LOCUS       NM_001440               8221 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens exostosin like glycosyltransferase 3 (EXTL3),
            transcript variant 1, mRNA.
ACCESSION   NM_001440
VERSION     NM_001440.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8221)
  AUTHORS   Huang,Y., Mei,H., Deng,C., Wang,W., Yuan,C., Nie,Y., Li,J.D. and
            Liu,J.
  TITLE     EXTL3 and NPC1 are mammalian host factors for Autographa
            californica multiple nucleopolyhedrovirus infection
  JOURNAL   Nat Commun 15 (1), 7711 (2024)
   PUBMED   39231976
  REMARK    GeneRIF: EXTL3 and NPC1 are mammalian host factors for Autographa
            californica multiple nucleopolyhedrovirus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8221)
  AUTHORS   Shin,J.H., Bozadjieva-Kramer,N., Shao,Y., Lyons-Abbott,S.,
            Rupp,A.C., Sandoval,D.A. and Seeley,R.J.
  TITLE     The gut peptide Reg3g links the small intestine microbiome to the
            regulation of energy balance, glucose levels, and gut function
  JOURNAL   Cell Metab 34 (11), 1765-1778 (2022)
   PUBMED   36240758
REFERENCE   3  (bases 1 to 8221)
  AUTHORS   Marques,C., Pocas,J., Gomes,C., Faria-Ramos,I., Reis,C.A.,
            Vives,R.R. and Magalhaes,A.
  TITLE     Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates
            heparan sulfate biosynthesis and shapes gastric cancer cell
            motility and invasion
  JOURNAL   J Biol Chem 298 (11), 102546 (2022)
   PUBMED   36181793
  REMARK    GeneRIF: Glycosyltransferases EXTL2 and EXTL3 cellular balance
            dictates heparan sulfate biosynthesis and shapes gastric cancer
            cell motility and invasion.
REFERENCE   4  (bases 1 to 8221)
  AUTHORS   Wilson,L.F.L., Dendooven,T., Hardwick,S.W., Echevarria-Poza,A.,
            Tryfona,T., Krogh,K.B.R.M., Chirgadze,D.Y., Luisi,B.F., Logan,D.T.,
            Mani,K. and Dupree,P.
  TITLE     The structure of EXTL3 helps to explain the different roles of
            bi-domain exostosins in heparan sulfate synthesis
  JOURNAL   Nat Commun 13 (1), 3314 (2022)
   PUBMED   35676258
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8221)
  AUTHORS   Kobayashi,S., Akiyama,T., Nata,K., Abe,M., Tajima,M.,
            Shervani,N.J., Unno,M., Matsuno,S., Sasaki,H., Takasawa,S. and
            Okamoto,H.
  TITLE     Identification of a receptor for reg (regenerating gene) protein, a
            pancreatic beta-cell regeneration factor
  JOURNAL   J Biol Chem 275 (15), 10723-10726 (2000)
   PUBMED   10753861
  REMARK    GeneRIF: These results suggest that EXTL3/EXTR1 is a cell surface
            Reg receptor that binds to Reg protein.
REFERENCE   6  (bases 1 to 8221)
  AUTHORS   McCormick,C., Duncan,G., Goutsos,K.T. and Tufaro,F.
  TITLE     The putative tumor suppressors EXT1 and EXT2 form a stable complex
            that accumulates in the Golgi apparatus and catalyzes the synthesis
            of heparan sulfate
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 668-673 (2000)
   PUBMED   10639137
REFERENCE   7  (bases 1 to 8221)
  AUTHORS   Arai,T., Akiyama,Y., Nagasaki,H., Murase,N., Okabe,S., Ikeuchi,T.,
            Saito,K., Iwai,T. and Yuasa,Y.
  TITLE     EXTL3/EXTR1 alterations in colorectal cancer cell lines
  JOURNAL   Int J Oncol 15 (5), 915-919 (1999)
   PUBMED   10536173
REFERENCE   8  (bases 1 to 8221)
  AUTHORS   Suzuki,A., Shao,X., Song,X.Q., Hanaoka,T., Irie,S., Kashiwada,M.,
            Samara,G., Close,L.G., Aoki,T., Fujimori,M., Ishikawa,Y.,
            Hatori,M., Hosaka,M., Sakurada,A., Sato,M., Ohuchi,N., Satomi,S.,
            Fukushige,S., Horii,A. and Sato,T.
  TITLE     Identification of a 5-cM region of common allelic loss on 8p12-p21
            in human breast cancer and genomic analysis of the
            hEXT1L/EXTR1/EXTL3 gene in this locus
  JOURNAL   Int J Oncol 15 (3), 443-451 (1999)
   PUBMED   10427123
REFERENCE   9  (bases 1 to 8221)
  AUTHORS   Saito,T., Seki,N., Yamauchi,M., Tsuji,S., Hayashi,A., Kozuma,S. and
            Hori,T.
  TITLE     Structure, chromosomal location, and expression profile of EXTR1
            and EXTR2, new members of the multiple exostoses gene family
  JOURNAL   Biochem Biophys Res Commun 243 (1), 61-66 (1998)
   PUBMED   9473480
REFERENCE   10 (bases 1 to 8221)
  AUTHORS   Van Hul,W., Wuyts,W., Hendrickx,J., Speleman,F., Wauters,J., De
            Boulle,K., Van Roy,N., Bossuyt,P. and Willems,P.J.
  TITLE     Identification of a third EXT-like gene (EXTL3) belonging to the
            EXT gene family
  JOURNAL   Genomics 47 (2), 230-237 (1998)
   PUBMED   9479495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA757362.1, AB011091.1,
            AW105691.1 and AC131969.5.
            
            On May 17, 2019 this sequence version replaced NM_001440.3.
            
            Summary: This gene encodes a single-pass membrane protein which
            functions as a glycosyltransferase. The encoded protein catalyzes
            the transfer of N-acetylglucosamine to glycosaminoglycan chains.
            This reaction is important in heparin and heparan sulfate
            synthesis. Alternative splicing results in the multiple transcript
            variants. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.3044309.1, AB011091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220562.9/ ENSP00000220562.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               DA757362.1         179-291
            114-6302            AB011091.1         1-6189
            6303-6312           AW105691.1         12-21               c
            6313-8221           AC131969.5         22557-24465         c
FEATURES             Location/Qualifiers
     source          1..8221
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..8221
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /note="exostosin like glycosyltransferase 3"
                     /db_xref="GeneID:2137"
                     /db_xref="HGNC:HGNC:3518"
                     /db_xref="MIM:605744"
     exon            1..159
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     exon            160..253
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     exon            254..2876
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             729..3488
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /EC_number="2.4.1.223"
                     /note="glucuronyl-galactosyl-proteoglycan
                     4-alpha-N-acetylglucosaminyltransferase; putative tumor
                     suppressor protein EXTL3; hereditary multiple exostoses
                     gene isolog; reg receptor; exostoses (multiple)-like 3;
                     exostosin tumor-like 3; EXT-related 1; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="exostosin-like 3"
                     /protein_id="NP_001431.1"
                     /db_xref="CCDS:CCDS6070.1"
                     /db_xref="GeneID:2137"
                     /db_xref="HGNC:HGNC:3518"
                     /db_xref="MIM:605744"
                     /translation="MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFP
                     LIAHYYLTTLDEADEAGKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQE
                     LNSEIAKLNLKIEACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLL
                     PEKDDAGLPPPKATRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAF
                     QATARANVYVTENADIACLYVILVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVII
                     NLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQ
                     VPVKRKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLD
                     QVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPRLVISSGCATR
                     LFEALEVGAVPVVLGEQVQLPYQDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAM
                     RRQGRFLWETYFSTADSIFNTVLAMIRTRIQIPAAPIREEAAAEIPHRSGKAAGTDPN
                     MADNGDLDLGPVETEPPYASPRYLRNFTLTVTDFYRSWNCAPGPFHLFPHTPFDPVLP
                     SEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPREQFTVVMLTYEREEVLMNSLER
                     LNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAI
                     LSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMV
                     LTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWT
                     FRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTK
                     CFKFI"
     exon            2877..3004
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3149
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3278
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..8221
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6287..6292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /note="hexamer: AATAAA"
     polyA_site      6309
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /note="major polyA site"
     regulatory      7771..7776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
                     /note="hexamer: AATGAA"
     polyA_site      7793
                     /gene="EXTL3"
                     /gene_synonym="BOTV; EXTL1L; EXTR1; ISDNA; REGR; RPR"
ORIGIN      
        1 ccgcagtcgc ctgtcggaaa tggctgccgg ccggcagggg gagcggcgga tcaggcgcgg
       61 cctggaaggc gggcggccgg cagccagaac ggcttctggg acgccgactt tcgcgcaggc
      121 ggcggcggcg gcggcggcgg gtccctgagc tggaagccgg agagcaagcc ctggaggttc
      181 actctttcaa gaagtcgtgt gctgaggtgt aatgctacac aagtcagagg aaggaagggt
      241 cctgaaacac atggcctgat tgttggcaaa ggcatcataa gaagctggca tttatttctg
      301 ttctaaccta ttactgtata actgtgaata gacactatgc atatttgttg gtcagcaaaa
      361 ccaagaaaca agagctatgg catttgaaaa agtctgtctg attccagggt gtttttcctg
      421 ggtttcatca tcaggtacct cctccctttc atctcagcaa gaatgtggca ccttttatcg
      481 tttgataaag attaaggaca tgttctttgg tcaacagcca gaacttaaaa tctgctggaa
      541 tagggtcaga gaccatttca gctgcagctg aggaaaatga aatgttcatt ttatttggtg
      601 ccttgtctgg ggagcacact aactcttctg gaaacgtgtc agtgaaacag agatcgtttt
      661 gtggaatagc aacccatggt tatggcgagt gacccgacgt gatctggggg gcaggctgca
      721 gaggactcat gacaggctat accatgctgc ggaatggggg cgcggggaac ggaggtcaga
      781 cctgcatgct gcgctggtcc aaccgcatcc gcctcacgtg gctcagcttc acgctctttg
      841 tcatcctggt cttcttcccg ctcatcgccc actattacct caccactctg gatgaggctg
      901 atgaggcagg caagcggatt tttggtcccc gggtggggaa cgagctgtgc gaggtgaagc
      961 acgtgctgga tctgtgccgc atccgggagt cggtgagtga agagctcctg cagctggagg
     1021 ccaagcgcca agagctgaac agcgagatcg ccaagctgaa tctgaagatc gaagcctgta
     1081 agaagagcat tgagaacgcc aagcaggacc tgctccagct caagaatgtc atcagccaga
     1141 ccgagcattc ctacaaggag ctcatggccc agaaccagcc caagctgtcc ctgcccatcc
     1201 gactgctccc agagaaggac gatgccggcc tccctccccc gaaggccact cggggctgcc
     1261 ggctacacaa ctgctttgat tattctcgtt gccctctcac ctctggcttc ccggtctacg
     1321 tctatgacag tgaccagttt gtctttggca gctacctgga tcccttggtc aagcaggctt
     1381 ttcaggcgac agcacgagct aacgtttatg ttacagaaaa tgcagacatc gcctgccttt
     1441 acgtgatact agtgggagag atgcaggagc cggtggtgct gcggcctgct gagctggaga
     1501 agcagttgta ttccctgcca cactggcgga cggatggaca caaccatgtc atcatcaatc
     1561 tgtcacgtaa gtcagataca cagaaccttc tctataacgt cagtactggc cgtgccatgg
     1621 tggcccagtc caccttctac actgtccagt acagacctgg ctttgacttg gtcgtatcac
     1681 cgctggtcca tgccatgtct gagcccaact tcatggaaat cccaccacag gtgccggtga
     1741 agcggaaata tctcttcacc ttccagggcg agaagattga gtctctgagg tctagccttc
     1801 aggaggcccg ctccttcgaa gaggaaatgg agggcgaccc tcccgccgac tacgatgacc
     1861 ggatcattgc caccctgaag gcggtgcagg acagcaagct ggatcaggtc ctggtggaat
     1921 tcacctgcaa aaaccagccc aaacccagcc tgccgactga gtgggcactg tgtggagagc
     1981 gggaggaccg cttggaattg ctgaagctct ccaccttcgc cctcatcatt acccccgggg
     2041 accctcgctt ggttatttcc tctgggtgtg caacacggct cttcgaagcc ctggaagtcg
     2101 gtgccgtccc ggtggtgctg ggggagcagg tccagcttcc ctaccaggac atgctgcagt
     2161 ggaacgaggc ggccctggtg gtgccaaagc ctcgtgttac cgaggttcat ttcctgctca
     2221 gaagcctctc cgatagtgac ctcctggcta tgaggcggca aggccgcttt ctctgggaga
     2281 cttacttctc cactgctgac agtattttta ataccgtgct ggctatgatt aggactcgca
     2341 tccagatccc agccgctccc atccgggaag aggcggcagc tgagatcccc caccgttcag
     2401 gcaaggcggc tggaactgac cccaacatgg ctgacaacgg ggacctggac ctggggccag
     2461 tggagacgga gccgccctac gcctcaccca gatacctccg caatttcact ctgactgtca
     2521 ctgactttta ccgcagctgg aactgtgctc cagggccttt ccatcttttc ccccacactc
     2581 cctttgaccc tgtgttgccc tcagaggcca aattcttggg ctcagggact ggctttcggc
     2641 ctattggtgg tggagctggg ggttctggca aggaatttca ggcagcgctt ggaggcaatg
     2701 ttccccgaga gcagttcacg gtggtgatgt tgacttatga gcgggaggaa gtgcttatga
     2761 actctttaga gaggctgaat ggcctccctt acctgaacaa ggtcgtggtg gtgtggaatt
     2821 ctcccaagct gccatcagag gaccttctgt ggcctgacat tggcgtcccc atcatggtgg
     2881 tccgtactga gaagaacagt ttgaacaacc gattcttacc ctggaatgaa attgagacag
     2941 aggccatcct gtccattgat gacgatgctc acctccgcca tgacgaaatc atgtttgggt
     3001 tccgggtgtg gagagaagct cgggaccgca tcgtgggctt ccctggccgt taccacgcat
     3061 gggacatccc ccatcagtcc tggctctaca actccaacta ctcctgtgag ctgtccatgg
     3121 tgctgacagg tgctgccttc tttcacaagt attatgccta cctgtattct tatgtgatgc
     3181 cccaggccat ccgggacatg gtggatgaat acatcaactg tgaggacatt gccatgaact
     3241 tccttgtctc ccacatcact cggaagcccc ccatcaaggt gacctcacgg tggacattcc
     3301 gatgcccagg atgccctcag gccctgtctc atgatgactc ccacttccac gagcggcaca
     3361 agtgcatcaa cttcttcgtg aaggtgtacg gctacatgcc cctcctgtac acgcagttca
     3421 gggtggattc tgtgctcttc aagacacgcc tgccccatga caagaccaag tgcttcaagt
     3481 tcatctaggg gcagcgcacg gtctggggaa gaggatgagc agagggagga agatggctcc
     3541 caaggttcct aggcattgca ggaccttggg cacatctgct ggtgggtggc ccagagcctc
     3601 tgctggaagg ggcagcagga ggagtggaag gaaaccgctg cctttatctt gaagtcagcc
     3661 acactgggcc tggagccctg ggcggagtcc ccggggttcc ccacacaggg cactgactga
     3721 tagcttacac tgaggactgt ggcgactctg cagagtcact cacaccgttc gtacgcccag
     3781 gacagctggt tcgtggtttt tacattcaat aacaactatt atgattattt aaaaagagaa
     3841 agtttcagat ttgccattca aggcttattt atatatatgt gtgtgtatat aaatacatgc
     3901 acacacttgc atacatatat atttttggct gggggagtgt gagttttgcc tttctaaggg
     3961 agggaccgcg caggctcctt tgttctgtat tctggcggag atgggtcctg gccttgtgtc
     4021 actggcttat ccttaaagat catctcccat cctccccagc gccatctgtg tgcagcaacc
     4081 agaaagggat gaacttggcc ctcttgcggg cctggacaag gtctcttcct taccctttct
     4141 gttgccagtc agcaacctgt aactcacatt ctcttcccag tgaatccctg ggagcgcctg
     4201 accctggtgg gctgttcagc ttcctgctgc tggggccagc gatttttgag gatttatctt
     4261 taggccaggc ttgcctccgt acttatccct gctctcccat ttctctcttg tttgagagag
     4321 aatgaggaag caaagagtga gaaagaatag gggctgaaga cgccactccc agatggctct
     4381 ttctatcctg ctcttctgtt gaaacacacg tgctgtgggc ctcaggcgtt tctgaagtgc
     4441 tctttcttgg attggacagg agatcagcag cgtgcacatc tgctgtggtc tgaagtggtt
     4501 tgcaggtcag cctcctctcc ctagtgtaga gcaagccagt gtccttcgag gaacccaccc
     4561 ggctggccgg gaagttttac agcaaggcgc ctgccttggg ataattcctt ggtgaaattc
     4621 accttccccc cgcctctgtc tggagcccca tcctgtgtta tctgtggttt ttggacccct
     4681 aatgtcagct tggctgtagg actccccgag gtttggtatg tgctagaaca atgggaggct
     4741 gtgatttgct gtgtaagctc acatccagcc ttggaatcta acgggcattc acaacccgag
     4801 ttaccacttt ccactccctg cttaggattc tgttccctgg gctgaaactg aaataagcta
     4861 attttttggg tcacggtggc agtaggggaa cctaggaggg tgtgagtggc atttgtcagg
     4921 gatttagccc atgacgtgtt tcttgaaccc tactttctgg aagtggagtt gactctggaa
     4981 gttttctagc aactgaacaa aagctcaggt ttgtcctggt catgcacatg ccttaagcca
     5041 gttccgtctt ccctagacct tggcatcctg tgcttctatt tcttggaata cgttctcctc
     5101 tgacctgcct gtaccacgtg ggtcctcttc aagtactgtt ttgaagctgg gctcttttgt
     5161 gtagctccca cccacctgta gggctagctc ggcttaaggg aactctcccc attggcaaac
     5221 cggacccggc cgccgccagg actgtgtttc caaaggttcc ccgcccccaa ccccagcatc
     5281 agcctgtagc tcccctgctg aggcagtgtg gttatgttcc cagcagtggg ggtcagacgc
     5341 ccttcctcag aactttctag ttgccctcta cctgactcct gacttgtatt ccttttagca
     5401 gtagccttct tccctcgggg agccaaagag tgtggtgtgt ggcgctatat tgtggctgct
     5461 atttcatctg gtttctttta atgtgaggaa ctcacatact gacttcagtg ggactcggtg
     5521 agccggggcc gtctgtgtgg tgggaccccc tttagcggga ctcagtgagc tggggccgtc
     5581 tgtgtggtgg agccagggcc tctcccttta gtggagccag gttgtcgggc cccgaatgtc
     5641 actggtggat ctaagaaggg ctgagtggtc tgacaccaaa acatgccgca gggagggctg
     5701 tggtgccggt gcttccaaca aggacagccc tccttgaccc tgaaaggaac actggcttga
     5761 aggactgcag acaggctctg aggggcacgc cctcctcagc gagaggcagc aaggtggcca
     5821 cagtgtcact ggtcaggtgc ttctcaccac gggaaagccg ccgacctgtg actcgcttga
     5881 gatgggaaag cggcgccaca gaccccgggt ctccttggct gtctgtgggc cgcccctggc
     5941 caccttgtcc tggctcgcag ggtgcaggag cgcctcgttc tctgggtggc cggcttgctg
     6001 ctccggtttg ggctgtctta ccataacacc gtcccagggc tctgcaggcc actgtgagcg
     6061 ctggctccct gggcagtgct cctccgtgtg gactgtgcct caggccaggg ctcaccagct
     6121 ggggtcctgt ccggaaggat gggatctttc tgggagctgc gccggacaga gtggggagct
     6181 cctagtttgt ggggggaagc tttgatatcc atgccacgtc catccacccc accccttttc
     6241 gtcacgagca caatggtctt acattggatt tttgtaaaaa aataaaaata aatggagact
     6301 ttaactcaag cagcttggag gtcttttgtg gttttcctca gcaagtatgg aagagtgacc
     6361 tgagagaagg cacctgcttg attgcttgat tccaggtcgc cacctgtgta tgccagctgg
     6421 gcctgctcgc agaagacgat gggaggcagc ctgaccaggc cctggtgtgg gctgtggacc
     6481 agagatgggt gaacagactc acactcacat gggcagcctt gcctgtgccc ggttccaggg
     6541 caagtcattt tgacaaaaca ggaacttagg ggctgttgag gtgctttaag caggatgtgg
     6601 aagggcatgt ggcccatata tgcaaagtta attttttcat gggaatttaa aatgcgtgtg
     6661 tgtgtgtgtg tgtgtgtgtg tgtagtggtt gtggggagct gtgtgtgcct gcgatcccag
     6721 gacaggtgag gcctcactgt gaatggctcg attcggtcca taggtcatgc ccctgaccta
     6781 taggtcacta aggcacctgt acctgcaccg agctgacgct ccctgactgc agagccccat
     6841 cctgttggtg cccacaggcc tagatcttgt gcttggctgt gggatcagag gcttcctcag
     6901 gagagggcac tgagctgtgg gcttcgggga gaaggatgga gatgggaaag ggggtaaagg
     6961 cgaggactcc tctcctgggc tctgcaggtg gcagctttgg tcacactgac agtcctaaga
     7021 atgggtgaga cttaacagtc ggtgtccctc ctcaagtggg gttcacgact gatcaggcaa
     7081 gtttgcagca gctgatgggt gagatgtcat cgaggggcat tcctctttgg gtctggagtt
     7141 ttggctgtca agctcctgtt cttccagcca tccatctcca tgttacgatt gtcctgggac
     7201 cagagagact tgagaaggtg gcatgaggct gtagaaaatg tgtcttccta tacacagaga
     7261 tatgatgtct gctttgagtc tatacctgtc gagttgtgtc ttggacttac ggtctgccaa
     7321 ggtggtaaat gttagctgtt gatgggatca tcactgaagt ggaaggctcc acaaggttta
     7381 caaaatgtgt taagaagaat gttgatggtg gtgtgtggtg cctaacatct taatctcagc
     7441 atttggtgag gcagaagtgg gaggatcaca tgaggccagt tcaagaccag tctgggcaac
     7501 atagcaagac ccccatctct acaaaaaaat tagaatgtta tgaagatact gaaaagaaga
     7561 aaggagaatg tagtgggtaa aggtctgggc cctggaacag actgggtgca gatcttgggc
     7621 tgcccatcac actggtggag agcaagttat ctattactat tttaggctct aatcccacca
     7681 tacggtggca aaagttgtgc ccatctctta agcatatgtt aaaagttaaa taatataata
     7741 tacgtagagt ccactgtttg acacaataaa aatgaactat tactggagta aaatagtgtc
     7801 cacttcttca tggctctttc tgccttccgc taggtttgag cgccagcgcc tggctgagtg
     7861 ccctgctcac ctcctattag agcccccacg ctctgtcgcc tcaccatgct gtgtgctggc
     7921 cactgctctg cctcccacac cggactgcag cctctcaaga acacaggagt tccatagttt
     7981 tctcatgaat gaatgctttg acaaagtgaa gagggtcact tagaaatcac agcttaggca
     8041 aattgtttta cctttcttca tctgtcttga cgtttatgaa agagtacagg ctgggtgcgg
     8101 tggttcacgc ctgtaatccc agcacctggg gaggccaagg cgggtggatc acctgaggtc
     8161 aggagtttga gaccagcctg gccaaaatgg cgaaacccct tctctactaa aaatacaaaa
     8221 a
//
