LOCUS       NM_001350197            7795 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ecotropic viral integration site 5 (EVI5), transcript
            variant 3, mRNA.
ACCESSION   NM_001350197 XM_017002280
VERSION     NM_001350197.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7795)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 7795)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7795)
  AUTHORS   Cai,T., Zhou,J., Zeng,Y., Du,W., Zhang,Y., Liu,T., Fu,Y.,
            Huang,J.A., Qian,Q., Zhu,J., Ling,C. and Liu,Z.
  TITLE     EVI5 is an oncogene that regulates the proliferation and metastasis
            of NSCLC cells
  JOURNAL   J Exp Clin Cancer Res 39 (1), 84 (2020)
   PUBMED   32393392
  REMARK    GeneRIF: EVI5 is an oncogene that regulates the proliferation and
            metastasis of NSCLC cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7795)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7795)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7795)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 7795)
  AUTHORS   Eldridge,A.G., Loktev,A.V., Hansen,D.V., Verschuren,E.W.,
            Reimann,J.D. and Jackson,P.K.
  TITLE     The evi5 oncogene regulates cyclin accumulation by stabilizing the
            anaphase-promoting complex inhibitor emi1
  JOURNAL   Cell 124 (2), 367-380 (2006)
   PUBMED   16439210
REFERENCE   8  (bases 1 to 7795)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 7795)
  AUTHORS   Faitar,S.L., Dabbeekeh,J.T., Ranalli,T.A. and Cowell,J.K.
  TITLE     EVI5 is a novel centrosomal protein that binds to alpha- and
            gamma-tubulin
  JOURNAL   Genomics 86 (5), 594-605 (2005)
   PUBMED   16033705
  REMARK    GeneRIF: a novel centrosomal protein with a complex expression
            pattern and subcellular localization, possibly involved in
            centrosome stability and dynamics
REFERENCE   10 (bases 1 to 7795)
  AUTHORS   Roberts,T., Chernova,O. and Cowell,J.K.
  TITLE     NB4S, a member of the TBC1 domain family of genes, is truncated as
            a result of a constitutional t(1;10)(p22;q21) chromosome
            translocation in a patient with stage 4S neuroblastoma
  JOURNAL   Hum Mol Genet 7 (7), 1169-1178 (1998)
   PUBMED   9618176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104332.2, BM835541.1, CN334472.1, BP282704.1, AB449875.1,
            BX378682.2, AB209513.1, BX369930.2, AC104456.2 and AA725529.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001350197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.1365.1,
                                           SRR11853559.1781.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684568.2/ ENSP00000506999.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC104332.2         179655-179656       c
            3-39                BM835541.1         1-37
            40-641              CN334472.1         25-626
            642-752             BP282704.1         430-540
            753-1227            AB449875.1         531-1005
            1228-1228           AC104332.2         89893-89893         c
            1229-1566           AB449875.1         1007-1344
            1567-1634           BX378682.2         1-68
            1635-1655           AC104332.2         57358-57378         c
            1656-1848           BX378682.2         90-282
            1849-2090           AB449875.1         1480-1721
            2091-2091           AB209513.1         788-788
            2092-2234           AB449875.1         1723-1865
            2235-2649           BX369930.2         34-448
            2650-2693           AB449875.1         2281-2324
            2694-7486           AC104456.2         119808-124600       c
            7487-7795           AA725529.1         10-318              c
FEATURES             Location/Qualifiers
     source          1..7795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..7795
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /note="ecotropic viral integration site 5"
                     /db_xref="GeneID:7813"
                     /db_xref="HGNC:HGNC:3501"
                     /db_xref="MIM:602942"
     exon            1..273
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            274..503
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..2835
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ecotropic viral integration site 5 protein homolog;
                     dJ846D11.1 (ecotropic viral integration site 5);
                     neuroblastoma stage 4S gene protein"
                     /codon_start=1
                     /product="ecotropic viral integration site 5 protein
                     homolog isoform 3"
                     /protein_id="NP_001337126.1"
                     /db_xref="CCDS:CCDS91002.1"
                     /db_xref="GeneID:7813"
                     /db_xref="HGNC:HGNC:3501"
                     /db_xref="MIM:602942"
                     /translation="MASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDDLELLAK
                     LEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWE
                     DVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRR
                     DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEE
                     AFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYA
                     SSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQH
                     FQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTEN
                     RLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQ
                     AENTIRKLQHQQQWHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIE
                     KRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRW
                     KDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEV
                     ISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQ
                     HIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFDG
                     IHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETED
                     SVLETRESNQVVQKERPPRRRESYSTTV"
     exon            504..693
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            694..918
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            919..993
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1119
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1263
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1353
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1451
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1512
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1566
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1599
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1746
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1881
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2022
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2181
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2328
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2424
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2520
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..7795
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7771..7776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /note="hexamer: ATTAAA"
     polyA_site      7795
                     /gene="EVI5"
                     /gene_synonym="EVI-5; NB4S"
                     /note="major polyA site"
ORIGIN      
        1 gggctctcct gacgcggccg ggccggaccc cggaggaacc agctggccag ctggcaaggg
       61 gctggctgca gttccgacag cggcggtgcc gggaggggta ggtgagggtc gcgaggcggc
      121 cctgagcttc tgagtgagcg tggtgctttt gggaactcgg gacgggcgac ccgtggagcc
      181 aggagcgggg ccgaggcgct gagacgcggc ggcgcggctg ccggctggat gggaagttaa
      241 tgtttacggc gaagtctact caacgtttcc aaggtggcga cagacaaagt tgcagaaaag
      301 ctgagctcta ctctctcatg ggtgaagaac acagtatcgc atacagtcag tcagatggcc
      361 agtcaggtgg caagtccatc tacttcatta cataccacat cctcatctac cacactatca
      421 acaccagccc tttcaccatc ttccccatca cagttgagtc cagacgactt agaactcctg
      481 gctaaactgg aagaacagaa tagattgtta gaaacggata gtaagtcttt aagatctgta
      541 aatgggtcaa gaagaaacag tggctcttct cttgtgtcga gttcatcagc ctctagcaac
      601 ctcagtcacc ttgaagaaga ttcttggatt ctttggggaa gaattgttaa tgaatgggaa
      661 gatgtacgca aaaagaagga aaagcaagtt aaggaacttg ttcataaagg gataccccat
      721 cactttagag caatagtttg gcaactttta tgcagtgcac aaagtatgcc aattaaggat
      781 cagtattcag aactcctgaa aatgacctcg ccttgtgaaa aattgatccg aagggacatt
      841 gctagaactt accctgaaca caactttttt aaggaaaaag atagccttgg acaggaggtt
      901 ttatttaatg taatgaaggc ttactcttta gtagatcgtg aggttggtta ctgtcaagga
      961 agtgctttta tagttggatt gttgcttatg cagatgccag aagaagaagc tttctgtgta
     1021 tttgttaaat taatgcaaga ttatagactt cgtgaacttt ttaaaccaag tatggcagaa
     1081 ttgggccttt gtatgtacca gtttgaatgt atgatacagg agcatcttcc agagctcttt
     1141 gtacattttc aatctcagag ttttcatacc tcaatgtatg catcatcctg gtttctgact
     1201 atctttctta caacttttcc actaccaatt gcaacaagga tatttgatat ctttatgtct
     1261 gagggtttag aaatagtgtt tcgtgtagga ttagcacttc ttcagatgaa tcaggcagaa
     1321 ctgatgcaac ttgacatgga agggatgtta cagcactttc aaaaggtcat tccacatcag
     1381 tttgatggtg tcccagacaa gctaatccaa gcagcttacc aagtcaaata caattcaaaa
     1441 aaaatgaaaa agcttgaaaa ggaatacact acaataaaaa cgaaagaaat ggaagagcaa
     1501 gttgaaatta aaaggttacg cacagaaaat agacttttaa aacagcgcat cgagacatta
     1561 gaaaaagaaa gtgcttcctt ggcagataga ttgatacagg gacaagtgac aagagcccag
     1621 gaggctgagg aaaactacct cataaaacgg gagttggcca ccatcaaaca gcagagtgat
     1681 gaggccagtg ctaagctgga gcaagctgaa aataccatca ggaagctcca gcaccaacaa
     1741 caatggcata aatgcagttc caactacaac gaagattttg tgctacagct agagaaggaa
     1801 ttggtccaag cccgactgag tgaagctgag tctcagtgtg cattaaaaga gatgcaggat
     1861 aaagtcttgg atatagagaa gaggaataac tcccttcctg atgagaataa tattgcaagg
     1921 cttcaggaag aactcattgc tgtgaaactt agagaagcag aagccattat gggtttgaaa
     1981 gaacttagac agcaagtcaa ggatttagag gaacactggc agcgccactt agctcgtact
     2041 actgggagat ggaaagaccc acccaagaaa aatgctatga atgagttaca agatgaactg
     2101 atgaccattc gacttagaga agctgaaaca caagcagaaa taagagaaat aaaacaaagg
     2161 atgatggaaa tggaaacaca gaaccagatc aatagtaacc atcttcgaag agcagaacaa
     2221 gaggtgatta gcctacagga gaaagtgcag tatctttctg cacagaacaa aggactcctt
     2281 actcaattaa gtgaagcaaa gcgtaaacaa gcagagattg aatgcaagaa taaggaagaa
     2341 gtgatggctg tgaggcttcg ggaagcagat agcatagctg ctgtggctga actacgacaa
     2401 cacattgctg agcttgaaat ccagaaagaa gaaggaaagc ttcaaggaca gcttaacaag
     2461 tctgattcta accagtatat tggggaactg aaagatcaga tagcagagct gaatcatgag
     2521 ctcaggtgcc taaaaggcca gaggggcttc tcaggccaac ctccttttga tggaatccac
     2581 attgtcaacc atttaatagg agatgatgaa tcattccatt cctccgatga agattttata
     2641 gataattcct tacaggaaac tggtgttggt tttcctttgc acggaaaatc tggttcgatg
     2701 tctttggacc ccgcagtggc agatggtagt gagagcgaaa cagaagacag tgtgctggag
     2761 accagagaga gcaaccaagt ggttcaaaag gagcggcccc cgagaagaag agagtcgtat
     2821 tcaaccactg tctgaccatc actgtgacct agactatgga tttatttaag ggatcagtta
     2881 tcatatgatt agggcttttt ggaaataatt tgtttcatat gtacatatat atatatatat
     2941 atatatatat atatatatat atatatatat atatatatat tttacagtct tatctgcctt
     3001 tttatctttg ccaaatcttt accactgatt taccattgcc ataaagtaga ctggtatatg
     3061 gttaatgtgt aaaacaaggt tctaacagta ttactgaata ttaatgtttc ttgtttagaa
     3121 aatgcaacta tatctatatg tgggaaccat tctgaagttc aaaactatgg aaaattgaat
     3181 tttcttcaga caaaactgct cttgtgcaat attttatgct cagtgagcaa attgtgtatt
     3241 tatgtttatc aatttgttct caaggtggct gtctacagac atttgaccaa gacatacatc
     3301 tgatttacct tgtgtttttt tttttattgt tgtttttttt tttaagacag agattcagtc
     3361 tgtcacccag gctggagtgc tgtggtgtga tcttagctca ctgcaacctc cgcctcccag
     3421 gttcaagcaa ttttcctgcc tcagcctccc gagtacctgg gactatatgt gcgcaccacc
     3481 acgcctggct aattttttgt atttttagta gagatggggt ttcaccatgt tggctgggct
     3541 ggtctcgaac tcctaacctc aagtgatcca cccgcctcag cctcccaaag tgctgggatt
     3601 acaggtgtga gccactgcac ccagcctacc ttgtctgttt gtgtctggga ggtttttttt
     3661 ttctattttt attttttcat gaaaattatt ggtgggccac tgaaagtccc cacacacaaa
     3721 gcctttattc tatataattt tataaacaca aattcatgat tatctgtttt gagagtttta
     3781 agttttgttt taatgtttaa cttttatgtg catatgatgc ttccatgtgt tggttactag
     3841 agtagtaggt taactacaga catactgttt tgtttgtaca tatttataaa tctgtaccac
     3901 ctaacattga acatcatttt atatgaagaa catacatgtt gcaaaatgac tgctttcagc
     3961 atctaacagg acttctgtaa ataataggtt aaaagttaaa aataaaacac taatgtttta
     4021 agagctttag tattttgctt agcattcaat actagcagat tcataactga tgcctgttca
     4081 aaaacactgt tggtggaatc ttttatttca tgtgtatgta actactaaat ttttcatgac
     4141 tgaagaggtt atagcacata ttagttagtg ctaatattct actgaatata atttaagcaa
     4201 tgggctaagg tccaagaaac atagcaatta tatctacaaa taatctatta acatgatctt
     4261 cagaatctct agtttttgtt ctatagataa agccataaga atcctttcct accagttttt
     4321 cctatatcat ttagatatta tttcctagaa aacaggatgc ctgtcactga taagttagag
     4381 aaaacaccca aattatactt gcactatgga aagacgacat gaatatgttg actgggtact
     4441 ttctactctc atttttgtta gcctatgaaa aaaaaaacat tttgttaacc tatggaaaaa
     4501 gccttggaag agaaaagtag aattcagtat gtatggaggc acagttttgc acagtatgtt
     4561 gcatgcggca aaaaaaaaaa tatgaaatag agtagaagag ataaaagtag ttttctgtca
     4621 aaaactagga gttaagcctt caggtacgtt gtggactagg ctttccagca aggtttttgt
     4681 agctatttgc ttgcctgaga aatgaaattg aaaacatacc cctgcgtgtc tgtccttaac
     4741 accaggctaa attctggtgg ttaaataact tatctgtggt tacaagctag taagtagcag
     4801 agccaagatt ttttttaata tagagacagg tgtctcactg tgttgtccag gctggtcttg
     4861 aactcctggc ctcaagtggt cctcctgcct cagcctccca aagtgtgggg attacaggtg
     4921 cgagctactg ctcccagcaa gagccaagat tttaacctag atctccctaa caccaaagct
     4981 tttgaaaggg ttcagctgaa gaatttctca attctctgtt ttgttttgtt tttatttttg
     5041 ttttttgaga tgaagtctca ctgcactcag gctggagtgc agtggtacga tcttggctca
     5101 ctgcaacctc cacctcccgg gttcaagcga ttctcctgcc tcagctccca agtagctggg
     5161 actacaggtg cacgccacca caactggcta atttttgtat ttttagtaga gatggggttt
     5221 cgctatgttg gccaggctga tctcaaactt ctgacctcag gtgatccacc cactttgacc
     5281 tcccaaagtg ctgggattac tagacgtaag ccaccacacc tggcaattcc ctgctttttt
     5341 gacaacataa tttaaatgaa tttgatttaa atgtttcctg aatatatata cagatagata
     5401 gatgagtatc aacacttaca agctctacac agtctgtgag tgtagatact acttactcgt
     5461 aggattgtct tgtgctttgg ggatttttgt tcggagttct atactatcag cccagaaagc
     5521 tatcaatgtc caagtgaagt gagatgatgc atggccacat tattgctttg accctcacat
     5581 caagaaatct gaatgatctg gaccaggggt cagcaaagtg cagcctacaa gctattgcag
     5641 tcagctgcca gtttttactt ttttaaatag ttgggaaaaa aattccaaag actgatattt
     5701 tgtgtcacat gaaaattata tgaaattcaa attgcagtgt ccataagtaa agttttattg
     5761 gggcacaccc atgctcaccc ttttaaatat tgtgtatggc cgctttgtgc tacagtagca
     5821 gagttgagtc attgcaaggg agaccatatg gcccaggtag cctaaaatat ttatctgatc
     5881 ctttacagaa aaagtttgct aacccttgat aacagatact ctaaaatgca ggtttttctt
     5941 cttcaattta gctcagtggt aggtcaaatt gtttgctttt gctattaagc ttatgatttg
     6001 gaaacgtaaa atttcatggt ggatattata atcagaacta ttcaaaaggg aaaacatgcc
     6061 agccatttta tatgatgaag tctcttattc catagaaaac tgtagaaaga tatctgtatc
     6121 tttggagaag gagaaagaaa ggaaagaact ccagaatccc atcactgttc tttaaagcat
     6181 gcatcacaga cctttaagag tatgctttat tgagtaaagg ttatagtttg actttaagat
     6241 aagaaatttt ctagaatcat gtttgaattc taaacgttga tattcttaag taccatttct
     6301 gattaggaat taggtgttaa aagaatcatg gtaaggaaac cttaatccgt tgaaactctt
     6361 gtaatttgga caacaaaaaa ctagaaataa cactcttttc tttgaagatc tgattcaaat
     6421 acaccttaga agagtttaaa atctcccagg cctttaggat gcaataggat attatgcctt
     6481 ggtttgactc cttttcattc aaattaatgt aagtatgttg ttcaagactt tgaagcattg
     6541 aacaatgttc tcgatgaatt ttatttaatt actgacattt tgtgatattt gaatgttatt
     6601 aagttaaaca cttagagttg agtatattca ggggagaaaa gtgaatgaaa tgactcataa
     6661 taagaaagct tgctcccttg ggacagttac cttcctggtg tcattgccat cctgggttga
     6721 caagctgaga gtagaggata caagtgatgt gaataaaatg gaaattgcat tgagttaatg
     6781 aaacagacac ttttagatca agaaaacact tcaacagcct ttttagaaat tggcacactc
     6841 ctatagtccc acctactcaa gaggctgagg caggaggatc actagagtac aggagtttgg
     6901 ggctgtagtg tgtaatgatc acacctgtga aagaataacc actgcactcc aacctgggca
     6961 acatggcaag accctgtctc tttaaaaaaa aaaaaaatcc tgggaaaaga agtcaaagat
     7021 gtaattttac acaatttctg cccccaccgt cttttttgtt tgtttgtttg tttgtttgtt
     7081 ttttggctag atactaggta ttcagtgttt gctgagatga caggtttcta ctaatcagcc
     7141 agttatttgg gaaggagaaa aactttttct caattctgaa catgatgcag cttgttaact
     7201 ctccagatag tgcctttgat tgaaaataag gtctacacct ttttaagtat attatttctg
     7261 acatcgtaag aaataattta gttccttatt ctcatttatc ttttatataa tgtactgtaa
     7321 tattcaggtt taaagtaaaa taagtatatg aattatattt tggtaaaact gtttcatgac
     7381 cagcttgatt aatgtatatt aacataccag acattgacag cgaacatttc atgaaatcag
     7441 ttatttactt accaaaacaa tgagttttag cttgaaagtt actgctgctc tattattaac
     7501 aaaactaagt tttaaaaatt aattttaatt ctactgaagt ttaatttctg gttaaaggta
     7561 tagtggatgc tatttatgat ccaagttttt acatcacatc cattgatctg cctatccctt
     7621 ctttttactc caaagaggag atgatagaat aatacattca gtatactacc aagaagcaaa
     7681 gttataatgt gtttcatttt gctattggaa ttttttattg taacattgta tgataacctg
     7741 aaatgtttac ttgtgccttt tctttaaaca attaaagttt tccattttat aagaa
//
