LOCUS       NM_001351574             894 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens exocyst complex component 1 like (EXOC1L), transcript
            variant 1, mRNA.
ACCESSION   NM_001351574 NR_003935 XM_927355 XM_936785
VERSION     NM_001351574.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Venter,J.C., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J.,
            Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A., Holt,R.A.,
            Gocayne,J.D., Amanatides,P., Ballew,R.M., Huson,D.H., Wortman,J.R.,
            Zhang,Q., Kodira,C.D., Zheng,X.H., Chen,L., Skupski,M.,
            Subramanian,G., Thomas,P.D., Zhang,J., Gabor Miklos,G.L.,
            Nelson,C., Broder,S., Clark,A.G., Nadeau,J., McKusick,V.A.,
            Zinder,N., Levine,A.J., Roberts,R.J., Simon,M., Slayman,C.,
            Hunkapiller,M., Bolanos,R., Delcher,A., Dew,I., Fasulo,D.,
            Flanigan,M., Florea,L., Halpern,A., Hannenhalli,S., Kravitz,S.,
            Levy,S., Mobarry,C., Reinert,K., Remington,K., Abu-Threideh,J.,
            Beasley,E., Biddick,K., Bonazzi,V., Brandon,R., Cargill,M.,
            Chandramouliswaran,I., Charlab,R., Chaturvedi,K., Deng,Z., Di
            Francesco,V., Dunn,P., Eilbeck,K., Evangelista,C., Gabrielian,A.E.,
            Gan,W., Ge,W., Gong,F., Gu,Z., Guan,P., Heiman,T.J., Higgins,M.E.,
            Ji,R.R., Ke,Z., Ketchum,K.A., Lai,Z., Lei,Y., Li,Z., Li,J.,
            Liang,Y., Lin,X., Lu,F., Merkulov,G.V., Milshina,N., Moore,H.M.,
            Naik,A.K., Narayan,V.A., Neelam,B., Nusskern,D., Rusch,D.B.,
            Salzberg,S., Shao,W., Shue,B., Sun,J., Wang,Z., Wang,A., Wang,X.,
            Wang,J., Wei,M., Wides,R., Xiao,C., Yan,C., Yao,A., Ye,J., Zhan,M.,
            Zhang,W., Zhang,H., Zhao,Q., Zheng,L., Zhong,F., Zhong,W., Zhu,S.,
            Zhao,S., Gilbert,D., Baumhueter,S., Spier,G., Carter,C.,
            Cravchik,A., Woodage,T., Ali,F., An,H., Awe,A., Baldwin,D.,
            Baden,H., Barnstead,M., Barrow,I., Beeson,K., Busam,D., Carver,A.,
            Center,A., Cheng,M.L., Curry,L., Danaher,S., Davenport,L.,
            Desilets,R., Dietz,S., Dodson,K., Doup,L., Ferriera,S., Garg,N.,
            Gluecksmann,A., Hart,B., Haynes,J., Haynes,C., Heiner,C.,
            Hladun,S., Hostin,D., Houck,J., Howland,T., Ibegwam,C., Johnson,J.,
            Kalush,F., Kline,L., Koduru,S., Love,A., Mann,F., May,D.,
            McCawley,S., McIntosh,T., McMullen,I., Moy,M., Moy,L., Murphy,B.,
            Nelson,K., Pfannkoch,C., Pratts,E., Puri,V., Qureshi,H.,
            Reardon,M., Rodriguez,R., Rogers,Y.H., Romblad,D., Ruhfel,B.,
            Scott,R., Sitter,C., Smallwood,M., Stewart,E., Strong,R., Suh,E.,
            Thomas,R., Tint,N.N., Tse,S., Vech,C., Wang,G., Wetter,J.,
            Williams,S., Williams,M., Windsor,S., Winn-Deen,E., Wolfe,K.,
            Zaveri,J., Zaveri,K., Abril,J.F., Guigo,R., Campbell,M.J.,
            Sjolander,K.V., Karlak,B., Kejariwal,A., Mi,H., Lazareva,B.,
            Hatton,T., Narechania,A., Diemer,K., Muruganujan,A., Guo,N.,
            Sato,S., Bafna,V., Istrail,S., Lippert,R., Schwartz,R., Walenz,B.,
            Yooseph,S., Allen,D., Basu,A., Baxendale,J., Blick,L., Caminha,M.,
            Carnes-Stine,J., Caulk,P., Chiang,Y.H., Coyne,M., Dahlke,C.,
            Deslattes Mays,A., Dombroski,M., Donnelly,M., Ely,D., Esparham,S.,
            Fosler,C., Gire,H., Glanowski,S., Glasser,K., Glodek,A.,
            Gorokhov,M., Graham,K., Gropman,B., Harris,M., Heil,J.,
            Henderson,S., Hoover,J., Jennings,D., Jordan,C., Jordan,J.,
            Kasha,J., Kagan,L., Kraft,C., Levitsky,A., Lewis,M., Liu,X.,
            Lopez,J., Ma,D., Majoros,W., McDaniel,J., Murphy,S., Newman,M.,
            Nguyen,T., Nguyen,N., Nodell,M., Pan,S., Peck,J., Peterson,M.,
            Rowe,W., Sanders,R., Scott,J., Simpson,M., Smith,T., Sprague,A.,
            Stockwell,T., Turner,R., Venter,E., Wang,M., Wen,M., Wu,D., Wu,M.,
            Xia,A., Zandieh,A. and Zhu,X.
  TITLE     The sequence of the human genome
  JOURNAL   Science 291 (5507), 1304-1351 (2001)
   PUBMED   11181995
  REMARK    Erratum:[Science 2001 Jun 5;292(5523):1838]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110611.3.
            
            On Dec 30, 2019 this sequence version replaced NM_001351574.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN831484.1, SRR5189664.33317.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2142586 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636125.2/ ENSP00000490760.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC110611.3         34036-34393
            359-489             AC110611.3         45580-45710
            490-894             AC110611.3         51331-51735
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..894
                     /gene="EXOC1L"
                     /note="exocyst complex component 1 like"
                     /db_xref="GeneID:644145"
                     /db_xref="HGNC:HGNC:53433"
     exon            1..358
                     /gene="EXOC1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..756
                     /gene="EXOC1L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocyst -like pseudogene; exocyst complex component 1
                     pseudogene"
                     /codon_start=1
                     /product="exocyst complex component 1-like isoform 1"
                     /protein_id="NP_001338503.1"
                     /db_xref="CCDS:CCDS87223.1"
                     /db_xref="GeneID:644145"
                     /db_xref="HGNC:HGNC:53433"
                     /translation="MSSLVKEDLEKKLFKPLSQNLYEFIEIEFSVQDRYYLCVSVTKK
                     EEVKIVMVKHYRIGLDEKYEVTKKWSLNDLQMIDGKEADTDNPFFDLHFKKVYSLEAY
                     SCASKYAFARTVNKLNHAYLKKDLQIVNFDSTYINDDSIWSSNNKDCLVLMRICFYAF
                     NLVCLSLCPLPL"
     exon            359..489
                     /gene="EXOC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            490..894
                     /gene="EXOC1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      869..874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC1L"
                     /note="hexamer: AATAAA"
     polyA_site      894
                     /gene="EXOC1L"
                     /note="major polyA site"
ORIGIN      
        1 ttttggctgc cgccgccgct gctgccactg ggcagatacc gcagtgaggg gtctgaccgc
       61 gctgagtgct ctcgggaatc tgggctctgg ctaggaatga gaagttaaga gagggagggc
      121 tgagaggtgg gcaggactca ccaaggagct gcaaacccaa acgagaaatc tagggagcaa
      181 aaggagagga aagagtgagc ttgagccaag acatcaggcc aagtggaact ggaggaaatg
      241 tcatcattgg taaaggagga cttggagaag aaactgttta agccactctc gcagaatctg
      301 tacgagttta ttgaaataga gttctccgtc caggacaggt attacctctg tgtgtcagtg
      361 accaaaaagg aagaagtaaa aatagtcatg gtgaaacact acagaatagg tttagatgaa
      421 aaatatgaag taacaaaaaa gtggtctttg aacgatctgc agatgattga tggaaaagaa
      481 gcagatactg acaatccatt ttttgatctg cacttcaaga aagtgtacag tttggaagca
      541 tatagctgtg cttctaaata tgcctttgct cgaactgtaa ataagctgaa tcatgcatat
      601 cttaaaaagg acttacagat cgtgaacttt gattctacat acattaacga tgattccatt
      661 tggtcctcca acaataagga ttgtttggtc cttatgagaa tatgctttta cgctttcaat
      721 cttgtgtgct tgtccctatg tcccttgcca ctctgaagct gtgtaccaca ttccttcatc
      781 agtgacctat gaaaatggtt tcccaagtaa atattgattg tcataatttt gtttttcctt
      841 catcagtgat tattataatt taaataaaaa taaagtaatg ctttgtgaat tgca
//
