LOCUS       NM_147127               4382 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens EvC ciliary complex subunit 2 (EVC2), transcript
            variant 1, mRNA.
ACCESSION   NM_147127
VERSION     NM_147127.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Negrete-Torres,N., Chima-Galan,M.D.C., Sierra-Lopez,E.A.,
            Sanchez-Ramos,J., Alvarez-Gonzalez,I., Reyes-Reali,J.,
            Mendoza-Ramos,M.I., Garrido-Guerrero,E., Amato,D.,
            Mendez-Catala,C.F., Pozo-Molina,G. and Mendez-Cruz,A.R.
  TITLE     Identification of Compound Heterozygous EVC2 Gene Variants in Two
            Mexican Families with Ellis-van Creveld Syndrome
  JOURNAL   Genes (Basel) 14 (4), 887 (2023)
   PUBMED   37107645
  REMARK    GeneRIF: Identification of Compound Heterozygous EVC2 Gene Variants
            in Two Mexican Families with Ellis-van Creveld Syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4382)
  AUTHORS   Kantaputra,P., Dejkhamron,P., Sittiwangkul,R., Katanyuwong,K.,
            Ngamphiw,C., Sonsuwan,N., Intachai,W., Tongsima,S., Beales,P.L. and
            Buranaphatthana,W.
  TITLE     Dental Anomalies in Ciliopathies: Lessons from Patients with BBS2,
            BBS7, and EVC2 Mutations
  JOURNAL   Genes (Basel) 14 (1), 84 (2022)
   PUBMED   36672825
  REMARK    GeneRIF: Dental Anomalies in Ciliopathies: Lessons from Patients
            with BBS2, BBS7, and EVC2 Mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4382)
  AUTHORS   Gokhman,D., Agoglia,R.M., Kinnebrew,M., Gordon,W., Sun,D.,
            Bajpai,V.K., Naqvi,S., Chen,C., Chan,A., Chen,C., Petrov,D.A.,
            Ahituv,N., Zhang,H., Mishina,Y., Wysocka,J., Rohatgi,R. and
            Fraser,H.B.
  TITLE     Human-chimpanzee fused cells reveal cis-regulatory divergence
            underlying skeletal evolution
  JOURNAL   Nat Genet 53 (4), 467-476 (2021)
   PUBMED   33731941
  REMARK    GeneRIF: Human-chimpanzee fused cells reveal cis-regulatory
            divergence underlying skeletal evolution.
            Erratum:[Nat Genet. 2021 Apr;53(4):587. doi:
            10.1038/s41588-021-00849-4.. PMID: 33762754]
REFERENCE   4  (bases 1 to 4382)
  AUTHORS   Zhao,K., Lian,M., Zou,D., Huang,W., Zhou,W., Shen,Y., Wang,F. and
            Wu,Y.
  TITLE     Novel mutations identified in patients with tooth agenesis by
            whole-exome sequencing
  JOURNAL   Oral Dis 25 (2), 523-534 (2019)
   PUBMED   30417976
  REMARK    GeneRIF: Novel Wnt10A mutations (c.521T>C and c.653T>G) and EVC2
            mutation (c.1472C>T) were identified in families with selective
            tooth agenesis. The Wnt10A c.521T>C mutation and the EVC2 c.1472C>T
            mutation were considered as pathogenic for affecting highly
            conserved amino acids, co-segregated with phenotype and predicted
            to be disease-causing by SIFT and PolyPhen2.
REFERENCE   5  (bases 1 to 4382)
  AUTHORS   Ye,X., Song,G., Fan,M., Shi,L., Jabs,E.W., Huang,S., Guo,R. and
            Bian,Z.
  TITLE     A novel heterozygous deletion in the EVC2 gene causes Weyers
            acrofacial dysostosis
  JOURNAL   Hum Genet 119 (1-2), 199-205 (2006)
   PUBMED   16404586
  REMARK    GeneRIF: Data provide conclusive evidence that Weyers acrofacial
            dysostosis and EvC syndrome are allelic and genetically
            heterogeneous conditions.
REFERENCE   6  (bases 1 to 4382)
  AUTHORS   Ruiz-Perez,V.L., Tompson,S.W., Blair,H.J., Espinoza-Valdez,C.,
            Lapunzina,P., Silva,E.O., Hamel,B., Gibbs,J.L., Young,I.D.,
            Wright,M.J. and Goodship,J.A.
  TITLE     Mutations in two nonhomologous genes in a head-to-head
            configuration cause Ellis-van Creveld syndrome
  JOURNAL   Am J Hum Genet 72 (3), 728-732 (2003)
   PUBMED   12571802
  REMARK    GeneRIF: Mutations in this gene cause Ellis-van Creveld syndrome.
REFERENCE   7  (bases 1 to 4382)
  AUTHORS   Galdzicka,M., Patnala,S., Hirshman,M.G., Cai,J.F., Nitowsky,H.,
            Egeland,J.A. and Ginns,E.I.
  TITLE     A new gene, EVC2, is mutated in Ellis-van Creveld syndrome
  JOURNAL   Mol Genet Metab 77 (4), 291-295 (2002)
   PUBMED   12468274
  REMARK    GeneRIF: EVC2 is mutated in an Ashkenazi individual with Ellis-van
            Creveld syndrome
REFERENCE   8  (bases 1 to 4382)
  AUTHORS   Takeda,H., Takami,M., Oguni,T., Tsuji,T., Yoneda,K., Sato,H.,
            Ihara,N., Itoh,T., Kata,S.R., Mishina,Y., Womack,J.E., Moritomo,Y.,
            Sugimoto,Y. and Kunieda,T.
  TITLE     Positional cloning of the gene LIMBIN responsible for bovine
            chondrodysplastic dwarfism
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10549-10554 (2002)
   PUBMED   12136126
REFERENCE   9  (bases 1 to 4382)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   10 (bases 1 to 4382)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY185210.1, BG755658.1 and
            AW137166.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_147127.4.
            
            Summary: This gene encodes a protein that functions in bone
            formation and skeletal development. Mutations in this gene, as well
            as in a neighboring gene that lies in a head-to-head configuration,
            cause Ellis-van Creveld syndrome, an autosomal recessive skeletal
            dysplasia that is also known as chondroectodermal dysplasia.
            Mutations in this gene also cause acrofacial dysostosis Weyers
            type, also referred to as Curry-Hall syndrome, a disease that
            combines limb and facial abnormalities. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2009].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.14192.1, AY185210.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344408.10/ ENSP00000342144.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4133              AY185210.1         9-4141
            4134-4359           BG755658.1         52-277
            4360-4382           AW137166.1         37-59               c
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2"
     gene            1..4382
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /note="EvC ciliary complex subunit 2"
                     /db_xref="GeneID:132884"
                     /db_xref="HGNC:HGNC:19747"
                     /db_xref="MIM:607261"
     exon            1..274
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..3973
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     limbin; ellis-van Creveld syndrome protein 2; Ellis van
                     Creveld syndrome 2"
                     /codon_start=1
                     /product="limbin isoform 1"
                     /protein_id="NP_667338.3"
                     /db_xref="CCDS:CCDS3382.2"
                     /db_xref="GeneID:132884"
                     /db_xref="HGNC:HGNC:19747"
                     /db_xref="MIM:607261"
                     /translation="MDPSGSRGRPTWVLAGGLLAVALALGGRGCLGASSRPRWRPLGA
                     QPPRDPQVAPRSGPGLRIPPGRSGAGPESSTQDLPCMIWPKVECCHFKTAVEAPLGMK
                     LDKKMEVFIPLSTSAASSGPWAHSLFAFIPSWPKKNLFKRESPITHRLYGDISREVQG
                     TSENGVIFQKCALVSGSSEAQTARIWLLVNNTKTTSSANLSELLLLDSIAGLTIWDSV
                     GNRTSEGFQAFSKKFLQVGDAFAVSYAATLQAGDLGNGESLKLPAQLTFQSSSRNRTQ
                     LKVLFSITAEENVTVLPHHGLHAAGFFIAFLLSLVLTWAALFLMVRYQCLKGNMLTRH
                     RVWQYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRAD
                     ADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRK
                     MVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQE
                     HLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNY
                     SKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLI
                     QKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQK
                     HREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLT
                     LSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDR
                     DQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVH
                     GCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKS
                     KSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF
                     QKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLED
                     QLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQH
                     QQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVV
                     LPTASQPQLLALLDSATERHVDHAAESDGGAEQADVGRRRKHQSWWQALDGKLRGDLI
                     SRGLEKMLWARKRKQSILKKTCLPLRERMIFSGKGSWPHLSLEPIGELAPVPIVGAET
                     IDLLNTGEKLFIFRNPKEPEISLHVPPRKKKNFLNAKKAMRALGMD"
     exon            275..329
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            330..496
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            497..565
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            566..752
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            753..862
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            863..916
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1051
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1191
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1516
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1756
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1932
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2092
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2547
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2752
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2875
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3103
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3318
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3406
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3603
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3705
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..4382
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4343..4348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /note="hexamer: TATAAA"
     polyA_site      4356
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /note="major polyA site"
     regulatory      4362..4367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /note="hexamer: AATAAA"
     polyA_site      4367
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
     polyA_site      4382
                     /gene="EVC2"
                     /gene_synonym="LBN; WAD"
                     /note="major polyA site"
ORIGIN      
        1 gactcggcgg cacccgccgc tttgaggtag cgggtcccga caggcgatgg acccctcggg
       61 ctcccggggg cgccccacgt gggtgctggc cgggggtctc ctggcagtgg ccctggcgct
      121 ggggggccga ggctgtctcg gcgccagctc acgtccccgc tggcgccccc tcggcgcgca
      181 gccaccccgg gatccccagg tggctcctag gtctgggccc ggcctgagga tccctccggg
      241 gcggagcggg gcggggcccg agagcagcac gcaggacttg ccctgtatga tttggcccaa
      301 agtggaatgc tgtcacttta agactgcagt ggaagcacca cttggaatga aattggacaa
      361 gaaaatggaa gtcttcatcc cactctcaac ttctgcagcc tctagtgggc catgggctca
      421 ttccttattt gcttttatac cctcctggcc taagaagaac ttatttaaaa gagagtctcc
      481 tataacacac cgcctgtatg gggacatttc aagagaagtt caagggactt ctgaaaatgg
      541 agtaattttt cagaaatgtg cactggtgtc tgggtcgagt gaagcacaga cagcccgcat
      601 atggctgctt gttaacaaca ccaagacaac ctcgtcagcc aacctctcgg agctgctctt
      661 gctggacagc attgctggtc tcaccatttg ggactctgtg ggaaacagga cctcggaagg
      721 attccaggct tttagcaaga agtttctgca agtgggagat gcctttgctg tcagctacgc
      781 agccacgctc caggctggag acctcgggaa cggggagagc ctcaagcttc ctgcccaact
      841 cacctttcag agctcgtcac ggaacagaac acagctgaaa gtgctttttt ccataacagc
      901 agaagaaaac gtaacggttc tgccgcacca cggcctccac gcagcagggt tcttcattgc
      961 cttcctcctc tcccttgtgc tgacctgggc tgccctcttc ctcatggttc gctatcagtg
     1021 tctgaaggga aacatgctca ccagacatcg ggtttggcag tatgagagca agctggaacc
     1081 cttgccgttc acctcagctg atggcgtgaa tgaggacctt tcccttaacg accaaatgat
     1141 agacattctg tcttccgagg accctgggag catgcttcaa gccttagaag agttggagat
     1201 tgcaaccctg aatcgggcag atgcagatct ggaggcttgt cgaacacaaa tcagcaagga
     1261 tatcattgcc cttctgctga aaaatctcac cagcagtggc cacctctcac cccaagtaga
     1321 gagaaaaatg agtgctgttt tcaaaaagca gtttctattg ctggaaaatg aaatacaaga
     1381 ggagtacgat cggaagatgg tggcattgac agctgaatgt gacctggaaa caagaaagaa
     1441 gatggaaaac cagtaccaga gagagatgat ggcaatggag gaagcagaag agttgctgaa
     1501 acgtgctggt gagaggtctg ctgtagagtg cagcaacctt ctgcggaccc tccatggcct
     1561 ggaacaggag cacttgagga agtctctcgc tttgcaacaa gaagaagact ttgccaaagc
     1621 tcacagacag ctggctgttt tccagagaaa tgaactgcac agtatctttt ttacccagat
     1681 aaaaagtgct attttcaaag gggaattgaa accagaggca gctaaaatgc tgctgcaaaa
     1741 ttattctaaa atacaggaga atgtagaaga gttaatggac tttttccagg ctagtaagag
     1801 gtatcatcta agtaaaagat ttggccacag ggaatatctg gtccagaacc tccagtcatc
     1861 agagacccgt gtgcagggcc ttctgagcac cgctgcagcc cagctgactc acctcattca
     1921 gaagcacgag agagcagggt acctggatga agaccaaatg gaaatgctat tggagcgggc
     1981 tcagacagaa gtcttttcaa tcaagcagaa gttggacaat gacttaaagc aggaaaagaa
     2041 aaagctccac caaaaattaa taactaagag aagacgagag ttgctacaaa agcacaggga
     2101 gcagcgtagg gagcaggcgt ccgtcggcga ggccttccga acggttgagg atgccggcca
     2161 gtacctgcac cagaagagga gcctgatgga ggagcacggt gccaccctgg aggagctgca
     2221 ggagcgtctg gaccaggccg ccctggacga tctcaggacc ctgacccttt cgctgtttga
     2281 aaaggccacc gacgagctgc ggcgcctgca gaactcagcc atgacccagg agctgctcaa
     2341 gcgtggggtg ccctggctct tcctgcagca gatcctggag gagcacggca aggagatggc
     2401 tgcacgggcc gagcagctgg agggggagga gagggacagg gaccaggagg gtgtccagag
     2461 cgtgaggcag agactgaagg atgacgctcc tgaggccgtg acagaggagc aggcagagct
     2521 gcgacgctgg gagcacctga tcttcatgaa gctctgctcc tcagtcttct ccctgtctga
     2581 agaggagctg ctcaggatga ggcaggaggt ccatggctgc tttgctcaga tggacaggag
     2641 cttggccctc cccaagatcc gggcccgagt tctgctgcag caatttcaga ctgcgtggcg
     2701 agaagcagag ttcgtgaagc tggaccaggc cgtggctgcc cctgagctgc agcaacagtc
     2761 caaggtgaga aagtcacggt ccaagagtaa aagcaaggga gagcttctga agaagtgcat
     2821 cgaagacaaa attcacctct gtgaggaaca ggcctctgaa gacctggtgg aaaaggttcg
     2881 aggtgaattg ctgcgggaga gagtgcagcg gatggaggca caggagggag gctttgcaca
     2941 gtcgcttgtt gctctgcagt tccagaaggc gtcccgggtg accgagactc tgtcggccta
     3001 caccgccctc ctcagcatcc aggacttgct cctggaagag ctgagtgcat ctgagatgct
     3061 gaccaagtcg gcctgcacac agatcctgga gtcgcacagc cgggagctcc aggagttgga
     3121 gaggaagctg gaggaccagc tggtgcagca ggaggcagcc cagcagcagc aggccctggc
     3181 gagctggcag cagtgggtgg ccgatgggcc cgggattctg aacgaacctg gggaggtgga
     3241 ttctgaaagg caggtctcta ctgtcctgca ccaagccctg agcaagagcc agacattact
     3301 ggagcaacat cagcagtgtt tgagagagga acaacagaac agtgtcgtgc tagaagactt
     3361 gttggaaaac atggaggcag acacctttgc aaccctgtgc agccaggagc tgagactggc
     3421 atcgtacctg gcgaggatgg ccatggtgcc cggggccacg cttcgccggc tcctgagtgt
     3481 ggtactgccc acagcctcac agcctcagct gctggccctg ctggattcgg ccaccgagag
     3541 acatgtggac cacgcagctg agagcgatgg cggagcggag caggccgacg tgggcaggcg
     3601 gaggaaacac cagagctggt ggcaagcctt agatggcaaa ctgcgaggag atctgataag
     3661 cagaggatta gaaaagatgc tgtgggcccg caagagaaag cagagcatat taaagaagac
     3721 atgtctccct ctcagagaga ggatgatatt ctctggaaaa ggaagttggc cacacctgtc
     3781 actggagccc attggcgaac tggcccctgt acccattgta ggggcagaaa ccattgatct
     3841 attaaacaca ggagagaagc tctttatatt cagaaatcca aaggagccag agatctcact
     3901 gcacgttcct cccaggaaaa agaagaactt tttgaatgcc aaaaaggcca tgagggcctt
     3961 gggcatggac tagcccaagg gaaagacctg cgggagcatc tgaagagaga agggatgatt
     4021 ttctcctgcc cgccggtgtt tgtgtgttta taatgcacaa ctcgcaaata taaattgcac
     4081 atgcagaagg cacagacccc gtagcgcatg ccaacttgca gggactcggt ttaatcttgt
     4141 ctcatgaatt tccagatggc ccactctctt ccatatcaca aggacataaa cactccttct
     4201 ttcagcccca cctccccagg gccctggagg agacccccac cctgcaatcc acaccccatc
     4261 ctctgctgca gaagctatgg tctgtgtggt gacagccaga ttctctactc ttatgttttg
     4321 tatttgttac atattctatt tttataaagg gaattttaaa aaataaatgt gttttgcaca
     4381 aa
//
