LOCUS       NM_015189               5910 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens exocyst complex component 6B (EXOC6B), transcript
            variant 2, mRNA.
ACCESSION   NM_015189 XM_039570 XM_945916
VERSION     NM_015189.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5910)
  AUTHORS   Simsek-Kiper,P.O., Jacob,P., Upadhyai,P., Taskiran,Z.E.,
            Guleria,V.S., Karaosmanoglu,B., Imren,G., Gocmen,R., Bhavani,G.S.,
            Kausthubham,N., Shah,H., Utine,G.E., Boduroglu,K. and Girisha,K.M.
  TITLE     Biallelic loss-of-function variants in EXOC6B are associated with
            impaired primary ciliogenesis and cause spondylo-epi-metaphyseal
            dysplasia with joint laxity type 3
  JOURNAL   Hum Mutat 43 (12), 2116-2129 (2022)
   PUBMED   36150098
  REMARK    GeneRIF: Biallelic loss-of-function variants in EXOC6B are
            associated with impaired primary ciliogenesis and cause
            spondylo-epi-metaphyseal dysplasia with joint laxity type 3.
            Review article
REFERENCE   2  (bases 1 to 5910)
  AUTHORS   Zheng,Y., Li,Z., Yang,S., Wang,Y. and Luan,Z.
  TITLE     CircEXOC6B Suppresses the Proliferation and Motility and Sensitizes
            Ovarian Cancer Cells to Paclitaxel Through miR-376c-3p/FOXO3 Axis
  JOURNAL   Cancer Biother Radiopharm 37 (9), 802-814 (2022)
   PUBMED   33006481
  REMARK    GeneRIF: CircEXOC6B Suppresses the Proliferation and Motility and
            Sensitizes Ovarian Cancer Cells to Paclitaxel Through
            miR-376c-3p/FOXO3 Axis.
REFERENCE   3  (bases 1 to 5910)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5910)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5910)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5910)
  AUTHORS   Heider,M.R. and Munson,M.
  TITLE     Exorcising the exocyst complex
  JOURNAL   Traffic 13 (7), 898-907 (2012)
   PUBMED   22420621
  REMARK    Review article
REFERENCE   7  (bases 1 to 5910)
  AUTHORS   Feng,S., Knodler,A., Ren,J., Zhang,J., Zhang,X., Hong,Y., Huang,S.,
            Peranen,J. and Guo,W.
  TITLE     A Rab8 guanine nucleotide exchange factor-effector interaction
            network regulates primary ciliogenesis
  JOURNAL   J Biol Chem 287 (19), 15602-15609 (2012)
   PUBMED   22433857
  REMARK    GeneRIF: Data suggest that the Rabin8-Rab8-Sec15 interaction may
            couple the activation of Rab8 to the recruitment of the Rab8
            effector and is involved in the regulation of vesicular trafficking
            for primary cilium formation.
REFERENCE   8  (bases 1 to 5910)
  AUTHORS   Borsani,G., Piovani,G., Zoppi,N., Bertini,V., Bini,R.,
            Notarangelo,L. and Barlati,S.
  TITLE     Cytogenetic and molecular characterization of a de-novo t(2p;7p)
            translocation involving TNS3 and EXOC6B genes in a boy with a
            complex syndromic phenotype
  JOURNAL   Eur J Med Genet 51 (4), 292-302 (2008)
   PUBMED   18424204
  REMARK    GeneRIF: TNS3-EXOC6B and EXOC6B-TNS3 fusion transcripts are
            detected in a premature male newborn with a complex multisystemic
            phenotype associated with a balanced translocation.
REFERENCE   9  (bases 1 to 5910)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
REFERENCE   10 (bases 1 to 5910)
  AUTHORS   Bhavani,G.S., Singh,S. and Girisha,K.M.
  TITLE     EXOC6B-Related Spondyloepimetaphyseal Dysplasia with Joint Laxity
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37229238
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092630.3, AK026474.1,
            AB023136.1, AC006461.2 and BM995822.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_015189.2.
            
            Summary: This gene encodes a protein which is a part of the
            evolutionarily conserved exocyst, a multimeric protein complex
            necessary for exocytosis, which in turn, is crucial for cell
            growth, polarity and migration. Disruption of this gene may be
            associated with phenotypes exhibiting multiple symptoms including
            intellectual disability and developmental delay (DD). [provided by
            RefSeq, Jun 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.16081.1,
                                           SRR11853559.18637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272427.11/ ENSP00000272427.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC092630.3         119787-120022       c
            237-402             AC092630.3         35293-35458         c
            403-450             AC092630.3         27060-27107         c
            451-496             AC092630.3         25189-25234         c
            497-1060            AK026474.1         1-564
            1061-1661           AB023136.1         1053-1653
            1662-2485           AK026474.1         1166-1989
            2486-5605           AC006461.2         168513-171632
            5606-5910           BM995822.1         18-322              c
FEATURES             Location/Qualifiers
     source          1..5910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..5910
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /note="exocyst complex component 6B"
                     /db_xref="GeneID:23233"
                     /db_xref="HGNC:HGNC:17085"
                     /db_xref="MIM:607880"
     exon            1..236
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2559
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /note="isoform 2 is encoded by transcript variant 2; SEC15
                     homolog B; SEC15-like protein 2; exocyst complex component
                     Sec15B"
                     /codon_start=1
                     /product="exocyst complex component 6B isoform 2"
                     /protein_id="NP_056004.1"
                     /db_xref="CCDS:CCDS46333.1"
                     /db_xref="GeneID:23233"
                     /db_xref="HGNC:HGNC:17085"
                     /db_xref="MIM:607880"
                     /translation="MERGKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGE
                     EHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRK
                     LQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPAL
                     KTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGE
                     TAMKQAQQQRNLDNIVLQQPRIGSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDVED
                     EEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMH
                     ETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYC
                     SDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGIFRNILD
                     SDNYSPIPVTSEEMYKKVVGQFPFQDIELEKQPFPKKFPFSEFVPKVYNQIKEFIYAC
                     LKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHL
                     EKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQL
                     ADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQL
                     LLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQW
                     DWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTV
                     AKQLRGLISSHHS"
     exon            237..402
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..450
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..541
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..587
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..792
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..969
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1038
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1122
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1169
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1290
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1362
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1460
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1566
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1676
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1788
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1923
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2103
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2245
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2319
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2432
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..5910
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5880..5885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /note="hexamer: AAGAAA"
     polyA_site      5910
                     /gene="EXOC6B"
                     /gene_synonym="SEC15B; SEC15L2; SEMDJL3"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcctgc gggtagccag aggctggggc ggctgtggag cctgtggtgg gagcggcatt
       61 gtggggcagg gaaaaggtga gccgagccga cggaggggac gcgctgcggg gcgcccccag
      121 tctatggagc ggggtaagat ggcggaggcg gagagcctgg agacagcggc agagcacgag
      181 cggatcctgc gagagatcga gagcactgac acggcctgca tcgggcccac gctcaggtct
      241 gtttatgatg gtgaagaaca tggacgtttc atggagaagc ttgaaactcg tatccgtaat
      301 cacgaccgag aaattgagaa aatgtgcaac tttcattacc agggctttgt ggactctata
      361 actgaactgc tgaaagtgag aggagaagcc cagaaactca aaaatcaagt gacggatact
      421 aatagaaaac tacaacatga gggaaaggaa ctggtaatag caatggaaga gctgaagcag
      481 tgtcgactac aacagagaaa tatttctgcc actgttgata aattaatgct gtgtcttcca
      541 gtcctagaga tgtacagcaa actgagggac cagatgaaaa ctaaaaggca ttatcctgca
      601 ctgaaaactc tggaacatct agagcatacc tacctgcctc aagtaagcca ctatcgattc
      661 tgcaaggtga tggtggacaa catccccaag cttcgagaag aaataaaaga tgtttctatg
      721 tccgatctca aagactttct ggagagcatc cgcaaacatt cagacaaaat tggagagact
      781 gccatgaagc aagcccagca gcaaagaaac ctggataaca tcgtcttgca acaacccaga
      841 ataggtagca agaggaaatc taagaaagat gcatatataa tctttgatac agagatagaa
      901 agtactagtc cgaagtctga acaggattca ggaattctgg atgttgaaga cgaggaagat
      961 gatgaagagg tacctggggc ccaagatttg gtggatttct ctccagttta tcgatgtcta
     1021 catatatatt ctgtcctggg tgcccgggaa acatttgaga attactaccg aaaacagagg
     1081 cgaaaacagg ctcgtttggt acttcaacct ccatctaaca tgcatgaaac tttagatggc
     1141 tacaggaagt attttaatca aattgtaggc ttttttgtgg ttgaagatca cattttacat
     1201 acaacccagg gcttagtaaa tagagcctac attgatgaac tgtgggaaat ggcactttca
     1261 aaaaccatcg cagcactccg tacccactcg tcttactgtt ctgatccaaa ccttgtgtta
     1321 gatttgaaga acctcattgt gctttttgct gacacacttc aggtgtatgg tttccctgta
     1381 aatcagcttt ttgacatgct gttagaaatc agagaccaat atagtgaaac tctgctaaag
     1441 aagtgggcag gtattttcag aaacatactt gattctgaca actacagtcc tataccagta
     1501 acaagtgaag agatgtacaa aaaggtggta ggacaattcc catttcaaga tatagaactg
     1561 gaaaagcaac catttccaaa aaagtttcct ttctctgaat ttgtgccaaa agtttacaac
     1621 caaattaaag aatttatcta cgcttgtctg aagttttcag aagatcttca tctaagctca
     1681 actgaagttg atgacatgat tcggaaatca acaaacctgt tgctaaccag gactctgagc
     1741 aactctctgc agaatgtaat taaaaggaag aatattgggc ttactgagct tgttcagatt
     1801 attatcaata caacacattt ggagaaatcc tgtaagtact tggaagaatt tatcaccaac
     1861 atcactaatg tgcttccaga gacagttcac actaccaagc tctatggcac cacaactttt
     1921 aaggatgcta gacatgcagc tgaagaagag atttatacca acttaaacca gaagattgac
     1981 cagttcctac agctggcaga ctatgactgg atgaccggag atttgggcaa caaagctagt
     2041 gattacctgg tagacctcat tgcctttctt cgtagcacct ttgctgtatt cacacacctt
     2101 cctggaaagg tggcccagac agcgtgtatg tcagcttgca agcatttagc cacatccttg
     2161 atgcaacttt tgttggaagc tgaagtgcgg cagctcacct tgggagcatt acagcagttc
     2221 aacttggacg tcagagaatg tgaacagttt gccagatccg gcccggtgcc tgggttccag
     2281 gaggacacgc tgcagttggc cttcatcgac ttgagacaac ttttggatct tttcatccag
     2341 tgggattggt caacctacct tgctgactat ggtcagccca actgcaagta cctccgggta
     2401 aacccagtga ctgctctgac cctgcttgag aagatgaagg atactagccg caagaacaac
     2461 atgtttgcac agtttcggaa aaatgagcga gacaagcaga aactcattga caccgtggcc
     2521 aagcagctcc gaggactcat cagcagccac cactcatgaa gggtgacccc ggacccacag
     2581 aggcgacctg ctgcagcctc tgtgtcagtc tggggtccag ccccagctga ccctgcattt
     2641 gtgcattctt cttcaaagag agcatatgta tttttttatt aacccctgtg cagtattcac
     2701 ataacatttc cctatagtaa aagaggcaca agaataagca agtacatgag atgttgctag
     2761 gctgggactc aggggaagtt attactacac tatctgtgtt atcttagaga tggtggtatc
     2821 atcaattcca cagtgatgaa ccacctttca tccatggctc taaagcttag gtctggggct
     2881 taggaaccat aaaaagtggg tatctggcgc tgggaggtag agtgagtaag caaaaggata
     2941 ctaaaatatg tcctgttcac tcttggatgc ccattcacca catagatgag gctgattctt
     3001 ctcaatacaa ggaaagggca tggcaaacat tactatttag tacactaagg gcagctctgg
     3061 agggtcatct cctcagtctg ctgactttca ctggcttgtg aacaagcatg gcatatggca
     3121 agatgacagc ttcattccaa tcccccaaga atggcggttt ctttagcctg atctaacccc
     3181 aggcttttat tgcaattttt tctagggcag gatacagcta agtagacagc agtaataatt
     3241 ggatcccatg tttaactgca tattgcccca gctctaggag tgttgagtct caactcgaag
     3301 agtttttctg gatcttgaaa gccagttttc atggaatcag agacccaatc ccttccctgt
     3361 tcatctcatt tccttcactt acagtcagag cacttggttc aggacataaa tcaacagtta
     3421 cttccatagg ccttcacagg gcgtttcaga cttagcctcc tccagtaatg ccattgaaat
     3481 agttcagatt tcggaagcct aaaaatggcc tttaccttac ccttaggtgt aacctgagga
     3541 ttagttggga ttgttccttt atgttttaaa accagctttt tggttatcat ctttaaggaa
     3601 atgtcaccag ctctgcactg tgggggcagc catgcctgga ctggatgcct ctagggatgg
     3661 agacattgtt accataaagt cgacagagcc aaccatggct tgtggcttgt tgcctctggc
     3721 ccaactgtcc ttcactaaat aatatcctag atattatttt gttgctcaag cccaaggttc
     3781 ccaccctctt ttgagatccc caaagccatc tttggccttg tctaagaaag attgcctata
     3841 atcctgtcct ccaaactcta aagcctggag cagcttagcg tggaggctgc actcattgac
     3901 ccagatggac tcctgagact taacgcaagg gctttgctat gaggtcagtc gggggaaact
     3961 gtactttaag acacttcaga aagatgctac tggctagtag cagaaagatg gctagtggca
     4021 agagtataat tgtgcatcac caaacaatga caaataagcc acacaggcat ttccagcttg
     4081 gattgatggg aggagagact catcaaacag aattcttcac tacctttgtc agctactgag
     4141 ttgcttctgg ggagggaagt acttccttgc ccctccccaa cccccctacc tcaccatatc
     4201 ctatcatatc ttgatagtca tggggaagag gatgtgcaca cagacataca aatttcctca
     4261 aagctggaga gaccaggcta catgtgagct catagatgct gctgaggctc atcctgaggg
     4321 ctggatggtt ggccagggtt tcagaatgag ggtaagggat gagcactgcc acccagaact
     4381 tgataagcca agagaaggca ggagccaaaa tggcatcgcc aagctctcat ctttgttgaa
     4441 acaagtgaga aacgattata ttaatctgaa gttctattgc ttgagaagag ttcaaaacac
     4501 ttctctttgc tagtacccag tttgcagcaa gatctcttca gctttaagtg ctgagagact
     4561 ttgaagtgga aatggagaga tgtgtaagca tggcacagtg tttgtctttt tagaggatca
     4621 tcattgctgg tctggtctca aacctctgcc ttggaagaac tgtgctatac aggaaaaagt
     4681 gaacaaggtg gaggaatagg ggttattctg cacagaagtc ccatgaaagg aaaagcttat
     4741 tcaagctcaa gacataaaga tggacccttt gatatatctt ctctccattc ttagtctgcc
     4801 ttcaccttat ctaacaaaaa acaacatgca gctactgagt tgtatgtaga gacatactct
     4861 tggtgggcca gggaaggtaa aaacagggac cagcaatgtc aagtttttga actagaaaag
     4921 tgggatgttt ttagttttgt ctataacctg tagctgggcc aacccttgag aggacttgtg
     4981 caaagcatgt gtgcccagac ccatcagact cctcagatat ggcctcaaat acctagagat
     5041 gtagaagtac cgtggagggc ctcaataaga gggcaagcac acagatggct agaagcctgt
     5101 atggcttctg gtcaggatga acccttggcc aagttcttga ggaaaccagg tctatattcc
     5161 tgaagggaca gttcagtttg ggactctatt aggtttcagt agtaatatag gctgcttgca
     5221 tcattttaac attcataggg aaaatctctt tgagcaggct ataaatgaag ctgttgcagg
     5281 tagggaagaa caggacctga aaatgggaac caggaagtga gatcctgttg gcaaagggaa
     5341 tgtagagctt ccagggtgca ttgcccactg ttctcattgc ataccagtcc tccaagtcag
     5401 tctagcctta ctgtacactt gacaagtgct tactcagcaa gtcccagacc cacggccttt
     5461 tatctcccaa gactggcttt ggccatgacc ttcctcatca ggcctctgag cacactctct
     5521 aggaactgct gcagaaattc ccctacctta gcctcccttc tcccaggact cctctcttga
     5581 ctgcaattgc ctcttcttct tcttcttctt cttccttttt gttttttttt tttttgcctg
     5641 cattcacaat tacttttcac aaaggtgttg gaaatggcat ttttatttta cacagatagt
     5701 tgcacatata tagagaaaat taggaaagtc catttttaac tctaaaggga acttttttct
     5761 ctaaaactta cttgtaaagc tactgataca gatgggccgc atggttaggg gaaagctcct
     5821 ctgtgaaaag agcatgttta ttcctcttgt acattttcct cttttaactg ctattaaaca
     5881 agaaagccta catacctgtt tcaaaagcca
//
