LOCUS       NM_018303               4456 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens exocyst complex component 2 (EXOC2), transcript
            variant 1, mRNA.
ACCESSION   NM_018303
VERSION     NM_018303.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Halim,D.O., Krishnan,G., Hass,E.P., Lee,S., Verma,M., Almeida,S.,
            Gu,Y., Kwon,D.Y., Fazzio,T.G. and Gao,F.B.
  TITLE     The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC
            repeats in C9ORF72-ALS/FTD
  JOURNAL   Cell Rep 43 (7), 114375 (2024)
   PUBMED   38935506
  REMARK    GeneRIF: The exocyst subunit EXOC2 regulates the toxicity of
            expanded GGGGCC repeats in C9ORF72-ALS/FTD.
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4456)
  AUTHORS   Van Bergen,N.J., Ahmed,S.M., Collins,F., Cowley,M., Vetro,A.,
            Dale,R.C., Hock,D.H., de Caestecker,C., Menezes,M., Massey,S.,
            Ho,G., Pisano,T., Glover,S., Gusman,J., Stroud,D.A., Dinger,M.,
            Guerrini,R., Macara,I.G. and Christodoulou,J.
  TITLE     Mutations in the exocyst component EXOC2 cause severe defects in
            human brain development
  JOURNAL   J Exp Med 217 (10) (2020)
   PUBMED   32639540
  REMARK    GeneRIF: Mutations in the exocyst component EXOC2 cause severe
            defects in human brain development.
REFERENCE   4  (bases 1 to 4456)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4456)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4456)
  AUTHORS   Sjolinder,M., Uhlmann,J. and Ponstingl,H.
  TITLE     DelGEF, a homologue of the Ran guanine nucleotide exchange factor
            RanGEF, binds to the exocyst component Sec5 and modulates secretion
  JOURNAL   FEBS Lett 532 (1-2), 211-215 (2002)
   PUBMED   12459492
  REMARK    GeneRIF: SEC5 has been identified as a binding partner of deafness
            locus putative guanine nucleotide exchange factor.
REFERENCE   7  (bases 1 to 4456)
  AUTHORS   Sugihara,K., Asano,S., Tanaka,K., Iwamatsu,A., Okawa,K. and Ohta,Y.
  TITLE     The exocyst complex binds the small GTPase RalA to mediate
            filopodia formation
  JOURNAL   Nat Cell Biol 4 (1), 73-78 (2002)
   PUBMED   11744922
REFERENCE   8  (bases 1 to 4456)
  AUTHORS   Matern,H.T., Yeaman,C., Nelson,W.J. and Scheller,R.H.
  TITLE     The Sec6/8 complex in mammalian cells: characterization of
            mammalian Sec3, subunit interactions, and expression of subunits in
            polarized cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9648-9653 (2001)
   PUBMED   11493706
REFERENCE   9  (bases 1 to 4456)
  AUTHORS   Hsu,S.C., Hazuka,C.D., Roth,R., Foletti,D.L., Heuser,J. and
            Scheller,R.H.
  TITLE     Subunit composition, protein interactions, and structures of the
            mammalian brain sec6/8 complex and septin filaments
  JOURNAL   Neuron 20 (6), 1111-1122 (1998)
   PUBMED   9655500
REFERENCE   10 (bases 1 to 4456)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA228027.1, AK314628.1,
            AL512308.19 and AL833213.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018303.5.
            
            Summary: The protein encoded by this gene is a component of the
            exocyst complex, a multi-protein complex essential for the
            polarized targeting of exocytic vesicles to specific docking sites
            on the plasma membrane. Though best characterized in yeast, the
            component proteins and the functions of the exocyst complex have
            been demonstrated to be highly conserved in higher eukaryotes. At
            least eight components of the exocyst complex, including this
            protein, are found to interact with the actin cytoskeletal
            remodeling and vesicle transport machinery. This interaction has
            been shown to mediate filopodia formation in fibroblasts. This
            protein has been shown to interact with the Ral subfamily of
            GTPases and thereby mediate exocytosis by tethering vesicles to the
            plasma membrane. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the shorter,
            protein coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833213.1, AK056564.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230449.9/ ENSP00000230449.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               DA228027.1         3-222
            221-2939            AK314628.1         223-2941
            2940-4087           AL512308.19        77645-78792         c
            4088-4456           AL833213.1         4036-4404
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..4456
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /note="exocyst complex component 2"
                     /db_xref="GeneID:55770"
                     /db_xref="HGNC:HGNC:24968"
                     /db_xref="MIM:615329"
     exon            1..121
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            122..282
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2939
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /note="exocyst complex component Sec5; SEC5-like 1"
                     /codon_start=1
                     /product="exocyst complex component 2"
                     /protein_id="NP_060773.3"
                     /db_xref="CCDS:CCDS34327.1"
                     /db_xref="GeneID:55770"
                     /db_xref="HGNC:HGNC:24968"
                     /db_xref="MIM:615329"
                     /translation="MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTIC
                     GHNCLLTAEWMSASKIVCRVGQAKNDKGDIIVTTKSGGRGTSTVSFKLLKPEKIGILD
                     QSAVWVDEMNYYDMRTDRNKGIPPLSLRPANPLGIEIEKSKFSQKDLEMLFHGMSADF
                     TSENFSAAWYLIENHSNTSFEQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDA
                     LSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNV
                     LQRFKFLFNLPLNIERNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYYAEVETRIEA
                     LRELLLDKLLETPSTLHDQKRYIRYLSDLHASGDPAWQCIGAQHKWILQLMHSCKEGY
                     VKDLKGNPGLHSPMLDLDNDTRPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVA
                     FVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQIERSKNVRQRQNDFKKMIQE
                     VMHSLVKLTRGALLPLSIRDGEAKQYGGWEVKCELSGQWLAHAIQTVRLTHESLTALE
                     IPNDLLQTIQDLILDLRVRCVMATLQHTAEEIKRLAEKEDWIVDNEGLTSLPCQFEQC
                     IVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINIMQVFIYCLEQLSTKPDADID
                     TTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQG
                     IEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPTGVRNY
                     LKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLMQCVSSFSKNGALQARL
                     EICALRDTVAVYLTPESKSSFKQALEALPQLSSGADKKLLEELLNKFKSSMHLQLTCF
                     QAASSTMMKT"
     exon            283..459
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            460..586
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            587..700
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            701..825
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            826..906
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1052
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1134
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1237
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1356
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1482
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1607
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1673
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1831
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1953
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2015
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2096
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2156
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2218
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2285
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2402
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2544
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2600
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2723
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2785
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2845
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..4456
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3482..3487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /note="hexamer: ATTAAA"
     polyA_site      3513
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
     regulatory      4437..4442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /note="hexamer: AATAAA"
     polyA_site      4456
                     /gene="EXOC2"
                     /gene_synonym="NEDFACH; SEC5; SEC5L1; Sec5p"
                     /note="major polyA site"
ORIGIN      
        1 acacgctcgg cgctcgcggc gggcggaagt gaggtgccgg cggctggcgg ccgcggagtc
       61 ttcggcgaga cctaccgggc cctgtctgtg ccggccgtga gctgcggcag gacggctgga
      121 gattacttct ctaacaggat caccagtttg ctccacaaag cacaatgtct cgatcacgac
      181 aaccccccct tgtgaccggc atctctccaa atgaagggat accatggacg aaggtcacaa
      241 tcaggggaga aaatctgggg actggcccca ccgacctcat aggcttgacc atttgtggac
      301 ataattgcct cctgacggca gaatggatgt ctgcaagtaa aatagtatgt cgagtgggac
      361 aagccaaaaa tgacaaagga gacattattg tcaccactaa gtcaggtggc agaggaacct
      421 caacagtctc tttcaagcta ctcaaacctg agaaaatagg cattttggat cagtctgctg
      481 tgtgggttga tgaaatgaat tattatgata tgcgcactga caggaacaaa ggaattccgc
      541 ccttgtcctt acgtcctgct aacccgcttg gcattgagat tgaaaaaagt aaattttcgc
      601 agaaggactt agaaatgcta ttccatggaa tgagtgctga ttttacaagt gagaatttct
      661 cagcagcctg gtatcttata gagaatcact caaacaccag ttttgagcag ctcaaaatgg
      721 cagtcaccaa cctaaagaga caggctaaca agaagagtga gggcagcctg gcctatgtga
      781 aaggcggtct cagtacattc ttcgaagcac aggatgccct ctcagccatc catcaaaaac
      841 tagaagcaga tggaacggaa aaagtagaag gatccatgac gcagaaactg gagaatgttc
      901 tgaacagagc aagtaatact gcagacacat tgtttcaaga agtattaggt cggaaagaca
      961 aggcagattc cactagaaat gcactcaatg tgcttcagcg atttaagttt cttttcaacc
     1021 ttcctctaaa tattgaaagg aatattcaaa agggtgatta tgatgtggtt attaatgatt
     1081 atgaaaaggc caagtcactt tttgggaaaa cggaggtgca agttttcaag aaatattatg
     1141 ctgaagtaga aacaaggatt gaagctttaa gagaattact tctggataaa ttgcttgaga
     1201 caccatcaac tttacatgac caaaaacgtt acataaggta cctgtctgac cttcatgcgt
     1261 ctggtgaccc tgcttggcaa tgcattggag cccaacacaa gtggatcctt cagctcatgc
     1321 acagttgcaa agagggctac gtgaaagatc tgaaaggtaa cccaggcctg cacagtccca
     1381 tgttggatct tgataatgat acacgtccct cagtgttggg ccatctcagt cagacagcgt
     1441 ccctgaagag gggcagcagc tttcagtctg gtcgagacga cacgtggaga tacaaaactc
     1501 cccacagggt ggcctttgtt gaaaaattga caaaactcgt cttgagccag ctgcctaact
     1561 tctggaaact ctggatctcc tacgttaatg gaagcctctt cagtgagact gctgagaagt
     1621 caggccagat tgaaagatca aagaatgtaa ggcaaagaca aaatgatttt aagaaaatga
     1681 ttcaggaagt aatgcactcc ctggtgaagc ttacccgcgg agccctgctt cccctcagca
     1741 tccgggatgg ggaagccaag cagtacggag gctgggaggt gaagtgcgag ctctccggac
     1801 agtggctcgc tcacgccatc cagactgtaa gacttactca tgaatcgttg actgcccttg
     1861 aaattcctaa tgacctgtta cagactatcc aggatctcat cttggatctc cgagtacgtt
     1921 gcgtaatggc cacgttgcag cacacggcgg aagaaataaa gagattagct gaaaaagaag
     1981 actggattgt tgacaatgaa ggactgactt ctctaccatg tcagtttgaa cagtgcatcg
     2041 tgtgttctct gcagtcactg aagggggttc tggagtgcaa gccgggagag gccagtgtct
     2101 tccaacaacc taaaacacag gaggaggttt gccagctaag catcaatata atgcaggttt
     2161 ttatatactg tctggaacag ttgagcacca agcctgatgc agatatagat actacacatc
     2221 tctctgttga tgtttcttcc cctgacttgt ttggaagtat ccatgaagac ttcagcttga
     2281 cctcagaaca gcgccttttg atagtcctaa gtaattgctg ctatctagaa cgtcacacct
     2341 tcctaaatat cgcagaacat tttgaaaagc acaacttcca gggaatagaa aaaatcacac
     2401 aggttagcat ggcctcattg aaagaactag atcaaagact ctttgaaaat tacatcgagt
     2461 tgaaagcaga tcccatcgtt ggctccttag aacctggaat ttatgcagga tattttgatt
     2521 ggaaggactg cctgcctcca acaggtgtca gaaactattt aaaagaagca ctggtgaata
     2581 taattgccgt gcatgcagag gtgttcacca tttccaaaga actggtccct cgggtactat
     2641 ccaaggtgat agaagcagtt tctgaagagc tcagtcgact gatgcagtgt gtttcatcct
     2701 tcagcaaaaa tggagcttta caggcgagac ttgaaatctg tgctttgagg gacactgtgg
     2761 ctgtttacct gacacccgaa agcaagtcaa gttttaagca ggctttggaa gccctgcccc
     2821 agctttccag tggagcagat aaaaagttac tggaagagct cctgaacaag ttcaagagta
     2881 gcatgcactt gcagctcacc tgtttccaag cagcttcttc aaccatgatg aaaacataaa
     2941 tatctgccac ataaaagaag tccaggaaaa taacacgtaa taagactgtt cactctctaa
     3001 gtaccctaaa ggtatttggt gtattaaaca ttgggtttgc catttttctc ttttttcttc
     3061 ctctgacttc gaaaattgtt ggtatacatt tcaaccaaaa tgacctcatt tgaaatgccc
     3121 aggaagtatt tgttttgcca ttcttactag atcagatcct gtatgacttt aaaatacatt
     3181 ttaaaatata ttttgcatct cagcagaagg ttgagtgctg caggaagagc tgcttctgca
     3241 gggagttttc tggaatggcg tggcacatat tgaagcattt ctcagtgtcc cgttcacgga
     3301 agcgcaggca gctcccacga cacacggaga gactgactga tacgagattt ggaaagctat
     3361 gtagacatct ttggagctct tactgtccta aactgtacag ctgtgcttaa aaccctcatt
     3421 tcatataaat ggccttaagt tttctaattc aagcgggttt ttggaaaaat ttatggtctc
     3481 cattaaaata catattacaa ctggggtaga ttatttgtgg tccaggtgtc tgtgatttaa
     3541 ctttgcgttt tgctatctga tttttatttt tcacagggct aagcatgagc tttcattctc
     3601 actcactctt aatttgtcgt gcgtcactac acatgcacgt gttgcagtcc ctgaggccct
     3661 gtgtgttatc tgtgatggag tgtgaatgtg taacgggcac tgtgttacac tctgaggtgt
     3721 tggcggggcg gtcgcagact tcagggtccc ctaacggaaa ggccaggctc cgcgtggacg
     3781 gccaactccc tgcccgctcc ttcagcaggt gactgtctct gccacttctt acctgctgaa
     3841 ggatcttgct cagtagctgg aacaatgctg ctgtcacaca gtctcttctc tgaaacttca
     3901 ggatgctcct tggtcaccag gcaatgggag ctgtagacca gccgcatgca cttgccccac
     3961 attcactgct gactggcttc actggaatag gttcaggtca ccgggacttc tctcagagtc
     4021 agcggcccac ccaactccct cataccgtcg catctgaaaa ttttcagaga ggaattctct
     4081 ttgtagtcgg cttgtcaggg ttttcaagtt tttctatggt tatttttaaa tctctttttt
     4141 taaatgctaa aattaatgtc ctcattaatg caagtaattt tagagcacag tgtagccatg
     4201 tacagtttcc attatttaaa ataaataaat gtgttggttc atttggtgta tggggggaca
     4261 tcatggtaac tggaaatgaa agtttaatct ttcacaaatg tgcttgataa agctgttaag
     4321 aattgtcttt cctaagtatg ttaactgttg tatctaactc aactgtgagc taagtttaaa
     4381 aactgcaatc atgaatgttt gtgatatttt aaatatctac tacagcacat tcagccaata
     4441 aagaatctgc ctttaa
//
