LOCUS       NM_019037                842 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens exosome component 4 (EXOSC4), mRNA.
ACCESSION   NM_019037
VERSION     NM_019037.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 842)
  AUTHORS   Wang,N., Miao,X., Lu,W., Ji,Y., Zheng,Y., Meng,D., Liu,H. and
            Xiang,C.
  TITLE     RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4
            expression
  JOURNAL   Funct Integr Genomics 24 (3), 103 (2024)
   PUBMED   38913281
  REMARK    GeneRIF: RUNX3 exerts tumor-suppressive role through inhibiting
            EXOSC4 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 842)
  AUTHORS   Taniue,K., Tanu,T., Shimoura,Y., Mitsutomi,S., Han,H., Kakisaka,R.,
            Ono,Y., Tamamura,N., Takahashi,K., Wada,Y., Mizukami,Y. and
            Akimitsu,N.
  TITLE     RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is
            Required for the Cancer Cell Survival
  JOURNAL   Int J Mol Sci 23 (1), 496 (2022)
   PUBMED   35008922
  REMARK    GeneRIF: RNA Exosome Component EXOSC4 Amplified in Multiple Cancer
            Types Is Required for the Cancer Cell Survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 842)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 842)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 842)
  AUTHORS   Pan,Y., Tong,J.H.M., Kang,W., Lung,R.W.M., Chak,W.P., Chung,L.Y.,
            Wu,F., Li,H., Yu,J., Chan,A.W.H. and To,K.F.
  TITLE     EXOSC4 functions as a potential oncogene in development and
            progression of colorectal cancer
  JOURNAL   Mol Carcinog 57 (12), 1780-1791 (2018)
   PUBMED   30155936
  REMARK    GeneRIF: Findings show that EXOSC4 is highly expressed in
            colorectal cancer (CRC) tumors and cell lines and demonstrate its
            oncogenic role in development and progression of CRC.
REFERENCE   6  (bases 1 to 842)
  AUTHORS   Raijmakers,R., Noordman,Y.E., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions of hCsl4p with other human exosome
            subunits
  JOURNAL   J Mol Biol 315 (4), 809-818 (2002)
   PUBMED   11812149
REFERENCE   7  (bases 1 to 842)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 842)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
REFERENCE   9  (bases 1 to 842)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
REFERENCE   10 (bases 1 to 842)
  AUTHORS   Allmang,C., Petfalski,E., Podtelejnikov,A., Mann,M., Tollervey,D.
            and Mitchell,P.
  TITLE     The yeast exosome and human PM-Scl are related complexes of 3' -->
            5' exonucleases
  JOURNAL   Genes Dev 13 (16), 2148-2158 (1999)
   PUBMED   10465791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM839994.1, BC002777.2 and AK000598.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019037.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.324876.1,
                                           SRR1660803.24566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316052.6/ ENSP00000315476.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BM839994.1         54-86
            34-840              BC002777.2         1-807
            841-842             AK000598.1         811-812
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..842
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /note="exosome component 4"
                     /db_xref="GeneID:54512"
                     /db_xref="HGNC:HGNC:18189"
                     /db_xref="MIM:606491"
     exon            1..228
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..795
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /note="exosome complex exonuclease RRP41; exosome
                     component Rrp41; ribosomal RNA-processing protein 41"
                     /codon_start=1
                     /product="exosome complex component RRP41"
                     /protein_id="NP_061910.1"
                     /db_xref="CCDS:CCDS6414.1"
                     /db_xref="GeneID:54512"
                     /db_xref="HGNC:HGNC:18189"
                     /db_xref="MIM:606491"
                     /translation="MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQG
                     NTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQ
                     LRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCAC
                     SAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAA
                     QAARDVHTLLDRVVRQHVREASILLGD"
     exon            229..435
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /inference="alignment:Splign:2.1.0"
     exon            436..842
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      818..823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /note="hexamer: AATAAA"
     polyA_site      842
                     /gene="EXOSC4"
                     /gene_synonym="hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6;
                     Ski6p"
                     /note="major polyA site"
ORIGIN      
        1 gtagttctcc cgcggctcag agaagtaggc agagagcgga cctggcggcc gggcagcatg
       61 gcggggctgg agctcttgtc ggaccagggc taccgggtgg acgggcggcg cgccggggag
      121 ctgcgcaaga tccaggcgcg gatgggcgtg ttcgcgcagg ctgacggctc ggcctacatt
      181 gagcagggca acaccaaggc actggctgtg gtctacggcc cgcacgagat ccggggctcc
      241 cgggctcgag ccctgccgga cagggcccta gtgaactgtc aatatagttc agcgaccttc
      301 agcacaggtg agcgcaagcg acggccacat ggggaccgta agtcctgtga gatgggcctg
      361 cagctccgcc agactttcga agcagccatc ctcacacagc tgcacccacg ctcccagatt
      421 gatatctatg tgcaggtgct acaggcagat ggtgggacct atgcagcttg tgtgaatgca
      481 gccacgctgg cagtgctgga tgccgggata cccatgagag actttgtgtg tgcgtgctca
      541 gctggcttcg tggacggcac agccctggcg gacctcagcc atgtggagga agcagctggt
      601 ggcccccagc tggccctggc cctgctgcca gcctcaggac agattgcgct gcttgagatg
      661 gatgcccggc tgcacgagga ccacctggag cgggtgttgg aggctgctgc ccaggctgcc
      721 cgagatgtgc acaccctctt agatcgagtg gtccggcagc atgtgcgtga ggcctctatc
      781 ttgctggggg actgaccacc cagccaccca tgtccagaat aaaaccctcc tctgcccaca
      841 ca
//
