LOCUS       NM_006495               1937 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ecotropic viral integration site 2B (EVI2B), mRNA.
ACCESSION   NM_006495
VERSION     NM_006495.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Saharafi,P., Akar,I., Ersoy-Evans,S., Anlar,B., Varan,A.,
            Vargel,I., Cetin,M. and Ayter,S.
  TITLE     Assessment of Ecotropic Viral Integration Site 2B (EVI2B) Gene in
            Juvenile Myelomonocytic Leukemia and Neurofibromatosis Type 1 NF1
            Tumors
  JOURNAL   Biochem Genet 62 (2), 1263-1276 (2024)
   PUBMED   37584733
  REMARK    GeneRIF: Assessment of Ecotropic Viral Integration Site 2B (EVI2B)
            Gene in Juvenile Myelomonocytic Leukemia and Neurofibromatosis Type
            1 NF1 Tumors.
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Fu,Y., He,J., Chen,J., Hu,J., Guan,W. and Lou,G.
  TITLE     EVI2B may be a novel prognostic marker for lung adenocarcinoma
  JOURNAL   Biomark Med 17 (14), 599-612 (2023)
   PUBMED   37843407
  REMARK    GeneRIF: EVI2B may be a novel prognostic marker for lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Zjablovskaja,P., Kardosova,M., Danek,P., Angelisova,P.,
            Benoukraf,T., Wurm,A.A., Kalina,T., Sian,S., Balastik,M.,
            Delwel,R., Brdicka,T., Tenen,D.G., Behre,G., Fiore,F., Malissen,B.,
            Horejsi,V. and Alberich-Jorda,M.
  TITLE     EVI2B is a C/EBPalpha target gene required for granulocytic
            differentiation and functionality of hematopoietic progenitors
  JOURNAL   Cell Death Differ 24 (4), 705-716 (2017)
   PUBMED   28186500
  REMARK    GeneRIF: EVI2B is significantly downregulated in human acute
            myeloid leukemia samples characterized by defects in CEBPA.
            Erratum:[Cell Death Differ. 2019 Jan;26(1):198. doi:
            10.1038/s41418-018-0146-z.. PMID: 29991745]
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Park,G.H., Lee,S.J., Yim,H., Han,J.H., Kim,H.J., Sohn,Y.B., Ko,J.M.
            and Jeong,S.Y.
  TITLE     TAGLN expression is upregulated in NF1-associated malignant
            peripheral nerve sheath tumors by hypomethylation in its promoter
            and subpromoter regions
  JOURNAL   Oncol Rep 32 (4), 1347-1354 (2014)
   PUBMED   25109740
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Xu,G., O'Connell,P., Stevens,J. and White,R.
  TITLE     Characterization of human adenylate kinase 3 (AK3) cDNA and mapping
            of the AK3 pseudogene to an intron of the NF1 gene
  JOURNAL   Genomics 13 (3), 537-542 (1992)
   PUBMED   1639383
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Wallace,M.R., Andersen,L.B., Saulino,A.M., Gregory,P.E.,
            Glover,T.W. and Collins,F.S.
  TITLE     A de novo Alu insertion results in neurofibromatosis type 1
  JOURNAL   Nature 353 (6347), 864-866 (1991)
   PUBMED   1719426
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Cawthon,R.M., Andersen,L.B., Buchberg,A.M., Xu,G.F., O'Connell,P.,
            Viskochil,D., Weiss,R.B., Wallace,M.R., Marchuk,D.A., Culver,M. et
            al.
  TITLE     cDNA sequence and genomic structure of EV12B, a gene lying within
            an intron of the neurofibromatosis type 1 gene
  JOURNAL   Genomics 9 (3), 446-460 (1991)
   PUBMED   1903357
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Viskochil,D., Cawthon,R., O'Connell,P., Xu,G.F., Stevens,J.,
            Culver,M., Carey,J. and White,R.
  TITLE     The gene encoding the oligodendrocyte-myelin glycoprotein is
            embedded within the neurofibromatosis type 1 gene
  JOURNAL   Mol Cell Biol 11 (2), 906-912 (1991)
   PUBMED   1899288
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Cawthon,R.M., Weiss,R., Xu,G.F., Viskochil,D., Culver,M.,
            Stevens,J., Robertson,M., Dunn,D., Gesteland,R., O'Connell,P. et
            al.
  TITLE     A major segment of the neurofibromatosis type 1 gene: cDNA
            sequence, genomic structure, and point mutations
  JOURNAL   Cell 62 (1), 193-201 (1990)
   PUBMED   2114220
  REMARK    Erratum:[Cell 1990 Aug 10;62(3):following 608]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005926.1, AA251185.1 and AW576194.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006495.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.566137.1, BC005926.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330927.5/ ENSP00000333779.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1106              BC005926.1         20-1125
            1107-1473           AA251185.1         80-446
            1474-1932           BC005926.1         1493-1951
            1933-1937           AW576194.1         15-19               c
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1937
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /note="ecotropic viral integration site 2B"
                     /db_xref="GeneID:2124"
                     /db_xref="HGNC:HGNC:3500"
                     /db_xref="MIM:158381"
     exon            1..76
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1937
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1444
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /note="protein EVI2B; EVI-2B; ecotropic viral integration
                     site 2B protein homolog"
                     /codon_start=1
                     /product="protein EVI2B precursor"
                     /protein_id="NP_006486.3"
                     /db_xref="CCDS:CCDS11266.1"
                     /db_xref="GeneID:2124"
                     /db_xref="HGNC:HGNC:3500"
                     /db_xref="MIM:158381"
                     /translation="MDPKYFILILFCGHLNNTFFSKTETITTEKQSQPTLFTSSMSQV
                     LANSQNTTGNPLGQPTQFSDTFSGQSISPAKVTAGQPTPAVYTSSEKPEAHTSAGQPL
                     AYNTKQPTPIANTSSQQAVFTSARQLPSARTSTTQPPKSFVYTFTQQSSSVQIPSRKQ
                     ITVHNPSTQPTSTVKNSPRSTPGFILDTTSNKQTPQKNNYNSIAAILIGVLLTSMLVA
                     IIIIVLWKCLRKPVLNDQNWAGRSPFADGETPDICMDNIRENEISTKRTSIISLTPWK
                     PSKSTLLADDLEIKLFESSENIEDSNNPKTEKIKDQVNGTSEDSADGSTVGTAVSSSD
                     DADLPPPPPLLDLEGQESNQSDKPTMTIVSPLPNDSTSLPPSLDCLNQDCGDHKSEII
                     QSFPPLDSLNLPLPPVDFMKNQEDSNLEIQCQEFSIPPNSDQDLNESLPPPPAELL"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /note="hexamer: AATAAA"
     polyA_site      1813
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /note="major polyA site"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /note="hexamer: ATTAAA"
     polyA_site      1937
                     /gene="EVI2B"
                     /gene_synonym="CD361; D17S376; EVDB"
                     /note="major polyA site"
ORIGIN      
        1 cctttcttag ccaaatcacc aaaatgtcca gttagaacaa gaatttagca ttctgcaaaa
       61 gaagttaaca gctgagataa cgaggaaata ttctgaaatg gatcccaaat atttcatctt
      121 aattttgttt tgtggacacc tgaacaatac atttttttca aagacagaga caattacaac
      181 agagaagcag tcacagccta ccttattcac atcatcaatg tcacaggtat tggctaattc
      241 tcaaaacaca acagggaatc ctttgggtca accaacacaa ttcagcgaca ctttttctgg
      301 acaatcaata tcacctgcca aagtcactgc tggacaacca acaccagctg tctatacctc
      361 ttctgaaaaa ccagaagcac atacttctgc tggacaacca cttgcctaca acaccaaaca
      421 accaacacca atagccaaca cctcctccca gcaagccgtg ttcacctctg ccagacaact
      481 accatctgcc cgtacttcta ccacacaacc accaaagtca tttgtctata cttttactca
      541 acaatcatca tctgtccaga tcccttctag aaaacaaata actgttcata atccatccac
      601 acaaccaaca tcaactgtca aaaattcacc taggagtaca ccaggattta tcttagatac
      661 taccagtaac aaacaaaccc cacaaaaaaa caattataat tcaatagctg ccatactaat
      721 tggtgtactt ctgacttcta tgttggtagc tataatcatc attgtacttt ggaaatgctt
      781 aaggaaacca gttttaaatg atcaaaattg ggcaggtaga tctccatttg ctgatggaga
      841 aacccctgac atttgtatgg ataacatcag agaaaatgaa atatccacaa aacgtacatc
      901 aatcatttca cttacaccct ggaaaccaag caaaagcaca cttttagcag atgacttaga
      961 aattaagttg tttgaatcaa gtgaaaacat tgaagactcc aacaacccca aaacagagaa
     1021 aataaaagat caagtaaatg gtacatcaga agatagtgct gatggttcaa cagttggaac
     1081 tgctgtttct tcttcagatg atgcagatct gcctccacca cctccccttc tggatttgga
     1141 aggacaggaa agtaaccaat ctgacaaacc cacaatgaca attgtatctc ctcttccaaa
     1201 tgattctact agtctccctc catctctgga ctgtctcaat caagactgtg gagatcataa
     1261 atctgagata atacaatcat ttccaccgct tgactcactt aacttgcccc tgccaccagt
     1321 agattttatg aaaaaccaag aagattccaa ccttgagatc cagtgtcagg agttctctat
     1381 tcctcccaac tctgatcaag atcttaatga atccctgcca cctccacctg cagaactgtt
     1441 ataaatatta caacttgctt tttagctgat cttccatcct caaatgactc ttttttcttt
     1501 atatgttaac atatataaaa tggcaactga tagtcaattt tgatttttat tcaggaacta
     1561 tctgaaatct gctcagagcc tatgtgcata gatgaaactt ttttttaaaa aaagttattt
     1621 aacagtaatc tatttactaa ttatagtacc tatctttaaa gtatagtaca ttttacatat
     1681 gtaaatggta tgtttcaata atttaagaac tctgaaacaa tctacatata cttattaccc
     1741 agtacagttt tttttcccct gaaaagctgt gtataaaatt atggtgaata aacttttatg
     1801 tttccatttc aaagaccagg gtggagagga ataagagact aagtatatgc ttcaagtttt
     1861 aaattaatac ctcaagtatt aaataaatat tccaagtttg tgggaatggg agattaaaat
     1921 gcatgtttga gaataga
//
