LOCUS       NM_001001998            2796 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens exosome component 10 (EXOSC10), transcript variant 1,
            mRNA.
ACCESSION   NM_001001998
VERSION     NM_001001998.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2796)
  AUTHORS   Filippopoulou,C., Thome,C.C., Perdikari,S., Ntini,E., Simos,G.,
            Bohnsack,K.E. and Chachami,G.
  TITLE     Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes
            in the transcriptome profile
  JOURNAL   Cell Mol Life Sci 81 (1), 58 (2024)
   PUBMED   38279024
  REMARK    GeneRIF: Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive
            changes in the transcriptome profile.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2796)
  AUTHORS   Meng,Z.Y., Fan,Y.C., Zhang,C.S., Zhang,L.L., Wu,T., Nong,M.Y.,
            Wang,T., Chen,C. and Jiang,L.H.
  TITLE     EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a
            comprehensive bioinformatics analysis and experiment verification
  JOURNAL   PeerJ 11, e15860 (2023)
   PUBMED   37701829
  REMARK    GeneRIF: EXOSC10 is a novel hepatocellular carcinoma prognostic
            biomarker: a comprehensive bioinformatics analysis and experiment
            verification.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2796)
  AUTHORS   Chen,Y., Li,Y., Dai,R.S., Savage,J.C., Shinde,U., Klimek,J.,
            David,L.L., Young,E.A., Hafner,M., Sears,R.C., Sun,X.X. and
            Dai,M.S.
  TITLE     The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and
            promotes the nucleolar RNA exosome function in rRNA processing
  JOURNAL   Nucleic Acids Res 51 (8), 3934-3949 (2023)
   PUBMED   36912080
  REMARK    GeneRIF: The ubiquitin-specific protease USP36 SUMOylates EXOSC10
            and promotes the nucleolar RNA exosome function in rRNA processing.
REFERENCE   5  (bases 1 to 2796)
  AUTHORS   Fujiwara,N., Shigemoto,M., Hirayama,M., Fujita,K.I., Seno,S.,
            Matsuda,H., Nagahama,M. and Masuda,S.
  TITLE     MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of
            MTR4-sensitive substrates in the human nucleus
  JOURNAL   Nucleic Acids Res 50 (15), 8779-8806 (2022)
   PUBMED   35902094
  REMARK    GeneRIF: MPP6 stimulates both RRP6 and DIS3 to degrade a specified
            subset of MTR4-sensitive substrates in the human nucleus.
REFERENCE   6  (bases 1 to 2796)
  AUTHORS   Stover,C., Endo,Y., Takahashi,M., Lynch,N.J., Constantinescu,C.,
            Vorup-Jensen,T., Thiel,S., Friedl,H., Hankeln,T., Hall,R.,
            Gregory,S., Fujita,T. and Schwaeble,W.
  TITLE     The human gene for mannan-binding lectin-associated serine
            protease-2 (MASP-2), the effector component of the lectin route of
            complement activation, is part of a tightly linked gene cluster on
            chromosome 1p36.2-3
  JOURNAL   Genes Immun 2 (3), 119-127 (2001)
   PUBMED   11426320
REFERENCE   7  (bases 1 to 2796)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
REFERENCE   8  (bases 1 to 2796)
  AUTHORS   Allmang,C., Petfalski,E., Podtelejnikov,A., Mann,M., Tollervey,D.
            and Mitchell,P.
  TITLE     The yeast exosome and human PM-Scl are related complexes of 3' -->
            5' exonucleases
  JOURNAL   Genes Dev 13 (16), 2148-2158 (1999)
   PUBMED   10465791
REFERENCE   9  (bases 1 to 2796)
  AUTHORS   Bluthner,M. and Bautz,F.A.
  TITLE     Cloning and characterization of the cDNA coding for a
            polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD
            protein
  JOURNAL   J Exp Med 176 (4), 973-980 (1992)
   PUBMED   1383382
REFERENCE   10 (bases 1 to 2796)
  AUTHORS   Ge,Q., Frank,M.B., O'Brien,C. and Targoff,I.N.
  TITLE     Cloning of a complementary DNA coding for the 100-kD antigenic
            protein of the PM-Scl autoantigen
  JOURNAL   J Clin Invest 90 (2), 559-570 (1992)
   PUBMED   1644924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC073788.1, BC028687.1 and CA307576.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001001998.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028687.1, BC073788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376936.9/ ENSP00000366135.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1426              BC073788.1         18-1443
            1427-2619           BC028687.1         1444-2636
            2620-2796           CA307576.1         23-199              c
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..2796
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /note="exosome component 10"
                     /db_xref="GeneID:5394"
                     /db_xref="HGNC:HGNC:9138"
                     /db_xref="MIM:605960"
     exon            1..149
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2696
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /note="isoform 1 is encoded by transcript variant 1;
                     autoantigen PM-SCL; polymyositis/scleroderma autoantigen
                     100 kDa; P100 polymyositis-scleroderma overlap
                     syndrome-associated autoantigen; polymyositis/scleroderma
                     autoantigen 2; exosome complex component 10"
                     /codon_start=1
                     /product="exosome complex component 10 isoform 1"
                     /protein_id="NP_001001998.1"
                     /db_xref="CCDS:CCDS30584.1"
                     /db_xref="GeneID:5394"
                     /db_xref="HGNC:HGNC:9138"
                     /db_xref="MIM:605960"
                     /translation="MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVV
                     AVTKASGGLPQFGDEYDFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSK
                     VTELEDKFDLLVDANDVILERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKA
                     AEYGKKAKSETFRLLHAKNIIRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSK
                     ERRERPQDRPEDLDVPPALADFIHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQ
                     PQLYRPIEETPCHFISSLDELVELNEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTR
                     TEDFIIDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQA
                     ARLLNLGRHSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDK
                     MRLEMWERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLT
                     AFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQI
                     NEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIP
                     TSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQ
                     NIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVK
                     KKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKR
                     LKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAK
                     KIKQSVGNKSMSFPTGKSDRGFRYNWPQR"
     exon            150..286
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            287..410
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            411..515
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            516..681
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            682..796
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            797..872
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            873..983
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1127
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1318
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1475
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1624
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1675
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1787
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1838
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1917
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2024
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2120
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2195
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2280
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2354
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2526
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2588
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2665
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2796
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /note="hexamer: ATTAAA"
     polyA_site      2796
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /note="major polyA site"
ORIGIN      
        1 gacaagctct cgcgagacga gccgtgcagg ctgaaaaaat ggcgccaccc agtacccggg
       61 agcccagggt cctgtcggcg accagcgcaa ccaaatccga cggagagatg gtgctgccag
      121 gcttcccgga cgccgacagc tttgtgaagt ttgctcttgg gtccgtggtg gcagtcacca
      181 aggcatctgg gggcctacca cagtttggcg atgagtatga tttttaccga agttttcctg
      241 gcttccaagc attttgcgaa acacagggag acaggttgct tcagtgcatg agcagagtaa
      301 tgcagtacca tgggtgtcgc agcaacatta aggatcgaag taaagtgact gagctggaag
      361 acaagtttga tttactagtt gatgccaatg atgtaattct ggagagagtg ggtattttac
      421 tggatgaagc ctcaggtgta aacaagaatc aacagcctgt cctccctgcc ggcttgcagg
      481 tccccaaaac ggtagtgtcc agctggaacc gtaaggcagc agaatatggc aaaaaagcaa
      541 aatctgaaac tttccggctg cttcatgcaa aaaatatcat ccgacctcag ctcaagtttc
      601 gagagaagat tgacaattcc aacacaccat ttcttcctaa aatcttcatc aaacccaatg
      661 ctcagaaacc tctccctcaa gctctctcta aggaaaggcg ggaacgccca caggatcgtc
      721 ctgaggactt ggacgtcccc cctgcactgg ctgatttcat ccatcagcag agaacccagc
      781 aggttgagca agacatgttt gcacatcctt atcaatatga actaaatcac tttaccccag
      841 cagatgcagt gcttcaaaag ccacaacccc agttatacag acctatagaa gagacaccat
      901 gccatttcat atcctccctg gatgaactcg tggaactcaa cgaaaagctc ttgaattgtc
      961 aggaatttgc agttgacttg gagcaccact cttacaggag cttcctggga ctgacctgcc
     1021 tgatgcaaat ttctactcgg acggaagact tcatcattga caccctcgag cttcgaagtg
     1081 acatgtacat tctcaatgag agcctcacag acccagccat cgttaaggtc tttcatggtg
     1141 ctgattcaga catagaatgg ctacagaaag actttgggtt gtatgtagta aacatgtttg
     1201 atactcatca ggcagcacgc cttcttaacc tgggcaggca ctcactcgat catctcctga
     1261 aactctactg caacgtggac tcaaacaagc aatatcagct ggctgattgg agaatacgcc
     1321 ctctgcccga ggagatgctc agctacgccc gggatgacac ccattacctg ctatatatct
     1381 atgacaaaat gaggctggag atgtgggagc gcggcaacgg gcagccggtg cagctgcagg
     1441 tggtgtggca acggagcagg gacatctgcc tcaagaaatt catcaaacct atcttcacgg
     1501 atgagtccta ccttgaactc tataggaagc agaagaagca ccttaacaca cagcagttga
     1561 cagcctttca gctgctgttt gcctggaggg ataaaacagc tcgcagggaa gatgaaagtt
     1621 acggatatgt actgccaaac cacatgatgc tgaaaatagc tgaagaactg cctaaggaac
     1681 ctcagggcat catagcttgc tgcaacccag taccgcccct tgtgcggcag cagatcaacg
     1741 aaatgcacct tttaatccag caggcccgag agatgcccct gctcaagtct gaagttgcag
     1801 ccggagtgaa gaagagcgga ccgctgccca gtgctgagag attggagaat gttctctttg
     1861 gacctcacga ctgctcccat gcccctccgg atggctatcc aatcatccca accagtggat
     1921 ctgtgccagt tcagaagcag gcgagcctct tccctgatga aaaagaagat aacttgctgg
     1981 gtaccacatg cctgattgcc acagctgtca tcacgttatt taatgaacct agtgctgaag
     2041 acagtaaaaa gggtccattg acagttgcac agaaaaaagc ccagaacatc atggagtcct
     2101 ttgaaaatcc atttaggatg tttctgccct cactgggaca ccgtgctccc gtctctcagg
     2161 cagcgaagtt cgatccatca accaaaatct atgaaatcag caaccgctgg aagctggccc
     2221 aggtacaagt acaaaaagac tctaaagaag ctgtcaagaa gaaggcagct gagcaaacag
     2281 ctgcccggga acaggcaaag gaggcgtgca aagctgcagc agaacaggcc atctccgtcc
     2341 gacagcaggt cgtgctagaa aatgctgcaa agaagagaga gcgagcaaca agcgacccaa
     2401 ggaccacaga acagaaacaa gagaagaaac gactcaaaat ttccaagaag ccaaaggacc
     2461 cagagccacc agaaaaagag tttacgcctt acgactacag ccagtcagac ttcaaggctt
     2521 ttgctggaaa cagcaaatcc aaagtttctt ctcagtttga tccaaataaa cagaccccgt
     2581 ctggcaagaa atgcattgca gccaaaaaaa ttaaacagtc ggtgggaaac aaaagcatgt
     2641 cctttccaac tggaaagtca gacagaggct tcaggtacaa ctggccacag agatagtcct
     2701 ggaagacacg tggcgcctgt ggaccggaag caccaaatgc tggtgctgct tttgtacata
     2761 catattttta aaccattaaa attcttcctg aagaaa
//
