LOCUS       NM_015004               1042 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens exosome component 7 (EXOSC7), transcript variant 1,
            mRNA.
ACCESSION   NM_015004
VERSION     NM_015004.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Wasmuth,E.V., Januszyk,K. and Lima,C.D.
  TITLE     Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA
  JOURNAL   Nature 511 (7510), 435-439 (2014)
   PUBMED   25043052
REFERENCE   6  (bases 1 to 1042)
  AUTHORS   Butler,J.S.
  TITLE     The yin and yang of the exosome
  JOURNAL   Trends Cell Biol 12 (2), 90-96 (2002)
   PUBMED   11849973
  REMARK    Review article
REFERENCE   7  (bases 1 to 1042)
  AUTHORS   Raijmakers,R., Noordman,Y.E., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions of hCsl4p with other human exosome
            subunits
  JOURNAL   J Mol Biol 315 (4), 809-818 (2002)
   PUBMED   11812149
  REMARK    GeneRIF: The association of hCsl4p with the exosome is mediated by
            protein-protein interactions with hRrp42p and hRrp46p.
REFERENCE   8  (bases 1 to 1042)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 1042)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
REFERENCE   10 (bases 1 to 1042)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104165.2, AK315741.1 and BC012831.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015004.3.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.375812.1,
                                           SRR1803611.260374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265564.8/ ENSP00000265564.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC104165.2         70085-70089
            6-28                AK315741.1         1-23
            29-853              BC012831.2         1-825
            854-942             AC104165.2         105124-105212
            943-1041            BC012831.2         915-1013
            1042-1042           AC104165.2         105312-105312
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1042
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /note="exosome component 7"
                     /db_xref="GeneID:23016"
                     /db_xref="HGNC:HGNC:28112"
                     /db_xref="MIM:606488"
     exon            1..91
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..910
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /EC_number="3.1.13.-"
                     /note="exosome complex exonuclease RRP42; ribosomal
                     RNA-processing protein 42"
                     /codon_start=1
                     /product="exosome complex component RRP42"
                     /protein_id="NP_055819.2"
                     /db_xref="CCDS:CCDS2725.1"
                     /db_xref="GeneID:23016"
                     /db_xref="HGNC:HGNC:28112"
                     /db_xref="MIM:606488"
                     /translation="MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSN
                     TSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLG
                     TEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAAL
                     FNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQE
                     EACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHK
                     EESLGPKRQKVGFLG"
     exon            92..193
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     exon            194..288
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     exon            289..454
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     exon            455..525
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     exon            526..649
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     exon            650..805
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1042
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1022..1027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /note="hexamer: ATTAAA"
     polyA_site      1042
                     /gene="EXOSC7"
                     /gene_synonym="EAP1; hRrp42p; p8; RRP42; Rrp42p"
                     /note="major polyA site"
ORIGIN      
        1 agatgacgtg cggctcgtgg ggcagctcgg cagcatggcg tccgtgacgc tgagcgaggc
       61 ggagaaggtg tacatcgtgc atggcgtcca ggaagacctc cgtgtggatg gccgtggctg
      121 tgaggactac cgatgtgtcg aagtggaaac tgatgtggtg tccaacacta gtgggtccgc
      181 cagggtcaag ctgggtcaca cagacatctt ggtgggagtg aaagcagaaa tggggacgcc
      241 gaagctggag aaaccaaatg aaggctactt ggagttcttt gttgactgtt cagccagtgc
      301 tacccctgaa tttgaaggta gaggaggtga tgaccttggc accgagatcg ctaacaccct
      361 ctatcggata tttaacaata aaagcagtgt cgacttaaag accctctgca ttagtcctcg
      421 ggagcactgc tgggttctct atgtggatgt gctgcttctg gaatgtggtg gaaatttgtt
      481 tgatgccatt tccattgctg taaaggctgc tctcttcaat acaaggatac caagggttcg
      541 agttttggag gatgaagagg ggtcgaagga cattgaattg tcagatgacc cttatgactg
      601 catacgacta agtgtggaga atgtcccctg cattgtcact ctgtgcaaga ttggctatcg
      661 gcatgtggtg gatgctactc ttcaggagga ggcctgctcg ctggccagct tgctggtgtc
      721 ggtgaccagc aagggagttg tgacgtgcat gaggaaagtg gggaagggca gcctggaccc
      781 agagagcatc ttcgagatga tggagactgg caagcgtgtg ggcaaggtac tgcatgcctc
      841 cttgcagagt gttgtgcaca aggaagaaag cctggggccc aagagacaga aagttggatt
      901 cctgggatga tttgcacatc aactgctcaa ctgtggattg ttttttactt ttccttttaa
      961 accggttcgt atatattttt cttcgctgtt acgaatttac agcagcattt gtacatgtaa
     1021 aattaaaggc tattttctgg tc
//
