LOCUS       NM_130398               3449 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens exonuclease 1 (EXO1), transcript variant 2, mRNA.
ACCESSION   NM_130398
VERSION     NM_130398.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3449)
  AUTHORS   Yang,H., Fouad,S., Smith,P., Bae,E.Y., Ji,Y., Lan,X., Van Ess,A.,
            Buffa,F.M., Fischer,R., Vendrell,I., Kessler,B.M. and
            D'Angiolella,V.
  TITLE     Cyclin F-EXO1 axis controls cell cycle-dependent execution of
            double-strand break repair
  JOURNAL   Sci Adv 10 (32), eado0636 (2024)
   PUBMED   39121215
  REMARK    GeneRIF: Cyclin F-EXO1 axis controls cell cycle-dependent execution
            of double-strand break repair.
REFERENCE   2  (bases 1 to 3449)
  AUTHORS   Garcia-Rodriguez,N., Dominguez-Garcia,I., Dominguez-Perez,M.D.C.
            and Huertas,P.
  TITLE     EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR
            activation and to maintain viability in BRCA1-deficient cells
  JOURNAL   Nucleic Acids Res 52 (11), 6376-6391 (2024)
   PUBMED   38721777
  REMARK    GeneRIF: EXO1 and DNA2-mediated ssDNA gap expansion is essential
            for ATR activation and to maintain viability in BRCA1-deficient
            cells.
REFERENCE   3  (bases 1 to 3449)
  AUTHORS   van de Kooij,B., Schreuder,A., Pavani,R., Garzero,V., Uruci,S.,
            Wendel,T.J., van Hoeck,A., San Martin Alonso,M., Everts,M.,
            Koerse,D., Callen,E., Boom,J., Mei,H., Cuppen,E.,
            Luijsterburg,M.S., van Vugt,M.A.T.M., Nussenzweig,A., van
            Attikum,H. and Noordermeer,S.M.
  TITLE     EXO1 protects BRCA1-deficient cells against toxic DNA lesions
  JOURNAL   Mol Cell 84 (4), 659-674 (2024)
   PUBMED   38266640
  REMARK    GeneRIF: EXO1 protects BRCA1-deficient cells against toxic DNA
            lesions.
REFERENCE   4  (bases 1 to 3449)
  AUTHORS   Wang,Z., Chao,Z., Wang,Q., Zou,F., Song,T., Xu,L., Ning,J. and
            Cheng,F.
  TITLE     EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate
            cancer progression
  JOURNAL   J Transl Med 22 (1), 104 (2024)
   PUBMED   38279172
  REMARK    GeneRIF: EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes
            prostate cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3449)
  AUTHORS   Li,M., Huang,F., Zhu,W., Peng,Y., Xu,F., Li,W., Zhao,Q. and Liu,L.
  TITLE     Dynamic regulation of EXO1 promotes the progression from liver
            fibrosis to HCC through TGF-beta1/Smad signaling feedback loop
  JOURNAL   Hepatol Commun 8 (1), e0342 (2023)
   PUBMED   38126949
  REMARK    GeneRIF: Dynamic regulation of EXO1 promotes the progression from
            liver fibrosis to HCC through TGF-beta1/Smad signaling feedback
            loop.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3449)
  AUTHORS   Qiu,J., Qian,Y., Chen,V., Guan,M.X. and Shen,B.
  TITLE     Human exonuclease 1 functionally complements its yeast homologues
            in DNA recombination, RNA primer removal, and mutation avoidance
  JOURNAL   J Biol Chem 274 (25), 17893-17900 (1999)
   PUBMED   10364235
REFERENCE   7  (bases 1 to 3449)
  AUTHORS   Tishkoff,D.X., Amin,N.S., Viars,C.S., Arden,K.C. and Kolodner,R.D.
  TITLE     Identification of a human gene encoding a homologue of
            Saccharomyces cerevisiae EXO1, an exonuclease implicated in
            mismatch repair and recombination
  JOURNAL   Cancer Res 58 (22), 5027-5031 (1998)
   PUBMED   9823303
REFERENCE   8  (bases 1 to 3449)
  AUTHORS   Schmutte,C., Marinescu,R.C., Sadoff,M.M., Guerrette,S.,
            Overhauser,J. and Fishel,R.
  TITLE     Human exonuclease I interacts with the mismatch repair protein
            hMSH2
  JOURNAL   Cancer Res 58 (20), 4537-4542 (1998)
   PUBMED   9788596
REFERENCE   9  (bases 1 to 3449)
  AUTHORS   Wilson,D.M. 3rd, Carney,J.P., Coleman,M.A., Adamson,A.W.,
            Christensen,M. and Lamerdin,J.E.
  TITLE     Hex1: a new human Rad2 nuclease family member with homology to
            yeast exonuclease 1
  JOURNAL   Nucleic Acids Res 26 (16), 3762-3768 (1998)
   PUBMED   9685493
REFERENCE   10 (bases 1 to 3449)
  AUTHORS   Holle,G.E.
  TITLE     [Pathophysiology of ulcer disease]
  JOURNAL   Langenbecks Arch Chir 366, 81-87 (1985)
   PUBMED   2414623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA661516.1, CN348533.1,
            BC007491.2, AL365366.20 and CA430743.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_130398.3.
            
            Summary: This gene encodes a protein with 5' to 3' exonuclease
            activity as well as an RNase H activity. It is similar to the
            Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and
            which is involved in mismatch repair and recombination. Alternative
            splicing of this gene results in three transcript variants encoding
            two different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) includes a unique exon in its
            5' UTR, as compared to variant 1. Both variants 1 and 2 encode
            isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007491.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366548.8/ ENSP00000355506.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA661516.1         15-23
            10-400              CN348533.1         8-398
            401-2577            BC007491.2         362-2538
            2578-2678           AL365366.20        106826-106926
            2679-2780           AL365366.20        109499-109600
            2781-2974           AL365366.20        112897-113090
            2975-3256           AL365366.20        117048-117329
            3257-3449           CA430743.1         17-209              c
FEATURES             Location/Qualifiers
     source          1..3449
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3449
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /note="exonuclease 1"
                     /db_xref="GeneID:9156"
                     /db_xref="HGNC:HGNC:3511"
                     /db_xref="MIM:606063"
     exon            1..150
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            151..447
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            448..552
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            553..730
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     CDS             570..3110
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /note="isoform b is encoded by transcript variant 2; rad2
                     nuclease family member, homolog of S. cerevisiae
                     exonuclease 1"
                     /codon_start=1
                     /product="exonuclease 1 isoform b"
                     /protein_id="NP_569082.2"
                     /db_xref="CCDS:CCDS1620.1"
                     /db_xref="GeneID:9156"
                     /db_xref="HGNC:HGNC:3511"
                     /db_xref="MIM:606063"
                     /translation="MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAE
                     KLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLK
                     GKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNK
                     AGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYM
                     CILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFI
                     RANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINT
                     FEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKE
                     NPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGN
                     KSLSFSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFC
                     SSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARNSSDDIPNN
                     HIPGDHIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSP
                     SPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREEACSSQSQESGEF
                     SLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLRLSHFSKKDTPLRNKVPG
                     LYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNF
                     GFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ"
     exon            731..850
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            851..974
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1112
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1325
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1513
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1610
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1836
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2083
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2678
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2780
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2974
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3449
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /note="hexamer: AATACA"
     polyA_site      3256
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /note="major polyA site"
     regulatory      3430..3435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
                     /note="hexamer: AGTAAA"
     polyA_site      3449
                     /gene="EXO1"
                     /gene_synonym="HEX1; hExoI"
ORIGIN      
        1 agcctttcgc gcgctgtgta ggcaagttac ccgtgttctg cgttgccggc cgtgggtgct
       61 ctggccacag tgagttaggg gcgtcggagc gggtttctcc aaccgcaatc ggctccgctc
      121 aaggggagga ggagagtccc ttctcggaag gcctaaggaa acgtgtcgtc tggaatgggc
      181 ttgggggcca cgcctgcaca tctccgcgag acagagggat aaagtgaaga tggtgctgtt
      241 attgttacct cgagtgccac atgcgacctc tgagatatgt acacagtcat tcttactatc
      301 gcactcagcc attcttacta cgctaaagaa gaaataatta ttcgaggata tttgcctggc
      361 ccagaagaaa cttatgtaaa tttcatgaac tattatatcc gttttcctcg gagtgagaga
      421 aaactctttt tagatatcat ctgagagaac tagtgaatcc cagtcactga gtggagttga
      481 gagtctaaga acctctgaaa tttgagaact gctggaccag agcctttaga gctctgataa
      541 ggtgtcaaca gggtagttaa tttggcacca tggggataca gggattgcta caatttatca
      601 aagaagcttc agaacccatc catgtgagga agtataaagg gcaggtagta gctgtggata
      661 catattgctg gcttcacaaa ggagctattg cttgtgctga aaaactagcc aaaggtgaac
      721 ctactgatag gtatgtagga ttttgtatga aatttgtaaa tatgttacta tctcatggga
      781 tcaagcctat tctcgtattt gatggatgta ctttaccttc taaaaaggaa gtagagagat
      841 ctagaagaga aagacgacaa gccaatcttc ttaagggaaa gcaacttctt cgtgagggga
      901 aagtctcgga agctcgagag tgtttcaccc ggtctatcaa tatcacacat gccatggccc
      961 acaaagtaat taaagctgcc cggtctcagg gggtagattg cctcgtggct ccctatgaag
     1021 ctgatgcgca gttggcctat cttaacaaag cgggaattgt gcaagccata attacagagg
     1081 actcggatct cctagctttt ggctgtaaaa aggtaatttt aaagatggac cagtttggaa
     1141 atggacttga aattgatcaa gctcggctag gaatgtgcag acagcttggg gatgtattca
     1201 cggaagagaa gtttcgttac atgtgtattc tttcaggttg tgactacctg tcatcactgc
     1261 gtgggattgg attagcaaag gcatgcaaag tcctaagact agccaataat ccagatatag
     1321 taaaggttat caagaaaatt ggacattatc tcaagatgaa tatcacggta ccagaggatt
     1381 acatcaacgg gtttattcgg gccaacaata ccttcctcta tcagctagtt tttgatccca
     1441 tcaaaaggaa acttattcct ctgaacgcct atgaagatga tgttgatcct gaaacactaa
     1501 gctacgctgg gcaatatgtt gatgattcca tagctcttca aatagcactt ggaaataaag
     1561 atataaatac ttttgaacag atcgatgact acaatccaga cactgctatg cctgcccatt
     1621 caagaagtca tagttgggat gacaaaacat gtcaaaagtc agctaatgtt agcagcattt
     1681 ggcataggaa ttactctccc agaccagagt cgggtactgt ttcagatgcc ccacaattga
     1741 aggaaaatcc aagtactgtg ggagtggaac gagtgattag tactaaaggg ttaaatctcc
     1801 caaggaaatc atccattgtg aaaagaccaa gaagtgcaga gctgtcagaa gatgacctgt
     1861 tgagtcagta ttctctttca tttacgaaga agaccaagaa aaatagctct gaaggcaata
     1921 aatcattgag cttttctgaa gtgtttgtgc ctgacctggt aaatggacct actaacaaaa
     1981 agagtgtaag cactccacct aggacgagaa ataaatttgc aacattttta caaaggaaaa
     2041 atgaagaaag tggtgcagtt gtggttccag ggaccagaag caggtttttt tgcagttcag
     2101 attctactga ctgtgtatca aacaaagtga gcatccagcc tctggatgaa actgctgtca
     2161 cagataaaga gaacaatctg catgaatcag agtatggaga ccaagaaggc aagagactgg
     2221 ttgacacaga tgtagcacgt aattcaagtg atgacattcc gaataatcat attccaggtg
     2281 atcatattcc agacaaggca acagtgttta cagatgaaga gtcctactct tttgagagca
     2341 gcaaatttac aaggaccatt tcaccaccca ctttgggaac actaagaagt tgttttagtt
     2401 ggtctggagg tcttggagat ttttcaagaa cgccgagccc ctctccaagc acagcattgc
     2461 agcagttccg aagaaagagc gattccccca cctctttgcc tgagaataat atgtctgatg
     2521 tgtcgcagtt aaagagcgag gagtccagtg acgatgagtc tcatccctta cgagaagagg
     2581 catgttcttc acagtcccag gaaagtggag aattctcact gcagagttca aatgcatcaa
     2641 agctttctca gtgctctagt aaggactctg attcagagga atctgattgc aatattaagt
     2701 tacttgacag tcaaagtgac cagacctcca agctacgttt atctcatttc tcaaaaaaag
     2761 acacacctct aaggaacaag gttcctgggc tatataagtc cagttctgca gactctcttt
     2821 ctacaaccaa gatcaaacct ctaggacctg ccagagccag tgggctgagc aagaagccgg
     2881 caagcatcca gaagagaaag catcataatg ccgagaacaa gccggggtta cagatcaaac
     2941 tcaatgagct ctggaaaaac tttggattta aaaaagattc tgaaaagctt cctccttgta
     3001 agaaacccct gtccccagtc agagataaca tccaactaac tccagaagcg gaagaggata
     3061 tatttaacaa acctgaatgt ggccgtgttc aaagagcaat attccagtaa atgcagactg
     3121 ctgcaaagct tttgcctgca agagaatctg atcaatttga agtccctgtt tgggaatgag
     3181 gcacttatca gcatgaagaa ttttttctca ttctgtgcca ttttaaaaat agaatacatt
     3241 ttgtatatta actttataat tgggttgtgg tttttttgct cagcttttta tatttttata
     3301 agaagctaaa tagaagaata attgtatctc tgacaggttt ttggaggttt tagtgttaat
     3361 tgggaaaatc ctctggagtt tataaaagtc tactctaaat atttctgtaa tgttgtcaag
     3421 tagaaagata gtaaatggag aaactacaa
//
