LOCUS       NM_006544              10486 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens exocyst complex component 5 (EXOC5), mRNA.
ACCESSION   NM_006544
VERSION     NM_006544.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10486)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 10486)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 10486)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 10486)
  AUTHORS   Zuo,X., Kwon,S.H., Janech,M.G., Dang,Y., Lauzon,S.D., Fogelgren,B.,
            Polgar,N. and Lipschutz,J.H.
  TITLE     Primary cilia and the exocyst are linked to urinary extracellular
            vesicle production and content
  JOURNAL   J Biol Chem 294 (50), 19099-19110 (2019)
   PUBMED   31694916
  REMARK    GeneRIF: The EXOC5 knockdown increases ARF6 levels and decreases
            EPS8L2 levels, and that EXOC5 overexpression increases EPS8L2.
REFERENCE   5  (bases 1 to 10486)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10486)
  AUTHORS   Polzin,A., Shipitsin,M., Goi,T., Feig,L.A. and Turner,T.J.
  TITLE     Ral-GTPase influences the regulation of the readily releasable pool
            of synaptic vesicles
  JOURNAL   Mol Cell Biol 22 (6), 1714-1722 (2002)
   PUBMED   11865051
REFERENCE   7  (bases 1 to 10486)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
REFERENCE   8  (bases 1 to 10486)
  AUTHORS   Hsu,S.C., Hazuka,C.D., Roth,R., Foletti,D.L., Heuser,J. and
            Scheller,R.H.
  TITLE     Subunit composition, protein interactions, and structures of the
            mammalian brain sec6/8 complex and septin filaments
  JOURNAL   Neuron 20 (6), 1111-1122 (1998)
   PUBMED   9655500
REFERENCE   9  (bases 1 to 10486)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
REFERENCE   10 (bases 1 to 10486)
  AUTHORS   Guo,W., Roth,D., Gatti,E., De Camilli,P. and Novick,P.
  TITLE     Identification and characterization of homologues of the Exocyst
            component Sec10p
  JOURNAL   FEBS Lett 404 (2-3), 135-139 (1997)
   PUBMED   9119050
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139195.4, BI460915.1,
            BC041126.1, U85946.1, AL391152.3, BM723045.1, CB145811.1,
            AK025802.1, AL118623.1, CN268669.1 and AA837306.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006544.3.
            
            Summary: The protein encoded by this gene is a component of the
            exocyst complex, a multiple protein complex essential for targeting
            exocytic vesicles to specific docking sites on the plasma membrane.
            Though best characterized in yeast, the component proteins and
            functions of exocyst complex have been demonstrated to be highly
            conserved in higher eukaryotes. At least eight components of the
            exocyst complex, including this protein, are found to interact with
            the actin cytoskeletal remodeling and vesicle transport machinery.
            The complex is also essential for the biogenesis of epithelial cell
            surface polarity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.8661.1, BC041126.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621441.5/ ENSP00000484855.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL139195.4         67497-67502         c
            7-490               BI460915.1         12-495
            491-1889            BC041126.1         451-1849
            1890-2405           U85946.1           1828-2343
            2406-4373           AL391152.3         6338-8305
            4374-4771           BM723045.1         255-652
            4772-5160           CB145811.1         2-390
            5161-7193           AK025802.1         227-2259
            7194-7596           AL118623.1         253-655
            7597-8156           CN268669.1         82-641
            8157-8517           AA837306.1         17-377              c
            8518-10486          AL391152.3         12450-14418
FEATURES             Location/Qualifiers
     source          1..10486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..10486
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="exocyst complex component 5"
                     /db_xref="GeneID:10640"
                     /db_xref="HGNC:HGNC:10696"
                     /db_xref="MIM:604469"
     exon            1..284
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..2384
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="exocyst complex component Sec10; SEC10-like 1"
                     /codon_start=1
                     /product="exocyst complex component 5"
                     /protein_id="NP_006535.1"
                     /db_xref="CCDS:CCDS45111.1"
                     /db_xref="GeneID:10640"
                     /db_xref="HGNC:HGNC:10696"
                     /db_xref="MIM:604469"
                     /translation="MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLE
                     EFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEH
                     ISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAA
                     DIIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEISRMREVAAV
                     LLHFKGYSHCVDVYIKQCQEGAYLRNDIFEDAGILCQRVNKQVGDIFSNPETVLAKLI
                     QNVFEIKLQSFVKEQLEECRKSDAEQYLKNLYDLYTRTTNLSSKLMEFNLGTDKQTFL
                     SKLIKSIFISYLENYIEVETGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIR
                     QRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTIL
                     VEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLI
                     SSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDEN
                     NVLIQYTNACVKVCAYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYS
                     CMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLAN
                     LDKNILHSFVQLRADYRSARLARHFS"
     exon            285..379
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            380..527
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            528..722
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            723..787
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            788..816
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            817..926
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            927..971
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1112
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1195
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1405
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1553
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1662
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1783
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1870
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1979
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2195
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..10486
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4157..4162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="hexamer: AATAAA"
     polyA_site      4191
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="major polyA site"
     regulatory      4383..4388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="hexamer: AATAAA"
     polyA_site      4401
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="major polyA site"
     regulatory      6392..6397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="hexamer: AGTAAA"
     polyA_site      6416
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
     regulatory      10464..10469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /note="hexamer: AATAAA"
     polyA_site      10486
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
ORIGIN      
        1 agttccactt ccggcgtatg aggcggtgac aatgggagca gcgcgggcgg cgccgggagg
       61 cagctgacaa gcgtttgcgg cttcgcttca tggccgctct cccgcccctc ctgggatctg
      121 tggggagctg gggagcccgc agcggcccgg agccggagct ggcgagccga gcggagacct
      181 gtgcgccgcg cctctgaggc gcagcatgtg aagcggagac ggcatccagt ggggggcgag
      241 cctctcagcc ggccgggatg gctaccacgg ccgagctctt cgaggagcct tttgtggcag
      301 atgaatatat tgaacgtctt gtatggagaa ccccaggagg aggctctaga ggtggacctg
      361 aagcttttga tcctaaaaga ttattagaag aatttgtaaa tcatattcag gaactccaga
      421 taatggatga aaggattcag aggaaagtag agaaactaga gcaacaatgt cagaaagaag
      481 ccaaggaatt tgccaagaag gtacaagagc tgcagaaaag caatcaggtt gccttccaac
      541 atttccaaga actagatgag cacattagct atgtagcaac taaagtctgt caccttggag
      601 accagttaga gggggtaaac acacccagac aacgggcagt ggaggctcag aaattgatga
      661 aatactttaa tgagtttcta gatggagaat tgaaatctga tgtttttaca aattctgaaa
      721 agataaagga agcagcagac atcattcaga agttgcacct aattgcccaa gagttacctt
      781 ttgatagatt ttcagaagtt aaatccaaaa ttgcaagtaa ataccatgat ttagaatgcc
      841 agctgattca ggagtttacc agtgctcaaa gaagaggtga aatctccaga atgagagaag
      901 tagcagcagt tttacttcat tttaagggtt attcccattg tgttgatgtt tatataaagc
      961 agtgccagga gggtgcttat ttgagaaatg atatatttga agacgctgga atactctgtc
     1021 aaagagtgaa caaacaagtt ggagatatct tcagtaatcc agaaacagtc ctggctaaac
     1081 ttattcaaaa tgtatttgaa atcaaactac agagttttgt gaaagagcag ttagaagaat
     1141 gtaggaagtc cgatgcagag caatatctca aaaatctcta tgatctgtat acaagaacca
     1201 ccaatctttc cagcaagctg atggagttta atttaggtac tgataaacag actttcttgt
     1261 ctaagcttat caaatccatt ttcatttcct atttggagaa ctatattgag gtggagactg
     1321 gatatttgaa aagcagaagt gctatgatcc tacagcgcta ttatgattcg aaaaaccatc
     1381 aaaagagatc cattggcaca ggaggtattc aagatttgaa ggaaagaatt agacagcgta
     1441 ccaacttacc acttgggcca agtatcgata ctcatgggga gacttttcta tcccaagaag
     1501 tggtggttaa tcttttacaa gaaaccaaac aagcctttga aagatgtcat aggctctctg
     1561 atccttctga cttaccaagg aatgccttca gaatttttac cattcttgtg gaatttttat
     1621 gtattgagca tattgattat gctttggaaa caggacttgc tggaattccc tcttcagatt
     1681 ctaggaatgc aaatctttat tttttggacg ttgtgcaaca ggccaatact atttttcatc
     1741 tttttgacaa acagtttaat gatcacctta tgccactaat aagctcttct cctaagttat
     1801 ctgaatgcct tcagaagaaa aaagaaataa ttgaacaaat ggagatgaaa ttggatactg
     1861 gcattgatag gacattaaat tgtatgattg gacagatgaa gcatattttg gctgcagaac
     1921 agaagaaaac agattttaag ccagaagatg aaaacaatgt tttgattcaa tatactaatg
     1981 cctgtgtaaa agtctgtgct tacgtaagaa aacaagtgga gaagattaaa aattccatgg
     2041 atgggaagaa tgtggataca gttttgatgg aacttggagt acgttttcat cgacttatct
     2101 atgagcatct tcaacaatat tcctacagtt gtatgggtgg catgttggcc atttgtgatg
     2161 tagccgaata taggaagtgt gccaaagact tcaagattcc aatggtatta catctttttg
     2221 atactctgca tgctctttgc aatcttctgg tagttgcccc agataattta aagcaagtct
     2281 gctcaggaga acaacttgct aatctggaca agaatatact tcactccttc gtacaacttc
     2341 gtgctgatta tagatctgcc cgccttgctc gacacttcag ctgagattga atttacaaag
     2401 gaattcagtg tcagttcctt tacagaggaa tgtcttatac ttcagcagcc ctcggttgat
     2461 agaaagcaca ggagatacct tatgacacag ccaacatttt gtgaaacaat gactggaaca
     2521 aaacagcagc catacttacc tttgaggttt tatttaaagt ttggatacca ctagctatat
     2581 tttgcttttt tcccctcaca ttgaatttta attccattct tgaatgtaga aatttcagat
     2641 tctctaaaac tacatgtcac tgtttttatc ctagaaaatg ttgctgtcag aaggcaaagg
     2701 aaatgttacc agtgttttcg gttcttgtac ttttaacata ttccatttag aaattttgcc
     2761 attctgtttt ccattaataa taggtgaaat acaggaaaac tacatttgtt attcctcagt
     2821 ttttaatgac cttttcagca tcaattgtta atcagattat tttaggtttt cgtaaataat
     2881 ttttttgcct ctttcaaaag gttaacaatt aagcatactt tctgcagttg gttgattgga
     2941 tttttttctg aggtacagca ttaatactag tccaaaaaat gtcataaact gaactaaaat
     3001 gatgaactat tttatgtaga cattaggagt ggatcggaat acttctgctt tctgggtaaa
     3061 acttaaaagt ttactatttc ttatttggta aatagatttt aagccaattc tagtaagaaa
     3121 ttaataaaac taccttattt tgtatttcac ttaaggtgga ggaccttaac taaaggacca
     3181 tatttattca ttattttaat attataaggg aagtaaaaaa aagtgaggta tagtctaaat
     3241 ggtgcatata ggaaatactg acagtgttta gcaacatgca gccctttgag atttctgtcg
     3301 taatgctaaa cttgaataag atggaatggc tgaacatgtg gttagtcttt tattttaaga
     3361 agaattgaga attgatagat ttggagatga gctttgcaaa ggctgtttgc ttttcatgtc
     3421 tataggtctg tcattgtcct ttttcaaagc atttctgaag ttattcctac ttggatatag
     3481 ttaatggaat tggcttaatt tgatgacata ataaatcact tataaaattt taaatatcaa
     3541 gtgaaaattt agaaaggcca ttactattct ataaacctta taaacttgct ctgggagaat
     3601 gcattctaaa ttatatatag tgtttcagct cccattgtgg tgttcatagt cttctaggaa
     3661 cagataaact taagtattca attcactctt ggcatttttt ctttaatata ggctttttag
     3721 cctatttttg gaaaactgct tttcttctga gaaccttatt ctgaatgtca tcaactttac
     3781 caaaccttct aagtccagag ctaacttagt actgtttaag ttactattga ctgaattttc
     3841 ttcattttct gtttagtcca gtgttaccaa ggtaagctgg ggaatgaagt ataccaactt
     3901 ctttcagagc attttaggac attatggcag ctttagaagg ctgtcttgtt tctagccaag
     3961 ggagagccag cgcaggtttt ggatactaga gaaagtcatt tgcttgtact attgccattt
     4021 tagaaagctc tgatgtgaat tcaaatttta cctctgttac ttaaagccaa caattttaag
     4081 gcagtagttt tactggccat ttaagctctt tgtacagtgt caatttgtaa aaaagaaaaa
     4141 acgaaaaaaa atctcaaata aaacatgaga taacatttta agacttccaa atcagagaag
     4201 tgcttcaaat tattttgttt ggattaattt ttaaaatgta aagcatatac ttgttgctta
     4261 gttattttgt ttattatttt catgtttgag ttctgtgcaa tattttctat tatgtccgtt
     4321 gataggacag tgacaaaatt cgtaagtgaa tacttaattt aaaagtgtta acattaatgc
     4381 tcaataaaca aattccctgc agttgttttt tttatttcac tctttttata ttttagagcc
     4441 atccatcctg aattttataa atgatttttt atttaaaaat ttgagatttt taaaattttt
     4501 cacagcacag gtcttctcat tttctttttt agcaaaaaat acttgactat ataaacaaga
     4561 ctagaaattt atcctaaaca gatggtcttt ctctgaggga aaaaaaaaaa tgtgtcatgt
     4621 gaggcaatat gcattctttg tattctgatt ttttaagtgt tttcatattt atagccatca
     4681 caaaattttg cccaaagtgt atggctcaga agagatgatc aataactaaa atgtttttcg
     4741 ttttgcacat ggtaaaattt taggtagaga gtggagcttt gtataattgg taactttaac
     4801 caacatttac gtaagtacgg tctttgcagt attacacaat accgcatgag ctaatatgca
     4861 gtatttaggt aatgcattga atgaagttga aaatatgctc ttaacacact gtgcattgtt
     4921 tttctaaaat tgagaaatat ctgaaataca gaatacgaat ttaataaagg aagcctacct
     4981 tatgtaaatt atgatgttga aaatgacagt caaccagagt agatgaagtg tccttatgaa
     5041 gaattattaa atagtagctg gatggatctt tagatggatg accacctgac cattccagga
     5101 caatttttgg tcccattttg aggattgcca tagttgcaag tccttaggat cttccttgtt
     5161 ttaaaaaact atcaaagtag gttaaattaa aatctaattt aaattaggtt aatttatatt
     5221 acattgtaga tcattctttt ttcccccctc tttcacttct aaatattttg ctttctaaat
     5281 actagccttc tggttcacag tgaaataatt taattatcaa tcagtagatt gattccaagt
     5341 ggagaattca ctgcttccct aaaatgcgtt tttcttacct gtaatggtga atatttacaa
     5401 ggatctggat aaagagattt tgatttttga aatgccacaa aaccccttaa agtggtcaag
     5461 tacctaaggt agtggctaag gcatgcttga actgtgtttg agagacagca gttcagtcag
     5521 tacataattt gttggtgact aacaaagctc acatctggga gattaacttt ttttaacgca
     5581 aaaatattct gcacattacc catatattgt tgaattttac atacaaagca ttttgtgctt
     5641 tcattcaatt agtttaacta tattcagttt ctgtattatt tctctctgat ctatcctgta
     5701 attattctat actttagaag aaaagatcag ttcatattgt tagactgaat aattctacat
     5761 gaagttaaaa gttagcaatt taaaaaattt tgctgcataa taaagataat tatagttaca
     5821 tgtattgatt taagtctcac acactgtgct aataagtcct ttgcacatat tattggattc
     5881 tagagcaacc ctaggatttg ggtactatta tttccatttg acagatgaaa aacctaatgc
     5941 atagaaagat aagtagacca gtcaaggtct acagctagta aaatgctcag attgaaacct
     6001 aaatcttttc tcactcactt ttaggttcta tatgctattc tccttacgta acgttaaata
     6061 gatcctttag tttgataggt tcattagttt tgcttaatcg ttgcttccaa tatgattctt
     6121 attgtagtat ttatattaca aagttggcat acagggtcaa tatctaattt actgttgtgt
     6181 ttttcttaat atgttcaatg tatggtcata ctttttaaat ttgatttttt aaatattata
     6241 agtggtcatg aaattttaat gttaagtttg tacctaatag aaatatgtct atcacaaatc
     6301 tttattggta ttattttata tacttttcca gcttgataat tttcacaata gaaagagacc
     6361 aaatattttg tactatattt tgtgacatag aagtaaatga caactctacc ttggaagata
     6421 tgaagaaatc agtgttttta tgttcaaaaa ctattttaaa tgtcataggc ttgccaattg
     6481 tgttaactat ttagtacatt ggtagttttt aaatgactaa tgctggagtg aaaatgtaag
     6541 gcaaaatatt tagtatatta acagtagata gtcattttca tgtaatcaga attgcatgtt
     6601 aagggtttta aaagctgtca taactcttac cttttatttc taccagtgat caatcatttc
     6661 tctttacaaa tttagggagg aaacaactgt tcaaatgtat aggggacaga aacctgacat
     6721 ttagagaaca gaaattttaa ttgccaaatt aaagcagcta ggctgcccct gggcttaaca
     6781 aaattcctat ttttgaacta gacccgaggt attttatcat tattatttga taggtaccat
     6841 taacctttgt tttgtgatta tcgacttttg gggggaaaga tgagtaatta aacacactcg
     6901 cccattttct aagtggttta gaaggttgca gtctgcctca ccatacaaag ccagtttaaa
     6961 taggaatata tcacatcata cttcacatag cagtcaacct cagaggaaag tcatttattc
     7021 agaaggcata gattttgcta gacagcagtg atgcattaca aatatataat tatttgcact
     7081 aatatttgag caggtggaat ggattagaac atggtcaaca tcatgctgct gataacatgt
     7141 atttttctat attaatatgt actgtgcaac atgtattaaa attgtcaata attcatttta
     7201 gccaagatac taatatttat attactgtgt ttaagagaca gtatccaact gagccacttt
     7261 taatttaaaa gtctgaaact ggaattaagt ttactttcaa aaatcactta aattacttta
     7321 taatcagtga aaggtcagta aaatgtagaa ttataagtgc ctagtgactt aataggagga
     7381 aatatggagg gttaaggaag gaagtaggaa cctggaataa gaaagctaag tttcatttat
     7441 agttccaatg agtgactttc tttgttttca ccactgggaa tcttaaatga agaaagtgtc
     7501 gtatcccttc cagttatctt tatgttaata aactaagtga agtttggata gaactaacaa
     7561 aggaattagt ctccattggt ggacttccag agttttgaga ttaaactttg agaggtgaga
     7621 agccttcctg atgcccctgt aatcttaaat tggcaggtgc ctctaagtga ggccatccct
     7681 ctttgcctgc ctatcatttt aatctttata ctgtaactgg ttcctttcaa ctctggcctt
     7741 ttattgtagc acttttatca agtctgcagc ttcccagcta cttgggaggc tgaggtggga
     7801 agaacacttg aagctaggag ttcaagacca ctctgggcaa catagtgagt ccctgttttt
     7861 agaaaaataa ataaccttta ggtttttgct atagaaaata tccaaataga gtctggacaa
     7921 tgctggatgt aaagaaaact gtgaagctac ctctaagcat attgtttgtg aatactgtgt
     7981 accatttaga ggataacatg ggggattcac atgaagttat gtgaaaatat tttataagga
     8041 ataataccta agtgcctctc ttaagttctc cagtagaatg tattttcaat ttttgccaca
     8101 agggggagaa gttattttta tagtaatatg tacatttttt tattttaaaa atagaattca
     8161 cacaacttta cagcatctat gaacattttg ctatcccaat tatgtgtgtg tgtgcatgtg
     8221 tgtaaacaag attctgaaag tcttgcatga gaaaaatttc aaaggaaatt aataacaaaa
     8281 ccaaaacagt tttgaagaac atgtgcacag tggacacagg aattgaacaa agtttaccat
     8341 gattaacatt atgttttctt agttatatat cacattgaat tcctttatca actctaataa
     8401 gaatctactg attagtgttc tacattctgc tttttaaaga aaaatttttg aaacaatcag
     8461 acttaacaga agggttgtaa atactgtaca aataaaattt ttcccttttg agaataagtc
     8521 gctgtcatga tgctgcacca ccctccaata cttttgtatt tccaagaaga aagaatgctt
     8581 cagtataact acaatacatg aaaattggga agttaacatt gacatattac tactatctaa
     8641 tcctcagaca ccaatcattt tactagctgt cctaattcct tttaaggatc tcagttcaaa
     8701 atcatgtatt gctttaggtt gtagtggctc tagtctcatt cattctgaca cagttccaca
     8761 gtctttcctt gacttttttg actctggaca tttttataga ttatagggta gttactttgt
     8821 aaaacacccc tacatttgga tttctgtttc cacgtaatta gattctgttt gtgctttttg
     8881 gcagacatac cacggatgca actctgtgtt attgttgcat cctatcacat agtacacaat
     8941 ttcaatttgc cccatttctg atgatgttca tttttatcac tttcttaagg tactatttac
     9001 caggcttctc cactttaaaa ctattacttt tccctttgta aatattttgg aggtagatat
     9061 atattaatag atacagacat atataggtcc cccttattta tttatttgca gacagagtct
     9121 cgctctgttg cccaagctgg agtgcggtgg cgtgatctca gctcactgca acctctacct
     9181 cctgggttca agcgattctc ccacctcagc ctcccaagta gctaggacta caggcacatg
     9241 ccaccatgcc tggccaattt ttctatttgt agtagaaatg gggttttgcc gtgttggtca
     9301 ggctggtgtc aaactcctag ccttaagtga tctgcccacc tcaacctccc aaagtcctgg
     9361 gattacaggt gtgagccacc ttaaccagcc atcctttata tatatatata tatatatata
     9421 tataatatta atatatataa aaatatatgt atatgtgtgg tgtgtgtgta tatatataca
     9481 tatgtgtgtg tatatacacg tgtgtttata cacgtgtgtg tacatataca cgcgtgtgta
     9541 tatatacaca cgtgtgtgtg tgtatatata tatactaatc agaattctct tgatatcact
     9601 atgtattcat agttttctgt tcaactaatt ataatctgtc attttaccaa atctcaaatt
     9661 atcccaaatt tggtcagaag tagcctcttc aggttgtctc ctgtgtcgtt ttggcatgtt
     9721 cccatcattt ttacagcaat ttattctggg cacaacagga ttttccaagg tcatcttgta
     9781 cttgccttgc cccagctctg gaatcagcca ttcctccacc ttttagtgaa attggcagtt
     9841 agaaatcaag atttgtgcat gagatgtgct tattattatt gagatgtctc accctactct
     9901 ttctcaatag ataatgctag ggggctttat gtgtgcatac acacacacac actcacgcat
     9961 attttaaata tacacccaca cccatgcgcc cctctgcaac atcttcctca cctcacttga
    10021 gcttccatac tccatactgg gcttcccctc tctctggagg agaccatcct catctcacat
    10081 agctcttgaa gttttggctt taggaccaaa ttgagggaat aagaatggtc attgcagaaa
    10141 tcctgtaaaa attttaaaat attaaattta aaaattacaa ttttatcacg cagaaacaac
    10201 tatatttttg gtggaagttt tttttttttt tttttaatgt agtgagcaaa ttagtaaagc
    10261 tgaattgagg agggggtaaa gtgttatgcc caagacacag aacttacatt ttgaaagaat
    10321 taaatttgaa atgcataccg tatgtttttc tattatacaa tctccttgct actgtaattg
    10381 ctatttaata agagtgcatc agagaaactg tatgaatgga aacctgacca ttaagcactg
    10441 aataccaata ggatattttt actaataaag ttcaaaggaa aaatga
//
