LOCUS       NM_058219               5163 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens exosome component 6 (EXOSC6), mRNA.
ACCESSION   NM_058219
VERSION     NM_058219.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5163)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 5163)
  AUTHORS   Basu,U., Meng,F.L., Keim,C., Grinstein,V., Pefanis,E.,
            Eccleston,J., Zhang,T., Myers,D., Wasserman,C.R., Wesemann,D.R.,
            Januszyk,K., Gregory,R.I., Deng,H., Lima,C.D. and Alt,F.W.
  TITLE     The RNA exosome targets the AID cytidine deaminase to both strands
            of transcribed duplex DNA substrates
  JOURNAL   Cell 144 (3), 353-363 (2011)
   PUBMED   21255825
REFERENCE   3  (bases 1 to 5163)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   4  (bases 1 to 5163)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   5  (bases 1 to 5163)
  AUTHORS   Seth,D., Hogg,P.J., Gorrell,M.D., McCaughan,G.W. and Haber,P.S.
  TITLE     Direct effects of alcohol on hepatic fibrinolytic balance:
            implications for alcoholic liver disease
  JOURNAL   J Hepatol 48 (4), 614-627 (2008)
   PUBMED   18289715
  REMARK    GeneRIF: We have recently identified increased expression of p11
            genes that implicate fibrinolysis in ALD progression.
REFERENCE   6  (bases 1 to 5163)
  AUTHORS   Raijmakers,R., Egberts,W.V., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions between human exosome components
            support the assembly of RNase PH-type subunits into a six-membered
            PNPase-like ring
  JOURNAL   J Mol Biol 323 (4), 653-663 (2002)
   PUBMED   12419256
  REMARK    GeneRIF: Protein-protein interactions between human exosome
            components support the assembly of RNase PH-type subunits into a
            six-membered PNPase-like ring.
REFERENCE   7  (bases 1 to 5163)
  AUTHORS   van Hoof,A. and Parker,R.
  TITLE     Messenger RNA degradation: beginning at the end
  JOURNAL   Curr Biol 12 (8), R285-R287 (2002)
   PUBMED   11967169
REFERENCE   8  (bases 1 to 5163)
  AUTHORS   Raijmakers,R., Noordman,Y.E., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions of hCsl4p with other human exosome
            subunits
  JOURNAL   J Mol Biol 315 (4), 809-818 (2002)
   PUBMED   11812149
REFERENCE   9  (bases 1 to 5163)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
REFERENCE   10 (bases 1 to 5163)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX866575.1, BC052252.1 and
            AC009060.7.
            
            On Nov 28, 2018 this sequence version replaced NM_058219.2.
            
            Summary: This gene product constitutes one of the subunits of the
            multisubunit particle called exosome, which mediates mRNA
            degradation. The composition of human exosome is similar to its
            yeast counterpart. This protein is homologous to the yeast Mtr3
            protein. Its exact function is not known, however, it has been
            shown using a cell-free RNA decay system that the exosome is
            required for rapid degradation of unstable mRNAs containing AU-rich
            elements (AREs), but not for poly(A) shortening. The exosome does
            not recognize ARE-containing mRNAs on its own, but requires
            ARE-binding proteins that could interact with the exosome and
            recruit it to unstable mRNAs, thereby promoting their rapid
            degradation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435634.3/ ENSP00000398597.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CX866575.1         20-29
            11-1710             BC052252.1         1-1700
            1711-5163           AC009060.7         148055-151507       c
FEATURES             Location/Qualifiers
     source          1..5163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..5163
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /note="exosome component 6"
                     /db_xref="GeneID:118460"
                     /db_xref="HGNC:HGNC:19055"
                     /db_xref="MIM:606490"
     exon            1..5163
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..859
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /note="homolog of yeast mRNA transport regulator 3; Mtr3
                     (mRNA transport regulator 3)-homolog; exosome complex
                     exonuclease MTR3; mRNA transport regulator 3 homolog"
                     /codon_start=1
                     /product="exosome complex component MTR3"
                     /protein_id="NP_478126.1"
                     /db_xref="CCDS:CCDS10887.1"
                     /db_xref="GeneID:118460"
                     /db_xref="HGNC:HGNC:19055"
                     /db_xref="MIM:606490"
                     /translation="MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAG
                     LLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRR
                     APFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAA
                     ALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPV
                     LNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /note="hexamer: AGTAAA"
     polyA_site      1710
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /note="major polyA site"
     regulatory      5137..5142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /note="hexamer: AATAAA"
     polyA_site      5163
                     /gene="EXOSC6"
                     /gene_synonym="EAP4; hMtr3p; MTR3; Mtr3p; p11"
                     /note="major polyA site"
ORIGIN      
        1 agggcgttgg gcggaagggg ttcgcacgcc aagaaccgcc atgcctgggg atcaccgccg
       61 catccgcggc cctgaagaat cgcagccgcc gcagctgtac gcggccgacg aggaggaggc
      121 gcccggcacc cgcgacccaa cgcggctacg gcccgtgtac gcgcgcgccg ggctgctgag
      181 ccaggccaag ggctcggcct acctggaggc gggaggcacc aaggtgctgt gtgccgtgtc
      241 gggcccgcga caggccgagg gcggcgagcg cggcggcggc ccggccggag caggcggcga
      301 ggccccggcc gcgctgcgcg gtcgcctgct ctgcgacttc cgccgcgcac ccttcgcggg
      361 ccgccggcgc cgcgctcccc cgggcggctg cgaggagcgt gagctggcgc tggcgctgca
      421 ggaggcgctg gagccggctg tgcgcctggg ccgctacccg cgcgcgcagc tcgaggtgtc
      481 ggcgctgctg ctggaggacg gtggctcggc cctggccgcc gcgctcaccg ccgccgcgct
      541 cgccctggcc gacgcgggcg tggagatgta cgacctggtg gtgggctgcg gcctcagcct
      601 cgcgccgggg cccgcgccca cctggctcct ggaccccacg cggctcgagg aagagcgcgc
      661 cgccgccggc ctcaccgtgg cgctcatgcc tgtgctgaat caggtggccg ggctgctggg
      721 cagcggcgag ggcggcctga cagagagctg ggcggaggcc gtacgcctgg gcctcgaggg
      781 ctgccagcgc ctctaccccg tgctgcagca gagcctggtg cgggccgccc gccgcagggg
      841 cgccgccgcc cagccctgaa ccagaagcct gagcaactac ggacgcaagc cgaggaccgt
      901 gctgccgccg tccacgaaaa gacccgcgcc atcggcctcc agtttgcgtc gagaattcct
      961 ggaagggccc tgatatgact gtggttggac tgacctgact gccagatggt gggacttggt
     1021 ctggagcagg gactacttgg aatgataaag gcaaaactca acagcccctg gagctgcgct
     1081 tgtggtggag ctggaccctg aaattacctg gacctttttt ttagagacag ggtttctttc
     1141 tgcagtctca aactcctagc cttgattgat cctcctgcct tggcctccca aagtgctggg
     1201 actacaggtg catgcaacca cacctggcta attttctttt cttctttctt tctttttttt
     1261 tttttttttt ttttgatgga gtcttgttct gttgcccagg ctggagtgca atggtgcaat
     1321 cttggctcac tgcaacctct gcctcctggg ttcaatccat tctcctgcct cagcctccca
     1381 agtagctggg attacaggca catgcctcca taccgggcta atttttgtat ttttagtaga
     1441 gatggggttt cgccatgtgg gccaggctgt tctcgaatgc ctgacctcag gtgatccacc
     1501 cgccttggcc tcccaaagtg ctggaattac aggtgtgagc cactgtgccc agctgagtaa
     1561 atttcttgat tgcacagaat gtacggtgat attggcggac ttaaggacat cgaattgttt
     1621 atcaggaata aagtattatg tgtgttttct gcggccctgg ataatgctgt agcattcagg
     1681 gtcgattgag taaaaaaaat gtagagatgg tttcctgttt gtttttgctt ctagttttca
     1741 ttcatttgct atttattctc ttctggcttt gcttgtgtat gcatatatat aaaaccatta
     1801 ttattattat tattattttt agtttctagt ggaaggcttt tatttggttc tgtgaatagt
     1861 cattttgttt cctaagaact tccagcaagt tgtattcatt ccattcatct agaattccta
     1921 ggctgccttt gtcgggcctg caggtattaa tggagaatag cagcttttta tttttttata
     1981 tttatttttt gagacagagt ctcactctgt tgcccaggct ggagtgcaat ggcgcgatct
     2041 cagctcactg caacctccgc ctcagaggtt caagtgattc tcctgcctca gcctctggaa
     2101 tagctgggac tacaggcacc tgccaccaca cccagctaac tttttgtatt tttagagaag
     2161 atggggtttc atcatgttgg ccaagctggt ctcaaactcc tgatctcagt gatccatctg
     2221 cctcagcctc ccaaagttat aagatttttt tcctctggtt tttagtaaat gttttttttg
     2281 agattgctta gcaccagaat gatttgcaaa tttgaaaata ggaactccac taggaatgcc
     2341 ggatagaaga gtgcttcaca tttgtagagg gagacaagaa ctaaatatca cgacgtcttt
     2401 ctgagccttt tggtttgcta acgtgcccca aattcttatt ccaaacggta taagataatt
     2461 atgtgtaaat gaataccagc tctacttagt tttatttcat atttgtgtat ctgaatatat
     2521 taaaatatct tttttttttt tttgatgcgg agtcttgctc tgttgtccag cctggagtgc
     2581 agtggcatga tctcggctca ctgcaacctc tgcctcccag gttcaagcga ttctcctgcc
     2641 tcagcctcct aagtagctgg tattacagga gtgtgccatt agcctggcta atttttgtat
     2701 ttttagtaga gatggatttt cattgtgttg gccatgctgg tcttgaactc ctgacctcaa
     2761 gtgatcctcc tgccttggcc tcccaaagta ctgtgattac tatcatgagc caccacacct
     2821 ggcctaaaag atcattgatt tagttttgag taagatttta agtgattaaa ttatggtatt
     2881 gttgtgtctg gaatatctga tattagggtt tttttttttt ttttttacag tttttgatat
     2941 gctttatttt gggtatgtag tttacaaaat ataaaggaaa tataaggagt gttctctttt
     3001 ttttttaaat aaaaagtgta tttttaactg ggcatggtgg ctcactcctg taaccccagc
     3061 actgtgggag gctgaggctg gtgaatcgcc tgagtccagg agtttgagac cagcctgggc
     3121 aacaaggtga aaccctgttt ctatcaaaaa aaaaaaaaaa aaaaaaaaag gaaaaaaaat
     3181 aagtcaggca tggtggtatg cacctgtagt cccagctact tgaaggctga ggcaggagga
     3241 tcgcttgtgc ctgggaggtt gaagctacag tgagctatgg tcaagctact gcactccatt
     3301 ataggcaacc ctatctcaaa aaagcaaagc aaaacaaaac atttttcccc ttgattatag
     3361 aggtttgaga aaaatttgag ggaagattca gaaaattacc tgtaactgaa cagaatgcca
     3421 ccagcttggg cttattctgc atgcataatt atgaacattt tcccagctct tgtgaaaatt
     3481 ctcacattca tagaaagata gatgcaccag taaaataaat acctgtaaat acgataataa
     3541 tttcataata atatgcttca cctagattta ccagttacta atattttgcc agttttattt
     3601 tctcacacac ttttgttgag catctgaaaa ccatacacat gatgacagtt caacccataa
     3661 tgttttagtt tgcatctccc aagaataagg tttttcttct gtataacaag aatattgtaa
     3721 tcatacctaa gaaaatgaat tttattacat atgtgttcta tattcaaatt tctgtaatta
     3781 cccctaagat gtcttttaaa tgatttttag cattgatagt ctgtgcctgt gtagattata
     3841 acattggcta ttgcaaaata atggttttct ttttctcttt ttttttgaga cgaaatcttg
     3901 ctctattgtc caagctggag ggcagtggca caatctcggc tcactgcaac ctccgcctcc
     3961 caggttcaag cagttctcat gcttcaccct cctgagtagc tgggattaca ggcaggtgcc
     4021 actgtgctct gctaattttt atatttttag tagagacgga gtttcatcga gctggccaga
     4081 ctggtcttga actcctgacc tcaagtgatc cacctgcctc gtcctcccaa agtgctgggg
     4141 ttacaggtgt gagccactgc acccagccta aaatgatggt tttctgattc tagcatttct
     4201 tttataagat tgctatgtaa agcacagctt ttcttttttt agggaaaaat gtcttttaac
     4261 agctgcaaaa taaatattct ttcaatggaa tgacaattat tatttttgcc atatatttat
     4321 tttaaaaatt tatgtataat ggtaacctga gcctgcatgt tattcatgtg tggtgccata
     4381 ctgatcttta attttaatgt gaagcaagta ctaatatagt aaagcataaa ttatataaaa
     4441 tttgctttat attttggatt gcaaattaat tgctgtactt tatagaaaag tttcccaaat
     4501 ccgttttact tttttgtatt tgaaatttaa tcacaggtgg aatcttaaag agagcattta
     4561 gggatattgt aaacagatgt tattaaggac taatgttaac aaacattgaa gaagagaaaa
     4621 cagtatttgt ttttagctta acatcttagt ggagtgaaat attttcagta tatttatttt
     4681 atttatttat taattatttt tttttttgag atggagtctg gctgtattgt ccaggctgga
     4741 gtgcagcggt gcaatctcag ctcactgcaa cctctgcctc ctgggttcaa gcgattcttg
     4801 tgtctcagcc tcccgagtag ttgggattta caagtcaatt ttttttttaa ctaaaactac
     4861 agaatctatt tttcttggtc tcatactcag ttttttatgt agtcacttag taaataacct
     4921 aatttgcttg ttttctccac actaatttta gggtgaattc ctcatttcgc ttttcagatc
     4981 atggggtgag ggggatggtt gtgtgtgtga ggaactgagg aatcagatgg aaaacaatgc
     5041 ctctgctcct ttgagtataa tcagtgatat ttgaggttcc agggttaaat gctgcatttt
     5101 tatttctgac gttcgtacct taaaatattt gaagaaaata aactatttca ttgttgtcag
     5161 aaa
//
