LOCUS       NM_007277               2801 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens exocyst complex component 3 (EXOC3), mRNA.
ACCESSION   NM_007277
VERSION     NM_007277.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2801)
  AUTHORS   Guo,J. and Mei,K.
  TITLE     Structural Study of the Exocyst Subunit Human Sec6
  JOURNAL   Stud Health Technol Inform 308, 351-358 (2023)
   PUBMED   38007759
  REMARK    GeneRIF: Structural Study of the Exocyst Subunit Human Sec6.
REFERENCE   2  (bases 1 to 2801)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2801)
  AUTHORS   Tanaka,T., Iino,M. and Goto,K.
  TITLE     Sec6 enhances cell migration and suppresses apoptosis by elevating
            the phosphorylation of p38 MAPK, MK2, and HSP27
  JOURNAL   Cell Signal 49, 1-16 (2018)
   PUBMED   29729335
  REMARK    GeneRIF: Sec6 increased the phosphorylation of p38 MAPK through the
            activation of MAPK kinase 3/6 (MKK3/6). Moreover, Sec6 knockdown
            suppressed the phosphorylation of HSP27 at Ser(78) and Ser(82)
            sites via suppression of activated MK2.
REFERENCE   4  (bases 1 to 2801)
  AUTHORS   Tanaka,T., Kikuchi,N., Goto,K. and Iino,M.
  TITLE     Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant
            peripheral nerve sheath tumor cells
  JOURNAL   Apoptosis 21 (5), 594-608 (2016)
   PUBMED   26892009
  REMARK    GeneRIF: Sec6 regulate Bcl-2 and Mcl-1 expressions but not Bcl-xl
            in malignant peripheral nerve sheath tumor cells.
REFERENCE   5  (bases 1 to 2801)
  AUTHORS   Torres,M.J., Pandita,R.K., Kulak,O., Kumar,R., Formstecher,E.,
            Horikoshi,N., Mujoo,K., Hunt,C.R., Zhao,Y., Lum,L., Zaman,A.,
            Yeaman,C., White,M.A. and Pandita,T.K.
  TITLE     Role of the Exocyst Complex Component Sec6/8 in Genomic Stability
  JOURNAL   Mol Cell Biol 35 (21), 3633-3645 (2015)
   PUBMED   26283729
  REMARK    GeneRIF: The study explores the role of the exocyst complex
            component Sec6/8 in genomic stability.
REFERENCE   6  (bases 1 to 2801)
  AUTHORS   Polzin,A., Shipitsin,M., Goi,T., Feig,L.A. and Turner,T.J.
  TITLE     Ral-GTPase influences the regulation of the readily releasable pool
            of synaptic vesicles
  JOURNAL   Mol Cell Biol 22 (6), 1714-1722 (2002)
   PUBMED   11865051
REFERENCE   7  (bases 1 to 2801)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
REFERENCE   8  (bases 1 to 2801)
  AUTHORS   Hsu,S.C., Hazuka,C.D., Roth,R., Foletti,D.L., Heuser,J. and
            Scheller,R.H.
  TITLE     Subunit composition, protein interactions, and structures of the
            mammalian brain sec6/8 complex and septin filaments
  JOURNAL   Neuron 20 (6), 1111-1122 (1998)
   PUBMED   9655500
REFERENCE   9  (bases 1 to 2801)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
REFERENCE   10 (bases 1 to 2801)
  AUTHORS   Hsu,S.C., Ting,A.E., Hazuka,C.D., Davanger,S., Kenny,J.W., Kee,Y.
            and Scheller,R.H.
  TITLE     The mammalian brain rsec6/8 complex
  JOURNAL   Neuron 17 (6), 1209-1219 (1996)
   PUBMED   8982167
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010442.7, AL545132.3,
            BC064569.1, AL832434.1, BC001511.2 and AA487875.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007277.4.
            
            Summary: The protein encoded by this gene is a component of the
            exocyst complex, a multiple protein complex essential for targeting
            exocytic vesicles to specific docking sites on the plasma membrane.
            Though best characterized in yeast, the component proteins and
            functions of exocyst complex have been demonstrated to be highly
            conserved in higher eukaryotes. At least eight components of the
            exocyst complex, including this protein, are found to interact with
            the actin cytoskeletal remodeling and vesicle transport machinery.
            The complex is also essential for the biogenesis of epithelial cell
            surface polarity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.898436.1, GU727644.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512944.6/ ENSP00000425587.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC010442.7         59217-59259         c
            44-101              AL545132.3         33-90
            102-387             BC064569.1         1-286
            388-2538            AL832434.1         1-2151
            2539-2797           BC001511.2         1908-2166
            2798-2801           AA487875.1         25-28               c
FEATURES             Location/Qualifiers
     source          1..2801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..2801
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /note="exocyst complex component 3"
                     /db_xref="GeneID:11336"
                     /db_xref="HGNC:HGNC:30378"
                     /db_xref="MIM:608186"
     exon            1..115
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            116..315
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2409
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /note="Sec 6 homolog; exocyst complex component Sec6;
                     SEC6-like 1"
                     /codon_start=1
                     /product="exocyst complex component 3"
                     /protein_id="NP_009208.2"
                     /db_xref="CCDS:CCDS54830.1"
                     /db_xref="GeneID:11336"
                     /db_xref="HGNC:HGNC:30378"
                     /db_xref="MIM:608186"
                     /translation="MKETDREAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVE
                     ARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDA
                     VVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMYEQY
                     RMDSGNTRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIER
                     EEKIDRRILDRKKQTGFVPPGRPKNWKEKMFTILERTVTTRIEGTQADTRESDKMWLV
                     RHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLNMYHQALSTRMQDLASEDLEAN
                     EIVSLLTWVLNTYTSTEMMRNVELAPEVDVGTLEPLLSPHVVSELLDTYMSTLTSNII
                     AWLRKALETDKKDWVKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKV
                     LVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHCYVQYMIAIINNCQTFKESIVSLK
                     RKYLKNEVEEGVSPSQPSMDGILDAIAKEGCSGLLEEVFLDLEQHLNELMTKKWLLGS
                     NAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSPEERK
                     EGAEKMVREAEQLRFLFRKLASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLV
                     SKYPDIRDDHIGALLAVRGDASRDMKQTIMETLEQGPAQASPSYVPLFKDIVVPSLNV
                     AKLLK"
     exon            316..535
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1217
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1335
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1461
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1562
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1673
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1824
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1947
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2109
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2237
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2801
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /note="hexamer: ATTAAA"
     polyA_site      2801
                     /gene="EXOC3"
                     /gene_synonym="SEC6; SEC6L1; Sec6p"
                     /note="major polyA site"
ORIGIN      
        1 acttccggcc gggaccccgg aggcggaggc agcgaaggcg gagggggcgg cgggggcggc
       61 ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg gcgtagccgt agaggtgcac
      121 agagaacacc cctagcatga acagtgtgag gattccacca gctttttcac catgaaggag
      181 acagaccggg aggccgttgc gacagcagtg caaagggttg ctgggatgct ccagcgcccg
      241 gaccagctgg acaaggtgga gcagtatcgc aggagagaag cgcggaagaa ggcctccgtg
      301 gaggccagat tgaaggccgc catccagtca cagttggacg gggtgcgcac aggcctcagc
      361 cagctccaca acgccctgaa tgacgtcaaa gacatccagc agtcgctggc agacgtcagc
      421 aaggactgga ggcagagcat caacaccatt gagagcctca aggacgtcaa agacgccgtg
      481 gtgcagcaca gccagctcgc cgcagccgtg gagaacctca agaacatctt ctcagtgcct
      541 gagattgtga gggagaccca ggacctaatt gaacaagggg cactcctgca agcccaccgg
      601 aagctgatgg acctggagtg ctcccgggac gggctgatgt acgagcagta ccgcatggac
      661 agtgggaaca cgcgtgacat gaccctcatc catggctact ttggcagcac gcaggggctc
      721 tctgatgagc tggctaagca gctgtggatg gtgctgcaga ggtcactggt cactgtccgc
      781 cgtgacccca ccttgctggt ctcagttgtc aggatcattg aaagggaaga gaaaattgac
      841 aggcgcatac ttgaccggaa aaagcaaact ggctttgttc ctcctgggag gcccaagaat
      901 tggaaggaga aaatgttcac catcttggag aggactgtga ccaccagaat tgagggcaca
      961 caggcagata ccagagagtc tgacaagatg tggcttgtcc gccacctgga aattataagg
     1021 aagtacgtcc tggatgacct cattgtcgcc aaaaacctga tggttcagtg ctttcctccc
     1081 cactatgaga tctttaagaa cctcctgaac atgtaccacc aagccctgag cacgcggatg
     1141 caggacctcg catcggaaga cctggaagcc aatgagatcg tgagcctctt gacgtgggtc
     1201 ttaaacacct acacaagtac tgagatgatg aggaacgtgg agctggcccc ggaagtggat
     1261 gtcggcaccc tggagccatt gctttctcca cacgtggtct ctgagctgct tgacacgtac
     1321 atgtccacgc tcacttcaaa catcatcgcc tggctgcgga aagcgctgga gacagacaag
     1381 aaagactggg tcaaagagac agagccagaa gccgaccagg acgggtacta ccagaccaca
     1441 ctccctgcca ttgtcttcca gatgtttgaa cagaatcttc aagttgctgc tcagataagt
     1501 gaagatttga aaacaaaggt actagtttta tgtcttcagc agatgaattc tttcctaagc
     1561 agatataaag atgaagcgca gctgtataaa gaagagcacc tgaggaatcg gcagcaccct
     1621 cactgctacg ttcagtacat gatcgccatc atcaacaact gccagacctt caaggaatcc
     1681 atagtcagtt taaaaagaaa gtatttaaag aatgaagtgg aagagggtgt gtctccgagc
     1741 cagcccagca tggacgggat tttagacgcc atcgcgaagg agggctgcag cggtttgctg
     1801 gaggaggtct tcctggacct ggagcaacat ctgaatgaat tgatgacgaa gaagtggcta
     1861 ttagggtcaa acgctgtaga cattatctgt gtcaccgtgg aagactattt caacgatttt
     1921 gccaaaatta aaaagccgta taagaagagg atgacggccg aggcgcaccg gcgcgtggtg
     1981 gtggagtacc tgcgggcggt catgcagaag cgcatttcct tccggagccc ggaggagcgc
     2041 aaggagggtg ccgagaagat ggttagggag gcagagcagc tgcgcttcct gttccggaag
     2101 ctggcgtccg gtttcgggga agacgtggac ggatactgcg acaccatcgt ggctgtggcc
     2161 gaagtgatca agctgacaga cccttctctg ctctacctgg aggtctccac tctggtcagc
     2221 aagtatccag acatcaggga tgaccacatc ggtgcgctgc tggctgtgcg tggggacgcc
     2281 agccgtgaca tgaagcagac catcatggag accctggagc agggcccagc acaggccagc
     2341 cccagctacg tgcccctctt caaggacatt gtggtgccca gcctgaacgt ggccaagctg
     2401 ctcaagtagc ctccgccggc ctgccctgct cgcccctcca cagcctcggt ccctgccttt
     2461 agaaacgcgg gacagctgat tgctctcctt ggccacacgt gctcctttta gctgcacggc
     2521 ctgtctttag gtgccagtgt gatgcaccgg gtgtgcgtcg agtgagcgtc ccgaggccac
     2581 gtgcggaggc ccctcactgt gctgtcaaag gcctgtgggt gcagggctct gccgcacagc
     2641 ctctcttggg tgcttgtttg ttgcagtggt tgaaagtgtg tggggcacag aggacgtgca
     2701 cctccctgcc ctcctcctcc ctgggccttc accgcacccc atctgcttaa gtgctcggaa
     2761 ccccgtcacc taattaaagt ttctcggctt cctcagagaa a
//
