LOCUS       NM_021807               4182 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens exocyst complex component 4 (EXOC4), transcript
            variant 1, mRNA.
ACCESSION   NM_021807
VERSION     NM_021807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4182)
  AUTHORS   Cullell,N., Soriano-Tarraga,C., Gallego-Fabrega,C.,
            Carcel-Marquez,J., Muino,E., Llucia-Carol,L., Lledos,M.,
            Esteller,M., de Moura,M.C., Montaner,J., Rosell,A., Delgado,P.,
            Marti-Fabregas,J., Krupinski,J., Roquer,J., Jimenez-Conde,J. and
            Fernandez-Cadenas,I.
  TITLE     Altered methylation pattern in EXOC4 is associated with stroke
            outcome: an epigenome-wide association study
  JOURNAL   Clin Epigenetics 14 (1), 124 (2022)
   PUBMED   36180927
  REMARK    GeneRIF: Altered methylation pattern in EXOC4 is associated with
            stroke outcome: an epigenome-wide association study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4182)
  AUTHORS   Li,H., Fu,X., Zhao,J., Li,C., Li,L., Xia,P., Guo,J., Wei,W.,
            Zeng,R., Wu,J., Sun,Y., Huang,L. and Wang,X.
  TITLE     EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via
            Activating FAK Signal
  JOURNAL   Mol Cancer Res 20 (7), 1021-1034 (2022)
   PUBMED   35471457
  REMARK    GeneRIF: EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via
            Activating FAK Signal.
REFERENCE   3  (bases 1 to 4182)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4182)
  AUTHORS   Fais,M., Sanna,G., Galioto,M., Nguyen,T.T.D., Tran,M.U.T., Sini,P.,
            Carta,F., Turrini,F., Xiong,Y., Dawson,T.M., Dawson,V.L., Crosio,C.
            and Iaccarino,C.
  TITLE     LRRK2 Modulates the Exocyst Complex Assembly by Interacting with
            Sec8
  JOURNAL   Cells 10 (2), 203 (2021)
   PUBMED   33498474
  REMARK    GeneRIF: LRRK2 Modulates the Exocyst Complex Assembly by
            Interacting with Sec8.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4182)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
REFERENCE   7  (bases 1 to 4182)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 4182)
  AUTHORS   Hsu,S.C., Hazuka,C.D., Roth,R., Foletti,D.L., Heuser,J. and
            Scheller,R.H.
  TITLE     Subunit composition, protein interactions, and structures of the
            mammalian brain sec6/8 complex and septin filaments
  JOURNAL   Neuron 20 (6), 1111-1122 (1998)
   PUBMED   9655500
REFERENCE   9  (bases 1 to 4182)
  AUTHORS   Grindstaff,K.K., Yeaman,C., Anandasabapathy,N., Hsu,S.C.,
            Rodriguez-Boulan,E., Scheller,R.H. and Nelson,W.J.
  TITLE     Sec6/8 complex is recruited to cell-cell contacts and specifies
            transport vesicle delivery to the basal-lateral membrane in
            epithelial cells
  JOURNAL   Cell 93 (5), 731-740 (1998)
   PUBMED   9630218
REFERENCE   10 (bases 1 to 4182)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK027688.1 and AF132734.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021807.3.
            
            Summary: The protein encoded by this gene is a component of the
            exocyst complex, a multiple protein complex essential for targeting
            exocytic vesicles to specific docking sites on the plasma membrane.
            Though best characterized in yeast, the component proteins and
            functions of exocyst complex have been demonstrated to be highly
            conserved in higher eukaryotes. At least eight components of the
            exocyst complex, including this protein, are found to interact with
            the actin cytoskeletal remodeling and vesicle transport machinery.
            The complex is also essential for the biogenesis of epithelial cell
            surface polarity. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831989.2, AF380839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253861.5/ ENSP00000253861.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2831              AK027688.1         6-2836
            2832-4182           AF132734.1         1799-3149
FEATURES             Location/Qualifiers
     source          1..4182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..4182
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /note="exocyst complex component 4"
                     /db_xref="GeneID:60412"
                     /db_xref="HGNC:HGNC:30389"
                     /db_xref="MIM:608185"
     exon            1..110
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2949
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /note="isoform a is encoded by transcript variant 1;
                     exocyst complex component Sec8; SEC8-like 1"
                     /codon_start=1
                     /product="exocyst complex component 4 isoform a"
                     /protein_id="NP_068579.3"
                     /db_xref="CCDS:CCDS5829.1"
                     /db_xref="GeneID:60412"
                     /db_xref="HGNC:HGNC:30389"
                     /db_xref="MIM:608185"
                     /translation="MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEK
                     GRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKM
                     LLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSA
                     VESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKI
                     SSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENST
                     LFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQ
                     PRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQEDIKLYDMADVWVKIQDV
                     LQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
                     ISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQ
                     EIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADT
                     MKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYR
                     GIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKE
                     SEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPA
                     QDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGN
                     YAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGA
                     QYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVV
                     DQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQAAIKQATKDKKIT
                     TV"
     exon            111..300
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            301..495
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            496..680
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            681..787
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1031
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1206
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1352
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1441
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1538
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1758
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1895
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2051
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2230
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2372
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2551
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2711
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..4182
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4156..4161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /note="hexamer: ATTAAA"
     polyA_site      4182
                     /gene="EXOC4"
                     /gene_synonym="SEC8; SEC8L1; Sec8p"
                     /note="major polyA site"
ORIGIN      
        1 ctagcggctc tccccgcgtc caagatggcg gcagaagcag ctggtgggaa atacagaagc
       61 acagtcagca aaagcaaaga cccctcgggg ctgctcatct ctgtgatcag gactctgtct
      121 actagtgacg atgtcgaaga cagggaaaat gaaaagggtc gccttgaaga agcctacgag
      181 aaatgtgacc gtgacctgga tgaattgatt gtacagcact acacagaatt gacgacagcc
      241 attcgcacat accagagcat cacagagcgc atcactaact cccgaaataa aataaagcag
      301 gtaaaagaga acctgctttc atgcaagatg ctgctgcact gcaaacggga tgagcttcgg
      361 aaactgtgga ttgaaggaat tgagcataag catgtcctga acttgttgga tgaaattgag
      421 aatatcaagc aagtgcctca aaagctggaa cagtgcatgg ccagcaagca ctatctcagt
      481 gccactgaca tgttggtgtc agcagttgag tctttggagg gccccctgct ccaggtggaa
      541 ggactgagtg accttcgact agagcttcac agcaagaaga tgaaccttca cttggttctc
      601 atagatgaac tacaccggca cctgtacatc aaatcgacta gccgagttgt gcagcgtaac
      661 aaggaaaaag ggaaaatcag ctccctcgtg aaagatgctt ctgttcctct gattgatgtt
      721 acaaacctcc ctactcctcg aaaattcctt gatacctctc actattctac tgctggaagc
      781 tcaagtgtga gggagataaa tctgcaggac atcaaggaag atttagaatt ggatccagag
      841 gaaaacagca ccctgtttat gggtatcctc attaagggct tggcgaaact gaagaagatc
      901 ccagaaacag ttaaggcaat catagagcgc ttggagcagg agttgaagca aattgtgaag
      961 aggtctacaa cccaggtggc agacagtggc tatcagcggg gggagaacgt tactgtggag
     1021 aaccaaccaa ggttgcttct agaactgctg gagttactgt ttgacaagtt taatgctgta
     1081 gccgctgcac actctgtggt cctgggatac ctgcaggaca ctgtagtgac tccactgact
     1141 cagcaggaag atatcaaact gtatgatatg gcagatgtat gggtgaagat ccaagatgtt
     1201 ctacagatgc tattaactga gtacttggat atgaaaaata ctcgtacggc ctctgaacca
     1261 tcagctcaac taagctatgc cagcactgga cgagagtttg cagccttttt tgccaagaag
     1321 aaacctcaaa ggccaaaaaa ttctcttttc aagttcgaat cgtcctccca tgccatcagt
     1381 atgagcgcct atctgcgaga acagagaagg gagctctata gtcggagtgg agaactgcaa
     1441 gggggtcctg atgacaactt aattgaaggt ggaggaacaa aatttgtctg caaacctgga
     1501 gccagaaaca ttaccgtcat attccaccca ttactaagat ttattcagga gattgagcat
     1561 gctctgggtc ttggcccagc caaacagtgt cctcttcgag agtttctcac cgtgtacatc
     1621 aaaaacatct ttctcaatca agtcttggct gagatcaaca aggagattga aggagtcact
     1681 aaaacatctg accctttgaa gattctggcc aacgcagaca ccatgaaggt gctgggagtg
     1741 cagcggcctc tcctacagag cacaatcatt gtggagaaga cagttcaaga cctcctgaac
     1801 ctgatgcatg acttgagtgc atattcagat caattcctca acatggtgtg cgtgaagctc
     1861 caggagtaca aggacacctg cactgcagct tacaggggta ttgtccagtc agaagaaaaa
     1921 cttgtcatca gtgcatcctg ggcaaaagat gatgatatca gcagactctt gaaatctcta
     1981 ccaaactgga tgaatatggc tcaacccaaa cagctgaggc caaaaagaga ggaggaagaa
     2041 gatttcataa gggcagcttt tggcaaggag tctgaagttc ttattgggaa cctgggtgat
     2101 aaattaatcc ctccacaaga catccttcgt gacgtcagtg acctcaaagc cttggccaac
     2161 atgcatgaaa gcctggaatg gttggcaagt cgaacaaagt cagctttctc caatctttct
     2221 acatcccaga tgctttctcc tgctcaagac agccacacga acacggatct ccccccagtg
     2281 tcagagcaga tcatgcagac tctcagtgaa cttgccaaat cgttccagga tatggctgac
     2341 cgctgcttgc ttgtcttaca tctggaagtg agggttcact gtttccacta tcttatccct
     2401 cttgcaaagg aggggaacta tgccattgtg gctaatgtgg aaagtatgga ttatgacccc
     2461 ctggtggtca agctcaacaa agatatcagc gccattgaag aggccatgag cgccagcctt
     2521 cagcagcaca agttccagta tatcttcgaa ggcctgggcc acctgatctc ctgcatcctc
     2581 attaatggtg cccagtactt caggcgcatc agtgagtctg gcatcaagaa aatgtgtagg
     2641 aacatttttg ttcttcagca gaatttgacc aacatcacca tgtcgcggga ggcagacctg
     2701 gactttgcaa ggcagtacta cgagatgctt tacaacacag ctgacgagct cctgaacctg
     2761 gtggtggacc agggtgtgaa gtacacggag ctggagtaca tccacgctct gaccctgctg
     2821 caccgcagcc agactggggt gggggaactg accacccaga acacgaggct gcagaggctc
     2881 aaagagatca tctgcgagca ggctgccatc aagcaagcca ccaaggacaa gaagataact
     2941 accgtttagc agggcgtact gcggttggtg acgggggtcc cctcagtcac actcactttt
     3001 ttccttggta tgttattgag tatattctga gcttagtttt ctctacagtg atactttagt
     3061 ggagaggagg tgtaaggatt ctttctctct ggttttggct tttcatataa atgctaaagg
     3121 aaggcgacag tacagagtgt tttggttgaa caactacttt aatgcagtca aatctaacgg
     3181 gactagggtg ggatagggag gaaggtggta tcaaattgtt ggactctgaa aaacaagtgg
     3241 atggattact aatatttgat ttattactca atatatatat aattccagcc ttggaaagta
     3301 ggaaagtagg ctgctaccta acttttagtc ccttccaaaa ccatttagta gggttctatt
     3361 acataaacag tagggttttt cctctcctga ccttatccgt ttacagttca atgaaataag
     3421 tgtatgtgca ttgctgtctg tctctattgc caaaatcaaa taaatggctt ctcagctgct
     3481 gtttacaaca aacttcccta accaaaacag aacctctaat ttagggctag gaatagaagt
     3541 cttttgatcc cagtccctgg gacagttttg tatgctgtat cttgtacaca ggttgtaggt
     3601 tggtttattg ccattttgtt ttatttctgc tgtataaaaa ccaagagcca gacaattaga
     3661 caactatgga ggaatgaaag gcaattcaaa catctgcttg attcccgccc cgccacccct
     3721 aatttctgag agaataatgg ttagagaaca ttgcatctca cttgaaacat cctttggggg
     3781 taaatgattc ttaggtgctc acttggtctg agctcagctg aatgcaggga agatgggaca
     3841 gagtgacatt tctcctctgt gcggcctcca gctgagcctg tctctgaatt gttccctccc
     3901 ccgcaatgtg ggcacttacc atgttcctgg cacactggac ctcaccatgt cccccggtca
     3961 ccagtcctct tgctgcccat ggttcatagg tcatagaagg cagcaatgca ctgactgggc
     4021 cacatcttga aaactcgtgg aaagggaaag gggaggagat gggactttga ccacacacag
     4081 tgatgcctca caccctgaag gtgggggatt ttgtacctgt ttgtacaact ttggtcttga
     4141 tgggaaaaat ggagaattaa aaagtgtttt gagaagctta aa
//
