LOCUS       NM_015065              10304 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens exophilin 5 (EXPH5), transcript variant 1, mRNA.
ACCESSION   NM_015065
VERSION     NM_015065.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10304)
  AUTHORS   Yang,Y., Cao,Y., Han,X., Ma,X., Li,R., Wang,R., Xiao,L. and Xie,L.
  TITLE     Revealing EXPH5 as a potential diagnostic gene biomarker of the
            late stage of COPD based on machine learning analysis
  JOURNAL   Comput Biol Med 154, 106621 (2023)
   PUBMED   36746116
  REMARK    GeneRIF: Revealing EXPH5 as a potential diagnostic gene biomarker
            of the late stage of COPD based on machine learning analysis.
REFERENCE   2  (bases 1 to 10304)
  AUTHORS   Kim,H.J., Kim,E., Lee,H., Jung,J.W., Kim,J.E., Pack,C.G. and
            Lee,J.W.
  TITLE     SLAC2B-dependent microtubule acetylation regulates extracellular
            matrix-mediated intracellular TM4SF5 traffic to the plasma
            membranes
  JOURNAL   FASEB J 35 (3), e21369 (2021)
   PUBMED   33554392
  REMARK    GeneRIF: SLAC2B-dependent microtubule acetylation regulates
            extracellular matrix-mediated intracellular TM4SF5 traffic to the
            plasma membranes.
REFERENCE   3  (bases 1 to 10304)
  AUTHORS   Bare,Y., Chan,G.K., Hayday,T., McGrath,J.A. and Parsons,M.
  TITLE     Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate
            Keratinocyte Adhesion and Migration
  JOURNAL   J Invest Dermatol 141 (3), 523-532 (2021)
   PUBMED   32890627
  REMARK    GeneRIF: Slac2-b Coordinates Extracellular Vesicle Secretion to
            Regulate Keratinocyte Adhesion and Migration.
REFERENCE   4  (bases 1 to 10304)
  AUTHORS   McGrath,J.A., Stone,K.L., Begum,R., Simpson,M.A.,
            Dopping-Hepenstal,P.J., Liu,L., McMillan,J.R., South,A.P.,
            Pourreyron,C., McLean,W.H., Martinez,A.E., Mellerio,J.E. and
            Parsons,M.
  TITLE     Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein
            Slac2-b in Inherited Skin Fragility
  JOURNAL   Am J Hum Genet 91 (6), 1115-1121 (2012)
   PUBMED   23176819
  REMARK    GeneRIF: our findings identify an unexpected role for Slac2-b in
            inherited skin fragility and expand the clinical spectrum of human
            disorders of GTPase effector proteins.
REFERENCE   5  (bases 1 to 10304)
  AUTHORS   Ostrowski,M., Carmo,N.B., Krumeich,S., Fanget,I., Raposo,G.,
            Savina,A., Moita,C.F., Schauer,K., Hume,A.N., Freitas,R.P.,
            Goud,B., Benaroch,P., Hacohen,N., Fukuda,M., Desnos,C.,
            Seabra,M.C., Darchen,F., Amigorena,S., Moita,L.F. and Thery,C.
  TITLE     Rab27a and Rab27b control different steps of the exosome secretion
            pathway
  JOURNAL   Nat Cell Biol 12 (1), 19-30 (2010)
   PUBMED   19966785
REFERENCE   6  (bases 1 to 10304)
  AUTHORS   Kondo,H., Shirakawa,R., Higashi,T., Kawato,M., Fukuda,M., Kita,T.
            and Horiuchi,H.
  TITLE     Constitutive GDP/GTP exchange and secretion-dependent GTP
            hydrolysis activity for Rab27 in platelets
  JOURNAL   J Biol Chem 281 (39), 28657-28665 (2006)
   PUBMED   16880209
REFERENCE   7  (bases 1 to 10304)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   8  (bases 1 to 10304)
  AUTHORS   Nagashima,K., Torii,S., Yi,Z., Igarashi,M., Okamoto,K., Takeuchi,T.
            and Izumi,T.
  TITLE     Melanophilin directly links Rab27a and myosin Va through its
            distinct coiled-coil regions
  JOURNAL   FEBS Lett 517 (1-3), 233-238 (2002)
   PUBMED   12062444
REFERENCE   9  (bases 1 to 10304)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Slac2-b/KIAA0624 contains an N-terminal Slp homology
            domain (SHD) (PMID: 11327731). The SHD of Slac2-b specifically and
            directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277,
            (2002) 9212-9218; PMID: 11773082).
REFERENCE   10 (bases 1 to 10304)
  AUTHORS   So,J.Y. and Teng,J.
  TITLE     Epidermolysis Bullosa Simplex
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002453.4, BP358360.1,
            BC117701.1, KF455497.1, AP005718.3 and AI203086.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015065.2.
            
            Summary: The protein encoded by this gene is a member of the
            synaptotagmin-like protein (Slp) family lacking a C2 domain. It
            contains an N-terminal synaptotagmin-like homology domain (SHD),
            and is a ras-related protein Rab-27B effector protein. This protein
            is thought to be involved in exosome secretion and intracellular
            vesicle trafficking. Reduced expression of this gene results in
            keratin filament defects. Mutations in this gene have been
            associated with some cases of epidermolysis bullosa, an inherited
            skin fragility disorder. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY099469.1, BC113119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265843.9/ ENSP00000265843.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AP002453.4         65702-65822         c
            122-606             BP358360.1         1-485
            607-6261            BC117701.1         457-6111
            6262-6329           KF455497.1         1-68                c
            6330-10010          AP005718.3         181838-185518       c
            10011-10304         AI203086.1         26-319              c
FEATURES             Location/Qualifiers
     source          1..10304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..10304
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /note="exophilin 5"
                     /db_xref="GeneID:23086"
                     /db_xref="HGNC:HGNC:30578"
                     /db_xref="MIM:612878"
     exon            1..351
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..6202
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptotagmin-like homologue lacking C2 domains b; slp
                     homolog lacking C2 domains b; synaptotagmin-like protein
                     homolog lacking C2 domains b"
                     /codon_start=1
                     /product="exophilin-5 isoform 1"
                     /protein_id="NP_055880.2"
                     /db_xref="CCDS:CCDS8341.1"
                     /db_xref="GeneID:23086"
                     /db_xref="HGNC:HGNC:30578"
                     /db_xref="MIM:612878"
                     /translation="MTKVPPAFDFSFLNDEEARKILQVLERNEELQRAEKDRISKLQK
                     TKRDIRWLQGVTGEWFEEIQRKKFCNETDVSQMLKQPLTYRLSKEMAKNDPIELPTSR
                     SKNVTNQKKPTPFSSRMSFRSSFASLFSFRKSGKETSKLPSLGQKGCDGHAGPPMPVR
                     GAAVQAKIYNSPLENHLVDSTFVPKPAVMREESGMPPPWDASLLENEFFQVLDDLDSK
                     LAQEQSASSVNTRTPLNYGSRTQFGHFYSSGNRHGNITERHKKHYNETSNMSIYDILR
                     PGTPREGFKTFSPRTSTIYDMYRTREPRVFKEDYVQKNTFGSTSLCFDSRQRSALPAT
                     GHFTARSLHFPATTQSKSGFIPPRHQQSPKRTPLSSIIWNRSDSSRDRENQEEFLRAP
                     SPMEIDPADKYVYPRGFQENKRYESYHSQNVYQRVSLNAPMENAMSPDTFENSENMPF
                     YHQSNTFTRSFFSNTFGRSGEQRRFGQGPFWGQEKGHSFWSDFHRSRKSFSSSDRDFE
                     MISMEANSVSAIHGHNVSSEHWESFSSGYGTDVSRGQEEPHPWQFDFQRSTLDSMVVS
                     HGNETQLTPHFGTPNVCSMTGSSYHVKSSELVSQQDSSPVEVHINKEASSFGIAQTLA
                     SSFKTSFSQISDDRRNPQSPNLQNPTVTLQKIFPNKPASHPMRSHTEVTVTSSNSVDS
                     LPLAKSQPNILVTEVNNEKDLNESISEEDKQLSKMDQTNKAGEIPQPVSQTGISNSLP
                     DFQNPLSQDSAKSNGFGFNASTIISSKKSPRVFSRKDTSKMYIPHTDKSNDIKQDKRF
                     TENRKLGSTASLPFIQEHRTPPSFPRTDQGCHQELTVNNEDISRIITNNHWSSALTDT
                     QNAQYSKCKLTPGHKTSCDSLDLSSAALPDSSPSKNSSLDAPVVPSTTVFSRRSPSDK
                     DPSLGEREEKDNAGKNQKNQFIVSHSENQERNDSPVPTHDEVVDVKCHSHSPFRNERG
                     KGKIRHHISCIEKLSKTESISVPTSDHRSLIEANQSNSKVSELDTIYCTLPRKSSSFL
                     IHGRQSGSKIMAASLRNGPPPFQIKNNVEDAMGNYMLNKFSPSSPESANECSKVLSDS
                     ALEAPEATERMTNVKSSGSTSVRKGPLPFLINRAMSCPSGEPHASTGREGRKKPLTSG
                     MDASELTPRAWERIISPVESDSSVRDCSLTKRQHQKENFQEYTEKEGKMAASRRSVFA
                     LSNEDPLPFCSDLSGKERGKTLHKVKTTSTFSVSGDEDNVKCLEVVSIYYTLPRKPSK
                     KFCNLLQQYTQNTNLLIESPQVETETFPNALEKDKQNYSTREQSGTPSCENLKMSVNS
                     DQTLTTENMTAFRLSNRGPLAPTLQEMASVEAAVSLPEEESKAREIFSDNLAKTPLGD
                     SENKKERGKKLQSETLHTSLMLQRKNVSEEKSENCQQSINSSNSGPSSLPALSEVNIG
                     NSQTRRSSWECTGSGRAIPFTGSGKCPQKDHTSTAVGDGSSGSQPREGRGDIGTNCQK
                     MTNKTLSHSESQVFALTPALHKLQLGEETQSDEPNLESLQSEPRELPQRSQEANMTES
                     RKAEDEMQKSAWDQPSLPEGNKNKTNLDDLVKGENRSSVKHRLAAMSKASRKFPAKDV
                     SPRRHVATIFPQSGSRSGFDHLSLGTVECNPLFPEPTPKSAESIGESRLSENGKHVKK
                     SENLLPITVLPNREPSTHVSNQKSNSISQRHQNEFKNVSESPSKHENSKDVTAAQNLV
                     RESGAPSPITFTSLREAEFSDNQRRLSPPFPLEPAQKSRVSSPLASFLQQQRSASSLE
                     WEPEPHLYRSKSLKSINVHGDLLRKSHPPKVRERHFSESTSIDNALSRLTLGNEFSVN
                     NGYSRRFRSFSELPSCDGNESWAYRSGTKTGPRSAISIYRPIDYGIFGKEQQLAFLEN
                     VKRSLTQGRLWKPSFLKNPGFLKDDLRNPPNPSESLSSNSPSSQVPEDGLSPSEPLNI
                     YEDDPVDSDCDTDTTTDDEYYLDENDKESEL"
     exon            352..512
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            513..675
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            676..724
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            725..863
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /inference="alignment:Splign:2.1.0"
     exon            864..10304
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10286..10291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /note="hexamer: AATAAA"
     polyA_site      10304
                     /gene="EXPH5"
                     /gene_synonym="EBS4; SLAC2-B; SLAC2B"
                     /note="major polyA site"
ORIGIN      
        1 cactttgcat ctcggttgga caggttgaga gaaacatgtc attaaggtat tgtcaatatg
       61 agcccttcag gtgtgggcgt tccctaggtt tgtggtttta gactttcaaa ggggcggact
      121 tattattggc tgtgggatca agttcgtgaa actggtcttg tacaggttga aaaatgcctt
      181 cctaacagga ggcgccaagg agcttaagtg taactcacac acagtaaaga aaatgacgaa
      241 agttcctccg gcgtttgatt tcagtttctt aaatgacgaa gaggccagga agatccttca
      301 ggtgctggaa aggaatgagg agttacagag ggccgagaag gacaggatca gcaaacttca
      361 gaagacaaag agggatatca gatggcttca gggagtgact ggtgaatggt ttgaagaaat
      421 tcaaagaaaa aagttttgca atgaaacaga tgttagccaa atgttaaaac aaccacttac
      481 atacaggcta agtaaggaga tggcaaaaaa tgatccgata gaattaccta catcaagatc
      541 taaaaatgta actaatcaaa aaaagccgac acctttttct tcccggatga gcttcagatc
      601 gtcatttgct tccctgttct cattcaggaa atctggaaag gagacttcaa agcttccatc
      661 actgggacag aaaggatgtg atggccatgc aggacctcct atgcctgtga ggggagctgc
      721 tgtgcaggca aaaatataca attcacctct ggaaaatcat ctagttgaca gtacatttgt
      781 cccaaagcca gcagtcatga gggaggagag tggcatgcct ccaccgtggg atgcttcact
      841 gctggagaat gagtttttcc aagttttaga tgacttggat agcaaattgg ctcaggaaca
      901 gtctgcaagc tcagtgaata ccagaacacc cctcaactat ggatcaagaa cacagttcgg
      961 tcacttttat tccagtggta acagacatgg taatatcaca gaaaggcaca aaaaacacta
     1021 taatgaaact tccaatatgt ctatctatga catcctaaga ccaggaactc ctagggaagg
     1081 ttttaaaacc ttttctccta ggacaagcac aatttatgat atgtatagga caagggagcc
     1141 cagagtcttt aaagaagatt atgtgcaaaa gaatactttt ggcagtactt cgctgtgttt
     1201 tgacagcagg caacggtcgg ccttaccagc cacagggcat ttcacagcaa gaagcttaca
     1261 ttttccagcc acaactcaga gcaagagtgg gtttatacca ccaaggcacc agcagagtcc
     1321 aaagagaact cctttatcat ccatcatatg gaacagatca gattcctcta gagacaggga
     1381 gaaccaggaa gagttcctga gggcaccatc accaatggaa attgatcccg ctgacaagta
     1441 tgtgtatccc aggggttttc aggagaataa gagatatgaa tcgtaccatt cacagaatgt
     1501 ttaccaacgt gttagtttaa atgctcccat ggagaatgca atgagtcccg acacttttga
     1561 gaactcagag aacatgccat tctaccatca aagcaacaca tttaccagat ctttcttcag
     1621 caataccttt ggacgaagcg gagaacagag gagatttgga caaggtcctt tttggggcca
     1681 agagaaagga cattctttct ggtctgactt tcatcgaagc aggaaatcat tcagttcttc
     1741 tgacagagac tttgaaatga tttccatgga agcaaatagt gtatcagcca ttcatggcca
     1801 taatgtttct tctgaacact gggaatcatt ttcttctggt tatggaacag atgtttccag
     1861 aggccaagaa gagccacatc cttggcagtt tgattttcag agatccacac tggatagcat
     1921 ggtggtatca catggtaatg agacccagtt gactcctcat tttggcacac caaatgtttg
     1981 ctccatgact ggttcaagct atcacgtcaa atctagtgag ttggtaagtc aacaggacag
     2041 ttctcctgta gaagtacata taaacaaaga agcttcctca tttggaattg ctcagactct
     2101 agcatcctca ttcaaaactt ccttttccca gatttctgat gacagaagga atcctcagag
     2161 tcccaacttg cagaatccca cagtcacttt gcagaaaatt tttccaaata agcctgcctc
     2221 tcatccaatg agaagccata cagaagtcac tgtgaccagc agcaattcag ttgactctct
     2281 gcctcttgcc aaaagccagc ccaatatctt ggtcacagaa gtaaataatg agaaagactt
     2341 aaatgaatct atttcagaag aagacaaaca gctaagcaag atggaccaga caaacaaggc
     2401 aggtgaaata ccccaacctg tttcacagac agggatctca aactctttac ctgattttca
     2461 aaatccctta tcccaggact cagccaagag caacgggttt ggttttaatg catctaccat
     2521 aataagttca aaaaagtcac ccagagtctt ttccaggaaa gatacctcca aaatgtatat
     2581 accgcacaca gataaatcca atgacattaa acaagataag aggtttactg aaaacagaaa
     2641 acttggctca acagcttccc ttcctttcat tcaggaacac agaacaccac catctttccc
     2701 caggacagac caaggttgtc accaggaatt aactgtaaat aatgaagata tttcaagaat
     2761 tattacaaat aaccactgga gctctgcact gactgatact caaaatgcac aatactcaaa
     2821 atgcaagtta actcctggcc acaagacctc gtgtgattct ttagatctgt catcagctgc
     2881 actaccagat tcctcaccat caaagaattc ttcccttgat gctcctgtgg ttccatctac
     2941 tacagtgttc tccaggagaa gtccttcaga caaagatcca tcgctaggag aaagagaaga
     3001 aaaagacaat gctgggaaga accaaaagaa tcagtttatt gtaagccact cagaaaacca
     3061 agagagaaat gatagtcctg tgcctacaca tgatgaagtg gttgatgtca aatgccattc
     3121 acactctcct tttaggaatg aaagaggaaa aggaaaaata aggcatcata tatcctgtat
     3181 tgaaaagtta agcaaaacag aaagtatatc agtacccacc agtgatcaca ggagcctcat
     3241 tgaagcaaat caaagcaatt ccaaagtttc tgaacttgac acaatttatt gtaccttgcc
     3301 aagaaaatca agcagttttc tcatacatgg caggcagtca ggaagtaaaa taatggctgc
     3361 ttcattgagg aatgggccac ctcccttcca aatcaaaaat aatgtggaag atgcaatggg
     3421 gaactatatg ttaaacaaat ttagtcccag ttctcctgag tcagcgaatg aatgttccaa
     3481 agtcctttca gactcagccc tggaagcacc tgaagccaca gagagaatga caaatgtaaa
     3541 aagcagtgga tctacttccg ttagaaaagg accacttcca ttcctcatca acagggctat
     3601 gtcatgtccc tcaggggagc cacatgcctc aactggaaga gaaggaagaa aaaagccatt
     3661 gacctcaggc atggatgctt ctgagctaac accaagggct tgggagagaa tcattagccc
     3721 tgtggaaagt gactcatctg ttagagattg ttctttaacc aaaagacaac accaaaagga
     3781 aaacttccaa gaatacactg agaaagaggg taaaatggct gcctccagga gaagtgtatt
     3841 tgctctttca aatgaagacc ctttaccttt ttgctcagac ttgtcaggaa aagaacgtgg
     3901 gaaaacatta cataaagtta agacgactag tacgttttct gtttctggtg atgaagataa
     3961 tgtaaaatgt ctggaggtgg tctcaatata ttacactcta ccgaggaaac ccagcaaaaa
     4021 attctgtaac ctccttcaac agtatacaca aaatactaat ttacttatag aatcacctca
     4081 agtggagact gaaacatttc ctaacgcttt agaaaaagac aaacagaatt attctacacg
     4141 agagcagtca ggaacacctt catgtgaaaa tctaaagatg tccgtcaact ctgatcagac
     4201 gctcaccact gaaaatatga ctgccttccg attatcaaat agggggcccc tagctcctac
     4261 attacaggaa atggcttctg ttgaggcagc tgtttctctt cctgaagagg aatctaaagc
     4321 tagagagatt ttttcagata atttagctaa aacacctcta ggtgattcag aaaacaagaa
     4381 ggaaagaggc aaaaagttgc aaagtgaaac cctgcatact tcattgatgc ttcagagaaa
     4441 aaatgtatcc gaagaaaaat ctgaaaattg tcaacaatcc attaattcaa gtaacagtgg
     4501 tccctctagt cttccagctc tttcagaagt taatattgga aattcccaaa ctagaagaag
     4561 ttcttgggag tgtacaggga gtggtagagc cattccattt actggaagtg gcaagtgtcc
     4621 ccagaaagat cacacatcca cagctgtagg tgatggctcc agtggatcac agcctaggga
     4681 aggcagaggg gacattggaa ccaactgcca aaaaatgact aataaaacac tttctcactc
     4741 agagagtcaa gtctttgccc ttactccagc attgcataaa ctacagcttg gtgaggagac
     4801 tcagtcagat gaaccaaact tagagagtct gcagtctgaa ccaagagaat tacctcaaag
     4861 aagtcaggag gcaaatatga cagagagcag gaaggctgaa gatgaaatgc agaagtcagc
     4921 ttgggatcaa ccttcacttc ctgaaggaaa caaaaataaa accaacttgg atgacctagt
     4981 aaagggggaa aatagatctt cagttaaaca cagattggca gccatgtcta aagccagcag
     5041 aaaattccca gctaaagatg taagccccag aagacatgta gctactatct tcccccaaag
     5101 tggaagcaga tctggctttg accatttatc tcttggcaca gtggagtgca acccactgtt
     5161 ccctgagcct actccaaaat ctgcagagtc cattggcgaa agcaggttga gtgagaacgg
     5221 aaagcatgtg aagaaatccg agaaccttct ccccattact gtactaccca acagagaacc
     5281 ttctacacac gtcagcaacc agaagtctaa cagcatttca caacgacatc agaatgagtt
     5341 taaaaacgtc tcagaatcac catcaaagca tgagaattct aaagacgtca cagcagctca
     5401 gaatttagta agagaatcag gagccccatc acccatcaca ttcaccagcc tcagggaagc
     5461 agaattctct gacaatcaga ggaggctgag ccctcctttt ccactggagc ctgcacagaa
     5521 atctagagta agcagtccac tggccagttt tctgcagcaa caaaggagtg cttcatctct
     5581 ggagtgggaa cctgagccac acctctatcg ttcaaagagt ttaaaaagca ttaatgttca
     5641 tggcgatcta ctacgaaaaa gccatcctcc aaaagtcagg gagcgccatt tttctgaaag
     5701 cacttctatt gacaatgccc tgagtcgact gacccttggg aatgaattct ctgtcaacaa
     5761 tgggtacagt cgaagattca gatctttttc tgaactcccc tcctgtgatg gaaatgaaag
     5821 ttgggcttat cgcagcggga caaaaacagg tcccaggtct gcaatatcta tatacagacc
     5881 tatcgactat gggatctttg ggaaagaaca acagttagct ttcttagaaa atgtaaagag
     5941 gtcacttaca caaggaagat tatggaaacc aagttttctt aagaaccctg gcttcctaaa
     6001 agatgatttg aggaaccctc ccaacccctc agagtcatta agctcaaatt ctcccagtag
     6061 tcaggtgcca gaagatggct tatctccaag tgaaccgctt aatatctatg aggatgaccc
     6121 agtggactca gattgtgaca cagacacaac cacagatgat gaatactacc tggatgaaaa
     6181 tgacaaagag tcagaactgt gaggcttttt caataaaatg ctttactttt ttcaccaaaa
     6241 gcttataatg gaactaaggt gtacatgtgc atgtgcatgg aaggataaaa gatctagtct
     6301 gggcagtgtc tgctctgaaa tgtcccacat ctcctttttt ttcctccaca ccctatatag
     6361 acacttcctg aatgctagaa caatgaattc ttgttttgag agagtctctg ctattttcta
     6421 tctctgtaaa tgttcttagc ctgcctttcc accactccca cttaatccct gattcactgt
     6481 ctgatttggg ctttctgctt tacttccctc ctaacatttt tcatctttaa ttgtgattta
     6541 caaccctaat atcccaggca catacaaaac ttatgaatta cccagcacaa ctgtgaaact
     6601 ctgtattgct tcttccggtc cacaccctat actcatgaca ttaaataaaa ggtagggatg
     6661 ataacagtgg ggtaaatatt atcatcctgt ttgactcatg aacatttagg aagtttaagg
     6721 tggtgatctt ctctttcaaa caaagataaa ggaatttatt ttttaacctg agaaactgat
     6781 tgcaaaaagg aaaaaaaaaa gataaaggaa ttttgtaagt acttcctgtt atatccgtag
     6841 tggagcctgg gaggcacatg gtcaaagcac atgttgaggt tatagattag gacctgaatc
     6901 cctagtaagc caatagaagg ttagcagtcc tagaaattcc tctgaaaccg tgggggactg
     6961 gctggattat taagggcttt tagtcaagcc aaggacttag gccaggcaac ctgaccatac
     7021 agaaagttgc ctggtcacag aatttctgct tatgaagaga acatagctga ggagcagagg
     7081 taggaagtag gtatcccttc atgggaccga cttaccttta ctgcagttct ctcagcaact
     7141 ggcttttccc atttcctcag aactatccat tttcacattt tctttttttt gtttttgttt
     7201 tttgtttggt tttgttttgt ttttgttttt tggagacgga gttttgctct gtcacccagg
     7261 ctggagtgca gtggcatgat ctgggctcac tgcaacctcc gcctcccggg ttcaagcgat
     7321 tctcctgcct cagcctccag agtagctggg atcacaggcg cacccaggcg cacgctgcca
     7381 cgcccagcta atatttttgt attttagtag agacggggtt tcaccgtgtt gcccaggctg
     7441 gtctcgaact cctgagctca ggcaatccgc ccacttcagc ctcccagagt gctaggatta
     7501 caggcatgag ctaccatgcc cagtcttttt ttgttttgtt ttgtttttgt ttttgttttg
     7561 aggtggagtc ttgttcttgt tgctcaggct agagtgcaat ggcatgatct cagcttactg
     7621 caacctcctc ctcccaagtt caggcaattc tcctgcctca gcctcccaag tagctgggac
     7681 tacaggcacc caccaccaca cctggctaat tttttttttt tttttttttt ttttggtatt
     7741 tttagtagag ttggagtttc accaggttgg ccaggctggt ctcaaacttc tgacctcagg
     7801 tgatctgccc acctcggcct cccaaactgc tgggattaca ggcatgagcc accgtgcctg
     7861 gcccacattt tctttaattg caaggtagaa cgcttctttt caggtggggc attttagtcc
     7921 caaatatcaa gtgggaacct tggccaagtc cctaaaatgc catcaagtca gatctgacac
     7981 cctggaattc attctttgct gcaggatcat ctacgaaacc cttgggaaat tctaaggcag
     8041 agctcctaag ggcttgtcac tatgattcag tgatttatct agagtaaatc acttatgata
     8101 cccactgata ttttggcttt cctaactctt tatttgccat gcagaacctc gggggatttc
     8161 tctcctaatt caggataaag accaatagat ggcagtgaag ataatctgct ttaactacag
     8221 acagcatgga ttcctggatc tcaatactat gatagtcaac atgagtggat tttatcttgc
     8281 ttggtttata tttgcttcgc gacctaatct aattttccat tttttatacc tagtctgttt
     8341 catcattata aactaagaat aatgatagat gttggtgaag tgtatagaga tctggaactg
     8401 atagagagtt aagaaagaac tatgttgttg ttatccttct aatcattccc ttacatagac
     8461 gcaaaatgcg tgggttactt tacatggttc ccatgcaact caaagctaat gaacatgcgg
     8521 taactaacat gaaagctatt ccctaaatct gtcaactatt ttaaacttca agctctgacc
     8581 aatcctgagc tcagaaagct caaaaatcaa atattgtgaa cttttcaatg caaatttgta
     8641 tggtaaagaa taaataacac tatttcttgg ttaatatatg tttgtaaatt ctgcctttcc
     8701 tctttttcta tttatctgat tattattatt attattatta ttttctttga gacagagtct
     8761 cactctgttg cccaggctgg agtgcaatgg cgcaatctcg gctcactgca acctccgcct
     8821 cccaggttca agcgattctc ctgcctcagc ttcccgagta gctgggatta caggtgccca
     8881 ccaccacgcc cagctaattt ttgtattttt agcagagacg gggtttcgcc atgttggcca
     8941 ggctggtttc gaactcctga cctcaggtga tccgcctgcc tcagcctccc aaactgctgg
     9001 gattataggc atgagccacc tcgccagccc tatttatctg attatttaag taaaacttta
     9061 ataaaccatg acctacattt tctatgcaat tttaagatac tcagagttaa tattttaata
     9121 ttgaggttct tgattttttt aatgatcagc tttcaaatta tatttcagta tatactctga
     9181 gtctacgtgt atgctacaaa aggtgaaatg aagttagctt atttttcagt gagtttaggc
     9241 tatattaaga gttaggtaag ttaggtaagg gtgaaactgc tttggggccc agactgcgct
     9301 ggaatgtact gtttaaattc aaaggtaatt gatggccagt gttcagttgc tctatttgta
     9361 acgtttgcat gttggtctgg ctgaagtatc aggaaaacac aaaattcatg aaaatagcac
     9421 cttttataat tttatacttt tataaagcac ttgttaaaga agtatagcaa atttctatgt
     9481 attttaacat acaagtcgct gcattttaat gttcattttt ggtatagcta tggtaactta
     9541 taatagtcat ttttatattc ataacttgtt ttctgaaaga tatagtcatt attaaaataa
     9601 acattcatgt aaatggagta aatcataggg gaatcaatcg taataaatac cttataaatt
     9661 ataaacttgt ttagatacta gatttctata accataaatt ttatactgta aagtctgttt
     9721 aaaatagggt ttaatgaagt tattttaatt tttagagact cccctctaaa taatttactc
     9781 ctacattgta aatacattga tgccaacaaa attccaactg ctactaacaa aggtttggtt
     9841 ggtgataagc taataacagc tactttgtgt aggaggtaaa tatgtgtact ggagggggta
     9901 aaaatccatt taggttatgg caaagatggg aatcaaactg taaaactcat agccccataa
     9961 aattaatatt ctttgttaag tgccagaggg tttaagagaa cttcttgctt agagtttatt
    10021 gataataata atgcttcaga atatcccatt taaatgtaca gtgtaaatat gtaaaatatt
    10081 ttacttccca ggcaagtttg tggctgtatt gccacttagt ggctctttgt gactggcagt
    10141 tctgtatatc tgaaacaaat aagctgtaag cacttttgtt aaaactttgt caaataatcc
    10201 ttttatgtac ttgttctcag acctgttctc tggttatgaa atgtgttaaa gacaaggtgc
    10261 aaatttaaaa caatgcctgt attgaaataa atgacttaaa caga
//
