LOCUS       NM_001013839            4782 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens exocyst complex component 7 (EXOC7), transcript
            variant 1, mRNA.
ACCESSION   NM_001013839
VERSION     NM_001013839.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Hou,J., Mei,K., Wang,D., Ke,S., Chen,X., Shang,J., Li,G., Gao,Y.,
            Xiong,H., Zhang,H., Chen,L., Zhang,W., Deng,Y., Hong,X., Liu,D.A.,
            Hu,T., Guo,W. and Zhan,Y.Y.
  TITLE     TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis
            upon LKB1 inactivation
  JOURNAL   Cell Rep 43 (8), 114604 (2024)
   PUBMED   39146185
  REMARK    GeneRIF: TGM1/3-mediated transamidation of Exo70 promotes tumor
            metastasis upon LKB1 inactivation.
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4782)
  AUTHORS   Gong,D., Sun,Y., Guo,C., Sheu,T.J., Zhai,W., Zheng,J. and Chang,C.
  TITLE     Androgen receptor decreases renal cell carcinoma bone metastases
            via suppressing the osteolytic formation through altering a novel
            circEXOC7 regulatory axis
  JOURNAL   Clin Transl Med 11 (3), e353 (2021)
   PUBMED   33783995
  REMARK    GeneRIF: Androgen receptor decreases renal cell carcinoma bone
            metastases via suppressing the osteolytic formation through
            altering a novel circEXOC7 regulatory axis.
REFERENCE   4  (bases 1 to 4782)
  AUTHORS   Chen,Z.S., Huang,X., Talbot,K. and Chan,H.Y.E.
  TITLE     A fine balance between Prpf19 and Exoc7 in achieving degradation of
            aggregated protein and suppression of cell death in spinocerebellar
            ataxia type 3
  JOURNAL   Cell Death Dis 12 (2), 136 (2021)
   PUBMED   33542212
  REMARK    GeneRIF: A fine balance between Prpf19 and Exoc7 in achieving
            degradation of aggregated protein and suppression of cell death in
            spinocerebellar ataxia type 3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4782)
  AUTHORS   Guo,Y., Wang,X., Wang,K. and He,Y.
  TITLE     Appraising the Value of Serum and Serum-Derived Exosomal
            LncRNA-EXOC7 as a Promising Biomarker in Cervical Cancer
  JOURNAL   Clin Lab 66 (7) (2020)
   PUBMED   32658426
  REMARK    GeneRIF: Appraising the Value of Serum and Serum-Derived Exosomal
            LncRNA-EXOC7 as a Promising Biomarker in Cervical Cancer.
REFERENCE   6  (bases 1 to 4782)
  AUTHORS   Wang,S., Liu,Y., Adamson,C.L., Valdez,G., Guo,W. and Hsu,S.C.
  TITLE     The mammalian exocyst, a complex required for exocytosis, inhibits
            tubulin polymerization
  JOURNAL   J Biol Chem 279 (34), 35958-35966 (2004)
   PUBMED   15205466
REFERENCE   7  (bases 1 to 4782)
  AUTHORS   Inoue,M., Chang,L., Hwang,J., Chiang,S.H. and Saltiel,A.R.
  TITLE     The exocyst complex is required for targeting of Glut4 to the
            plasma membrane by insulin
  JOURNAL   Nature 422 (6932), 629-633 (2003)
   PUBMED   12687004
REFERENCE   8  (bases 1 to 4782)
  AUTHORS   Holtmeier,W., Hennemann,A. and Caspary,W.F.
  TITLE     IgA and IgM V(H) repertoires in human colon: evidence for clonally
            expanded B cells that are widely disseminated
  JOURNAL   Gastroenterology 119 (5), 1253-1266 (2000)
   PUBMED   11054383
REFERENCE   9  (bases 1 to 4782)
  AUTHORS   Soudeyns,H., Champagne,P., Holloway,C.L., Silvestri,G.U.,
            Ringuette,N., Samson,J., Lapointe,N. and Sekaly,R.P.
  TITLE     Transient T cell receptor beta-chain variable region-specific
            expansions of CD4+ and CD8+ T cells during the early phase of
            pediatric human immunodeficiency virus infection: characterization
            of expanded cell populations by T cell receptor phenotyping
  JOURNAL   J Infect Dis 181 (1), 107-120 (2000)
   PUBMED   10608757
REFERENCE   10 (bases 1 to 4782)
  AUTHORS   Ignatovich,O., Tomlinson,I.M., Popov,A.V., Bruggemann,M. and
            Winter,G.
  TITLE     Dominance of intrinsic genetic factors in shaping the human
            immunoglobulin Vlambda repertoire
  JOURNAL   J Mol Biol 294 (2), 457-465 (1999)
   PUBMED   10610771
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647763.1, BC011045.1,
            AB028990.1 and AI653861.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001013839.3.
            
            Summary: The protein encoded by this gene is a component of the
            exocyst complex. The exocyst complex plays a critical role in
            vesicular trafficking and the secretory pathway by targeting
            post-Golgi vesicles to the plasma membrane. The encoded protein is
            required for assembly of the exocyst complex and docking of the
            complex to the plasma membrane. The encoded protein may also play a
            role in pre-mRNA splicing through interactions with
            pre-mRNA-processing factor 19. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene, and a pseudogene of this gene is located on the long arm of
            chromosome 4. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028990.1, SRR18074969.2652357.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589210.6/ ENSP00000468404.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BX647763.1         2-67
            67-2220             BC011045.1         1-2154
            2221-3402           BX647763.1         1889-3070
            3403-4381           AB028990.1         3326-4304
            4382-4782           AI653861.1         18-418              c
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..4782
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /note="exocyst complex component 7"
                     /db_xref="GeneID:23265"
                     /db_xref="HGNC:HGNC:23214"
                     /db_xref="MIM:608163"
     exon            1..155
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2150
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocyst complex component Exo70"
                     /codon_start=1
                     /product="exocyst complex component 7 isoform 1"
                     /protein_id="NP_001013861.1"
                     /db_xref="CCDS:CCDS32738.1"
                     /db_xref="GeneID:23265"
                     /db_xref="HGNC:HGNC:23214"
                     /db_xref="MIM:608163"
                     /translation="MIPPQEASARRREIEDKLKQEEETLSFIRDSLEKSDQLTKNMVS
                     ILSSFESRLMKLENSIIPVHKQTENLQRLQENVEKTLSCLDHVISYYHVASDTEKIIR
                     EGPTGRLEEYLGSMAKIQKAVEYFQDNSPDSPELNKVKLLFERGKEALESEFRSLMTR
                     HSKVVSPVLILDLISGDDDLEAQEDVTLEHLPESVLQDVIRISRWLVEYGRNQDFMNV
                     YYQIRSSQLDRSIKGLKEHFHKSSSSSGVPYSPAIPNKRKDTPTKKPVKRPGTIRKAQ
                     NLLKQYSQHGLDGKKGGSNLIPLEGRDDMLDVETDAYIHCVSAFVKLAQSEYQLLADI
                     IPEHHQKKTFDSLIQDALDGLMLEGENIVSAARKAIVRHDFSTVLTVFPILRHLKQTK
                     PEFDQVLQGTAASTKNKLPGLITSMETIGAKALEDFADNIKNDPDKEYNMPKDGTVHE
                     LTSNAILFLQQLLDFQETAGAMLASQETSSSATSYSSEFSKRLLSTYICKVLGNLQLN
                     LLSKSKVYEDPALSAIFLHNNYNYILKSLEKSELIQLVAVTQKTAERSYREHIEQQIQ
                     TYQRSWLKVTDYIAEKNLPVFQPGVKLRDKERQIIKERFKGFNDGLEELCKIQKAWAI
                     PDTEQRDRIRQAQKTIVKETYGAFLQKFGSVPFTKNPEKYIKYGVEQVGDMIDRLFDT
                     SA"
     exon            156..221
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            222..406
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            407..512
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            513..735
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            736..903
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            904..996
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1142
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1295
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1394
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1457
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1524
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1590
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1711
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1807
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1871
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1913
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2047
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..4782
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4758..4763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /note="hexamer: AATAAA"
     polyA_site      4782
                     /gene="EXOC7"
                     /gene_synonym="2-5-3p; BLOM4; EX070; EXO70; Exo70p; EXOC1;
                     NEDSEBA; YJL085W"
                     /note="major polyA site"
ORIGIN      
        1 gggaccaaga gcggaagtgg gtgtgacggg gacgggggcc cggtgggccc gcggaggaaa
       61 gatactgggg agtgggagcc gcggggttca gagcgatgat tcccccacag gaggcatccg
      121 ctcgacggcg ggagattgag gacaagctga agcaggagga ggagactctg tccttcatcc
      181 gagacagcct ggagaagagc gaccagctca ctaagaacat ggtgtctatc ttatcatcct
      241 ttgagagccg ccttatgaag ctggagaact ccatcatccc tgtgcacaag cagacggaga
      301 atctgcagcg gctgcaggag aatgttgaga agacgctgtc ctgcctggac catgtcatca
      361 gctactacca tgtggccagt gacactgaga agatcatcag agagggcccc acaggtaggc
      421 tggaagagta cctgggaagc atggccaaga ttcagaaggc agtggagtat ttccaggaca
      481 acagcccaga cagcccggaa ctcaacaaag tgaaactgct ctttgagcgc gggaaggagg
      541 ccctggagtc cgaatttcgc agcctgatga cgcggcacag taaggtcgtc tcgcccgtgc
      601 tcatcttgga tctgatcagt ggtgacgatg atctggaggc ccaggaggac gtgaccctgg
      661 agcacctgcc cgagagcgtg ctccaggatg tcattcgcat ctcccgctgg ctggtggaat
      721 atggccgcaa ccaagatttc atgaacgtct actaccagat acgctccagc cagctggacc
      781 gctccatcaa aggactgaag gagcatttcc ataagagcag ttcttcctct ggggttccct
      841 actcccctgc tatccccaac aagaggaaag acacacctac caagaagcca gtcaagcggc
      901 cagggacgat ccgtaaggct cagaaccttc tgaaacagta ttcccagcat ggtctagatg
      961 ggaaaaaggg gggctctaac ctcattcctc tggaagggag agatgacatg ctggacgtgg
     1021 agaccgatgc ctacatccac tgcgtcagtg ccttcgtcaa gctggcgcag agcgagtacc
     1081 agctgctggc cgacatcatc cccgagcacc accagaagaa gaccttcgac tccctgatac
     1141 aggatgccct ggatgggctg atgcttgaag gggagaacat cgtgtctgct gcccggaagg
     1201 ccattgtgcg acacgacttc tccacggtgc tcaccgtctt ccccatcctg cgacacctca
     1261 agcagaccaa gcctgagttt gaccaggtgc tccagggcac ggctgccagc acaaagaaca
     1321 agctgcctgg cctcatcaca tccatggaga ccatcggtgc caaagcgctg gaggacttcg
     1381 cagacaacat caagaatgac ccggacaagg agtacaacat gccgaaggac ggcaccgtac
     1441 acgagctcac cagcaatgcc atcctcttcc tgcagcagct tttggacttc caggagacgg
     1501 caggcgccat gctggcctcc caagagacca gctcttcggc caccagctac agctctgagt
     1561 tcagcaagcg gctgctaagc acctatatct gtaaagtgct gggcaacctg cagttgaact
     1621 tgctgagcaa gtccaaggtg tacgaggacc cagctctgag cgccatcttc ctgcacaaca
     1681 actacaatta catcctcaag tccctggaga agtctgaact gatccagctg gtggcagtga
     1741 cacagaagac tgctgagcgc tcctaccggg agcacattga gcagcagatc cagacctacc
     1801 agcgcagctg gttaaaggtg actgattaca tcgcagagaa gaatctacct gtgttccagc
     1861 cgggagtcaa gctccgggac aaggagcggc agattatcaa ggagcgtttt aagggcttca
     1921 atgatggcct cgaagaactg tgcaaaatcc agaaggcctg ggctattcca gacacagagc
     1981 agagggacag gattcgccag gcccagaaga ccattgtcaa ggagacctac ggggcctttc
     2041 tacagaagtt tggcagcgtg cccttcacca agaacccgga gaagtacatc aagtacgggg
     2101 tggagcaggt gggcgacatg atcgatcgcc ttttcgacac ctctgcctga gcctgctgct
     2161 agccctgcct ggttccacca gactggcgtg tcattggaca gataaaccag tgttagcttg
     2221 cctctgggct gggtgagctt gaagtcctct gggacagaga cctgtctcca cgcctccggg
     2281 agctgtgtcc ctgagccccc tagtcctggc tcctgctttt tccccacagc ccgtgttccc
     2341 agccgaacca gcactctccc ggaagcctgg ggtccctcca caccttggct tttatgaccc
     2401 tgatggcttc tgaaacagga aaagagagaa ggaagacaga ggcctgtgcc cactgctgct
     2461 ccatgtgtac caagagcagc agggcagaag ggccctccct ccagcctagg tcagaggtgg
     2521 ggacagagaa ctcccctaca gcccagagat gtggcagggc tcagagaagc agccagagct
     2581 cctggaggaa aggcagtcgg gactgacccc ctctcttaaa acacattccc gcccgcccac
     2641 aggcctgagg tctgggacct ttccctccca ggagtcccct aggtggctgg gggaggcagg
     2701 ctcactggcc attttcccta gagtccagca cactgcagga ggcgttcgga ggaggagttc
     2761 cgccccaccc tctacagcct tcctcaggcc cctgtctctg gcccccagcc tcagtgcctc
     2821 ttggcccagg gccaggcagt cgtggttgca gaaggagcaa ttaggctgcc tgcctgtggg
     2881 ctgggagaca gggacaatgg ggaaaagtta aggagcaaaa tgggggttgg aagcaaaaaa
     2941 tagggcccca cctatttagg acgagattga agactgaccc ttgaggcaca cttgcactgg
     3001 agatgggttt atttcacgct ctgtgcttgt gtgctagcgg agggagagct cagggtggct
     3061 taatccagag gccctgtcat ggcccgcccc cagccatggg aaagcaaact tcatcctaag
     3121 gtgtgcagcc caggccctgc ccctttacag tctaggccgc ctgccatggg gtgcagcctc
     3181 tccaggggct gcgtcagact tgcacgctgc ccacatccag attcctgcaa agacgaattg
     3241 ggtgcacagc accccaacca catacacgag gaagaagatg cggtcagcag tctcaggcca
     3301 gcttctctgt gaccccttta ctcctctgga gggctctgtg gggagagata cagggaaagg
     3361 agctgttctt caaggtcccc tcaacatgag cggaagagcg aaccccaggg gtcatcagcc
     3421 tgtatcgctt cctttcttag attctcagct gatgaaaatt tgggtctggc ccatttcagg
     3481 ccatcttcag ttgaagaaac accctcttag gctgtgcaag gcatgggtta tcaggggatt
     3541 gaggtcacct gggacttcag ggaggctcag cttgctccct gccccagacc tgtttcttct
     3601 aagggaggag gacatggtgg agaccaggga caggagagcc agcagggtgg atgcaagggg
     3661 cctctaccca cacctggacc tccgtgccct caccccagcc ctaggtgtgc acctaggcct
     3721 cattccttac cccccagccc ctgcccacct tcagcaggat gaggccctgg gttgccgtgc
     3781 tctcgctgtt cccctctcgg ggctgggctg gggccgctct tggccccaag gttgccccgg
     3841 gccagcagcc cagccagcag cacagtctct atggtgctga ggaagagcag cagcagcagg
     3901 atggtgaagt agtaaactgg gggaggcagg gcacagggag atgctcaggg gccagtccct
     3961 gtgtctctgg tgcccagcga gctgagcacc agtgggtgac cggggagaaa cagggcagac
     4021 tgggtaaggg agcagggctt actgagcagt gggttgcagg aggaggagct gggcagggcc
     4081 tgcaccaggg aggagtggag gacgaggtaa ctcagcagca atgtcacctt gtagcctatg
     4141 cgctcaatgg cccggagggg cagcaacccc ccgcacacgt cagccaacag cagtgcctct
     4201 gcaggcacca agagagcgat gatggacttg agcgccgtgt tcttcagcct cagctggaag
     4261 gggaaaagtc agggccttcc cggcgggggg gaaggaggtg ggcatcgggg gcatggggcc
     4321 tggcctctgg ccgtgcatcc tcactcccac ccgcctccag cagccctctg tcggcctcct
     4381 cccgacttga ctcaccgtca cctggaagca gggcaccagc tgctggggtg ggacttgggt
     4441 cttcagatca taaactacgt attccctctt gacactcaca atctcgttca ccacgtgggc
     4501 ctggaactct aactccatcg ctgaggggtg ggaatgagaa ctatgaacca ggaaggagag
     4561 atcccagctg ccaagtctgg gggtagcaga ctggagccca ggggtgatgg agacttttga
     4621 tggcttttgg cagggacaga cttggacaca aaaccgatcc atagaagggc ttcccaaacc
     4681 ttgttttgca acatcccaaa ttgtctccag ttgaaggaag gcctttatca gattcataga
     4741 tgagctttca ttgtaaaaat aaatgtactt tgcaccactt ca
//
