LOCUS       NM_001286441            3254 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens exonuclease 3'-5' domain containing 1 (EXD1),
            transcript variant 1, mRNA.
ACCESSION   NM_001286441 XM_005254207
VERSION     NM_001286441.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3254)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3254)
  AUTHORS   Pandey,R.R., Homolka,D., Olotu,O., Sachidanandam,R., Kotaja,N. and
            Pillai,R.S.
  TITLE     Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via
            Its Interaction with TDRD12
  JOURNAL   Cell Rep 24 (13), 3423-3432 (2018)
   PUBMED   30257204
REFERENCE   3  (bases 1 to 3254)
  AUTHORS   Yang,Z., Chen,K.M., Pandey,R.R., Homolka,D., Reuter,M.,
            Janeiro,B.K., Sachidanandam,R., Fauvarque,M.O., McCarthy,A.A. and
            Pillai,R.S.
  TITLE     PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from
            Cytosolic Targets of the Mouse piRNA Pathway
  JOURNAL   Mol Cell 61 (1), 138-152 (2016)
   PUBMED   26669262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC404441.1, AK302864.1, AC022408.6 and BC030628.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001286441.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302864.1, SRR18074967.527352.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2145743 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458580.7/ ENSP00000415056.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DC404441.1         1-66
            67-1714             AK302864.1         1-1648
            1715-2931           AC022408.6         122297-123513       c
            2932-3254           BC030628.2         2617-2939
FEATURES             Location/Qualifiers
     source          1..3254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3254
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /note="exonuclease 3'-5' domain containing 1"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
     exon            1..279
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..465
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..2051
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exonuclease 3'-5' domain-containing protein 1; exonuclease
                     3'-5' domain-like-containing protein 1; inactive
                     exonuclease EXD1; piRNA biogenesis protein EXD1"
                     /codon_start=1
                     /product="piRNA biogenesis protein EXD1 isoform 1"
                     /protein_id="NP_001273370.1"
                     /db_xref="CCDS:CCDS66738.1"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
                     /translation="MDPSSDYHFLSQILWKRVKLTLVCGVFEGVLQHVDPNKIVVLKK
                     VKNVETGRSVPGVKLFFGHEIVNVELLDEVEQGSVRAKASSVSLHAERTWMEKMKVED
                     LNVCEPASPAPEAPATSLLNDLKYSPSEEEEVTYTVINQFQQKFGAAILHIKKQNVLS
                     VAAEGANVCRHGKLCWLQVATNCRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDC
                     RWLSDCLSHQYGILLNNVFDTQVADVLQFSMETGGYLPNCITTLQESLIKHLQVAPKY
                     LSFLEKRQKLIQENPEVWFIRPVSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVD
                     GYLNTYREGSADRLGGTEPTCMELPEELLQLKDFQKQRREKAAREYRVNAQGLLIRTV
                     LQPKKLVTETAGKEEKVKGFLFGKNFRIDKAPSFTSQDFHGDVNLLKEESLNKQATNP
                     QHLPPTEEGETSEDSSNKLICTKSKGSEDQRITQKEHFMTPKHEFQASLSLKEETEQL
                     LMVENKEDLKCTKQAVSMSSFPQETRVSPSDTFYPIRKTVVSTLPPCPALEKIDSWIS
                     PFLNLP"
     exon            466..534
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..592
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..720
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..779
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..866
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..971
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1052
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1196
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1388
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..3254
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /note="hexamer: AATAAA"
     polyA_site      3254
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /note="major polyA site"
ORIGIN      
        1 agacgagact ggacgttggg ccgggcgggc gtcgcctctg cggcgtgtgt ccccggcgtc
       61 gcggaccttt ctccaggttt tcagcctgtg atttgataac cgccgccggg tggcgtggag
      121 cgtcccgaga cttcttcctt cattgcagcc cctcttcttt tagttctaga ctgaagttcg
      181 aggaacgcac cacttggctg aaattaggat ccagatttcc caaacttcct tcggaggaaa
      241 aagccctaac gatggaggac agtgaattcc tagcttatgt gtttggatgc ttaaagaaga
      301 ttatttgaag acggcttttg gaatcaatta gcatggaccc cagcagtgac taccatttcc
      361 tcagccagat tttgtggaag agggtgaaac tcacattggt ctgtggtgtc ttcgagggtg
      421 tgcttcagca tgttgaccct aataagattg ttgtcctgaa gaaagtgaag aatgtggaga
      481 caggtcgaag tgtcccagga gtgaagttgt tttttgggca tgagattgtg aatgtggaac
      541 tactagatga agtggaacaa ggctcagtga gagcaaaagc atcttctgtt agtctacatg
      601 cagaaagaac ctggatggag aaaatgaaag ttgaagacct aaatgtatgt gagcctgctt
      661 ctcctgcccc tgaagcacca gctacctctc tgctgaatga cctcaagtac agcccatcag
      721 aggaagagga ggtgacatac acagtcatta atcaattcca gcagaagttt ggtgctgcga
      781 tactccatat caagaagcag aatgtcctga gtgtggcagc agaaggagcg aatgtatgtc
      841 gccatggcaa actgtgctgg ctgcaggtgg ccacaaattg ccgagtttac ttatttgaca
      901 ttttccttct gggaagtcga gctttccaca atggacttca gatgatacta gaagacaaga
      961 gaattttgaa ggttatccat gattgtcgtt ggctttctga ttgcctctct catcagtatg
     1021 gaattttgct gaataatgtc tttgacacac aggtagcaga tgtacttcag ttttccatgg
     1081 aaacgggtgg ctatcttcca aactgcatca ctactttgca ggagagttta atcaaacacc
     1141 ttcaagtagc ccctaaatat ctctcctttc tagaaaagag acaaaaacta attcaggaaa
     1201 atccagaagt atggttcatc cgacctgttt caccctcttt actgaaaatt ttggccctgg
     1261 aagctaccta cctgttaccc cttcgcttgg cactcctaga tgagatgatg tctgacctaa
     1321 ccaccctggt ggatggttac ctaaacacgt atcgcgaagg gtctgcagac cggcttggag
     1381 gcactgagcc tacatgtatg gagctgccag aggaactgct tcaactcaag gacttccaga
     1441 agcagcgcag ggagaaagct gcaagagaat atagggtgaa tgcacaggga ctcctgataa
     1501 ggacagtgct acagccaaag aaattagtga cagagacagc agggaaagag gagaaagtca
     1561 aaggcttctt atttggtaaa aattttagga tagataaagc tccaagtttt acatctcaag
     1621 actttcacgg ggatgtgaat ttactgaaag aagaatcttt gaataaacaa gctacaaatc
     1681 ctcaacatct acctcccaca gaggaagggg aaaccagtga ggattccagt aacaaactca
     1741 tttgcacaaa gtcaaagggg tcagaggacc agagaataac tcagaaagaa cactttatga
     1801 cacccaaaca tgagtttcag gcaagtttat ctttgaaaga ggagacagaa cagttattga
     1861 tggtggaaaa caaggaagat ttaaaatgca caaaacaggc tgtttcaatg tcttcctttc
     1921 ctcaggaaac cagagtgtct ccaagtgaca ctttttatcc tatcagaaag actgtggttt
     1981 ccacactccc tccctgtcca gccttggaga agatcgattc ctggataagt ccttttctaa
     2041 atctgcccta gagatgggca gtttgttctt aaggccatac agatggctta tttcctttgc
     2101 catcagggct ttccacagtg cccaggtttc tcatgttgta aatgtagtaa tgcttcagtc
     2161 acaggggaaa attatatcct cttgcttact cctgtgttcc tggtatgcgg agaatgagaa
     2221 tgaataagtt aaataatgga agaagtataa tttctgatta tgtcactgtg tagaaatgtt
     2281 ctcagtgacc agagtgcatt atttttcata atttgggttt agaggatttg aagaaaggaa
     2341 gaatcttggg cttagtatca ggaagactcc atcattttca aattttgttt tgcttcttga
     2401 cttttggatt cctttgaaga gacctggtaa aactattaac aattcattta aaaaattggt
     2461 acctgataac tttaccagta cttttttcct ttttatttat ttgttttatt tatttttttt
     2521 taccgctcct tgtggagcag ggctacacca taggcagtgt gcccagagta accacttttt
     2581 tcctttttaa aatataatat taactttatg tttgaatgtt gaatgttttg tctgtctctt
     2641 aggcaaataa tgttatagga atcaataatt taatttttgt tttatttgtt ttttgatgga
     2701 gtctcactct gtcacccagg ctggagtgta gtggtgtaat ctctgctcac tgcaacctcc
     2761 gcctcccggg ttcaagcaat tctcctgcct cagcctcctg agtagctggg attacaggtg
     2821 cgtgccacca cgcccggcta atttttgtat ttttagtaga gatggggttt caccatgttg
     2881 gccaggctgg tctcgaactc ctgactgacc ttgtggtcca cctgcctttg gcttccaaag
     2941 tgctgggatt acaggtgtga ggcacggtgc ccagccaata tctttatttt aatttgtttt
     3001 tatttccttt atttttagct ggttttgtcc attttcctaa caaagcaggg accctgggtt
     3061 tctttttagt ctgtctgtta tataaacttg aagcctgact ccattctatt tgcctggagt
     3121 tagtatactt tcttagggtg aaaggaaggc agcttgtatt gagcctttta aagtattgaa
     3181 tgcttgcaaa ttgctaacat tcttttgtgt aaaataacca ataaacctgt tttgtcatac
     3241 tctacttaaa aaaa
//
