LOCUS       NM_017820               2781 bp    mRNA    linear   PRI 21-JUN-2024
DEFINITION  Homo sapiens exonuclease 3'-5' domain containing 3 (EXD3),
            transcript variant 1, mRNA.
ACCESSION   NM_017820
VERSION     NM_017820.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Sun,D., Liu,M., Huang,F. and Huang,F.
  TITLE     [Bioinformatics analysis of expression and function of EXD3 gene in
            gastric cancer]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 39 (2), 215-221 (2019)
   PUBMED   30890511
  REMARK    GeneRIF: EXD3 may be a potential oncogene in gastric cancer
            possibly in relation to DNA damage repair. The up-regulation of
            EXD3 plays an important role in the development and prognosis of
            gastric cancer, and may serve as an important indicator for
            prognostic evaluation of the patients.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK094438.1, HM005438.1, AL536907.3, BX322799.22, BC131749.1 and
            AI682614.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017820.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005438.1, AK094438.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340951.9/ ENSP00000340474.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AK094438.1         1-409
            410-573             HM005438.1         510-673
            574-754             AL536907.3         545-725
            755-755             BX322799.22        53035-53035         c
            756-840             AK094438.1         756-840
            841-841             BX322799.22        52949-52949         c
            842-1061            AK094438.1         842-1061
            1062-1062           BX322799.22        49360-49360         c
            1063-1729           AK094438.1         1063-1729
            1730-1730           BX322799.22        46061-46061         c
            1731-2371           AK094438.1         1731-2371
            2372-2590           BC131749.1         1698-1916
            2591-2781           AI682614.1         9-199               c
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2781
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /note="exonuclease 3'-5' domain containing 3"
                     /db_xref="GeneID:54932"
                     /db_xref="HGNC:HGNC:26023"
                     /db_xref="MIM:620859"
     exon            1..49
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            50..151
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2727
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /note="isoform a is encoded by transcript variant 1;
                     exonuclease 3'-5' domain-containing protein 3; exonuclease
                     mut-7 homolog; testicular tissue protein Li 125; nibbler
                     homolog"
                     /codon_start=1
                     /product="exonuclease mut-7 homolog isoform a"
                     /protein_id="NP_060290.3"
                     /db_xref="CCDS:CCDS48066.1"
                     /db_xref="GeneID:54932"
                     /db_xref="HGNC:HGNC:26023"
                     /db_xref="MIM:620859"
                     /translation="MDPGDPAGDPAAGERHRMGRDPLLLLQALQTLWSTRERKQLREE
                     AWRGFAALDDPLAGLLDMLESCRGQRGEGPSLAAWISHQLQCWLQAQPCPSLAQHSLR
                     LKQLQARAVKVLTESPPSLAAPLASIFQLQDADRSCLLAHVHRLHHEGRFREAATLGA
                     TLKLQSELGVEKMSIPLLLQDKVALVERYVAGFPDLQRRLLVLMDSWCQPGFDIKDVA
                     RRYPEVTSLSLEKLSPKALSRQVLRLQERYGVAPALCPNAAIQQRLAALRHLCHKRFV
                     EKSLSQENWTDHVQGLVGQSPWLQEQLSQLLVSHSDPVTAAQCAMELLLPEERLPAAV
                     AVELRRFRLQGRATEADSRLEVKDMKDRYYQLPIPRENVHLLASWEDLTRHEGALLQC
                     HQVVGVDVEWTPVFVAGGRPRPSLLQVAVEGHVFLLDVLALSQPPTGQGAQAFSRLVA
                     QLLSDPSITKLGYGMVGDLQKLGTSCPALAHVEKQILGGMDLLLVHRQMRVASVPAPA
                     VDRARELRGLSLLVQQVLGTALDKTQQLSNWDRRPLCEEQVIYAAADAYCLLEVHQAL
                     CREPARFHLSEDLAGSRRPRHRERPGARKPPGLQKASAPAAPRQVPVAVAVSEGAAPQ
                     IPARAFRVVCDNMLQGLARSLRCLGVDARMLGNGEDHRRAAEVARQEGRIILTSGQPF
                     HKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSR
                     DMMKQLMWLSSHQEGPRSSGDEATQSQAVQEPGPAPDAAPEGCTYDRPCRWLQMADLR
                     AETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDML
                     ESAPSPCEPSPAPSPASSPF"
     exon            152..216
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            217..390
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            391..558
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            559..612
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            613..752
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            753..853
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            854..927
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            928..966
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1133
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1269
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1480
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1590
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1753
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1926
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2094
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2148
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2280
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2374
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2413
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2781
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /note="hexamer: AATAAA"
     polyA_site      2781
                     /gene="EXD3"
                     /gene_synonym="mut-7; Nbr"
                     /note="major polyA site"
ORIGIN      
        1 aaggttccgc gccgggcgtg gacggtgtgg ggcggtcccg gccccgcaga tcctcgttcc
       61 tagctgcctg ccagcgtcct cggcccggcc ctgaggatgg acccaggaga tcccgctggt
      121 gaccctgccg ctggcgagcg ccaccgcatg ggccgggacc ccctcctgct cctgcaggcc
      181 ctgcagaccc tgtggtccac gcgggagcgg aagcagctcc gggaggaagc ctggcggggg
      241 tttgctgcct tggacgaccc cctggccggg cttctggaca tgctggagag ctgccggggc
      301 cagcggggag agggcccctc cctggcggcc tggatctccc accagctgca gtgctggcta
      361 caggcacagc catgcccgag cctggcccag cacagcctga ggctgaagca gctgcaggcc
      421 cgagcggtca aagtcctcac tgagagcccc cccagccttg cggcaccact ggccagcatc
      481 ttccagctgc aggatgcaga caggagctgc ctgctggcac acgtccaccg cctccaccac
      541 gagggcaggt tcagagaagc agccacgctg ggcgcgacgt tgaagctgca gtcggagctt
      601 ggcgttgaaa agatgagcat cccactgctc ctccaggaca aggtggccct cgtggagcgc
      661 tatgtggccg gcttcccgga cctccagagg aggctgctgg tcctcatgga ttcctggtgc
      721 cagcccggct ttgacatcaa ggacgttgcc agacggtacc ctgaggtgac ctccttgagc
      781 ctggagaagc tgagtccgaa ggcgctgagc aggcaggtct tgcgtctgca ggagcggtac
      841 ggcgtagccc cagcgctgtg tcccaacgcg gccattcagc agcgcctggc ggccctgcgg
      901 cacctgtgcc acaagcggtt tgtggagaag agcctgtcac aggagaactg gaccgaccat
      961 gtgcagggcc tggtggggca gagcccgtgg cttcaggagc agctgtctca gctgctggtc
     1021 tcccacagtg acccagtcac ggccgcccag tgtgccatgg aactcttgct gcccgaggag
     1081 cggctgccgg ctgcggtggc tgtggaactc cgccggttca ggctccaggg gagggcgact
     1141 gaggctgact cgaggctgga ggtgaaggac atgaaggacc gttactacca gctgcccatc
     1201 cccagggaga acgtccacct cctggcctcg tgggaagacc tgaccagaca cgagggtgca
     1261 ctcctgcagt gccaccaagt ggttggtgta gacgtggagt ggacacctgt gtttgttgct
     1321 gggggccggc ctcggccgtc actcctgcag gtggccgtgg agggccacgt gttccttctg
     1381 gacgtcctgg cactctcgca gccaccaaca gggcagggag cccaggcctt ttcccggctg
     1441 gtggcccagc tcctctcgga cccctctatc accaagctgg gctacgggat ggtgggggac
     1501 ctgcaaaaac tgggcacgtc ctgccccgcc ctggcccatg tggagaagca gattctgggc
     1561 ggcatggacc tgctgctggt gcacagacag atgcgggtgg cgagcgtgcc agccccagcc
     1621 gtggacaggg ccagggagct gaggggcctg agcctcctgg tgcagcaggt gctgggcaca
     1681 gccctggaca agacgcagca gctgtccaac tgggaccgga ggccgctctg cgaggagcag
     1741 gtcatctacg cagctgccga cgcctactgc ctgctggagg tgcaccaagc cctgtgcaga
     1801 gagcccgccc gcttccacct gtcggaggac ctggctggga gccggaggcc caggcacaga
     1861 gagagaccag gggcacggaa gccacccggc ctgcagaaag cgtcagcacc ggccgcaccc
     1921 aggcaggtcc ctgtggctgt ggctgtgtct gagggcgctg cccctcagat tccggccagg
     1981 gccttccgtg tggtgtgtga caacatgctg caggggctgg cacggagcct ccgctgtctc
     2041 ggtgtggatg cacgcatgct gggcaatggt gaagaccacc gcagggcggc cgaggttgcc
     2101 aggcaggagg ggaggatcat tctgacgtcg gggcagccat tccacaagct ccgggcccag
     2161 gtcggggctg ggcgctgcct ctcggtcgac tgctccctga aggcccagca gcaggccaag
     2221 gctgtgctca agcatttcaa cgtgcgtgtc acccacgcag acatcttcag ccgctgccag
     2281 gcctgtaact gtgaccagta cctaaaggtc tccagggaca tgatgaagca gctcatgtgg
     2341 ctcagcagtc accaggaggg gcccaggagc tcaggtgacg aggccaccca gagccaggcg
     2401 gtgcaggagc caggcccagc cccagacgca gcccctgagg gctgcaccta tgaccgcccc
     2461 tgccgctggc tgcagatggc tgacctgcgg gcggagacac cggacatgct ggccgacggc
     2521 acccggctgc agctggcagg ggtcccggtg ggtgtgctga ggacacctgg gctgcggtgc
     2581 ttctactgct gcacgggctg tggaaaggtc ttctgggacg gctcccacct gggtcgtgtt
     2641 gccacccact tccgagacat gctggagagc gcccccagcc cctgcgagcc gagcccagcc
     2701 cccagcccgg ccagcagtcc cttctgagga cagccagaca ataaacatgg aaagtgcccg
     2761 actgctgggc ccatggccgt g
//
