LOCUS       NM_001024924            3592 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens exocyst complex component 1 (EXOC1), transcript
            variant 3, mRNA.
ACCESSION   NM_001024924
VERSION     NM_001024924.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3592)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3592)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3592)
  AUTHORS   Qian,X., Zhou,X., Shentu,P., Yao,Y., Jiao,D., Chen,Q., Zhou,J. and
            Xu,Y.
  TITLE     Sec3 knockdown inhibits TGF-beta induced epithelial-mesenchymal
            transition through the down-regulation of Akt phosphorylation in
            A549 cells
  JOURNAL   Biochem Biophys Res Commun 519 (2), 253-260 (2019)
   PUBMED   31495494
  REMARK    GeneRIF: study provides evidence that Sec3 is involved in TGF-beta
            induced cell migration and epithelial-mesenchymal transition
            processes, presumably through the regulation of PI3K/Akt signaling
            activation in A549 cancer cells
REFERENCE   4  (bases 1 to 3592)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3592)
  AUTHORS   Lazniak,S., Roszak,A., Balcerek,A., Warenczak-Florczak,Z.,
            Prokop,E., Sowinska,A., Sotiri,E., Tsibulski,A., Sajdak,S. and
            Jagodzinski,P.P.
  TITLE     Role of rs13117307 single nuclear polymorphism in the risk of
            uterine cervical cancer from Polish population and its impact on
            exocyst complex component 1 expression
  JOURNAL   Gene 627, 524-529 (2017)
   PUBMED   28694212
  REMARK    GeneRIF: rs13117307 is associated with cervical squamous cell
            carcinoma.  rs13117307 SNP upregulated EXCO1 transcript levels in
            the non-cancerous cervical and in the cervical SCC tissue.
REFERENCE   6  (bases 1 to 3592)
  AUTHORS   Hsu,S.C., TerBush,D., Abraham,M. and Guo,W.
  TITLE     The exocyst complex in polarized exocytosis
  JOURNAL   Int Rev Cytol 233, 243-265 (2004)
   PUBMED   15037366
  REMARK    Review article
REFERENCE   7  (bases 1 to 3592)
  AUTHORS   Moskalenko,S., Tong,C., Rosse,C., Mirey,G., Formstecher,E.,
            Daviet,L., Camonis,J. and White,M.A.
  TITLE     Ral GTPases regulate exocyst assembly through dual subunit
            interactions
  JOURNAL   J Biol Chem 278 (51), 51743-51748 (2003)
   PUBMED   14525976
REFERENCE   8  (bases 1 to 3592)
  AUTHORS   Inoue,M., Chang,L., Hwang,J., Chiang,S.H. and Saltiel,A.R.
  TITLE     The exocyst complex is required for targeting of Glut4 to the
            plasma membrane by insulin
  JOURNAL   Nature 422 (6932), 629-633 (2003)
   PUBMED   12687004
REFERENCE   9  (bases 1 to 3592)
  AUTHORS   Matern,H.T., Yeaman,C., Nelson,W.J. and Scheller,R.H.
  TITLE     The Sec6/8 complex in mammalian cells: characterization of
            mammalian Sec3, subunit interactions, and expression of subunits in
            polarized cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9648-9653 (2001)
   PUBMED   11493706
REFERENCE   10 (bases 1 to 3592)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110611.3, BC094751.1,
            BM468054.1 and AW589689.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001024924.1.
            
            Summary: The protein encoded by this gene is a component of the
            exocyst complex, a multiple protein complex essential for targeting
            exocytic vesicles to specific docking sites on the plasma membrane.
            Though best characterized in yeast, the component proteins and
            functions of the exocyst complex have been demonstrated to be
            highly conserved in higher eukaryotes. At least eight components of
            the exocyst complex, including this protein, are found to interact
            with the actin cytoskeletal remodeling and vesicle transport
            machinery. Alternatively spliced transcript variants encoding
            distinct isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' UTR, as compared to variant 1. Variants 1 and 3 encode
            the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094751.1, SRR1803614.231929.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381295.7/ ENSP00000370695.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC110611.3         67894-67895
            3-167               BC094751.1         1-165
            168-800             BM468054.1         129-761
            801-3519            BC094751.1         799-3517
            3520-3584           AW589689.1         1-65                c
            3585-3592           AC110611.3         119325-119332
FEATURES             Location/Qualifiers
     source          1..3592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3592
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /note="exocyst complex component 1"
                     /db_xref="GeneID:55763"
                     /db_xref="HGNC:HGNC:30380"
                     /db_xref="MIM:607879"
     exon            1..306
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            307..440
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..3001
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /note="isoform 1 is encoded by transcript variant 3;
                     exocyst complex component Sec3; SEC3-like 1"
                     /codon_start=1
                     /product="exocyst complex component 1 isoform 1"
                     /protein_id="NP_001020095.1"
                     /db_xref="CCDS:CCDS3502.1"
                     /db_xref="GeneID:55763"
                     /db_xref="HGNC:HGNC:30380"
                     /db_xref="MIM:607879"
                     /translation="MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTT
                     ERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVA
                     SSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEY
                     QELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILM
                     KLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFL
                     VNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLLLAVKQQQQ
                     RFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLM
                     EWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIKMTGTTKESKKFATLPRKE
                     SAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSSSLLDMGNMSASDLDVADR
                     TKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQSMPGTMAEAEDLDGGTLSRQHNC
                     GTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQ
                     NVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFA
                     GLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANESQKTPRDVVMMENFHHIFATL
                     SRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIREEEV
                     SYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIR
                     QYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH"
     exon            441..571
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            572..731
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            732..919
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1147
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1280
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1390
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1540
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1646
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1691
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1855
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1963
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2040
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2269
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2453
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2653
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2848
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..3592
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3503..3508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /note="hexamer: AATAAA"
     polyA_site      3519
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /note="major polyA site"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
                     /note="hexamer: ATTAAA"
     polyA_site      3592
                     /gene="EXOC1"
                     /gene_synonym="BM-102; SEC3; SEC3L1; SEC3P"
ORIGIN      
        1 gagtttgtca cgtgcccgga tataggaagt gttgggggaa cggccgcttc ccgttcaacg
       61 ctttattgag gggcgtatcc tagtggcccc catccggtct ccgttttgga agacccgcct
      121 cggcacagcc aggctcagtc cggccttgcg gtaagccttc ggccgcggct gcccggtagt
      181 cccggcggcg gcggacagac gagctgacag gcaccagggt ctaaggcggc tcctcagtcc
      241 ggctgctgtc tccacgcctg gggtcgggca ccgctccttc tgaccttcct ttccccgttt
      301 gtcccgctga gaaaagatga cagcaatcaa gcatgcatta caaagagaca tttttacacc
      361 aaatgatgaa cgcctgctga gcattgtgaa tgtctgcaaa gcaggaaaaa agaaaaagaa
      421 ctgtttttta tgtgccacag tgacaactga acgccctgtg caggttaagg tggtcaaagt
      481 caagaaatcc gataagggag atttctacaa aaggcagatt gcatgggccc ttcgagatct
      541 tgctgtggta gatgccaaag atgctatcaa agaaaatcct gaatttgatt tacactttga
      601 aaaaatatat aaatgggttg ccagcagcac tgctgaaaag aatgcattta tttcatgcat
      661 ttggaaattg aatcagcgat atctccggaa gaaaattgat tttgtcaatg ttagctcaca
      721 gcttttggaa gaatctgttc caagtggaga aaatcagagt gtgacaggag gtgatgaaga
      781 agtagtagat gaataccaag agttaaatgc aagagaagaa caggatatcg aaataatgat
      841 ggaaggctgt gaatatgcaa tctcgaatgc ggaagccttt gcagaaaaat tgtccagaga
      901 gctgcaggtg ctagatgggg ctaacatcca gtcaatcatg gcatctgaaa aacaagtcaa
      961 catcctgatg aaattgctag atgaggctct aaaggaggta gatcagattg aattgaaact
     1021 gagcagttat gaggaaatgc tccaaagtgt aaaagaacaa atggatcaga tctctgaaag
     1081 caaccaccta attcatctta gtaacactaa taatgtaaaa ctcctatctg agatagagtt
     1141 ccttgtgaac cacatggact tggccaaagg tcatataaag gcccttcagg aaggagatct
     1201 tgcttcttcc agaggcattg aggcctgcac caatgctgct gatgcccttc tgcagtgcat
     1261 gaatgtagct cttcgaccag gccatgactt gcttctggca gtcaaacagc aacagcagcg
     1321 attcagtgat ttgcgagagc tttttgcccg gagactggcc agtcacctca acaatgtttt
     1381 tgttcaacag ggtcatgatc agagttcgac tcttgcccaa cactctgttg aactgacttt
     1441 acccaatcat catccatttc atagagattt gctccgatat gccaagctga tggagtggct
     1501 aaagagtaca gattatggaa aatatgaagg actaacaaag aattacatgg attatttatc
     1561 ccgactatat gaaagagaaa tcaaagattt ctttgaagtt gcaaagatca agatgactgg
     1621 cacaactaaa gaaagcaaga agtttgctac actgcctcga aaagaaagtg ctgtcaaaca
     1681 ggaaacagag agtcttcatg gaagttcggg gaaattaact ggatctactt ctagtctaaa
     1741 taagctcagt gttcagagtt cagggaatcg cagatctcag tcatcttccc tgttggatat
     1801 gggaaacatg tctgcctctg atctcgatgt tgctgacagg accaaatttg ataagatctt
     1861 tgaacaggta ctaagtgaac tggagcccct atgtctggca gaacaggact tcataagtaa
     1921 atttttcaaa ctacagcaac atcaaagtat gcctggaact atggctgaag cagaggacct
     1981 ggatggagga acattatcac ggcaacataa ttgtggcaca ccactgcctg tttcatctga
     2041 gaaagatatg atccgccaaa tgatgattaa aatatttcgc tgcattgagc cagagctgaa
     2101 caacctaatt gcattaggag acaaaattga tagctttaac tctctttata tgttagtcaa
     2161 aatgagtcat catgtgtgga ctgcacaaaa tgtggaccct gcttctttcc taagtactac
     2221 attgggaaat gttttggtga ctgtcaaaag gaactttgac aaatgcatta gtaaccaaat
     2281 aaggcaaatg gaagaagtaa agatctcaaa aaagagtaaa gttggaattc ttccatttgt
     2341 tgctgaattt gaagaatttg ctggacttgc agaatcaatc ttcaaaaatg ctgagcgtcg
     2401 tggagacctg gataaagcat acaccaaact tatcagagga gtatttgtta atgtggagaa
     2461 agtagcaaat gaaagccaga agacccccag ggatgtggtt atgatggaaa actttcacca
     2521 tatttttgca actctttctc gattgaaaat ctcatgtcta gaagcagaaa aaaaagaagc
     2581 caaacaaaaa tacacagatc accttcagtc ttatgtcatt tactctttag gacaacctct
     2641 tgaaaaacta aatcatttct ttgaaggtgt tgaagctcgc gtggcacagg gcataaggga
     2701 ggaggaagta agttaccaac ttgcatttaa caaacaagaa cttcgtaaag tcattaagga
     2761 gtaccctgga aaggaagtaa aaaaaggtct agataacctc tacaagaaag ttgataaaca
     2821 tttatgtgaa gaagagaact tacttcaggt ggtgtggcac tccatgcaag atgaatttat
     2881 acgccagtat aagcactttg aaggtttgat agctcgctgt tatcctggat ctggtgttac
     2941 aatggaattc actattcagg acattctgga ttattgttcc agcattgcac agtcccacta
     3001 aaccttgtga aagaagaaaa gataactgaa tgaagcattt gagtataaca gacactatac
     3061 caaaatacca agcaactgtt ttgagaaccc agacttaaaa ttttatgtat tattaaatgt
     3121 tagataaatg ggtagtacca tactacaaat atttaaatgc aaaattacca acctatatag
     3181 cagttttatt tgccctatag gttgcatact aacttaagca ttcatgtcac cataaaatgc
     3241 ctttagcatt tctcaatgac tggatgggaa attttccttt attgcctagc tgcttgtgtt
     3301 tgagtggttg tcctatgagc aatgcatttg gagttcttca gctttcacta cttctctgtt
     3361 gcttgctaat catgtaacta ctaaaatact gtacaaaatt gttttttcac actaacaaat
     3421 gtgtatatgg agaagagggc tcatgtgatg atcatttgtg aacttagatt tttgaggatt
     3481 atgtgactag taataaatgt gaaataaatt ttcaaaaaag ttgacatttg ataatatttt
     3541 taggtctatc atatgctgtc ttctgtatta aagcaagttc ttacaaaatc ca
//
