LOCUS       NP_001273370             572 aa            linear   PRI 29-APR-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform 1 [Homo sapiens].
ACCESSION   NP_001273370 XP_005254264
VERSION     NP_001273370.1
DBSOURCE    REFSEQ: accession NM_001286441.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 572)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 572)
  AUTHORS   Pandey,R.R., Homolka,D., Olotu,O., Sachidanandam,R., Kotaja,N. and
            Pillai,R.S.
  TITLE     Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via
            Its Interaction with TDRD12
  JOURNAL   Cell Rep 24 (13), 3423-3432 (2018)
   PUBMED   30257204
REFERENCE   3  (residues 1 to 572)
  AUTHORS   Yang,Z., Chen,K.M., Pandey,R.R., Homolka,D., Reuter,M.,
            Janeiro,B.K., Sachidanandam,R., Fauvarque,M.O., McCarthy,A.A. and
            Pillai,R.S.
  TITLE     PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from
            Cytosolic Targets of the Mouse piRNA Pathway
  JOURNAL   Mol Cell 61 (1), 138-152 (2016)
   PUBMED   26669262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC404441.1, AK302864.1, AC022408.6 and BC030628.2.
            
            On Nov 5, 2013 this sequence version replaced XP_005254264.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302864.1, SRR18074967.527352.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2145743 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458580.7/ ENSP00000415056.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     Protein         1..572
                     /product="piRNA biogenesis protein EXD1 isoform 1"
                     /note="exonuclease 3'-5' domain-containing protein 1;
                     exonuclease 3'-5' domain-like-containing protein 1;
                     inactive exonuclease EXD1; piRNA biogenesis protein EXD1"
                     /calculated_mol_wt=64691
     Region          147..345
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(162..165,216..217,219..221,261..262,306,310)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(162,164,221,306,310)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(163..165,216..217,219..220,261..262,306,310)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..572
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="NM_001286441.2:333..2051"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS66738.1"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 mdpssdyhfl sqilwkrvkl tlvcgvfegv lqhvdpnkiv vlkkvknvet grsvpgvklf
       61 fgheivnvel ldeveqgsvr akassvslha ertwmekmkv edlnvcepas papeapatsl
      121 lndlkyspse eeevtytvin qfqqkfgaai lhikkqnvls vaaeganvcr hgklcwlqva
      181 tncrvylfdi fllgsrafhn glqmiledkr ilkvihdcrw lsdclshqyg illnnvfdtq
      241 vadvlqfsme tggylpncit tlqeslikhl qvapkylsfl ekrqkliqen pevwfirpvs
      301 psllkilale atyllplrla lldemmsdlt tlvdgylnty regsadrlgg teptcmelpe
      361 ellqlkdfqk qrrekaarey rvnaqgllir tvlqpkklvt etagkeekvk gflfgknfri
      421 dkapsftsqd fhgdvnllke eslnkqatnp qhlppteege tsedssnkli ctkskgsedq
      481 ritqkehfmt pkhefqasls lkeeteqllm venkedlkct kqavsmssfp qetrvspsdt
      541 fypirktvvs tlppcpalek idswispfln lp
//
