19        139355-139532
            817-959             AL359434.15        10555-10697
            960-1043            AL359434.15        18401-18484
            1044-1133           AL022342.7         17767-17856
            1134-1192           AL022342.7         43847-43905
            1193-1353           AL022342.7         47415-47575
            1354-1468           AL022342.7         54506-54620
            1469-1590           AL022342.7         55523-55644
            1591-1691           AL022342.7         57999-58099
            1692-2483           AL022342.7         62761-63552
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2483
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /note="EYA transcriptional coactivator and phosphatase 2"
                     /db_xref="GeneID:2139"
                     /db_xref="HGNC:HGNC:3520"
                     /db_xref="MIM:601654"
     exon            1..145
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..264
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1772
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1; eyes
                     absent homolog 2; protein phosphatase EYA2"
                     /codon_start=1
                     /product="protein phosphatase EYA2 isoform a"
                     /protein_id="NP_005235.3"
                     /db_xref="CCDS:CCDS13403.1"
                     /db_xref="GeneID:2139"
                     /db_xref="HGNC:HGNC:3520"
                     /db_xref="MIM:601654"
                     /translation="MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPL
                     RVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIK
                     TEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVH
                     QDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSES
                     LAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLD
                     ETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVD
                     DVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYN
                     TYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQ
                     LIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQ
                     GAKKHNMPFWRISCHADLEALRHALELEYL"
     exon            265..310
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..453
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..570
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..638
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..816
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..959
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1043
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1133
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1192
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1353
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1468
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1590
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1691
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2483
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="EYA2"
                     /gene_synonym="EAB1"
                     /note="major polyA site"
ORIGIN      
        1 agcagccgcg gcagcccagg aggcggaggc agcggcaacg gcagagacag caacgtgccc
       61 gccgcagtca gcccggcctc gtcggacccg caccggcccg cccgcccgcc cgcaccgcgt
      121 cggggcgccc tctccactgc gcgcggtaca aggaaatggt agaactagtg atctcaccca
      181 gcctcactgt aaacagcgat tgtctggata aactgaagtt taaccgtgct gacgctgctg
      241 tgtggactct gagtgacaga caaggcatca ccaaatcggc ccccctgaga gtgtcccagc
      301 tcttctccag atcttgccca cgtgtcctcc cccgccagcc ttccacagcc atggcagcct
      361 acggccagac gcagtacagt gcggggatcc agcaggctac cccctataca gcttacccac
      421 ctccagcaca agcctatgga atcccttcct acagcatcaa gacagaagac agcttgaacc
      481 attcccctgg ccagagtgga ttcctcagct atggctccag cttcagcacc tcacccactg
      541 gacagagccc atacacctac cagatgcacg gcacaacagg gttctatcaa ggaggaaatg
      601 gactgggcaa cgcagccggt ttcgggagtg tgcaccagga ctatccttcc taccccggct
      661 tcccccagag ccagtacccc cagtattacg gctcatccta caaccctccc tacgtcccgg
      721 ccagcagcat ctgcccttcg cccctctcca cgtccaccta cgtcctccag gaggcatctc
      781 acaacgtccc caaccagagt tccgagtcac ttgctggtga atacaacaca cacaatggac
      841 cttccacacc agcgaaagag ggagacacag acaggccgca ccgggcctcc gacgggaagc
      901 tccgaggccg gtctaagagg agcagtgacc cgtccccggc aggggacaat gagattgagc
      961 gtgtgttcgt gtgggacttg gatgagacaa taattatttt tcactcctta ctcacgggga
     1021 catttgcatc cagatacggg aaggacacca cgacgtccgt gcgcattggc cttatgatgg
     1081 aagagatgat cttcaacctt gcagatacac atctgttctt caatgacctg gaggattgtg
     1141 accagatcca cgttgatgac gtctcatcag atgacaatgg ccaagattta agcacataca
     1201 acttctccgc tgacggcttc cacagttcgg ccccaggagc caacctgtgc ctgggctctg
     1261 gcgtgcacgg cggcgtggac tggatgagga agctggcctt ccgctaccgg cgggtgaagg
     1321 agatgtacaa tacctacaag aacaacgttg gtgggttgat aggcactccc aaaagggaga
     1381 cctggctaca gctccgagct gagctggaag ctctcacaga cctctggctg acccactccc
     1441 tgaaggcact aaacctcatc aactcccggc ccaactgtgt caatgtgctg gtcaccacca
     1501 ctcaactaat tcctgccctg gccaaagtcc tgctatatgg cctggggtct gtgtttccta
     1561 ttgagaacat ctacagtgca accaagacag ggaaggagag ctgcttcgag aggataatgc
     1621 agagattcgg cagaaaagct gtctacgtgg tgatcggtga tggtgtggaa gaggagcaag
     1681 gagcgaaaaa gcacaacatg cctttctggc ggatatcctg ccacgcagac ctggaggcac
     1741 tgaggcacgc cctggagctg gagtatttat agcaggatca gcagcatctc cacctgccat
     1801 ctcaccctca gaccccctcg ccttccccac ctccccaccg agaactccag agacccagat
     1861 gttggacacc aggaaggggc cccacagccg agacgacgtg tccagtgacc atctcagaag
     1921 ccgtccatca gtccaaatgg gggttctgag aaggaaagta cccaacattg gcttcggagt
     1981 atttgacttt ggggaaaagg gctggctcgg agtctagact cttctgtaag actcacagaa
     2041 caaaagcaag gaattgctga tttggggggt gcctggtgat gaggagggga tgggtttgtc
     2101 ttgtcttctt tttaatttat ggactagtct cattactccg gaattatgct cttgtacctg
     2161 tgtggctggg tttcttagtc gttggtttgg tttggttttt tgaactggta tgtggggtgg
     2221 ttcacagttc taatgtaagc actctattct ccaagttgtg ctttgtgggg acaatcattc
     2281 tttgaacatt agagaggaag gcagttcaag ctgttgaaaa gactattgct tatttttgtt
     2341 tttaaagacc tacttgacgt catgtggaca gtgcacgtgc cttacgctac atcttgtttt
     2401 ctaggaagag ggggatgctg ggaaggaatg ggtgctttgt gatggataaa aggcattaaa
     2461 taaaaccacg tttacatttt gaa
//
