LOCUS       NM_001989               2858 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens even-skipped homeobox 1 (EVX1), transcript variant 1,
            mRNA.
ACCESSION   NM_001989
VERSION     NM_001989.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Mallak,A.J., Abbaszadegan,M.R., Khorasanizadeh,P.N. and
            Forghanifard,M.M.
  TITLE     Contribution of EVX1 in Aggressiveness of Esophageal Squamous Cell
            Carcinoma
  JOURNAL   Pathol Oncol Res 22 (2), 341-347 (2016)
   PUBMED   26552663
  REMARK    GeneRIF: Low EVX1 expression is Correlated with Aggressiveness of
            Esophageal Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Franceschini,N., Fox,E., Zhang,Z., Edwards,T.L., Nalls,M.A.,
            Sung,Y.J., Tayo,B.O., Sun,Y.V., Gottesman,O., Adeyemo,A.,
            Johnson,A.D., Young,J.H., Rice,K., Duan,Q., Chen,F., Li,Y.,
            Tang,H., Fornage,M., Keene,K.L., Andrews,J.S., Smith,J.A.,
            Faul,J.D., Guangfa,Z., Guo,W., Liu,Y., Murray,S.S., Musani,S.K.,
            Srinivasan,S., Velez Edwards,D.R., Wang,H., Becker,L.C., Bovet,P.,
            Bochud,M., Broeckel,U., Burnier,M., Carty,C., Chasman,D.I.,
            Ehret,G., Chen,W.M., Chen,G., Chen,W., Ding,J., Dreisbach,A.W.,
            Evans,M.K., Guo,X., Garcia,M.E., Jensen,R., Keller,M.F., Lettre,G.,
            Lotay,V., Martin,L.W., Moore,J.H., Morrison,A.C., Mosley,T.H.,
            Ogunniyi,A., Palmas,W., Papanicolaou,G., Penman,A., Polak,J.F.,
            Ridker,P.M., Salako,B., Singleton,A.B., Shriner,D., Taylor,K.D.,
            Vasan,R., Wiggins,K., Williams,S.M., Yanek,L.R., Zhao,W.,
            Zonderman,A.B., Becker,D.M., Berenson,G., Boerwinkle,E.,
            Bottinger,E., Cushman,M., Eaton,C., Nyberg,F., Heiss,G.,
            Hirschhron,J.N., Howard,V.J., Karczewsk,K.J., Lanktree,M.B.,
            Liu,K., Liu,Y., Loos,R., Margolis,K., Snyder,M., Psaty,B.M.,
            Schork,N.J., Weir,D.R., Rotimi,C.N., Sale,M.M., Harris,T.,
            Kardia,S.L., Hunt,S.C., Arnett,D., Redline,S., Cooper,R.S.,
            Risch,N.J., Rao,D.C., Rotter,J.I., Chakravarti,A., Reiner,A.P.,
            Levy,D., Keating,B.J. and Zhu,X.
  CONSRTM   Asian Genetic Epidemiology Network Consortium
  TITLE     Genome-wide association analysis of blood-pressure traits in
            African-ancestry individuals reveals common associated genes in
            African and non-African populations
  JOURNAL   Am J Hum Genet 93 (3), 545-554 (2013)
   PUBMED   23972371
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Kalisz,M., Winzi,M., Bisgaard,H.C. and Serup,P.
  TITLE     EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by
            directly repressing GOOSECOID expression
  JOURNAL   Dev Biol 362 (1), 94-103 (2012)
   PUBMED   22178155
  REMARK    GeneRIF: Even-skipped homeobox 1 controls human embryonic stem cell
            differentiation by directly repressing Goosecoid expression.
REFERENCE   5  (bases 1 to 2858)
  AUTHORS   Smith,N.L., Felix,J.F., Morrison,A.C., Demissie,S., Glazer,N.L.,
            Loehr,L.R., Cupples,L.A., Dehghan,A., Lumley,T., Rosamond,W.D.,
            Lieb,W., Rivadeneira,F., Bis,J.C., Folsom,A.R., Benjamin,E.,
            Aulchenko,Y.S., Haritunians,T., Couper,D., Murabito,J., Wang,Y.A.,
            Stricker,B.H., Gottdiener,J.S., Chang,P.P., Wang,T.J., Rice,K.M.,
            Hofman,A., Heckbert,S.R., Fox,E.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Rotter,J.I., Willerson,J.T., Levy,D., van
            Duijn,C.M., Psaty,B.M., Witteman,J.C., Boerwinkle,E. and Vasan,R.S.
  TITLE     Association of genome-wide variation with the risk of incident
            heart failure in adults of European and African ancestry: a
            prospective meta-analysis from the cohorts for heart and aging
            research in genomic epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 3 (3), 256-266 (2010)
   PUBMED   20445134
REFERENCE   6  (bases 1 to 2858)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2858)
  AUTHORS   Briata,P., Van De Werken,R., Airoldi,I., Ilengo,C., Di Blas,E.,
            Boncinelli,E. and Corte,G.
  TITLE     Transcriptional repression by the human homeobox protein EVX1 in
            transfected mammalian cells
  JOURNAL   J Biol Chem 270 (46), 27695-27701 (1995)
   PUBMED   7499236
  REMARK    Erratum:[J Biol Chem 1996 Aug 2;271(31):19008]
REFERENCE   8  (bases 1 to 2858)
  AUTHORS   Faiella,A., D'Esposito,M., Rambaldi,M., Acampora,D., Balsofiore,S.,
            Stornaiuolo,A., Mallamaci,A., Migliaccio,E., Gulisano,M. and
            Simeone,A.
  TITLE     Isolation and mapping of EVX1, a human homeobox gene homologous to
            even-skipped, localized at the 5' end of HOX1 locus on chromosome 7
  JOURNAL   Nucleic Acids Res 19 (23), 6541-6545 (1991)
   PUBMED   1684419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004080.2, X60655.1 and
            KF458418.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001989.4.
            
            Summary: This gene encodes a member of the even-skipped homeobox
            family characterized by the presence of a homeodomain closely
            related to the Drosophila even-skipped (eve) segmentation gene of
            the pair-rule class. The encoded protein may play an important role
            as a transcriptional repressor during embryogenesis. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000496902.7/ ENSP00000419266.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC004080.2         116172-116257
            87-1460             X60655.1           86-1459
            1461-2482           AC004080.2         119803-120824
            2483-2858           KF458418.1         153-528             c
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2858
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /note="even-skipped homeobox 1"
                     /db_xref="GeneID:2128"
                     /db_xref="HGNC:HGNC:3506"
                     /db_xref="MIM:142996"
     exon            1..656
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1453
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /note="isoform 1 is encoded by transcript variant 1; eve,
                     even-skipped homeo box homolog 1; even-skipped homeo box 1
                     (homolog of Drosophila); homeobox even-skipped homolog
                     protein 1; eve, even-skipped homeobox homolog 1"
                     /codon_start=1
                     /product="homeobox even-skipped homolog protein 1 isoform
                     1"
                     /protein_id="NP_001980.1"
                     /db_xref="CCDS:CCDS5413.1"
                     /db_xref="GeneID:2128"
                     /db_xref="HGNC:HGNC:3506"
                     /db_xref="MIM:142996"
                     /translation="MESRKDMVVFLDGGQLGTLVGKRVSNLSEAVGSPLPEPPEKMVP
                     RGCLSPRAVPPATRERGGGGPEEEPVDGLAGSAAGPGAEPQVAGAAMLGPGPPAPSVD
                     SLSGQGQPSSSDTESDFYEEIEVSCTPDCATGNAEYQHSKGSGSEALVGSPNGGSETP
                     KSNGGSGGGGSQGTLACSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAA
                     ALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAAGGLPYPFPSH
                     LPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPG
                     PAHGLGASAGGPCSCLACHSGPANGLAPRAAAASDFTCASTSRSDSFLTFAPSVLSKA
                     SSVALDQREEVPLTR"
     exon            657..913
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..2858
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /note="hexamer: AATAAA"
     polyA_site      2858
                     /gene="EVX1"
                     /gene_synonym="EVX-1"
                     /note="major polyA site"
ORIGIN      
        1 agaggcggtg cggcacagag gagcgctcgc ttcacaaggt gaccctagct cccaccgcca
       61 ccgccgcggt cgcggtccag accgcgctcc agcagctccg cgccctccca ggcacccggc
      121 ctttctttct ccctcttgca accaagatcc gtccggccgc tggagaccca gggagccggg
      181 gttaggaact cacttggggc tttcccctcc cccaccggag agccccggga tggagagccg
      241 aaaggacatg gttgtgtttc tggatggggg tcagcttggc actctggttg gcaagagagt
      301 ctcaaatttg tccgaagccg tgggcagccc gctgccggag ccgcccgaga aaatggtgcc
      361 ccgtggttgc ctgagccctc gggccgtccc tccggccacc cgggagcgcg gcgggggagg
      421 cccggaggag gagccggtag atggactcgc aggcagcgcg gcggggccgg gcgccgagcc
      481 ccaggtagct ggggcggcca tgctcggccc aggacccccg gccccctcag tcgacagcct
      541 ctccggacag gggcaaccca gtagctcgga caccgagtcg gatttctatg aagaaatcga
      601 ggtgagctgc accccggact gcgccaccgg gaacgccgag taccagcaca gcaaagggtc
      661 cggctccgag gcgctggtcg gcagtccgaa cggagggagc gagaccccca agagcaacgg
      721 cggcagtggt gggggcggct cgcaaggcac cctggcgtgc agcgccagtg accagatgcg
      781 tcgttaccgc accgccttca cccgagagca gattgcgcgg ctggagaagg aattctaccg
      841 ggagaactac gtatccaggc cgcggagatg tgagctggcg gccgccctaa acctgccgga
      901 aaccaccatc aaggtgtggt tccagaaccg gcgcatgaag gacaagcggc agcgcctggc
      961 catgacgtgg ccgcacccgg cggaccccgc cttctacact tacatgatga gccatgcggc
     1021 ggccgcgggc ggcctgccct accccttccc atcgcacctg cccctgccct actactcgcc
     1081 ggtgggcctg ggcgccgcat ccgccgcctc cgccgccgcc tcgcccttca gcggctcgct
     1141 gcgcccgctc gacacgttcc gcgtgctgtc gcagccctac ccgcggcccg aactgctgtg
     1201 cgccttccgc cacccgccgc tctaccccgg gcccgcgcac ggactgggcg cctctgccgg
     1261 cggcccctgc tcctgcctcg cctgtcacag cggcccggcc aacgggctgg cgccccgggc
     1321 tgccgccgcc tcggacttca cctgtgcctc cacctcccgc tcggactcct tcctcacctt
     1381 cgcgccctcg gtgctcagca aggcctcctc cgtcgcgctg gaccagaggg aggaggtgcc
     1441 cctcactaga taaggggccg ccggctggct gccggctcca tgacgcccgt ggggtcaccc
     1501 cccggccccg ggactcagcc agcctcgctc ctcgctcctc gctcctcgcc cctaggacgc
     1561 caagggggaa aggagagggc ggaaaaggac cagcgggatc cggccgcaag aattggaaag
     1621 cctaggaagt ggcggtggct ggcgcgtttg gggagcagga gtggggatag ggaagcagag
     1681 cttgagagac cttcctccgg ggcagcctcc ggacccaccg ccccccacca gggtcgaggc
     1741 tgtagctcca aagctaaaca aaacttagca gcaacagcaa ccaatatcca gtccctcggc
     1801 ccctcggccc ctcaccctcc acctcacact cccttctcac cgggccccct ctccccagcc
     1861 aaggcccaag cactggaaag ggaaattgct gtctctctga acaaaatgct gtgtatgcag
     1921 agcaggtaga gattaatctt tgccagcttt tccaaggcat gacaaggggc tggtggatgg
     1981 caacatacca gtcatttgga ggagagagtg agagatgatt tactaccagg gagaatccag
     2041 ccccttggca tgggacctgg agcctcgact acacagcatc ttctgggtct ggcgtctgcc
     2101 agcacctgat ctctttcctc attcccagct ttgtgacact tctcaacttg cggctccatc
     2161 tctccctgcc cccacttttt tgttggccag ggaggctgca gatgccccag gagccctttg
     2221 ccgcttctat gaggccaagc cttttttccc tgggcccagc acacaccctg attagcaagt
     2281 gatgtgtgcg aggagggttt gtgaatgttg aatgtgtaat aatgatcacc atggagctgg
     2341 ccactgaccc cagagctgag ctgttaacaa ggcgcccagg gaagagctta gggagtggga
     2401 acttcacctc cctctctcgg tatctggcgg taaattagag gcaattttca tcctttgctt
     2461 gttcaccttc acttcaccag gaactttctg gccctaccct ttgcattggg tattttacaa
     2521 ctttctctca ttttcttccc aagctaccac tggagcttga ctttcagata ccagtgggag
     2581 ccttctgtcc cttttgggga ccctgtctgt ggcctccacc agggtttgtt tagagccact
     2641 cccaaatcct cactcccaca ctcatccttg cagccagttt ttgaggaaga ggagaacgtg
     2701 taaccccaat gcaagcttca ccctgactga gagggagtgg ttcttcctgt agggaatgaa
     2761 tttggtttga tttggggttt tcctttgaag cccaaagaac ttgctgttat gattcgttaa
     2821 ccatattgca ataaaagctg gacataattc tcacttta
//
