LOCUS       NM_014210               2742 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens ecotropic viral integration site 2A (EVI2A),
            transcript variant 2, mRNA.
ACCESSION   NM_014210
VERSION     NM_014210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Jin,L., Qian,D., Tang,X., Huang,Y., Zou,J. and Wu,Z.
  TITLE     SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma
            Cells by Upregulating EVI2A
  JOURNAL   Mol Biotechnol 66 (10), 2920-2933 (2024)
   PUBMED   37812330
  REMARK    GeneRIF: SMYD2 Imparts Gemcitabine Resistance to Pancreatic
            Adenocarcinoma Cells by Upregulating EVI2A.
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Hu,M., Xie,J., Hou,H., Liu,M. and Wang,J.
  TITLE     Prognostic Value of DNA Methylation-Driven Genes in Clear Cell
            Renal Cell Carcinoma: A Study Based on Methylation and
            Transcriptome Analyses
  JOURNAL   Dis Markers 2020, 8817652 (2020)
   PUBMED   32733620
  REMARK    GeneRIF: Prognostic Value of DNA Methylation-Driven Genes in Clear
            Cell Renal Cell Carcinoma: A Study Based on Methylation and
            Transcriptome Analyses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Li,S., Yang,F., Yang,Y.K. and Zhou,Y.
  TITLE     Increased expression of ecotropic viral integration site 2A
            indicates a poor prognosis and promotes osteosarcoma evolution
            through activating MEK/ERK pathway
  JOURNAL   J Recept Signal Transduct Res 39 (4), 368-372 (2019)
   PUBMED   31774019
  REMARK    GeneRIF: Increased expression of ecotropic viral integration site
            2A promotes osteosarcoma evolution through activating MEK/ERK
            pathway.
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Xu,G., O'Connell,P., Stevens,J. and White,R.
  TITLE     Characterization of human adenylate kinase 3 (AK3) cDNA and mapping
            of the AK3 pseudogene to an intron of the NF1 gene
  JOURNAL   Genomics 13 (3), 537-542 (1992)
   PUBMED   1639383
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Wallace,M.R., Andersen,L.B., Saulino,A.M., Gregory,P.E.,
            Glover,T.W. and Collins,F.S.
  TITLE     A de novo Alu insertion results in neurofibromatosis type 1
  JOURNAL   Nature 353 (6347), 864-866 (1991)
   PUBMED   1719426
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Cawthon,R.M., Andersen,L.B., Buchberg,A.M., Xu,G.F., O'Connell,P.,
            Viskochil,D., Weiss,R.B., Wallace,M.R., Marchuk,D.A., Culver,M. et
            al.
  TITLE     cDNA sequence and genomic structure of EV12B, a gene lying within
            an intron of the neurofibromatosis type 1 gene
  JOURNAL   Genomics 9 (3), 446-460 (1991)
   PUBMED   1903357
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Viskochil,D., Cawthon,R., O'Connell,P., Xu,G.F., Stevens,J.,
            Culver,M., Carey,J. and White,R.
  TITLE     The gene encoding the oligodendrocyte-myelin glycoprotein is
            embedded within the neurofibromatosis type 1 gene
  JOURNAL   Mol Cell Biol 11 (2), 906-912 (1991)
   PUBMED   1899288
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   Cawthon,R.M., Weiss,R., Xu,G.F., Viskochil,D., Culver,M.,
            Stevens,J., Robertson,M., Dunn,D., Gesteland,R., O'Connell,P. et
            al.
  TITLE     A major segment of the neurofibromatosis type 1 gene: cDNA
            sequence, genomic structure, and point mutations
  JOURNAL   Cell 62 (1), 193-201 (1990)
   PUBMED   2114220
  REMARK    Erratum:[Cell 1990 Aug 10;62(3):following 608]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312348.1, BC035572.1, AC134669.4 and CF135330.1.
            
            On Jun 2, 2019 this sequence version replaced NM_014210.3.
            
            Transcript Variant: This variant (2) lacks a portion of the 5' UTR
            and 5' coding region, and uses a downstream translational start
            codon, compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation uses the 5'-most in-frame start
            codon, which is conserved in higher primates. An alternative
            downstream start codon, which is more widely conserved and has a
            stronger Kozak signal, also exists. It is possible that leaky
            scanning by ribosomes would allow the downstream start codon to be
            used, at least some of the time. The use of the downstream start
            codon would result in a protein that is 4 aa shorter at the
            N-terminus. Both the longer and shorter N-termini have predicted
            signal peptides according to SignalP 3.0. There is no experimental
            evidence showing which start codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.346121.1,
                                           SRR1803615.477039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000462804.3/ ENSP00000420557.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AK312348.1         81-217
            138-1495            BC035572.1         153-1510
            1496-2339           AC134669.4         55853-56696         c
            2340-2742           CF135330.1         6-408               c
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2742
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /note="ecotropic viral integration site 2A"
                     /db_xref="GeneID:2123"
                     /db_xref="HGNC:HGNC:3499"
                     /db_xref="MIM:158380"
     exon            1..128
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /inference="alignment:Splign:2.1.0"
     exon            129..2742
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..849
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protein EVI2A; ecotropic viral integration site
                     2A protein homolog"
                     /codon_start=1
                     /product="protein EVI2A isoform 2 precursor"
                     /protein_id="NP_055025.2"
                     /db_xref="CCDS:CCDS42293.1"
                     /db_xref="GeneID:2123"
                     /db_xref="HGNC:HGNC:3499"
                     /db_xref="MIM:158380"
                     /translation="MPTDMEHTGHYLHLAFLMTTVFSLSPGTKANYTRLWANSTSSWD
                     SVIQNKTGRNQNENINTNPITPEVDYKGNSTNMPETSHIVALTSKSEQELYIPSVVSN
                     SPSTVQSIENTSKSHGEIFKKDVCAENNNNMAMLICLIIIAVLFLICTFLFLSTVVLA
                     NKVSSLRRSKQVGKRQPRSNGDFLASGLWPAESDTWKRTKQLTGPNLVMQSTGVLTAT
                     RERKDEEGTEKLTNKQIG"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /note="hexamer: AATAAA"
     polyA_site      1495
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /note="major polyA site"
     regulatory      1568..1573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /note="hexamer: AATAAG"
     polyA_site      1611
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
     regulatory      1652..1657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
                     /note="hexamer: TATAAA"
     polyA_site      1678
                     /gene="EVI2A"
                     /gene_synonym="EVDA; EVI-2A; EVI2"
ORIGIN      
        1 cttttttact gcagatttac tttaaggctc atattctcca agtctattct gctttaaaaa
       61 gaagacaaga aaagaagtgg tttatcaaaa tcacgttata atcagatttt gaccaagcat
      121 tttgtaagat tgccaagcat gcccacggac atggaacaca caggacatta cctacatctt
      181 gcctttctga tgacaacagt tttttctttg tctcctggaa caaaagcaaa ctatacccgt
      241 ctgtgggcta acagtacttc ttcctgggat tcagttattc aaaacaagac aggcagaaac
      301 caaaatgaaa acattaacac aaaccctata actcctgaag tagattataa aggtaattct
      361 acaaacatgc ctgaaacatc tcacatcgta gctttaactt ctaaatctga acaggagctt
      421 tatatacctt ctgtcgtcag caacagtcct tcaacagtac agagcattga aaacacaagc
      481 aaaagtcatg gtgaaatttt caaaaaggat gtctgtgcgg aaaacaacaa caacatggct
      541 atgctaattt gcttaattat aattgcagtg ctttttctta tctgtacctt tctatttcta
      601 tcaactgtgg ttttggcaaa caaagtctct tctctcagac gatcaaaaca agtaggcaag
      661 cgtcagccta gaagcaatgg cgattttctg gcaagcggtc tatggcccgc tgaatcagac
      721 acttggaaaa gaacaaaaca gctcacagga cccaacctag tgatgcaatc tactggagtg
      781 ctcacagcta caagggaaag aaaagatgaa gaaggaactg aaaaacttac taacaaacag
      841 ataggttagt gaagaaaaat gcaaagtagc aatgagaagg cttatggagt aaaaatgaag
      901 tcagttggta tttaatccca aagtgttgtt ctgattatct aaaatttgac atggtagacc
      961 ttgcaattta gaatcaagca ggtgagacag ggagaagtat gcctgcttaa ttatttaaac
     1021 tgtgtacttt tgttttgaca ctgaatattt taaaaagcaa ataataaaat aactaagcat
     1081 ttgaggaaaa ttttaaggat aaattgagga aactgattaa tagagatagc aagggataat
     1141 taaataaata ttccctatgt agcaacagtg gttagatgat ctttgtctga atgtaattaa
     1201 actttgaata gttttagtgt gtccttaaag ccaagtatat gctttaacat caaatggaag
     1261 tcaaattcct aatgcataga tagagagagc taaactgtgt aatttaatgg tatcttcctt
     1321 gctggatgtg gcagaatcca caccagctta tcaaccaaca cagctaattt tagaatagat
     1381 cctttatctt tccatatggc acacgtaaga aagtgttttt ctactattaa tattaaatta
     1441 aaacctttac ttttgtataa taaattaaaa ctcagaataa acctgtgacc acgtatattt
     1501 gcattcactt tattacttta gagaacacat tgtaaagatc aataagaaat agagcacaac
     1561 taaaataaat aagatttata gccacaccaa taggctaagt gtaaacgcaa agtatgtttc
     1621 actgtttatg attaataata ttcatctttt ctataaatac tacttactgg aacattaaca
     1681 acaagtacca aaggttgatt aatttttgga cttcaaggat gccaagtagc ctaatgattt
     1741 attaggggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttcaaatc tggaaaactg
     1801 catacttcag gttataattt aacctttaaa gaaactggct tcaagtaaaa taatgactta
     1861 catttaagtt gagaaccccc ccatcttcaa ttaaatatat tacaaaaatt ggtttgagag
     1921 actttccaaa tatctactga aattaacaca gggctaagat caggccacat ttcaaaaatc
     1981 tcatccctta ctgggcattt atttcgggca atatagtaac cattttaaaa atatttttta
     2041 tatgtttttt cccaagtatg actacaatct tactctccct tctaagctag tgattcttac
     2101 cctggctgca tgtcagaatc acctgaagag tttttaaaaa acaccaatgc ctaattccca
     2161 tgtcttcctt ctgatgcaac tggaatgggg tgaactctaa gcattggtaa tttttacgta
     2221 actctcaagg tgataactgc tcttggtcat caaattcaaa cgtctagcta ttattaaaat
     2281 gagaggaaaa aaataaagca tcatttttat tatcaattta ttagcaattt gtaaaaaaca
     2341 aatctattct ctaaacgaga aatcataaca atattattcc agataaagtt aagtgttaac
     2401 aaagtaaaaa ggaaagcatg agaatattca tgccagtcat ggtgactgaa atcaggttat
     2461 cttttgaggg gaaaaataac ccagattaga aatgaaactg ggcagacttc ccattctgtg
     2521 caaaaattga aaatttgaga ttgtgcacca gtacatccag gagtaacaca aagcactcct
     2581 tgaatcaagg gtcataaata aacacgtgtc agagaaaatt aaaagaaatt aatatcatca
     2641 taaaaatagg aaattacttt catattcaac atactggtca aacattttct caccagagag
     2701 cttctaccac aaggatattt aaaagaatat ttaaaattca cc
//
