LOCUS       NM_001159944            3903 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ecotropic viral integration site 5 like (EVI5L),
            transcript variant 1, mRNA.
ACCESSION   NM_001159944 XM_005272458
VERSION     NM_001159944.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3903)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3903)
  AUTHORS   Anderson,A.E., Taniguchi,K., Hao,Y., Melhuish,T.A., Shah,A.,
            Turner,S.D., Sutherland,A.E. and Wotton,D.
  TITLE     Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l
  JOURNAL   Mol Cell Biol 37 (5), e00527-16 (2017)
   PUBMED   27956704
  REMARK    GeneRIF: Tgifs regulate ciliogenesis and suggests that Evi5l
            mediates at least part of this effect.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3903)
  AUTHORS   Lim,Y.S. and Tang,B.L.
  TITLE     The Evi5 family in cellular physiology and pathology
  JOURNAL   FEBS Lett 587 (12), 1703-1710 (2013)
   PUBMED   23669355
  REMARK    Review article
REFERENCE   4  (bases 1 to 3903)
  AUTHORS   Pelak,K., Goldstein,D.B., Walley,N.M., Fellay,J., Ge,D.,
            Shianna,K.V., Gumbs,C., Gao,X., Maia,J.M., Cronin,K.D.,
            Hussain,S.K., Carrington,M., Michael,N.L. and Weintrob,A.C.
  CONSRTM   Infectious Disease Clinical Research Program HIV Working Group;
            National Institute of Allergy and Infectious Diseases Center for
            HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Host determinants of HIV-1 control in African Americans
  JOURNAL   J Infect Dis 201 (8), 1141-1149 (2010)
   PUBMED   20205591
  REMARK    Erratum:[J Infect Dis. 2010 Aug 15;202(3):501]
REFERENCE   5  (bases 1 to 3903)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   6  (bases 1 to 3903)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   7  (bases 1 to 3903)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY051475.1, BI913004.1, AB449874.1, AC010336.8, KF456491.1 and
            BC014111.2.
            
            On or before Dec 20, 2018 this sequence version replaced
            XM_005272458.5, NM_001159944.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            CDS exon combination :: AB449874.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1966682, SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000538904.7/ ENSP00000445905.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               HY051475.1         2-169
            169-211             BI913004.1         112-154
            212-705             AB449874.1         1-494
            706-706             AC010336.8         30300-30300
            707-1161            AB449874.1         496-950
            1162-1162           AC010336.8         32946-32946
            1163-2502           AB449874.1         952-2291
            2503-2503           KF456491.1         183-183             c
            2504-2685           KF456491.1         1-182               c
            2686-2829           AC010336.8         44971-45114
            2830-3903           BC014111.2         2658-3731
FEATURES             Location/Qualifiers
     source          1..3903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3903
                     /gene="EVI5L"
                     /note="ecotropic viral integration site 5 like"
                     /db_xref="GeneID:115704"
                     /db_xref="HGNC:HGNC:30464"
     exon            1..164
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            165..348
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2629
                     /gene="EVI5L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EVI5-like protein; ecotropic viral integration site 5-like
                     protein; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="EVI5-like protein isoform 1"
                     /protein_id="NP_001153416.1"
                     /db_xref="CCDS:CCDS54209.1"
                     /db_xref="GeneID:115704"
                     /db_xref="HGNC:HGNC:30464"
                     /translation="MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQ
                     NRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRR
                     RKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIAR
                     TYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCV
                     FVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWF
                     LTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRV
                     IPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLK
                     QRIETLEKESAALADRLIQGQVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQST
                     IRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALREMQDKVLDMEKRNSSLPD
                     ENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDTWQAHLARGGRWKESPRKLVV
                     GELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRVEAERAALQEKLQY
                     LAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEMRQRIAELEIQR
                     EEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFEDPLAFDGLSLARHLDE
                     DSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERPAKDSEGSSDSDADELAAP
                     YSQGLDN"
     exon            349..538
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            539..763
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            764..838
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            839..964
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1108
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1198
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1296
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1357
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1411
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1444
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1585
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1714
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1855
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2011
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2158
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2254
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2350
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..3903
                     /gene="EVI5L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3881..3886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI5L"
                     /note="hexamer: AATAAA"
     polyA_site      3903
                     /gene="EVI5L"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcgggt gaaatggcag cggcggagcc ggcggcggcc gcggtcccgg ggggcggctg
       61 agggggccgg gccggggctg cggggcgaac ggcgcggcta ggatccggcg gctcagcccg
      121 gggcggcgag gctcggcacg gagatggcgg cgcgctcggc gcagacagag ctgtgaacca
      181 accccgctca cggctaacaa gcccacccac catggcgagc cccactctga gccccgactc
      241 ctcatcccag gaggccctgt cggcccccac ctgctcccca acctctgact ccgagaacct
      301 cagccccgat gagctggagc tgctggccaa gctcgaagag cagaaccggc tcctggaggc
      361 cgactccaag tccatgcgct ccatgaatgg ctcgcggcgg aacagtggct cctcgctagt
      421 gtccagctcc tcggcctcct ccaacctgag ccacctggag gaggacacgt ggatcctgtg
      481 gggccggatc gccaacgagt gggaggagtg gcggcgcagg aaggagaagc tgctcaagga
      541 gctgatccgc aagggcatcc cccaccactt ccgggccatc gtgtggcagc ttctgtgcag
      601 cgccacggac atgcccgtca agaaccagta ctccgagctg ctcaagatgt cctcgccgtg
      661 cgagaagctg atccgcaggg acatcgcccg cacctacccg gaacatgagt tcttcaaggg
      721 ccaggacagc ctgggccagg aggtcctctt caacgtcatg aaggcatact cgctggtaga
      781 ccgggaggtg ggctactgcc agggaagcgc cttcatcgtg ggcctgctcc tcatgcagat
      841 gcctgaggag gaggccttct gtgtgttcgt gcggctgatg caggagtacc ggctgcggga
      901 gctcttcaaa cccagcatgg ccgagctcgg gctctgcatc tatcagttcg agtacatgct
      961 gcaggagcag ctcccagacc tcaacaccca cttccgttcc caaagcttcc acacatccat
     1021 gtatgcctcg tcctggttcc tcacactgtt cctgaccacc ttcccactcc ccgtcgccac
     1081 ccgggtcttt gacatcttca tgtatgaggg gctggagatc gtgttccgag tgggcctcgc
     1141 cctgctgcag gtgaaccagg cagagctgat gcagctggac atggagggga tgtcccagta
     1201 cttccagaga gtgatccccc accagttcga cagctgcccg gacaagctgg tcctcaaagc
     1261 ctaccaggtc aagtacaacc ccaagaagat gaagaggctg gagaaggagt acgcagccat
     1321 gaagagcaag gagatggagg agcagatcga gatcaaaaga cttcggacgg agaaccggct
     1381 cctgaaacag cggattgaaa ccctagagaa ggagagcgct gctctggctg ataggttaat
     1441 ccaggggcaa gtgacacggg cgcaggaggc ggaggagaac tacgtcatca agcgggagct
     1501 ggcggtggtg cggcagcagt gcagctcggc ggccgaggac ctgcagaagg cacagagcac
     1561 catccggcag ctacaggagc agcaggagaa cccccgcctc acagaagact tcgtgtccca
     1621 cctggagacc gagctggagc agtcgaggct gcgggagacg gagacactgg gggcccttcg
     1681 ggagatgcag gacaaggttc tcgacatgga aaagaggaac agctcgctgc ccgacgagaa
     1741 caatgtggcg cagctgcagg aggagctgaa ggcgctcaag gtgcgggaag gccaggcggt
     1801 ggcctcgacg cgagagctta aactgcagct gcaggagctc tcggacacct ggcaggccca
     1861 tctggcccgc ggcggccgct ggaaggagtc cccacggaag ctggtcgtgg gcgagctgca
     1921 ggacgagctg atgagcgtgc gtctgcgcga ggcccaggcc ctggccgagg gccgcgagct
     1981 gcggcagcgc gtggtggaac ttgagacgca ggaccacatc caccgcaacc ttctgaaccg
     2041 cgtggaggcg gagcgcgcgg cgctgcagga gaagctgcag tacctggctg cacagaacaa
     2101 ggggctgcag acgcagctca gcgaaagccg ccgcaagcag gccgaggccg agtgcaagag
     2161 caaggaggag gtgatggctg tgcgactgcg ggaggcggac agcatggctg cggtggccga
     2221 gatgcggcag cgcattgccg agctggagat ccagagggag gaaggccgca tccagggcca
     2281 gctgaaccac tcggactcat cgcagtacat ccgcgagctc aaggaccaga tcgaggagct
     2341 gaaggccgag gtgcggctgc tgaagggccc gccgcccttc gaggacccgc tggctttcga
     2401 tgggctgagc ctggcgcggc acttggacga ggactcgctg ccgtcgtcgg acgaggagct
     2461 acttggcgta ggcgtgggcg ctgccctgca ggacgcattg taccctctgt ccccgcgcga
     2521 tgcgcgcttc ttccgccgtc tggagcggcc ggccaaggac agcgagggca gctcagacag
     2581 cgacgccgat gagctggccg cgccctacag ccagggtctg gacaactgag gccatgccca
     2641 gcgcgcccgg agtcaggagg ccgcagccgc ggggggcgcc cgggcagtcc gcgttctgct
     2701 ccccacctgc cgcacttgac aaactacgcg ccctctgtgg ctcggccacc cctaaagcga
     2761 ggcccggcga ggcagcgcag agggtagggt ccgacctggg ctcctcaggg ccccggggca
     2821 ggctctctat ccccagcagt gtttacccat cttggtctgt acccctccgg gccctctggc
     2881 gttccagggg tgcctggagg ggctgactgc tctcttaaca ggagggcaga gggcagggga
     2941 cagacgaccc agaggtccca gcactgaatg agcaggcagc tcccacctcc tggcaggctt
     3001 ccttctggga caggggcgac attgctggga agtgctcagg aggtagccga ggcctgagga
     3061 aggagagcgc cagctctggg ctggacatca gcaccccaca acactcctcg ggatgaagtg
     3121 acccttgact agcccctggc catctctagg ggagtcaggc cgctggggac agatggccag
     3181 gccggcctct cctgcctggc gcaggcaccg tggcccctgc agcggaaacc aaagtccccc
     3241 tactatgtgc ggggcgcctg gggactgagt ggctaacggg aagcctccct gcttctctgg
     3301 ggccagagca gcttccagga agtgaagaga cccctctccc cagtgcccca catctttctc
     3361 tgggagacac tcgcgccccc tatcctggcc agtgatggag gggtatctct acaggggtcc
     3421 tcggtctcca tctacttccc tttcttcatg tgtttccagc cccaccctca gccagagcca
     3481 ggcccccagg caggagcttc ccagcgagcg gcctcccctc acttcctcct ggtggtcccg
     3541 ttgtctctgc tgaatcagag ctgagaacgg tgccaaaatc caacgatgcc ccccaggccc
     3601 cttcctccct tcccccggcc ccccgggcct catgaccctg ggggctgccc ccctcggtgc
     3661 tcccggagcc tccagtagag tagcgtcaca agcaatctcc ctggcgcttc ctgggtgggg
     3721 acccctgctc cgtccccgct tcctagctgc ccacttttca gtgttacgaa gcctggggac
     3781 cggggcaggc acccacgggg ctctccacac gccccctaca ctgcccgcca ccattttgca
     3841 cactgcctgt tcacatgtcg cccaggcggg aaaaatggaa aataaagtgt atttacacag
     3901 tca
//
