LOCUS       NM_001988               6468 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens envoplakin (EVPL), transcript variant 2, mRNA.
ACCESSION   NM_001988
VERSION     NM_001988.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6468)
  AUTHORS   Reitermaier,R., Skoll,M., Touzeau-Roemer,V., Aichelburg,M.C.,
            Elbe-Burger,A., Bauer,W., Rieger,A. and Schuster,C.
  TITLE     Frequency of Envoplakin and Type VII Collagen Autoantibodies and
            Co-occurrence with Other Skin-specific Autoantibodies in
            HIV-infected Patients and Uninfected Controls
  JOURNAL   Acta Derm Venereol 101 (11), adv00601 (2021)
   PUBMED   34694419
  REMARK    GeneRIF: Frequency of Envoplakin and Type VII Collagen
            Autoantibodies and Co-occurrence with Other Skin-specific
            Autoantibodies in HIV-infected Patients and Uninfected Controls.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6468)
  AUTHORS   Wang,X., Chen,T., Zhao,J., Peng,Y., Chen,X., Tu,P., Zhu,X., Liu,Z.
            and Wang,M.
  TITLE     Extremities of the N-terminus of envoplakin and C-terminus of its
            linker subdomain are major epitopes of paraneoplastic pemphigus
  JOURNAL   J Dermatol Sci 84 (1), 24-29 (2016)
   PUBMED   27427435
  REMARK    GeneRIF: N-terminus extremities of envoplakin and C-terminus of its
            linker subdomain are major epitopes of paraneoplastic pemphigus
REFERENCE   3  (bases 1 to 6468)
  AUTHORS   Sigurdson,A.J., Brenner,A.V., Roach,J.A., Goudeva,L., Muller,J.A.,
            Nerlich,K., Reiners,C., Schwab,R., Pfeiffer,L., Waldenberger,M.,
            Braganza,M., Xu,L., Sturgis,E.M., Yeager,M., Chanock,S.J.,
            Pfeiffer,R.M., Abend,M. and Port,M.
  TITLE     Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO,
            EVPL, TICAM1 and SCARB1 are associated with papillary and
            follicular thyroid cancer risk: replication study in a German
            population
  JOURNAL   Carcinogenesis 37 (7), 677-684 (2016)
   PUBMED   27207655
  REMARK    GeneRIF: We confirmed associations with papillary thyroid cancer
            and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395),
            EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We
            found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and
            HSPA6 and and follicular thyroid cancer
REFERENCE   4  (bases 1 to 6468)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6468)
  AUTHORS   Martins-de-Souza,D., Guest,P.C., Mann,D.M., Roeber,S., Rahmoune,H.,
            Bauder,C., Kretzschmar,H., Volk,B., Baborie,A. and Bahn,S.
  TITLE     Proteomic analysis identifies dysfunction in cellular transport,
            energy, and protein metabolism in different brain regions of
            atypical frontotemporal lobar degeneration
  JOURNAL   J Proteome Res 11 (4), 2533-2543 (2012)
   PUBMED   22360420
  REMARK    GeneRIF: A protein encoded by this locus was found to be
            differentially expressed in postmortem brains from patients with
            atypical frontotemporal lobar degeneration.
REFERENCE   6  (bases 1 to 6468)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Parry,D.A. and Watt,F.M.
  TITLE     Periplakin, a novel component of cornified envelopes and desmosomes
            that belongs to the plakin family and forms complexes with
            envoplakin
  JOURNAL   J Cell Biol 139 (7), 1835-1849 (1997)
   PUBMED   9412476
REFERENCE   7  (bases 1 to 6468)
  AUTHORS   Robinson,N.A., Lapic,S., Welter,J.F. and Eckert,R.L.
  TITLE     S100A11, S100A10, annexin I, desmosomal proteins, small
            proline-rich proteins, plasminogen activator inhibitor-2, and
            involucrin are components of the cornified envelope of cultured
            human epidermal keratinocytes
  JOURNAL   J Biol Chem 272 (18), 12035-12046 (1997)
   PUBMED   9115270
REFERENCE   8  (bases 1 to 6468)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     Direct evidence that involucrin is a major early isopeptide
            cross-linked component of the keratinocyte cornified cell envelope
  JOURNAL   J Biol Chem 272 (3), 2021-2030 (1997)
   PUBMED   8999895
REFERENCE   9  (bases 1 to 6468)
  AUTHORS   Ruhrberg,C., Williamson,J.A., Sheer,D. and Watt,F.M.
  TITLE     Chromosomal localisation of the human envoplakin gene (EVPL) to the
            region of the tylosis oesophageal cancer gene (TOCG) on 17q25
  JOURNAL   Genomics 37 (3), 381-385 (1996)
   PUBMED   8938451
REFERENCE   10 (bases 1 to 6468)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Simon,M., Dooley,T.P. and Watt,F.M.
  TITLE     Envoplakin, a novel precursor of the cornified envelope that has
            homology to desmoplakin
  JOURNAL   J Cell Biol 134 (3), 715-729 (1996)
   PUBMED   8707850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA449929.1, U53786.1,
            BC126103.1 and BX114092.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001988.3.
            
            Summary: This gene encodes a member of the plakin family of
            proteins that forms a component of desmosomes and the epidermal
            cornified envelope. This gene is located in the tylosis oesophageal
            cancer locus on chromosome 17q25, and its deletion is associated
            with both familial and sporadic forms of oesophageal squamous cell
            carcinoma. Patients suffering from the autoimmune mucocutaneous
            disorder, paraneoplastic pemphigus, develop antibodies against the
            encoded protein. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            slice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53786.1, BC126105.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301607.8/ ENSP00000301607.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA449929.1         147-156
            11-1439             U53786.1           1-1429
            1440-3917           BC126103.1         1365-3842
            3918-6467           U53786.1           3908-6457
            6468-6468           BX114092.1         401-401
FEATURES             Location/Qualifiers
     source          1..6468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..6468
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /note="envoplakin"
                     /db_xref="GeneID:2125"
                     /db_xref="HGNC:HGNC:3503"
                     /db_xref="MIM:601590"
     exon            1..206
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..6210
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /note="isoform 2 is encoded by transcript variant 2; 210
                     kDa paraneoplastic pemphigus antigen; 210 kDa cornified
                     envelope precursor protein"
                     /codon_start=1
                     /product="envoplakin isoform 2"
                     /protein_id="NP_001979.2"
                     /db_xref="CCDS:CCDS11737.1"
                     /db_xref="GeneID:2125"
                     /db_xref="HGNC:HGNC:3503"
                     /db_xref="MIM:601590"
                     /translation="MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLIS
                     RMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVD
                     KARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQ
                     KQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAA
                     SWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHEL
                     LSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED
                     YRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERAT
                     GDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHAWVV
                     QGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATVQSRLKASAVESLR
                     PSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRI
                     HSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLC
                     SLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRREL
                     LEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDL
                     REKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQ
                     SRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQ
                     EKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRES
                     EALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSL
                     SRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDS
                     QAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEM
                     VKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDP
                     GLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDP
                     ETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHER
                     SPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH
                     EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVT
                     QKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVE
                     RELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTE
                     LNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQA
                     REEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT
                     LQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR
                     EELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEV
                     TTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET
                     KPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK
                     TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQ
                     KAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQA
                     LLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALE
                     GYRCYRSASPTVPRSLR"
     exon            207..306
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            307..461
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            462..588
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            589..714
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            715..753
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            754..915
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1023
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1119
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1245
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1392
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1547
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1645
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1818
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1997
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2136
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2330
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2481
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2565
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2676
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2769
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..6468
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6443..6448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /note="hexamer: AATAAA"
     polyA_site      6468
                     /gene="EVPL"
                     /gene_synonym="EVPK"
                     /note="major polyA site"
ORIGIN      
        1 gccagactta gctgaccagc cagtgaggac gcccgctgcc tcccacctgc cctcctgccg
       61 tctttcgcca gccaagccca gcctgagcca gcacttgcct ttacgaccat gttcaagggg
      121 ctgagcaaag gctcccaggg gaaggggtcc cccaagggct cccccgccaa ggggtccccc
      181 aaaggctccc ccagcaggca cagccgggct gccacccagg agctggccct tctcatctcc
      241 cgcatgcaag ccaacgccga ccaggtggag cgggacatcc tggagacgca gaagaggctg
      301 cagcaggacc ggctgaacag tgagcagagc caggccctgc agcaccagca ggagacgggc
      361 cgcagcctga aggaggctga ggtgctgctc aaggacctct tcctggacgt ggacaaggcc
      421 cggcggctca agcacccgca ggctgaggag attgagaagg acatcaagca gctgcacgag
      481 cgggtgaccc aggagtgtgc ggagtaccgt gccctgtacg agaagatggt gctgcccccc
      541 gacgtgggac ccagggtcga ctgggcacgc gtgctggagc agaaacagaa gcaggtctgc
      601 gcaggccagt acgggccggg catggcggag ctggagcaac agatcgccga gcacaacatc
      661 ctgcagaagg agatcgacgc ctatgggcag cagctgcgga gcctcgtggg gccggatgca
      721 gccaccatcc ggagccaata ccgagaccta ctgaaggcgg cgtcgtggcg cgggcagagc
      781 ctgggcagcc tgtacacgca cctccagggc tgcacgcggc agctgagcgc cctggctgag
      841 cagcagcgcc gcatcctgca gcaggactgg agcgacctca tggccgaccc tgcgggcgtg
      901 cggcgggagt acgagcactt caagcagcac gagctgctga gccaggagca gagcgtgaac
      961 cagctggagg acgacggcga gcgcatggtg gagctgcggc accccgcggt ggggcccatc
     1021 caggcccacc aggaggccct gaagatggag tggcagaact tcctgaacct gtgtatctgc
     1081 caggagaccc agctgcagca cgtggaggac taccgccggt tccaggaaga ggccgactca
     1141 gtcagccaga ccctggcgaa gctcaactcc aacttggatg ccaagtacag ccctgcacct
     1201 gggggccccc ctggcgcccc cacagagctg ctgcaacagc tggaggcaga ggaaaaacgg
     1261 ctggccgtca ccgagagggc cactggggac ctgcagcggc gaagccggga tgtggcccct
     1321 ctgccacagc gaagaaaccc ccctcagcag cccctgcacg tggacagcat ctgcgactgg
     1381 gactcaggag aagtgcagct gctgcagggt gagcggtata agctggtaga taacactgac
     1441 ccgcacgcct gggtcgtgca gggccctggc ggggagacca agcgtgctcc cgccgcctgc
     1501 ttctgcatcc cagcaccaga ccctgatgct gtggccaggg cctcccggct ggcctcagag
     1561 ctgcaggccc tgaagcagaa attggccaca gtccagagcc gcctgaaggc cagtgctgtg
     1621 gagtctcttc ggcccagcca gcaggctcca tctggctcag acctggccaa cccacaggcc
     1681 cagaagctcc tgacacagat gacccggctg gatggagacc tgggacagat agagaggcag
     1741 gtgctggcct gggcgcgggc cccgctgagc cgccccacac ccttggagga cttggagggc
     1801 cgcatccaca gccatgaggg cacagcccag cgcctgcaga gcctgggaac ggagaaggag
     1861 acagcccaga aggagtgcga ggcgtttctg tccacgcggc ccgtgggccc cgctgccctg
     1921 cagctgcccg tagccctcaa cagcgtgaag aacaagttca gtgacgtgca ggttctgtgc
     1981 agcctctacg gggagaaagc caaggctgcc ctggatctgg agcggcagat ccaggatgcg
     2041 gacagggtca tccgaggctt cgaggccacc ctggtgcagg aggcccccat ccctgctgaa
     2101 ccgggggctc tgcaggagag ggtcagcgag ctgcagcgcc agcggaggga gctgctggaa
     2161 cagcagacct gcgtgctgcg gctacaccgc gcgctgaagg cctcggagca cgcatgcgct
     2221 gccctgcaga acaacttcca ggagttctgc caagacctgc ctcgccagca gcgccaggtg
     2281 cgagccctca ccgaccgcta ccacgccgta ggggaccagc tggacctgcg ggagaaggtg
     2341 gtgcaggatg ccgccctcac ctaccagcag ttcaagaact gcaaggataa cctgagctcc
     2401 tggctggagc acctgccccg cagccaggtg cggcccagcg acggccccag ccagatcgcc
     2461 tacaagctgc aggcgcagaa gaggctgacg caggagatcc agagccgaga gcgggacagg
     2521 gccacagcat cccacctctc ccaggccctg caggcagcgc tccaggacta tgagctccag
     2581 gcagacacct accgctgctc tttggagccc accctggcag tgtcagcccc caagagaccc
     2641 cgagtggctc ccctgcaaga gagcatccaa gcccaggaga agaaccttgc aaaggcctat
     2701 actgaggttg cagcagcaca gcagcagctg ctccagcagc tggagtttgc tagaaaaatg
     2761 ctggagaaga aggagctcag tgaggacatc cgaaggaccc atgatgcaaa gcagggctcc
     2821 gagagccctg cccaagcagg gagagagtca gaggccctga aggcccagct ggaagaggag
     2881 aggaagcggg tggcccgggt gcagcatgag ctggaggcgc agaggagcca actgctgcag
     2941 ctgaggaccc agcggccctt ggagaggctg gaggagaagg aagtggtaga gttctaccgg
     3001 gacccccagc tggagggcag cctgtccagg gtgaaggccc aggtggagga ggagggcaag
     3061 cggcgggctg gcctgcaggc agacctggaa gtggcagccc agaaggtcgt gcagctggaa
     3121 agcaagagga agaccatgca gcctcatctg ctgaccaagg aggtcaccca ggtggagagg
     3181 gaccccggcc tggacagcca ggcggcccag ctcaggatcc agatccagca gctccgcggg
     3241 gaggatgccg tcatctcggc ccggctggaa gggctgaaga aggagctact ggcccttgag
     3301 aagagggagg tggacgtgaa ggagaaggtc gtggtgaaag aggtagtcaa ggtggagaag
     3361 aatctggaaa tggtcaaggc agcccaggct ctgaggctgc agatggagga ggatgctgcg
     3421 cggaggaagc aggcggagga ggctgtggcc aagctacagg ctcgcatcga agacctggag
     3481 cgggctatca gctcggtgga gcccaaggtc atcgtgaagg aggtgaagaa ggtggagcag
     3541 gacccagggc tcctccagga gtcctccagg ctgaggagcc tcctcgagga ggagaggacc
     3601 aagaacgcga cgctggccag ggagctgagc gacctgcaca gcaagtacag cgtggtggag
     3661 aagcagaggc ccaaagtgca gctccaggag cgcgtccacg agatcttcca ggtggatccg
     3721 gagacagagc aggagatcac tcggctcaag gccaagctgc aggagatggc gggcaagagg
     3781 agcggtgtgg agaaggaggt ggagaagctg ctgcccgacc tggaggtcct gcgggcccag
     3841 aagcccacgg tggagtacaa ggaggtgacc caggaggtgg tgaggcatga gaggagcccc
     3901 gaggtgctgc gtgagatcga ccgcctgaag gctcagctca acgagctcgt caacagccac
     3961 gggcgctccc aggagcagct catccgcctg cagggtgagc gcgacgagtg gaggcgcgag
     4021 cgggccaagg tggagaccaa gacggtgagc aaggaggtgg tgcgccacga gaaggacccg
     4081 gtgctggaga aagaagcaga gcggctccgc caggaggtgc gggaggcggc ccagaagagg
     4141 cgggccgcgg aggacgcggt gtacgagctg cagagcaagc gcctgctgct ggagaggagg
     4201 aagcccgagg agaaggtggt ggtgcaggag gtggtggtca cccagaagga cccgaagctg
     4261 cgcgaggagc acagccggct gagcgggagc ctggatgagg aggtgggccg gcggcgccag
     4321 ctagagcttg aggtgcagca gctgcgggcc ggcgtggagg agcaggaggg cctgctcagc
     4381 ttccaggagg accgcagcaa gaagctggcc gtggagaggg agctgcggca gctgaccttg
     4441 aggatccagg agctcgagaa gcggcctccc acggtgcagg agaagatcat catggaggaa
     4501 gtggtcaagc tggagaagga cccggacctg gagaagtcca cggaagccct gcggtgggac
     4561 ctggaccagg agaagaccca ggtaaccgag ctgaatcggg agtgcaagaa cctgcaggtc
     4621 cagattgacg tcctccagaa agccaaatcg caggagaaga ccatctacaa ggaagtgatc
     4681 cgggtgcaga aggaccgcgt cctggaagat gagcgggccc gcgtgtggga gatgctcaac
     4741 agggagcgca cggcccggca ggcccgggag gaggaggcac ggcgcctgcg ggagcgcatt
     4801 gaccgggccg agacgctggg gagaacctgg tcccgggagg agtccgagct gcagagggcc
     4861 cgggaccagg ccgaccagga gtgtgggcgg ctgcagcagg agctgcgggc tctggagagg
     4921 cagaagcagc agcagacact gcagctgcag gaggagtcga agctgctcag ccagaagacg
     4981 gagagcgagc gacagaaggc ggcccagcgg ggccaggagc tctcgcggct ggaggcggcc
     5041 atcctccgcg agaaggacca gatctacgag aaggagcgga cgctccggga cctccacgcc
     5101 aaggtgagcc gggaggagct cagccaggag acccagacgc gagagaccaa cctttccacc
     5161 aagatctcca tcctggaacc cgagacgggg aaggacatgt ccccatacga ggcctacaag
     5221 aggggcatca tcgacagggg ccagtacttg cagctgcagg agctcgagtg tgactgggag
     5281 gaggtcacca cctcggggcc ctgtggggag gagtctgtgc tcctggaccg caagagcggg
     5341 aagcagtact ccatcgaggc cgccctccgc tgccggcgca tctctaagga ggagtaccat
     5401 ctgtacaagg acggccacct gcccatctcc gagtttgcgc tgcttgtagc tggggagacc
     5461 aagccaagct cctcactctc catcggctct atcatctcca agtccccgct cgcctccccg
     5521 gccccccaga gcaccagttt cttctctccc agcttctctc tcgggctcgg tgatgacagc
     5581 ttccctatcg ccgggatcta tgacacaacc acagacaaca agtgcagcat caagacggcc
     5641 gtggccaaga acatgctgga ccccatcact gggcagaagc tactggaggc ccaggcggcc
     5701 acagggggca tcgtggacct gctcagccgt gagcgctact ctgtgcacaa ggcgatggag
     5761 aggggcctga tcgagaacac ctccacacag aggctgctta acgcccagaa ggccttcacc
     5821 ggcatcgagg accccgtcac caagaagagg ctctcggtgg gcgaggccgt ccagaagggc
     5881 tggatgcccc gggagagcgt gctcccacac ctgcaggtgc agcacctgac cggggggctc
     5941 atcgacccca agaggacagg ccgcatcccc atccagcagg ccctcctctc cgggatgatc
     6001 agtgaagagc tggcccagct cctgcaggac gagtccagct acgagaagga tttgacagac
     6061 cccatctcca aggaacggct gagctacaag gaggccatgg gccgctgccg caaagacccc
     6121 ctgagcggcc tgctgctcct gccagcggca ctggaggggt accgctgcta ccgctccgcc
     6181 tcccccaccg tcccgcgctc ccttcgctga cacgggccaa ggagccagtg gggaagtgcg
     6241 tgtgttgggc caggtaggat acgtacacct cttgcctcag agcagcctca tcccaggcag
     6301 tgggtcttcc ctctgtccaa ccactgtttt attattttac taacatggtg atgggctccc
     6361 tcccctaacc ttggtgcctg atccatcccc agaccaggac agcagccact cagttcttcc
     6421 tccacctcca cccagtgatc ccaataaacg aattctgtct ccccgtgc
//
