LOCUS       NP_001001998             885 aa            linear   PRI 20-FEB-2025
DEFINITION  exosome complex component 10 isoform 1 [Homo sapiens].
ACCESSION   NP_001001998
VERSION     NP_001001998.1
DBSOURCE    REFSEQ: accession NM_001001998.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 885)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 885)
  AUTHORS   Filippopoulou,C., Thome,C.C., Perdikari,S., Ntini,E., Simos,G.,
            Bohnsack,K.E. and Chachami,G.
  TITLE     Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes
            in the transcriptome profile
  JOURNAL   Cell Mol Life Sci 81 (1), 58 (2024)
   PUBMED   38279024
  REMARK    GeneRIF: Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive
            changes in the transcriptome profile.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 885)
  AUTHORS   Meng,Z.Y., Fan,Y.C., Zhang,C.S., Zhang,L.L., Wu,T., Nong,M.Y.,
            Wang,T., Chen,C. and Jiang,L.H.
  TITLE     EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a
            comprehensive bioinformatics analysis and experiment verification
  JOURNAL   PeerJ 11, e15860 (2023)
   PUBMED   37701829
  REMARK    GeneRIF: EXOSC10 is a novel hepatocellular carcinoma prognostic
            biomarker: a comprehensive bioinformatics analysis and experiment
            verification.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 885)
  AUTHORS   Chen,Y., Li,Y., Dai,R.S., Savage,J.C., Shinde,U., Klimek,J.,
            David,L.L., Young,E.A., Hafner,M., Sears,R.C., Sun,X.X. and
            Dai,M.S.
  TITLE     The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and
            promotes the nucleolar RNA exosome function in rRNA processing
  JOURNAL   Nucleic Acids Res 51 (8), 3934-3949 (2023)
   PUBMED   36912080
  REMARK    GeneRIF: The ubiquitin-specific protease USP36 SUMOylates EXOSC10
            and promotes the nucleolar RNA exosome function in rRNA processing.
REFERENCE   5  (residues 1 to 885)
  AUTHORS   Fujiwara,N., Shigemoto,M., Hirayama,M., Fujita,K.I., Seno,S.,
            Matsuda,H., Nagahama,M. and Masuda,S.
  TITLE     MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of
            MTR4-sensitive substrates in the human nucleus
  JOURNAL   Nucleic Acids Res 50 (15), 8779-8806 (2022)
   PUBMED   35902094
  REMARK    GeneRIF: MPP6 stimulates both RRP6 and DIS3 to degrade a specified
            subset of MTR4-sensitive substrates in the human nucleus.
REFERENCE   6  (residues 1 to 885)
  AUTHORS   Stover,C., Endo,Y., Takahashi,M., Lynch,N.J., Constantinescu,C.,
            Vorup-Jensen,T., Thiel,S., Friedl,H., Hankeln,T., Hall,R.,
            Gregory,S., Fujita,T. and Schwaeble,W.
  TITLE     The human gene for mannan-binding lectin-associated serine
            protease-2 (MASP-2), the effector component of the lectin route of
            complement activation, is part of a tightly linked gene cluster on
            chromosome 1p36.2-3
  JOURNAL   Genes Immun 2 (3), 119-127 (2001)
   PUBMED   11426320
REFERENCE   7  (residues 1 to 885)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
REFERENCE   8  (residues 1 to 885)
  AUTHORS   Allmang,C., Petfalski,E., Podtelejnikov,A., Mann,M., Tollervey,D.
            and Mitchell,P.
  TITLE     The yeast exosome and human PM-Scl are related complexes of 3' -->
            5' exonucleases
  JOURNAL   Genes Dev 13 (16), 2148-2158 (1999)
   PUBMED   10465791
REFERENCE   9  (residues 1 to 885)
  AUTHORS   Bluthner,M. and Bautz,F.A.
  TITLE     Cloning and characterization of the cDNA coding for a
            polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD
            protein
  JOURNAL   J Exp Med 176 (4), 973-980 (1992)
   PUBMED   1383382
REFERENCE   10 (residues 1 to 885)
  AUTHORS   Ge,Q., Frank,M.B., O'Brien,C. and Targoff,I.N.
  TITLE     Cloning of a complementary DNA coding for the 100-kD antigenic
            protein of the PM-Scl autoantigen
  JOURNAL   J Clin Invest 90 (2), 559-570 (1992)
   PUBMED   1644924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC073788.1, BC028687.1 and CA307576.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028687.1, BC073788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376936.9/ ENSP00000366135.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..885
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     Protein         1..885
                     /product="exosome complex component 10 isoform 1"
                     /note="autoantigen PM-SCL; polymyositis/scleroderma
                     autoantigen 100 kDa; P100 polymyositis-scleroderma overlap
                     syndrome-associated autoantigen; polymyositis/scleroderma
                     autoantigen 2; exosome complex component 10"
                     /calculated_mol_wt=100701
     Region          44..133
                     /region_name="PMC2NT"
                     /note="PMC2NT (NUC016) domain; pfam08066"
                     /db_xref="CDD:462352"
     Region          284..474
                     /region_name="Rrp6p_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of yeast Rrp6p,
                     human polymyositis/scleroderma autoantigen 100kDa, and
                     similar proteins; cd06147"
                     /db_xref="CDD:99850"
     Site            order(313..316,366..367,369..371,402..403,436,440)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99850"
     Site            order(313,315,371,436,440)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99850"
     Site            order(314..316,366..367,369..370,402..403,436,440)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99850"
     Region          503..583
                     /region_name="HRDC"
                     /note="Helicase and RNase D C-terminal; smart00341"
                     /db_xref="CDD:128635"
     Site            583
                     /site_type="other"
                     /note="Not ubiquitinated.
                     /evidence=ECO:0000269|PubMed:36912080; propagated from
                     UniProtKB/Swiss-Prot (Q01780.2)"
     Region          776..885
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01780.2)"
     Site            821
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q01780.2)"
     CDS             1..885
                     /gene="EXOSC10"
                     /gene_synonym="p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL;
                     PMSCL2; RRP6; Rrp6p"
                     /coded_by="NM_001001998.3:39..2696"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30584.1"
                     /db_xref="GeneID:5394"
                     /db_xref="HGNC:HGNC:9138"
                     /db_xref="MIM:605960"
ORIGIN      
        1 mappstrepr vlsatsatks dgemvlpgfp dadsfvkfal gsvvavtkas gglpqfgdey
       61 dfyrsfpgfq afcetqgdrl lqcmsrvmqy hgcrsnikdr skvteledkf dllvdandvi
      121 lervgillde asgvnknqqp vlpaglqvpk tvvsswnrka aeygkkakse tfrllhakni
      181 irpqlkfrek idnsntpflp kifikpnaqk plpqalsker rerpqdrped ldvppaladf
      241 ihqqrtqqve qdmfahpyqy elnhftpada vlqkpqpqly rpieetpchf issldelvel
      301 nekllncqef avdlehhsyr sflgltclmq istrtedfii dtlelrsdmy ilnesltdpa
      361 ivkvfhgads diewlqkdfg lyvvnmfdth qaarllnlgr hsldhllkly cnvdsnkqyq
      421 ladwrirplp eemlsyardd thyllyiydk mrlemwergn gqpvqlqvvw qrsrdiclkk
      481 fikpiftdes ylelyrkqkk hlntqqltaf qllfawrdkt arredesygy vlpnhmmlki
      541 aeelpkepqg iiaccnpvpp lvrqqinemh lliqqaremp llksevaagv kksgplpsae
      601 rlenvlfgph dcshappdgy piiptsgsvp vqkqaslfpd ekednllgtt cliatavitl
      661 fnepsaedsk kgpltvaqkk aqnimesfen pfrmflpslg hrapvsqaak fdpstkiyei
      721 snrwklaqvq vqkdskeavk kkaaeqtaar eqakeackaa aeqaisvrqq vvlenaakkr
      781 eratsdprtt eqkqekkrlk iskkpkdpep pekeftpydy sqsdfkafag nskskvssqf
      841 dpnkqtpsgk kciaakkikq svgnksmsfp tgksdrgfry nwpqr
//
