LOCUS       NM_181503               1166 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens exosome component 8 (EXOSC8), mRNA.
ACCESSION   NM_181503
VERSION     NM_181503.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1166)
  AUTHORS   Zaki,M.S., Abdel-Ghafar,S.F. and Abdel-Hamid,M.S.
  TITLE     A missense variant in EXOSC8 causes exon skipping and expands the
            phenotypic spectrum of pontocerebellar hypoplasia type 1C
  JOURNAL   J Hum Genet 69 (2), 79-84 (2024)
   PUBMED   38017281
  REMARK    GeneRIF: A missense variant in EXOSC8 causes exon skipping and
            expands the phenotypic spectrum of pontocerebellar hypoplasia type
            1C.
REFERENCE   3  (bases 1 to 1166)
  AUTHORS   Cui,K., Gong,L., Zhang,H., Chen,Y., Liu,B., Gong,Z., Li,J.,
            Wang,Y., Sun,S., Li,Y., Zhang,Q., Cao,Y., Li,Q., Fei,B. and
            Huang,Z.
  TITLE     EXOSC8 promotes colorectal cancer tumorigenesis via regulating
            ribosome biogenesis-related processes
  JOURNAL   Oncogene 41 (50), 5397-5410 (2022)
   PUBMED   36348012
  REMARK    GeneRIF: EXOSC8 promotes colorectal cancer tumorigenesis via
            regulating ribosome biogenesis-related processes.
REFERENCE   4  (bases 1 to 1166)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1166)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1166)
  AUTHORS   Raijmakers,R., Egberts,W.V., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions between human exosome components
            support the assembly of RNase PH-type subunits into a six-membered
            PNPase-like ring
  JOURNAL   J Mol Biol 323 (4), 653-663 (2002)
   PUBMED   12419256
  REMARK    GeneRIF: Protein-protein interactions between human exosome
            components support the assembly of RNase PH-type subunits into a
            six-membered PNPase-like ring.
REFERENCE   7  (bases 1 to 1166)
  AUTHORS   Jiang,T. and Altman,S.
  TITLE     A protein subunit of human RNase P, Rpp14, and its interacting
            partner, OIP2, have 3'-->5' exoribonuclease activity
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5295-5300 (2002)
   PUBMED   11929972
  REMARK    GeneRIF: A protein subunit of human RNase P, Rpp14, and its
            interacting partner, OIP2, have 3'-->5' exoribonuclease activity.
REFERENCE   8  (bases 1 to 1166)
  AUTHORS   Raijmakers,R., Noordman,Y.E., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions of hCsl4p with other human exosome
            subunits
  JOURNAL   J Mol Biol 315 (4), 809-818 (2002)
   PUBMED   11812149
REFERENCE   9  (bases 1 to 1166)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
REFERENCE   10 (bases 1 to 1166)
  AUTHORS   Williams,J.M., Chen,G.C., Zhu,L. and Rest,R.F.
  TITLE     Using the yeast two-hybrid system to identify human epithelial cell
            proteins that bind gonococcal Opa proteins: intracellular gonococci
            bind pyruvate kinase via their Opa proteins and require host
            pyruvate for growth
  JOURNAL   Mol Microbiol 27 (1), 171-186 (1998)
   PUBMED   9466265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020773.1, AL138706.9 and
            BU687776.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_181503.2.
            
            Summary: This gene encodes a 3'-5' exoribonuclease that
            specifically interacts with mRNAs containing AU-rich elements. The
            encoded protein is part of the exosome complex that is important
            for the degradation of numerous RNA species. A pseudogene of this
            gene is found on chromosome 6. [provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.117613.1,
                                           SRR1803613.75381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389704.4/ ENSP00000374354.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               BC020773.1         7-346
            341-341             AL138706.9         163046-163046
            342-948             BC020773.1         348-954
            949-1166            BU687776.1         17-234              c
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..1166
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /note="exosome component 8"
                     /db_xref="GeneID:11340"
                     /db_xref="HGNC:HGNC:17035"
                     /db_xref="MIM:606019"
     exon            1..37
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..851
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /EC_number="3.1.13.-"
                     /note="Opa interacting protein 2; exosome complex
                     exonuclease RRP43; ribosomal RNA-processing protein 43;
                     CBP-interacting protein 3; OIP-2"
                     /codon_start=1
                     /product="exosome complex component RRP43"
                     /protein_id="NP_852480.1"
                     /db_xref="CCDS:CCDS31958.1"
                     /db_xref="GeneID:11340"
                     /db_xref="HGNC:HGNC:17035"
                     /db_xref="MIM:606019"
                     /translation="MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSIST
                     ADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEA
                     QVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAAL
                     KNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLA
                     TGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
                     "
     exon            38..74
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            75..138
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            139..212
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            213..258
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            259..364
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            365..410
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            411..507
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            508..628
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            629..735
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1166
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      925..930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /note="hexamer: AATAAA"
     polyA_site      953
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /note="major polyA site"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
                     /note="hexamer: AACAAA"
     polyA_site      1166
                     /gene="EXOSC8"
                     /gene_synonym="bA421P11.3; CIP3; EAP2; OIP2; p9; PCH1C;
                     RRP43; Rrp43p"
ORIGIN      
        1 gcagacgcgc gggcgggaag atggcggctg ggttcaaaac cgtggaacct ctggagtatt
       61 acaggagatt tctgaaagag aactgccgtc ctgatggaag agaacttggt gaattcagaa
      121 ccacaactgt caacatcggt tcaattagta ccgcagatgg ttctgcttta gtgaagttgg
      181 gaaatactac agtaatctgt ggagttaaag cagaatttgc agcaccatca acagatgccc
      241 ctgataaagg atacgttgtt cctaatgtgg atctaccacc cctgtgttca tcgagattcc
      301 ggtctggacc tcctggagaa gaggcccaag tggctagcca gttcattgca gatgtcattg
      361 aaaattcaca gataattcag aaagaggact tatgcatttc tccaggaaag cttgtctggg
      421 ttctatactg tgatctcatt tgcctcgact acgatggaaa cattttggat gcctgcacat
      481 ttgctttgct agcggcttta aaaaatgtac agttgcctga agttactata aatgaagaaa
      541 ctgctttagc agaagttaat ttaaagaaga aaagttattt gaatattaga actcatccag
      601 ttgcaacttc ctttgctgtg tttgatgaca ctttgcttat agttgaccct actggagagg
      661 aggaacatct ggcaacagga accttaacaa tagtaatgga tgaggaaggc aaactctgtt
      721 gtcttcacaa accaggtgga agtgggctaa ctggagctaa acttcaggac tgtatgagcc
      781 gagcagttac aagacacaaa gaagttaaaa aactgatgga tgaagtaatt aagagtatga
      841 aacccaaata aacagccacc acattttcaa aacagatttg taaaaattgt atttgttaac
      901 actgtgcaca aacgttttat actaaataaa tatcaaacta cattcttctg aaagatgttt
      961 ctattatttc ttaggtcact tccatatata ttatgtatag tgaaaccatt tttaaaaagc
     1021 aatgacttag gcaaaccaac cctagtttgt taaaccattt ccctgttttt atttaaaaat
     1081 gataaggttg tgcttctgta taaagtttgt acatctagca atgtaaaata ctgacacatt
     1141 aaaaaaaaca aaaagtagaa actcaa
//
