LOCUS       NM_014285               2012 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens exosome component 2 (EXOSC2), transcript variant 1,
            mRNA.
ACCESSION   NM_014285
VERSION     NM_014285.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Moll,T., Odon,V., Harvey,C., Collins,M.O., Peden,A., Franklin,J.,
            Graves,E., Marshall,J.N., Dos Santos Souza,C., Zhang,S.,
            Castelli,L., Hautbergue,G., Azzouz,M., Gordon,D., Krogan,N.,
            Ferraiuolo,L., Snyder,M.P., Shaw,P.J., Rehwinkel,J. and
            Cooper-Knock,J.
  TITLE     Low expression of EXOSC2 protects against clinical COVID-19 and
            impedes SARS-CoV-2 replication
  JOURNAL   Life Sci Alliance 6 (1), e202201449 (2022)
   PUBMED   36241425
  REMARK    GeneRIF: Low expression of EXOSC2 protects against clinical
            COVID-19 and impedes SARS-CoV-2 replication.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Sterrett,M.C., Enyenihi,L., Leung,S.W., Hess,L., Strassler,S.E.,
            Farchi,D., Lee,R.S., Withers,E.S., Kremsky,I., Baker,R.E.,
            Basrai,M.A., van Hoof,A., Fasken,M.B. and Corbett,A.H.
  TITLE     A budding yeast model for human disease mutations in the EXOSC2 cap
            subunit of the RNA exosome complex
  JOURNAL   RNA 27 (9), 1046-1067 (2021)
   PUBMED   34162742
  REMARK    GeneRIF: A budding yeast model for human disease mutations in the
            EXOSC2 cap subunit of the RNA exosome complex.
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Mitchell,P., Petfalski,E., Shevchenko,A., Mann,M. and Tollervey,D.
  TITLE     The exosome: a conserved eukaryotic RNA processing complex
            containing multiple 3'-->5' exoribonucleases
  JOURNAL   Cell 91 (4), 457-466 (1997)
   PUBMED   9390555
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Adams,M.D., Dubnick,M., Kerlavage,A.R., Moreno,R., Kelley,J.M.,
            Utterback,T.R., Nagle,J.W., Fields,C. and Venter,J.C.
  TITLE     Sequence identification of 2,375 human brain genes
  JOURNAL   Nature 355 (6361), 632-634 (1992)
   PUBMED   1538749
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Morris,C.M., Heisterkamp,N., Groffen,J. and Fitzgerald,P.H.
  TITLE     Entire ABL gene is joined with 5'-BCR in some patients with
            Philadelphia-positive leukemia
  JOURNAL   Blood 78 (4), 1078-1084 (1991)
   PUBMED   1868241
REFERENCE   9  (bases 1 to 2012)
  AUTHORS   Soekarman,D., van Denderen,J., Hoefsloot,L., Moret,M., Meeuwsen,T.,
            van Baal,J., Hagemeijer,A. and Grosveld,G.
  TITLE     A novel variant of the bcr-abl fusion product in Philadelphia
            chromosome-positive acute lymphoblastic leukemia
  JOURNAL   Leukemia 4 (6), 397-403 (1990)
   PUBMED   2193202
REFERENCE   10 (bases 1 to 2012)
  AUTHORS   Zhu,Q.S., Heisterkamp,N. and Groffen,J.
  TITLE     Characterization of the human ABL promoter regions
  JOURNAL   Oncogene 5 (6), 885-891 (1990)
   PUBMED   2163052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU934039.1, BC000747.2 and AL359092.14.
            
            On Nov 22, 2018 this sequence version replaced NM_014285.6.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.38231.1,
                                           SRR1660803.108578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372358.10/ ENSP00000361433.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BU934039.1         24-33
            11-1989             BC000747.2         1-1979
            1990-2012           AL359092.14        99713-99735
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.12"
     gene            1..2012
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="exosome component 2"
                     /db_xref="GeneID:23404"
                     /db_xref="HGNC:HGNC:17097"
                     /db_xref="MIM:602238"
     exon            1..134
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..894
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5'
                     exoribonuclease (RRP4); exosome complex exonuclease RRP4;
                     homolog of yeast RRP4 (ribosomal RNA processing 4),
                     3'-5'-exoribonuclease; exosome complex component RRP4;
                     ribosomal RNA-processing protein 4"
                     /codon_start=1
                     /product="exosome complex component RRP4 isoform 1"
                     /protein_id="NP_055100.2"
                     /db_xref="CCDS:CCDS6935.1"
                     /db_xref="GeneID:23404"
                     /db_xref="HGNC:HGNC:17097"
                     /db_xref="MIM:602238"
                     /translation="MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHG
                     TYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNS
                     RLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRS
                     LKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGG
                     FIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEI
                     MEEIVMETRQRLLEQEG"
     exon            135..236
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            237..282
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            283..372
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            373..438
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            439..507
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            508..684
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            685..813
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            814..2012
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="hexamer: AATAGA"
     polyA_site      1282
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="major polyA site"
     regulatory      1663..1668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="hexamer: AACAAG"
     polyA_site      1694
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="major polyA site"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="hexamer: GATAAA"
     polyA_site      1978
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
                     /note="major polyA site"
     polyA_site      2012
                     /gene="EXOSC2"
                     /gene_synonym="hRrp4p; p7; RRP4; Rrp4p; SHRF"
ORIGIN      
        1 attggcgcca agatggcgat ggagatgagg cttccagtgg ctcgcaagcc tcttagcgag
       61 agactgggcc gcgacactaa gaaacatcta gtggtgccgg gggatacaat cactacggac
      121 acaggattca tgcggggcca tggaacgtat atgggagaag agaagctcat tgcatctgtt
      181 gctggctctg tggagagagt aaacaagttg atctgtgtga aagctttgaa aaccagatac
      241 attggtgaag taggagacat cgtagtggga cgaatcacag aggttcaaca gaagaggtgg
      301 aaggtggaga ccaactccag gctggattcg gtcttgctgc tctcgtccat gaaccttcct
      361 ggaggagagc tgaggagaag atctgcagaa gatgagcttg caatgagagg tttcttacag
      421 gaaggggacc ttatcagtgc tgaggtccag gcagtgttct ctgacggagc tgtctctttg
      481 cacacgagga gcctgaaata tggaaaacta ggtcaggggg ttttggtcca ggtttccccc
      541 tccctggtga aacggcagaa gacccacttt catgatttgc catgtggtgc ctcagtgatt
      601 ctcggtaaca acggcttcat ctggatttac ccaacacctg agcacaaaga agaggaagca
      661 gggggcttca ttgcaaacct ggagcctgtc tctcttgctg atcgagaggt gatatcccgg
      721 cttcggaact gcatcatctc gctggtaact cagaggatga tgctgtatga taccagcatc
      781 ctgtactgct atgaagcatc ccttccacat cagatcaaag acatcttaaa gccagaaata
      841 atggaggaga ttgtgatgga aacacgccag aggcttttgg aacaggaggg ataaggaggt
      901 gctccagaag cacgggactg tggaccttgc aggagtgaag actgtgatgt gtggtcccca
      961 tatgtggctc agcaaagact cgagagatca tccctttgtc tgcattgacg gccctgtgac
     1021 ggcctccagc ccacaggcct gctttctcct gtcctaacac caagcctggg tggcagatga
     1081 acagtgcttc cttgggttgc cagctgagtc ccggtattag ggaatagttt cagctctttc
     1141 aaagtgcaca gtgttacagt cgaatgggct cccatcctgg aataatatgg agaatccttt
     1201 gtcttccact cactgtcatt cacaaggcac agtgccccat gaaattgccc caatagaaaa
     1261 catggcatcc ctgacctcca aatggtctgt tttggcctcc attcctatat cctttaaatg
     1321 actgagaatg cagctggtaa agttggaaga ataaagttaa ccaagcaggc caggcacggt
     1381 ggctcacgcc tataatccca gcacttaggg aggccaaggc gggcagatca cctgaggtca
     1441 atagttcgag accagcctgg ccaacaaggt gaaaccccat ctctactaaa aatacaaaaa
     1501 attagccagg tgtggtggtg tgcacctgta gtcccagcta tttgggaggc tgaggtggga
     1561 gaatcacttg aacctgggag gcggaggttg cagtgagctg aaatcgcgta ccacactcca
     1621 gcctgggtga cagagcgaga ctgtgtttca aagaaaaaaa aaaacaagca gccttttgct
     1681 tggttggaat ctgattttct gttgcgtgtt ccttgtagcc atagatgtga ttatgtccac
     1741 accgggctgc cttaatctgt cctgcttgga gagtgacttg taagatgctg aattattcat
     1801 gataatacag tgaatgttct gggtccatgt actcagataa acatgaagaa aataagcaaa
     1861 gaaaaatgga gactgggaaa gcaaagctgt tttcatccta taattgaagt agtgtggagc
     1921 attaacttgt ggatgattca gagttaaaag ataaaaagac gccagagttc tcgctgaaga
     1981 atgtgagaat tcctgtgcat tgttttttct ga
//
