LOCUS       XM_011544321            3344 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens exonuclease 1 (EXO1), transcript variant
            X2, mRNA.
ACCESSION   XM_011544321
VERSION     XM_011544321.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011544321.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..3344
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /note="exonuclease 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 3 mRNAs, 38 ESTs, 1160
                     long SRA reads, 5 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     54 samples with support for all annotated introns"
                     /db_xref="GeneID:9156"
                     /db_xref="HGNC:HGNC:3511"
                     /db_xref="MIM:606063"
     CDS             465..3005
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /codon_start=1
                     /product="exonuclease 1 isoform X1"
                     /protein_id="XP_011542623.1"
                     /db_xref="GeneID:9156"
                     /db_xref="HGNC:HGNC:3511"
                     /db_xref="MIM:606063"
                     /translation="MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAE
                     KLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLK
                     GKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNK
                     AGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYM
                     CILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFI
                     RANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINT
                     FEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKE
                     NPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGN
                     KSLSFSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFC
                     SSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARNSSDDIPNN
                     HIPGDHIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSP
                     SPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREEACSSQSQESGEF
                     SLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLRLSHFSKKDTPLRNKVPG
                     LYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNF
                     GFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ"
ORIGIN      
        1 agcctttcgc gcgctgtgta ggcaagttac ccgtgttctg cgttgccggc cgtgggtgct
       61 ctggccacag tgagttaggg gcgtcggagc gggtttctcc aaccgcaatc ggctccgctc
      121 aaggggagga ggagagtccc ttctcggaag gcctaaggaa acgtgtcgtc tggaatgggc
      181 ttgggggcca cgcctgcaca tctccgcgag acagagggat aaagtgaaga tggtgctgtt
      241 attgttacct cgagtgccac atgcgacctc tgagatatgt acacagtcat tcttactatc
      301 gcactcagcc attcttacta cgctaaagaa gaaataatta ttcgaggata tttgcctggc
      361 ccagaagaaa cttatgtaaa tttcatgaac tattatatcc gttttcctcg gagtgagaga
      421 aaactctttt tagatatcat ctgagaggta gttaatttgg caccatgggg atacagggat
      481 tgctacaatt tatcaaagaa gcttcagaac ccatccatgt gaggaagtat aaagggcagg
      541 tagtagctgt ggatacatat tgctggcttc acaaaggagc tattgcttgt gctgaaaaac
      601 tagccaaagg tgaacctact gataggtatg taggattttg tatgaaattt gtaaatatgt
      661 tactatctca tgggatcaag cctattctcg tatttgatgg atgtacttta ccttctaaaa
      721 aggaagtaga gagatctaga agagaaagac gacaagccaa tcttcttaag ggaaagcaac
      781 ttcttcgtga ggggaaagtc tcggaagctc gagagtgttt cacccggtct atcaatatca
      841 cacatgccat ggcccacaaa gtaattaaag ctgcccggtc tcagggggta gattgcctcg
      901 tggctcccta tgaagctgat gcgcagttgg cctatcttaa caaagcggga attgtgcaag
      961 ccataattac agaggactcg gatctcctag cttttggctg taaaaaggta attttaaaga
     1021 tggaccagtt tggaaatgga cttgaaattg atcaagctcg gctaggaatg tgcagacagc
     1081 ttggggatgt attcacggaa gagaagtttc gttacatgtg tattctttca ggttgtgact
     1141 acctgtcatc actgcgtggg attggattag caaaggcatg caaagtccta agactagcca
     1201 ataatccaga tatagtaaag gttatcaaga aaattggaca ttatctcaag atgaatatca
     1261 cggtaccaga ggattacatc aacgggttta ttcgggccaa caataccttc ctctatcagc
     1321 tagtttttga tcccatcaaa aggaaactta ttcctctgaa cgcctatgaa gatgatgttg
     1381 atcctgaaac actaagctac gctgggcaat atgttgatga ttccatagct cttcaaatag
     1441 cacttggaaa taaagatata aatacttttg aacagatcga tgactacaat ccagacactg
     1501 ctatgcctgc ccattcaaga agtcatagtt gggatgacaa aacatgtcaa aagtcagcta
     1561 atgttagcag catttggcat aggaattact ctcccagacc agagtcgggt actgtttcag
     1621 atgccccaca attgaaggaa aatccaagta ctgtgggagt ggaacgagtg attagtacta
     1681 aagggttaaa tctcccaagg aaatcatcca ttgtgaaaag accaagaagt gcagagctgt
     1741 cagaagatga cctgttgagt cagtattctc tttcatttac gaagaagacc aagaaaaata
     1801 gctctgaagg caataaatca ttgagctttt ctgaagtgtt tgtgcctgac ctggtaaatg
     1861 gacctactaa caaaaagagt gtaagcactc cacctaggac gagaaataaa tttgcaacat
     1921 ttttacaaag gaaaaatgaa gaaagtggtg cagttgtggt tccagggacc agaagcaggt
     1981 ttttttgcag ttcagattct actgactgtg tatcaaacaa agtgagcatc cagcctctgg
     2041 atgaaactgc tgtcacagat aaagagaaca atctgcatga atcagagtat ggagaccaag
     2101 aaggcaagag actggttgac acagatgtag cacgtaattc aagtgatgac attccgaata
     2161 atcatattcc aggtgatcat attccagaca aggcaacagt gtttacagat gaagagtcct
     2221 actcttttga gagcagcaaa tttacaagga ccatttcacc acccactttg ggaacactaa
     2281 gaagttgttt tagttggtct ggaggtcttg gagatttttc aagaacgccg agcccctctc
     2341 caagcacagc attgcagcag ttccgaagaa agagcgattc ccccacctct ttgcctgaga
     2401 ataatatgtc tgatgtgtcg cagttaaaga gcgaggagtc cagtgacgat gagtctcatc
     2461 ccttacgaga agaggcatgt tcttcacagt cccaggaaag tggagaattc tcactgcaga
     2521 gttcaaatgc atcaaagctt tctcagtgct ctagtaagga ctctgattca gaggaatctg
     2581 attgcaatat taagttactt gacagtcaaa gtgaccagac ctccaagcta cgtttatctc
     2641 atttctcaaa aaaagacaca cctctaagga acaaggttcc tgggctatat aagtccagtt
     2701 ctgcagactc tctttctaca accaagatca aacctctagg acctgccaga gccagtgggc
     2761 tgagcaagaa gccggcaagc atccagaaga gaaagcatca taatgccgag aacaagccgg
     2821 ggttacagat caaactcaat gagctctgga aaaactttgg atttaaaaaa gattctgaaa
     2881 agcttcctcc ttgtaagaaa cccctgtccc cagtcagaga taacatccaa ctaactccag
     2941 aagcggaaga ggatatattt aacaaacctg aatgtggccg tgttcaaaga gcaatattcc
     3001 agtaaatgca gactgctgca aagcttttgc ctgcaagaga atctgatcaa tttgaagtcc
     3061 ctgtttggga atgaggcact tatcagcatg aagaattttt tctcattctg tgccatttta
     3121 aaaatagaat acattttgta tattaacttt ataattgggt tgtggttttt ttgctcagct
     3181 ttttatattt ttataagaag ctaaatagaa gaataattgt atctctgaca ggtttttgga
     3241 ggttttagtg ttaattggga aaatcctctg gagtttataa aagtctactc taaatatttc
     3301 tgtaatgttg tcaagtagaa agatagtaaa tggagaaact acaa
//
