LOCUS       NM_207122              10037 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens exostosin glycosyltransferase 2 (EXT2), transcript
            variant 2, mRNA.
ACCESSION   NM_207122
VERSION     NM_207122.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10037)
  AUTHORS   Wang,Y., Huang,Y., Zhu,H., Guo,Z., Cheng,J., Zhang,C. and Zhong,M.
  TITLE     Exostoisns (EXT1/2) in Head and Neck Cancers: An In Silico Analysis
            and Clinical Correlates
  JOURNAL   Int Dent J 74 (3), 446-453 (2024)
   PUBMED   37989698
  REMARK    GeneRIF: Exostoisns (EXT1/2) in Head and Neck Cancers: An In Silico
            Analysis and Clinical Correlates.
REFERENCE   2  (bases 1 to 10037)
  AUTHORS   Selvan,A.J.A., Kannan,B., Pandi,C., Jayaseelan,V.P. and Arumugam,P.
  TITLE     EXT2: a novel prognostic and predictive biomarker for head and neck
            squamous cell carcinoma
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 137 (3), 282-289 (2024)
   PUBMED   38155009
  REMARK    GeneRIF: EXT2: a novel prognostic and predictive biomarker for head
            and neck squamous cell carcinoma.
REFERENCE   3  (bases 1 to 10037)
  AUTHORS   Giambra,M., Di Cristofori,A., Conconi,D., Marzorati,M.,
            Redaelli,S., Zambuto,M., Rocca,A., Roumy,L., Carrabba,G.,
            Lavitrano,M., Roversi,G., Giussani,C. and Bentivegna,A.
  TITLE     Insights into the Peritumoural Brain Zone of Glioblastoma: CDK4 and
            EXT2 May Be Potential Drivers of Malignancy
  JOURNAL   Int J Mol Sci 24 (3), 2835 (2023)
   PUBMED   36769158
  REMARK    GeneRIF: Insights into the Peritumoural Brain Zone of Glioblastoma:
            CDK4 and EXT2 May Be Potential Drivers of Malignancy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10037)
  AUTHORS   Philippe,C., Porter,D.E., Emerton,M.E., Wells,D.E., Simpson,A.H.
            and Monaco,A.P.
  TITLE     Mutation screening of the EXT1 and EXT2 genes in patients with
            hereditary multiple exostoses
  JOURNAL   Am J Hum Genet 61 (3), 520-528 (1997)
   PUBMED   9326317
REFERENCE   5  (bases 1 to 10037)
  AUTHORS   Clines,G.A., Ashley,J.A., Shah,S. and Lovett,M.
  TITLE     The structure of the human multiple exostoses 2 gene and
            characterization of homologs in mouse and Caenorhabditis elegans
  JOURNAL   Genome Res 7 (4), 359-367 (1997)
   PUBMED   9110175
REFERENCE   6  (bases 1 to 10037)
  AUTHORS   Wuyts,W., Van Hul,W., Wauters,J., Nemtsova,M., Reyniers,E., Van
            Hul,E.V., De Boulle,K., de Vries,B.B., Hendrickx,J., Herrygers,I.,
            Bossuyt,P., Balemans,W., Fransen,E., Vits,L., Coucke,P.,
            Nowak,N.J., Shows,T.B., Mallet,L., van den Ouweland,A.M.,
            McGaughran,J., Halley,D.J. and Willems,P.J.
  TITLE     Positional cloning of a gene involved in hereditary multiple
            exostoses
  JOURNAL   Hum Mol Genet 5 (10), 1547-1557 (1996)
   PUBMED   8894688
REFERENCE   7  (bases 1 to 10037)
  AUTHORS   Stickens,D., Clines,G., Burbee,D., Ramos,P., Thomas,S., Hogue,D.,
            Hecht,J.T., Lovett,M. and Evans,G.A.
  TITLE     The EXT2 multiple exostoses gene defines a family of putative
            tumour suppressor genes
  JOURNAL   Nat Genet 14 (1), 25-32 (1996)
   PUBMED   8782816
REFERENCE   8  (bases 1 to 10037)
  AUTHORS   Wuyts,W., Ramlakhan,S., Van Hul,W., Hecht,J.T., van den
            Ouweland,A.M., Raskind,W.H., Hofstede,F.C., Reyniers,E.,
            Wells,D.E., de Vries,B. et al.
  TITLE     Refinement of the multiple exostoses locus (EXT2) to a 3-cM
            interval on chromosome 11
  JOURNAL   Am J Hum Genet 57 (2), 382-387 (1995)
   PUBMED   7668264
REFERENCE   9  (bases 1 to 10037)
  AUTHORS   Wu,Y.Q., Heutink,P., de Vries,B.B., Sandkuijl,L.A., van den
            Ouweland,A.M., Niermeijer,M.F., Galjaard,H., Reyniers,E.,
            Willems,P.J. and Halley,D.J.
  TITLE     Assignment of a second locus for multiple exostoses to the
            pericentromeric region of chromosome 11
  JOURNAL   Hum Mol Genet 3 (1), 167-171 (1994)
   PUBMED   8162019
REFERENCE   10 (bases 1 to 10037)
  AUTHORS   Wuyts,W., Schmale,G.A., Chansky,H.A. and Raskind,W.H.
  TITLE     Hereditary Multiple Osteochondromas
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U62740.1, BM997250.1 and
            AC103854.2.
            
            On Dec 2, 2019 this sequence version replaced NM_207122.1.
            
            Summary: This gene encodes one of two glycosyltransferases involved
            in the chain elongation step of heparan sulfate biosynthesis.
            Mutations in this gene cause the type II form of multiple
            exostoses. Alternatively spliced transcript variants encoding
            different isoforms have been noted for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) is the predominant transcript
            and differs in the 5' UTR and coding region, compared to variant 1.
            These differences causes translation initiation at a downstream
            start codon and result in isoform (2) which has a shorter
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1106072.1,
                                           SRR11853567.5212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533608.7/ ENSP00000431173.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3005              U62740.1           130-3134
            3006-3505           BM997250.1         18-517              c
            3506-10037          AC103854.2         84120-90651         c
FEATURES             Location/Qualifiers
     source          1..10037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..10037
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /note="exostosin glycosyltransferase 2"
                     /db_xref="GeneID:2132"
                     /db_xref="HGNC:HGNC:3513"
                     /db_xref="MIM:608210"
     exon            1..175
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            176..741
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2362
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /EC_number="2.4.1.224"
                     /note="isoform 2 is encoded by transcript variant 2;
                     N-acetylglucosaminyl-proteoglycan
                     4-beta-glucuronosyltransferase; exostosin-2; heparan
                     sulfate co-polymerase subunit EXT1; multiple exostoses
                     protein 2; putative tumor suppressor protein EXT2;
                     glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
                     acetylglucosaminyl-proteoglycan
                     4-alpha-N-acetylglucosaminyltransferase; multiple
                     exostosis 2"
                     /codon_start=1
                     /product="exostosin-2 isoform 2"
                     /protein_id="NP_997005.1"
                     /db_xref="CCDS:CCDS7908.1"
                     /db_xref="GeneID:2132"
                     /db_xref="HGNC:HGNC:3513"
                     /db_xref="MIM:608210"
                     /translation="MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQ
                     FWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKN
                     KIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL
                     NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFS
                     TWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKH
                     GESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDV
                     LQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQA
                     RWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIP
                     PQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVP
                     LKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGY
                     PGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHM
                     NCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFAS
                     VFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL"
     exon            742..831
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            832..948
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1144
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1284
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1378
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1510
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1700
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1867
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2011
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2140
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2223
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..10037
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2982..2987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /note="hexamer: ATTAAA"
     polyA_site      3006
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /note="major polyA site"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /note="hexamer: ATTAAA"
     polyA_site      3503
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /note="hexamer: ATTAAA"
     polyA_site      5264
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
     regulatory      10014..10019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
                     /note="hexamer: AATAAA"
     polyA_site      10037
                     /gene="EXT2"
                     /gene_synonym="SOTV; SSMS"
ORIGIN      
        1 agacggcccg gatcccggtt accggcccct cgctcgctgc tcgccagccc agactcggcc
       61 ctggcagtgg cggctggcga ttcggaccga tccgacctgg gcggaggtgg cccgcgcccc
      121 gcggcatgag ccggtgacca agctcggggc cgagcgggag gcagccgtgg ccgaggagtg
      181 tgaggaagag gctgtctgtg tcattatgtg tgcgtcggtc aagtataata tccggggtcc
      241 tgccctcatc ccaagaatga agaccaagca ccgaatctac tatatcaccc tcttctccat
      301 tgtcctcctg ggcctcattg ccactggcat gtttcagttt tggccccatt ctatcgagtc
      361 ctcaaatgac tggaatgtag agaagcgcag catccgtgat gtgccggttg ttaggctgcc
      421 agccgacagt cccatcccag agcgggggga tctcagttgc agaatgcaca cgtgttttga
      481 tgtctatcgc tgtggcttca acccaaagaa caaaatcaag gtgtatatct atgctctgaa
      541 aaagtacgtg gatgactttg gcgtctctgt cagcaacacc atctcccggg agtataatga
      601 actgctcatg gccatctcag acagtgacta ctacactgat gacatcaacc gggcctgtct
      661 gtttgttccc tccatcgatg tgcttaacca gaacacactg cgcatcaagg agacagcaca
      721 agcgatggcc cagctctcta ggtgggatcg aggtacgaat cacctgttgt tcaacatgtt
      781 gcctggaggt cccccagatt ataacacagc cctggatgtc cccagagaca gggccctgtt
      841 ggctggtggc ggcttttcta cgtggactta ccggcaaggc tacgatgtca gcattcctgt
      901 ctatagtcca ctgtcagctg aggtggatct tccagagaaa ggaccaggtc cacggcaata
      961 cttcctcctg tcatctcagg tgggtctcca tcctgagtac agagaggacc tagaagccct
     1021 ccaggtcaaa catggagagt cagtgttagt actcgataaa tgcaccaacc tctcagaggg
     1081 tgtcctttct gtccgtaagc gctgccacaa gcaccaggtc ttcgattacc cacaggtgct
     1141 acaggaggct actttctgtg tggttcttcg tggagctcgg ctgggccagg cagtattgag
     1201 cgatgtgtta caagctggct gtgtcccggt tgtcattgca gactcctata ttttgccttt
     1261 ctctgaagtt cttgactgga agagagcatc tgtggttgta ccagaagaaa agatgtcaga
     1321 tgtgtacagt attttgcaga gcatccccca aagacagatt gaagaaatgc agagacaggc
     1381 ccggtggttc tgggaagcgt acttccagtc aattaaagcc attgccctgg ccaccctgca
     1441 gattatcaat gaccggatct atccatatgc tgccatctcc tatgaagaat ggaatgaccc
     1501 tcctgctgtg aagtggggca gcgtgagcaa tccactcttc ctcccgctga tcccaccaca
     1561 gtctcaaggg ttcaccgcca tagtcctcac ctacgaccga gtagagagcc tcttccgggt
     1621 catcactgaa gtgtccaagg tgcccagtct atccaaacta cttgtcgtct ggaataatca
     1681 gaataaaaac cctccagaag attctctctg gcccaaaatc cgggttccat taaaagttgt
     1741 gaggactgct gaaaacaagt taagtaaccg tttcttccct tatgatgaaa tcgagacaga
     1801 agctgttctg gccattgatg atgatatcat tatgctgacc tctgacgagc tgcaatttgg
     1861 ttatgaggtc tggcgggaat ttcctgaccg gttggtgggt tacccgggtc gtctgcatct
     1921 ctgggaccat gagatgaata agtggaagta tgagtctgag tggacgaatg aagtgtccat
     1981 ggtgctcact ggggcagctt tttatcacaa gtattttaat tacctgtata cctacaaaat
     2041 gcctggggat atcaagaact gggtagatgc tcatatgaac tgtgaagata ttgccatgaa
     2101 cttcctggtg gccaacgtca cgggaaaagc agttatcaag gtaaccccac gaaagaaatt
     2161 caagtgtcct gagtgcacag ccatagatgg gctttcacta gaccaaacac acatggtgga
     2221 gaggtcagag tgcatcaaca agtttgcttc agtcttcggg accatgcctc tcaaggtggt
     2281 ggaacaccga gctgaccctg tcctgtacaa agatgacttt cctgagaagc tgaagagctt
     2341 ccccaacatt ggcagcttat gaaacgtgtc attggtggag gtctgaatgt gaggctggga
     2401 cagagggaga gaacaaggcc tcccagcact ctgatgtcag agtagtaggt taagggtgga
     2461 aggttgacct acttggatct tggcatgcac ccacctaacc cactttctca agaacaagaa
     2521 cctagaatga atatccaagc acctcgagct atgcaacctc tgttcttgta tttcttatga
     2581 tctctgatgg gttcttctcg aaaatgccaa gtggaagact ttgtggcatg ctccagattt
     2641 aaatccagct gaggctccct ttgttttcag ttccatgtaa caatctggaa ggaaacttca
     2701 cggacaggaa gactgctgga gaagagaagc gtgttagccc atttgaggtc tggggaatca
     2761 tgtaaagggt acccagacct cacttttagt tatttacatc aatgagttct ttcagggaac
     2821 caaacccaga attcggtgca aaagccaaac atcttggtgg gatttgataa atgccttggg
     2881 acctggagtg ctgggcttgt gcacaggaag agcaccagcc gctgagtcag gatcctgtca
     2941 gttccatgag ctattcctct ttggtttggc tttttgatat gattaaaatt attttttatt
     3001 cctttttcta ctgtgtctta aacaccaatt cctgatagtc caaggaacca cctttctccc
     3061 ttgatatatt taactccgtc tttggcctga caacagtctt ctgcccatgt ctgggaacac
     3121 acgccaggag gaatgtctga taccctctgc atcaagcgta agaaggtccc aaatcataac
     3181 cattttaaga acagatgact cagaaacctc cagaggaatc tgtttgcttc ctgattagat
     3241 ccagtcaatg ttttaaaggt attgtcagag aaaaacagag ggtctgtact agccatgcaa
     3301 ggagtcgctc tagctggtac ccgtaaaagt tgtgggaatt gtgaccccca tcccaagggg
     3361 atgccaaaat ttctctcatt cttttggtat aaacttaaca ttagccaggg aggttctggc
     3421 taacgttaaa tgctgctata caactgcttt gcaacagttg ctggtatatt taaatcatta
     3481 aatttcagca tttactaata ctgcacatgt gtgaattata cctctttaag cccagttgat
     3541 gaacaaatct accctggcga atgttaaatg ttatggattc gaaacagatt tatctggctc
     3601 tgatattaag attagccaca gtttgggctt tagccacaac atatgtcccc aaaacacaaa
     3661 atacataaca atttgcttag aatatggata taattacaga aacctagttg ttttgccagt
     3721 cagcgtcagt catacaccat ccattgttct gttgagtgac atgaaggtgg gcagttatta
     3781 tgctgtagtt tcatcaagag tcacttcaga tgtgttcccc agactttgag aggtcaaaga
     3841 aagtttcaga agtagcaaag ttggaagtgg aaatcataag agttttgtct tctttcattt
     3901 gaataagtga tcgaatcatg gactattatt gccaaagggg gcaagcgatc atctcatcca
     3961 gtttgttcat tttgcaaatg cagaaactga agctgcagat gttcattttg caaatgcaga
     4021 aactgaagtg atttttttca gtttctgaca gcagcaaaca caggtgctta ccaaatactt
     4081 ttgatttggg taatgtgtac tggtcagtag gagacatggg aaagcatttt ggtctcatgt
     4141 attcataata ttggggacga tatggtagaa agccaggaaa aatatttctg ttgtcaccca
     4201 ggtaccagag gctgacaagc acagtgagga cctctaatct ttctaggggt tttctagttt
     4261 gttttccaag atgtggggca ggtatagggg agggtcttac attgaaatct ctgctgaaag
     4321 ctatggactg tgctggcatt gtgtatgtgt catattgccc tggtttcttc aaatttctgc
     4381 ccttttgctc atcatcgaat gcactacctt agtggctggt ttctaatgca gcttctctcc
     4441 caaagggtac atttttaaat ttttattttt taaaatcttg agagtccttt gatttgggaa
     4501 gaggaactct ttcatctgag ttcattgtga gccctagaga gctgtgtgac tttatcatcg
     4561 tcataggagt cattggactt taaaggcatt acaactccat ttaaagtacc tcattactcc
     4621 caggaatatt gggtgttaga tcttgcaaca cagcataaaa caatttatgt taaagaagga
     4681 gcattatatc ctaggcactt gaaacaacct caaaggtgat gttaccctat gaacagatag
     4741 gtggtacagt caccgtagaa attcaagaca gggatatagc aggtgatggc gattcatgga
     4801 ttcagagtgg gctagggact ccactttatt gttcgtgtat ttctgagctg ctaaccagca
     4861 aacctcaccc ataagcttag gtcaggatca tctgtcctcg ggatgccata gagcctggtt
     4921 tcagaagcag aacaatcatg ctaattaaaa tgtcgtgttc tggcctacag cagacaacag
     4981 ctggttttag attaagaaat ctttttaaag aaacacatct tactggccta tagagaagac
     5041 gaacttgaac tggccctggc ccaagtgcac actgagccac tggctttgcc cccaggggcc
     5101 taactgggat gggcctgctt ggaatgccag ggctggaaat acttttttat tttgctgatt
     5161 aacattacat agttgttaaa atgtttatct catgtatttt accaaccctc acacatttag
     5221 gtataaacct ccttttctgg gagaattaaa gagaaaaaca gcaactttag ttgtcagaat
     5281 cttgtgttct ttcctgccag tgatgctctg ctgtatcctt tttttttttt ttttttttga
     5341 gacagagtct tgctcttgtc acccaggctg gagtgcaaca atagcatggt ctcggctcac
     5401 tacatcctcc gcctcccagg ttcaagtgat tctcctgcct cagcctcctg agtagctggg
     5461 attacaggcg cttgccacca cgcctggcta atttgtttgt aattttagta gaggcagggt
     5521 ttcaccacgt tagccaggct ggtctcgaac tcctgacctc aggtgatctg cacgccttga
     5581 cctcccaaag tgctgggatt acgggcgtga gtccccacgc tcagccactg tatcctttac
     5641 tcagtgtcat caagttcaaa gctctgacca ccctggtttc tctgccaaag cctcatctac
     5701 ttccagctgg gctttgaact tgtggttttt aagtgctggt ttctctgctg cctttggaaa
     5761 atagtgacca tcatgctggt ctgtgctgac gcagactggg agctggaaga gacaagctcc
     5821 ctctttgctc tcattggcca aagatgttgc taataaccct gtgatcctag cttccttcta
     5881 ggatgatagc ctctgacagg caccatgcca ggaggaaact agagcgtctt tatcactgaa
     5941 agatagcacg tttctagcca caggttctga agttgatttg aggttaaaat ccaagaacct
     6001 ttgatagttt tcagccaaga tagtaatcag aaagtagatg aagcagagac tgggtttggg
     6061 aagtggttgg gttctgggaa ggctcttcct agctctgcag ttagatcctg tgaggaccca
     6121 gctgatagag taaaggcttt gggtgttgga gacttcccat cagccaccca tcatgagcct
     6181 ggtgtgtttc ctttgctttg tagctccttt gggggtatgc tgctttttcc atttctcttg
     6241 gctcgggtac tcttccattg cagcaagaga agccacagtg ggctgttccc caagcagccc
     6301 tggcacagag aggcagagta gagaatgcta aactggcccc atgtctcctc cagccacttc
     6361 ctgaggagca gttctggcag gagtgttaac catattggca gcagcttcca tccagagaga
     6421 ctttgaaagc aacttgagct ttccactgca gggcctggag gcatatgaaa cctgtggggc
     6481 ctgcccctac tcacctcacc cctgagctct gtccaagccc tggacctcct gtcctcggcc
     6541 tgtgtttggt actcacccac tttctacttc tgagtagaat caagggcagc atttggtccc
     6601 attataccag ccatgcatca tctgtgaaca ggccttattg agcttatctt ggcagaggaa
     6661 agtcaggcag gcaagaccca ctctaaattt taatgtttcc ccctcatttt agggtgggag
     6721 ctgtgagttc atctgaagac tgggtgaggg cattgtaagc tcaagccaca gcctcttttc
     6781 cacctccatt aaatggactg ttagggatgc ccagcttccc caatttcctg ggagggtgtg
     6841 tgggtctgta caggcaacct tgtgtcattc tttcaatttc cggctcacca ttgctggcaa
     6901 cagtgggaag atgaccagag aaagtttggc cccctctccc aagcttccag gcctctttcc
     6961 ttttcaagaa atagttgagt caccagcatc tgtatctggc attttgtttc ttcacatttg
     7021 caaccatttc agggtagagt ttttttgttt gtttgtttgt ttgtttttgt tttttttgtt
     7081 ttttctttgg aaacagagtc tcactctgtc ccataggctg gagtgtagtg ctgtgatcat
     7141 ggctcgctgc agcctcaaac tcctggactc aagcagtctt cccatctcag ccttccaagt
     7201 agctgagact aaaagcgtgc accaccacac ctggctgatc ttttaatttt tttggagaga
     7261 cagggcctca ctatgttgcc taggctggtc tctaactcct gggatcaagt gatcctcctg
     7321 cctcagcgtc ccaaagtgtt gggattacag gtgtgaacca ccatgcctgg cccaggatag
     7381 cactttttcc tttcttctgc tctcagttgg ttggaccact ggttgcatct cttcccactc
     7441 tccctgaaag gcacagaact atcagacaga agacaaggta gttctcaaga agtaccaggc
     7501 agctgtgtct gctagaggct tcctcagcaa agccccatct tgtggacaac ctctcaggaa
     7561 ttgcaggtgg tgtgggagtg gctgacagag gagggatcca tatgtcttag accaaagcca
     7621 ccagtcaggc cttgccacca tatagaacct tccctttaga atatatttat ttggaatttt
     7681 acttatagct gcaaatatat cattggctac tatacccaag catcaactca aggaacattt
     7741 ggttttctgg tgagcacagc tgaagaccaa ccaactagtt actgatccag atgagggaag
     7801 agaacattta ttcagtcatt ctgttatgct aactattcat tttctcatga aaatgtagtc
     7861 tttggctggg catggtggct catgcctgta atcccagcat tttgggaggc caaagcgggc
     7921 agatcatgag gtcacgagat cgagaccctc ctggctaaca cggtgaaacc ccatctctac
     7981 taaaaataca aagaattagc cgggcatagt ggcaggcacc tgtagcccca gctactcggg
     8041 aggctgaggc aggagaatgg cgtgaacctg agaggtggag cttgcagtga gctgagattg
     8101 tgccactaca ctccagcctg ggcgacagag caagactccg tctcaaaaga gaaaatgttg
     8161 tctttgccag gcagtgtggt aggcccaaga gatatagcaa ttagagttga ctaagacagt
     8221 gtccctatcc tgttcttgag ctccagttct agtgggagtt cttgagcttg gtaagatgat
     8281 gtgagtccat cagtggccca ggactctaag catgtatgtt ttagtcccag ctgtaaatga
     8341 ggattccatt aaccccatct tctccaatgt atggaggatg caagaagctt taaaatgtcc
     8401 ttttctcaca gtgacttccc ttgaccatgc cttagtttcc tcagccagaa attggagaca
     8461 gcaagagcac ttatgcctga gttggtgaga tggaatgatg tatcatatct cttccccttt
     8521 tattaaccag atcgtttacc agattgtacc tggtgatgct ggcagccagc cctcttccgg
     8581 cccctatttc tgcttaccgt gttaccagag agcctggggg tctggatcct atctggcccc
     8641 gtcagggtgg attaccaaat gagcagttct cttgccccag tccctttcct gtgctataaa
     8701 taagccccat gtttattttc ttatgttatt gaaatgagca cttgtgattt gggcctcttt
     8761 tgaggagtcc agagagcgtc catccggtgc ctggtgaggg ccctgcatgg ctggctgctg
     8821 tctgaagcta tttggagtcc tctccctgtg ttttctatgt ggcttaattt caatagaaag
     8881 ggttatatgc aaccctgtat ctgctgattt tcaggtttca actttctgcc agcgtcactg
     8941 cctgcttaga agtaaagtta tgtttctcat taaggggata acagccacaa ttgaggtaat
     9001 taacgaaaat tgtacattgg tggcagcacc tcctatagga tttccaatag tctttctcta
     9061 gtagatcatt gggggctcac cttgatctcc tctcttctgt ctaccctgca ccaaaatacc
     9121 ttgtcctgtt ttctggatat agttccaata atttttttcc taacagcctt tttgtcacca
     9181 gttggtttga tatcttacaa cttggccaaa tgagggttcc attaactcca tcttgtctaa
     9241 tgcatggaga attcaaggat tttttttttc tcttttcata gcaccttcca gttgccagtt
     9301 gtaccctggc ccttctttgg aagtcataat gatgaatatc cattaataag agattgatgc
     9361 tctttcaact ctcatgtcat ctataccatc tcagtggaga ggatgacttt ggatgaggtt
     9421 ggaatagaaa ggaaacattt ggaagtccac tgcagtgtat tatatgctgt gtggaagtct
     9481 gggggttagg aaatacctgg agggagaact tcctaagaaa tgatttttgg ttcttttagg
     9541 ccttaacagc acaataaaag tatcccatga gaccattatg agcaggacac gacattgttt
     9601 cacaccttgg gctgtgacta tttacttctc ggtacagatt actctggtta aatcactcag
     9661 taaagaaatc ttttcatgct cacaatctga acctgaaggc tattactgaa gagaattgca
     9721 tctgacaaca aaatttaatt tacttccaga gaaaggacca gaagaaagta aattttcatt
     9781 tatgttttta agtctattgt cttaaaaaga ttcttttccc ttaaaaaata aaaaaacctg
     9841 atgtgatggg ttccttcagt caacaaatac ttattgagca gttattgtgt gccagatact
     9901 gttcttggtg tgaggatatg gcactgaaca aaacaatgta cctactttcg tcaagcttac
     9961 attctaatga ggaagataac caaaacaagt gactgaatat aatttcaaat gtcaataaat
    10021 gctgtgaaga aaataaa
//
