LOCUS       NM_178516               2429 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens exocyst complex component 3 like 1 (EXOC3L1), mRNA.
ACCESSION   NM_178516
VERSION     NM_178516.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Zhang,Z.F.
  TITLE     EXOC3L1: A Novel Prognostic Biomarker Correlated with Immune
            Infiltration in Esophageal Squamous Cell Carcinoma
  JOURNAL   Med Sci Monit 29, e938512 (2023)
   PUBMED   36852560
  REMARK    GeneRIF: EXOC3L1: A Novel Prognostic Biomarker Correlated with
            Immune Infiltration in Esophageal Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2429)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2429)
  AUTHORS   Lanktree,M.B., Elbers,C.C., Li,Y., Zhang,G., Duan,Q.,
            Karczewski,K.J., Guo,Y., Tragante,V., North,K.E., Cushman,M.,
            Asselbergs,F.W., Wilson,J.G., Lange,L.A., Drenos,F., Reiner,A.P.,
            Barnes,M.R. and Keating,B.J.
  TITLE     Genetic meta-analysis of 15,901 African Americans identifies
            variation in EXOC3L1 is associated with HDL concentration
  JOURNAL   J Lipid Res 56 (9), 1781-1786 (2015)
   PUBMED   26199122
  REMARK    GeneRIF: EXOC3L1 is strongly expressed in vascular endothelium and
            forms part of the exocyst complex, a key facilitator of the
            trafficking of lipid receptors
REFERENCE   4  (bases 1 to 2429)
  AUTHORS   Saito,T., Shibasaki,T. and Seino,S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA945486.1, AK092858.1 and AI796350.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178516.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292004.1, AK092858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314586.11/ ENSP00000325674.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DA945486.1         69-108
            41-2272             AK092858.1         1-2232
            2273-2417           AI796350.1         21-165              c
            2418-2428           AK092858.1         2357-2367
            2429-2429           AI796350.1         9-9                 c
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2429
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /note="exocyst complex component 3 like 1"
                     /db_xref="GeneID:283849"
                     /db_xref="HGNC:HGNC:27540"
                     /db_xref="MIM:614117"
     exon            1..166
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            167..219
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2414
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /note="protein Jiangli"
                     /codon_start=1
                     /product="exocyst complex component 3-like protein"
                     /protein_id="NP_848611.2"
                     /db_xref="CCDS:CCDS10832.1"
                     /db_xref="GeneID:283849"
                     /db_xref="HGNC:HGNC:27540"
                     /db_xref="MIM:614117"
                     /translation="MDSAAKDEMQPALSPGPEWPEQERAEQLARGAALKWASGIFYRP
                     EQLARLGQYRSREVQRTCSLESRLKSVMQSYLEGVQTGVWQLAQAIEVVQGTREALSQ
                     ARGLLQGMSQALQTLEPLRERVAQHKQLQALSHLLPRLRAVPAAVSHTQTLIDGQQFL
                     EAYVSLRELEQLREDTWAPLGGLELPVFQGLDLLFEALGQAVEAAAGAAGKLAREDPA
                     LLVAAVRVAEVETGRTTPLGQVPRDWRQRCLRALQEGLEQAHFGSPLLPAPGALPGWL
                     EALRVALPVELATAEALVAPCCPPQYNVVQLWAHTLHSGLRRSLQNLLAGPELEAADA
                     FALLHWALHVYLGQEMMGSLELGPEADVSQLEPLLTLENIEQLEATFVANIQASVSQW
                     LQNALDGEVAEWGREHGPNTDPSGSYYSPMPAIVLQILEENIRVASLVSESLQQRVHG
                     MALSELGTFLRSFSDALIRFSRDHFRGKSMAPHYVPYLLAALNHKSALSSSVSVLQLD
                     GAPSGALAPVEAALDELQRRIYRLVLEALQAELQPLFADLPSRQWLSSPELLQSVCER
                     TGRFCRDFWRVRNPTVQLLLAEAERAVVLQYLSALMQGRLVCRGADERTQAAERLRHD
                     AAQLQQLFLSLGLEENAHCAPVLLALRELLNLRDPALLGLEVAGLRQQFPDVSEDHVS
                     ALLGLRGDLSREQHLAALSSLQAALPPSPRASRRVLFSLVPAPALAPASCLPSGSCAR
                     ALLLAE"
     exon            220..380
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            381..600
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1213
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1331
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1457
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1558
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1669
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1799
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1922
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2078
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2203
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2429
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /note="hexamer: AATAAA"
     polyA_site      2429
                     /gene="EXOC3L1"
                     /gene_synonym="EXOC3L"
                     /note="major polyA site"
ORIGIN      
        1 gagagagact tccttgggga gaggaattca gctgcacgct ggagtcagct ggagttgccc
       61 aggccctgtg agcaagtggc aggcgtgccc agctgcattg gggagagggc tgttctcaag
      121 gccaaggtca tttttggagg gagaactgga cgcctgatca aatctggccc acaatggact
      181 cagcagccaa ggatgagatg cagccggcgt tgtcccctgg acctgagtgg ccagagcagg
      241 agcgggcaga gcagctggcc cggggtgcag cgctcaagtg ggcctcaggc atcttctacc
      301 ggccggagca gctggccagg ctaggccagt accgcagccg cgaggtgcag cgtacctgct
      361 ccctggaatc gcgcctcaag tcagtgatgc agtcatacct ggaaggcgtg cagactggtg
      421 tgtggcagct ggcccaggcc attgaggtgg tgcagggaac ccgggaggcc ctgagccagg
      481 cccgtgggtt gctccagggc atgtcccagg ccttacagac tctagagccc ctacgggagc
      541 gggttgccca gcacaagcaa ctgcaggccc tgtctcacct gctgcctcgg ctgcgggcag
      601 tgccggctgc agtgtcccac acacagactc tgattgatgg ccaacagttc ttggaggcat
      661 atgtgagcct tcgggagctg gagcagctgc gagaggatac gtgggcaccc ctggggggcc
      721 tggagttgcc agtcttccag gggctggacc ttctgttcga ggcactgggc caggctgtgg
      781 aagcagctgc aggggccgca gggaagctgg cacgggagga cccagccctg ttggtggctg
      841 ctgtgcgtgt ggcggaggtg gagactggac gaacaacccc cctgggccag gtcccccggg
      901 actggcgtca gcgctgtctg agggcactac aggagggcct ggagcaggcc cactttgggt
      961 cacctctgct gcctgcacca ggggccctac cagggtggct ggaggctctg cgagtggccc
     1021 tgccagtcga gttggccaca gctgaggcac tagtagcgcc ttgctgcccg ccacagtaca
     1081 acgtggtcca gctatgggcc cacacgctgc atagtggttt gcgccgcagc ctgcagaacc
     1141 tccttgcagg gcctgagcta gaagctgcgg atgccttcgc cttgctgcac tgggcactgc
     1201 atgtgtacct ggggcaggaa atgatgggga gcctggagtt ggggcctgag gctgatgtgt
     1261 cccagctgga gccccttctg accttggaga acattgagca gctggaggca acatttgtgg
     1321 ccaacatcca ggcaagtgtg tctcagtggc tgcagaatgc actggatggg gaggtagctg
     1381 agtggggccg ggagcatggg cccaacacag acccgtctgg ctcctattac tcaccaatgc
     1441 cagccattgt gctgcagatc ctggaagaga acattcgtgt ggccagcctg gtcagtgagt
     1501 cactgcaaca gcgagtgcat ggcatggcac tgtcagaact gggcacattc ttgaggagct
     1561 tcagtgatgc tctgatccga ttctcccgag accacttcag ggggaaatca atggcccctc
     1621 attacgtgcc ctacctactg gccgccctca accacaagtc agcactcagc tcctcagtgt
     1681 ctgtcctgca gctggacggg gcgccttcag gggccttggc tccagtggaa gctgcgctgg
     1741 acgagttgca gaggaggatc taccgcttgg tgttggaggc gctgcaggcg gagctccagc
     1801 ccctgttcgc ggatctgccc tcgcgccaat ggctgtcgag ccctgagctc ctgcaaagtg
     1861 tgtgtgaacg gacggggcgc ttctgccggg acttctggcg cgtgcggaac cccacggttc
     1921 agctgctgct ggctgaggcc gagcgtgccg tggtgctcca gtacctgagc gcgctgatgc
     1981 aaggccgcct ggtgtgccgc ggagccgacg agaggaccca ggcggccgag cgcctgcggc
     2041 acgatgctgc ccagcttcag cagcttttcc tcagtttggg cctggaggag aacgcgcact
     2101 gcgcgccggt gctgctcgcc ctgagggagc tgctaaacct ccgcgacccc gcgctgctgg
     2161 gcctggaggt ggctggcctg cggcaacaat ttcccgacgt gagcgaggac cacgtctccg
     2221 ccctcttggg cctgcgcggg gacttgtccc gggagcagca cctggccgcg ctcagctccc
     2281 tgcaggctgc gctgccgccg tcgccccgcg cgagccgccg cgtcctcttc agcctagtgc
     2341 ccgcgcccgc gctcgcgccg gcctcctgcc tgccctcggg gtcctgcgcc cgagccctgc
     2401 tgctcgcaga ataaaccacg gctgccgga
//
