LOCUS       NM_019053               3564 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens exocyst complex component 6 (EXOC6), transcript
            variant 1, mRNA.
ACCESSION   NM_019053
VERSION     NM_019053.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3564)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3564)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3564)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3564)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3564)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3564)
  AUTHORS   Chang,H., Jeung,H.C., Jung,J.J., Kim,T.S., Rha,S.Y. and Chung,H.C.
  TITLE     Identification of genes associated with chemosensitivity to
            SAHA/taxane combination treatment in taxane-resistant breast cancer
            cells
  JOURNAL   Breast Cancer Res Treat 125 (1), 55-63 (2011)
   PUBMED   20224928
REFERENCE   7  (bases 1 to 3564)
  AUTHORS   France,Y.E., Boyd,C., Coleman,J. and Novick,P.J.
  TITLE     The polarity-establishment component Bem1p interacts with the
            exocyst complex through the Sec15p subunit
  JOURNAL   J Cell Sci 119 (Pt 5), 876-888 (2006)
   PUBMED   16478783
  REMARK    GeneRIF: The SEC15 protein plays a crucial role in integrating the
            signals between Sec4p and the components of the
            early-polarity-establishment machinery.
REFERENCE   8  (bases 1 to 3564)
  AUTHORS   Zhang,X.M., Ellis,S., Sriratana,A., Mitchell,C.A. and Rowe,T.
  TITLE     Sec15 is an effector for the Rab11 GTPase in mammalian cells
  JOURNAL   J Biol Chem 279 (41), 43027-43034 (2004)
   PUBMED   15292201
  REMARK    GeneRIF: Sec15 has a role as an effector for the Rab11 GTPase in
            mammalian cells
REFERENCE   9  (bases 1 to 3564)
  AUTHORS   Hsu,S.C., TerBush,D., Abraham,M. and Guo,W.
  TITLE     The exocyst complex in polarized exocytosis
  JOURNAL   Int Rev Cytol 233, 243-265 (2004)
   PUBMED   15037366
  REMARK    Review article
REFERENCE   10 (bases 1 to 3564)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590080.25, AL392103.6,
            AL157705.19 and AL358613.16.
            
            On Nov 23, 2018 this sequence version replaced NM_019053.5.
            
            Summary: The protein encoded by this gene is highly similar to the
            Saccharomyces cerevisiae SEC15 gene product, which is essential for
            vesicular traffic from the Golgi apparatus to the cell surface in
            yeast. It is one of the components of a multiprotein complex
            required for exocytosis. The 5' portion of this gene and two
            neighboring cytochrome p450 genes are included in a deletion that
            results in an autosomal-dominant form of nonsyndromic optic nerve
            aplasia (ONA). Alternative splicing and the use of alternative
            promoters results in multiple transcript variants. A paralogous
            gene encoding a similar protein is present on chromosome 2.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) lacks two 5' exons but instead
            contains an alternate 5' terminal exon, and it thus differs in the
            5' UTR and 5' coding region, compared to variant 3. The encoded
            isoform (a) has a distinct and shorter N-terminus, compared to
            isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028395.2, SRR1803611.8309.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260762.10/ ENSP00000260762.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL590080.25        184147-184261
            116-287             AL392103.6         40831-41002
            288-335             AL392103.6         42276-42323
            336-426             AL392103.6         42412-42502
            427-472             AL392103.6         47081-47126
            473-677             AL392103.6         56909-57113
            678-833             AL392103.6         63240-63395
            834-902             AL392103.6         67464-67532
            903-986             AL392103.6         75821-75904
            987-1033            AL392103.6         81626-81672
            1034-1154           AL392103.6         81792-81912
            1155-1226           AL392103.6         83296-83367
            1227-1324           AL392103.6         88209-88306
            1325-1430           AL392103.6         95756-95861
            1431-1540           AL392103.6         99755-99864
            1541-1652           AL392103.6         102112-102223
            1653-1787           AL392103.6         103062-103196
            1788-1967           AL392103.6         121535-121714
            1968-2109           AL157705.19        20870-21011
            2110-2183           AL157705.19        37590-37663
            2184-2296           AL358613.16        6556-6668
            2297-3564           AL358613.16        7855-9122
FEATURES             Location/Qualifiers
     source          1..3564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3564
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /note="exocyst complex component 6"
                     /db_xref="GeneID:54536"
                     /db_xref="HGNC:HGNC:23196"
                     /db_xref="MIM:609672"
     exon            1..115
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2429
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /note="isoform a is encoded by transcript variant 1;
                     exocyst complex component Sec15A; SEC15-like protein 3;
                     SEC15-like 1; rsec15-like protein"
                     /codon_start=1
                     /product="exocyst complex component 6 isoform a"
                     /protein_id="NP_061926.3"
                     /db_xref="CCDS:CCDS7424.2"
                     /db_xref="GeneID:54536"
                     /db_xref="HGNC:HGNC:23196"
                     /db_xref="MIM:609672"
                     /translation="MAENSESLGTVPEHERILQEIESTDTACVGPTLRSVYDDQPNAH
                     KKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQ
                     DAGKEVIVHTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSAKRYYSALKT
                     MEQLENVYFPWVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETA
                     MKQAQHQKTFSVSLQKQNKMKFGKNMYINRDRIPEERNETVLKHSLEEEDENEEEILT
                     VQDLVDFSPVYRCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRY
                     FTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLEL
                     KNLTVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPV
                     VNEEEYKIVISKFPFQDPDLEKQSFPKKFPMSQSVPHIYIQVKEFIYASLKFSESLHR
                     SSTEIDDMLRKSTNLLLTRTLSSCLLNLIRKPHIGLTELVQIIINTTHLEQACKYLED
                     FITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSE
                     PDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQI
                     SMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADY
                     GQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVN
                     GMSQHM"
     exon            116..287
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            288..335
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            336..426
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            427..472
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            473..677
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            678..833
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            834..902
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            903..986
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1033
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1154
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1226
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1324
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1430
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1540
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1652
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1787
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1967
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2109
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2183
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2296
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..3564
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /note="hexamer: ATTAAA"
     polyA_site      3564
                     /gene="EXOC6"
                     /gene_synonym="EXOC6A; SEC15; SEC15L; SEC15L1; SEC15L3;
                     Sec15p"
                     /note="major polyA site"
ORIGIN      
        1 agcttccagc caaaatggcg gagaacagcg agagtctggg caccgtcccc gagcacgagc
       61 ggatcttgca ggagatcgag agcaccgaca ccgcctgtgt ggggcccacc ctccggtctg
      121 tgtatgatga ccaaccaaat gcgcacaaga agtttatgga aaagttagat gcttgtatcc
      181 gtaatcatga caaggaaatt gaaaagatgt gtaattttca tcatcagggt tttgtagatg
      241 ctattacaga actccttaaa gtaaggactg atgcagaaaa actgaaggtg caagttactg
      301 ataccaaccg aaggtttcaa gatgctggaa aagaggtgat agtccacaca gaagatatca
      361 ttcgatgtag aattcagcag agaaatatta caactgtagt agaaaaattg cagttatgcc
      421 ttcctgtgct agaaatgtac agtaagctga aagaacagat gagtgccaaa aggtactatt
      481 ctgccctaaa aactatggaa caattagaga atgtgtactt tccctgggtt agtcaatacc
      541 ggttttgtca gctcatgata gaaaatcttc ccaaactccg tgaggatatt aaagaaatct
      601 ccatgtctga tctcaaagac tttttggaaa gtattcgaaa acattctgac aaaataggtg
      661 aaacagcaat gaaacaggca cagcatcaga aaaccttcag tgtttctctg cagaaacaaa
      721 ataaaatgaa atttgggaaa aatatgtata taaatcgtga tagaattcca gaggaaagga
      781 atgaaactgt attgaaacat tcacttgaag aagaggatga gaatgaagaa gagatcttaa
      841 ctgttcagga tcttgttgat ttttcccctg tttatcgatg tttgcacatt tattctgttt
      901 tgggtgacga ggaaacattt gaaaactatt atcgaaaaca aagaaagaaa caagcaagac
      961 tggtattgca accccagtcg aatatgcatg aaacagttga tggctataga agatatttca
     1021 ctcaaattgt agggttcttt gtggtagaag atcacatttt acatgtgacc caaggattag
     1081 taaccagggc atacactgat gaactttgga acatggccct ctcaaagata attgctgtcc
     1141 ttagagctca ttcatcctat tgcactgatc ctgatcttgt tctggagctg aagaatctta
     1201 ctgtaatatt tgcagatact ttacagggtt atggttttcc agtgaaccga ctttttgacc
     1261 ttttatttga aataagagac caatacaatg aaacactgct taagaaatgg gctggagttt
     1321 tcagggacat ttttgaagaa gataattaca gccccatccc tgttgtcaat gaagaagaat
     1381 ataaaattgt catcagcaaa tttccctttc aagatccaga ccttgaaaag cagtctttcc
     1441 caaagaaatt ccccatgtct cagtcagtgc ctcatattta cattcaagtt aaagaattta
     1501 tttatgccag ccttaaattt tcagagtcac tacaccggag ctcaacagaa atagacgata
     1561 tgcttagaaa atcaacaaat ctgctgctga ccagaacttt gagtagctgt ttactgaacc
     1621 ttattagaaa acctcatata ggtttgacag agctggtaca aatcatcata aacacaacac
     1681 acctggagca agcttgtaaa tatcttgagg actttataac taacattaca aatatttccc
     1741 aagaaactgt tcatactaca agactttatg gactttctac tttcaaggat gctcgacatg
     1801 cagcagaagg agaaatatat accaaactga atcaaaaaat tgatgaattt gttcagcttg
     1861 ctgattatga ctggacaatg tctgagccag atggaagagc tagtggttat ttaatggacc
     1921 ttataaattt tttgagaagc atctttcaag tgtttactca tttgcctggg aaagttgctc
     1981 agacagcttg catgtcagcc tgccagcatc tgtcaacatc cttaatgcag atgctactgg
     2041 acagtgagtt aaaacaaata agcatgggag ctgttcagca gtttaactta gatgtcatac
     2101 agtgtgaatt gtttgccagc tctgagcctg tgccaggatt ccagggggat accctgcagc
     2161 tagcattcat tgacctcaga caactccttg acctgtttat ggtttgggat tggtctactt
     2221 acctagctga ttatgggcag ccagcttcta agtaccttcg ggtgaatcca aacacagccc
     2281 ttactctttt ggagaagatg aaggatacta gcaaaaagaa caatatattt gctcagttca
     2341 ggaagaatga tcgagacaaa cagaagttga tagagacagt cgtgaaacag ctgagaagtt
     2401 tggtgaatgg tatgtcccag cacatgtaga cctcacatgg cttgcactca gtgacaccaa
     2461 atccatgatt caatgttgat cttgagcaag tattggtcat gatacagtaa tttgtttaca
     2521 gaatccaaaa atacaataga gaagatacat gagggcttaa acaagaaata gtaataaata
     2581 tcatttgtat ggatttttaa ataatcgaat actattttat atatggaaaa aaatgaccat
     2641 tttttcactt ttaggggaaa atgcaaaagt gtaatacata aattgtcaca aattatacat
     2701 gaaattgatt acaaatacat ttgaaaaaca tatgcctcta ctcataagta tttttttcta
     2761 tttagacttg aatgataatc tgttttttga tcagtatatg gctttggaat tcaatcatgt
     2821 ctgatatggt agtatttcac taccattttc tgacttttag cttttatttt cacctcaatg
     2881 tgatttaagc agaccaaaat ttctaattct gctaattctg aaggggaaat agacaaatct
     2941 taaaagctgc ctgaaatcaa acttgattta actcagtaag aatgtgaatt atttgttcta
     3001 cttgggtggt ttaatttaat cgttctgaat atgaacaaaa ggttttggat tttctaaaga
     3061 tgcagtgttg tttctgttca tcagggttaa tatttctaac tatattgctt gtaggtgacc
     3121 ccattctgga tttgtttggt ttggtttggt tccagttaaa agagaggaca ggaactaaat
     3181 ggggctaacc acttcaggtg cagcttgtgc gagggtagat ggttcctgca cacagaagtt
     3241 accacagggg tcaggttact ttcttcaaat agcagatttc agtactttat cctcattgtg
     3301 gaaacaagcc aaaccaaatg aactctggaa aacctaaaac aaatgtacat tttcctttgt
     3361 gtatgtttcc gtggtccaaa tggcaatata aatccagtct ttattctccc tttgttgtat
     3421 ttatgctgaa tcttcccttt gccttttcag gatttaggcc tgtaagaaac tatgcctgat
     3481 tctgtaaaat aagtgtaaag aattatatgt acatctctgg attttgtgat gaaatattaa
     3541 aaatattgag caagttgttg aaaa
//
