LOCUS       NM_153717               6427 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens EvC ciliary complex subunit 1 (EVC), transcript
            variant 1, mRNA.
ACCESSION   NM_153717
VERSION     NM_153717.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6427)
  AUTHORS   Zaka,A., Shahzad,S., Rao,H.Z., Kanwal,S., Gul,A. and Basit,S.
  TITLE     An intrafamilial phenotypic variability in Ellis-Van Creveld
            syndrome due to a novel 27 bps deletion mutation
  JOURNAL   Am J Med Genet A 185 (10), 2888-2894 (2021)
   PUBMED   34037314
  REMARK    GeneRIF: An intrafamilial phenotypic variability in Ellis-Van
            Creveld syndrome due to a novel 27 bps deletion mutation.
REFERENCE   2  (bases 1 to 6427)
  AUTHORS   Liu,F., Liu,X., Xu,Z., Yuan,P., Zhou,Q., Jin,J., Yan,X., Xu,Z.,
            Cao,Q., Yu,J., Cheng,Y., Wan,R. and Hong,K.
  TITLE     Molecular mechanisms of Ellis-van Creveld gene variations in
            ventricular septal defect
  JOURNAL   Mol Med Rep 17 (1), 1527-1536 (2018)
   PUBMED   29257216
  REMARK    GeneRIF: The molecular mechanism underlying the development of
            ventricular septal defect induced by the EVC c.343C>G mutation may
            be due to a reduction in the anti-apoptotic and proliferative
            abilities of cardiomyocytes via downregulation of Hh pathway
            activity.
REFERENCE   3  (bases 1 to 6427)
  AUTHORS   Ibarra-Ramirez,M., Campos-Acevedo,L.D., Lugo-Trampe,J.,
            Martinez-Garza,L.E., Martinez-Glez,V., Valencia-Benitez,M.,
            Lapunzina,P. and Ruiz-Perez,V.
  TITLE     Phenotypic Variation in Patients with Homozygous c.1678G>T Mutation
            in EVC Gene: Report of Two Mexican Families with Ellis-van Creveld
            Syndrome
  JOURNAL   Am J Case Rep 18, 1325-1329 (2017)
   PUBMED   29229899
  REMARK    GeneRIF: Here, we report on two Mexican families with patients
            diagnosed with Ellis-van Creveld syndrome. In all cases, molecular
            analysis by Sanger sequencing identified the same homozygous
            mutation in exon 12 of EVC, c.1678G>T, which leads to a premature
            stop codon.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6427)
  AUTHORS   Umair,M., Seidel,H., Ahmed,I., Ullah,A., Haack,T.B., Alhaddad,B.,
            Jan,A., Rafique,A., Strom,T.M., Ahmad,F., Meitinger,T. and Ahmad,W.
  TITLE     Ellis-van Creveld syndrome and profound deafness resulted by
            sequence variants in the EVC/EVC2 and TMC1 genes
  JOURNAL   J Genet 96 (6), 1005-1014 (2017)
   PUBMED   29321360
  REMARK    GeneRIF: the whole exome sequencing (WES) in this family revealed
            two homozygous variants in EVC2 (c.30dupC; p.Thr11Hisfs*45) and
            TMC1 (c.1696-1G>A) genes. In family B, WES revealed novel compound
            heterozygous variants (p.Ser307Pro, c.2894+3A>G) in the EVC gene.
REFERENCE   5  (bases 1 to 6427)
  AUTHORS   Ruiz-Perez,V.L., Tompson,S.W., Blair,H.J., Espinoza-Valdez,C.,
            Lapunzina,P., Silva,E.O., Hamel,B., Gibbs,J.L., Young,I.D.,
            Wright,M.J. and Goodship,J.A.
  TITLE     Mutations in two nonhomologous genes in a head-to-head
            configuration cause Ellis-van Creveld syndrome
  JOURNAL   Am J Hum Genet 72 (3), 728-732 (2003)
   PUBMED   12571802
REFERENCE   6  (bases 1 to 6427)
  AUTHORS   .
  TITLE     Correction to 'NPHS2, encoding the glomerular protein podocin, is
            mutated in autosomal recessive steroid-resistant nephrotic
            syndrome'
  JOURNAL   Nat Genet 25 (1), 125 (2000)
   PUBMED   10802674
REFERENCE   7  (bases 1 to 6427)
  AUTHORS   Ruiz-Perez,V.L., Ide,S.E., Strom,T.M., Lorenz,B., Wilson,D.,
            Woods,K., King,L., Francomano,C., Freisinger,P., Spranger,S.,
            Marino,B., Dallapiccola,B., Wright,M., Meitinger,T.,
            Polymeropoulos,M.H. and Goodship,J.
  TITLE     Mutations in a new gene in Ellis-van Creveld syndrome and Weyers
            acrodental dysostosis
  JOURNAL   Nat Genet 24 (3), 283-286 (2000)
   PUBMED   10700184
  REMARK    Erratum:[Nat Genet 2000 May;25(1):125]
REFERENCE   8  (bases 1 to 6427)
  AUTHORS   Polymeropoulos,M.H., Ide,S.E., Wright,M., Goodship,J.,
            Weissenbach,J., Pyeritz,R.E., Da Silva,E.O., Ortiz De Luna,R.I. and
            Francomano,C.A.
  TITLE     The gene for the Ellis-van Creveld syndrome is located on
            chromosome 4p16
  JOURNAL   Genomics 35 (1), 1-5 (1996)
   PUBMED   8661097
REFERENCE   9  (bases 1 to 6427)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   10 (bases 1 to 6427)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF216185.1 and AC105915.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_153717.2.
            
            Summary: This gene encodes a protein containing a leucine zipper
            and a transmembrane domain. This gene has been implicated in both
            Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF216185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264956.11/ ENSP00000264956.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-946               AF216185.1         5-950
            947-952             AC105915.5         11457-11462
            953-6426            AF216185.1         957-6430
            6427-6427           AC105915.5         83982-83982
FEATURES             Location/Qualifiers
     source          1..6427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2"
     gene            1..6427
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /note="EvC ciliary complex subunit 1"
                     /db_xref="GeneID:2121"
                     /db_xref="HGNC:HGNC:3497"
                     /db_xref="MIM:604831"
     exon            1..354
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3159
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ellis-van Creveld syndrome protein; Ellis van Creveld
                     syndrome; Ellis van Creveld protein; evC complex member
                     EVC"
                     /codon_start=1
                     /product="evC complex member EVC isoform 1"
                     /protein_id="NP_714928.1"
                     /db_xref="CCDS:CCDS3383.1"
                     /db_xref="GeneID:2121"
                     /db_xref="HGNC:HGNC:3497"
                     /db_xref="MIM:604831"
                     /translation="MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGL
                     WLGCRAGRQRTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDEC
                     EPPSNSNITAFALKAKVIYPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSS
                     LGSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHL
                     KDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGL
                     QVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKC
                     SSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEE
                     TRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTA
                     SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEE
                     NVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAA
                     WQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLG
                     GLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQ
                     GSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHM
                     ECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIG
                     RIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRML
                     SQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPL
                     AESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQ
                     ESEAGDSGNSKKMLKRRSNL"
     exon            355..480
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            481..564
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            565..797
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            798..882
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            883..981
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1119
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1278
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1495
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1644
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1743
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1956
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2066
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2277
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2484
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2629
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2741
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2868
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2962
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3074
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..6427
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6399
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
     polyA_site      6427
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /note="major polyA site"
ORIGIN      
        1 ccggctcggc gaagcaggga aggggagaga agcaggagtc gggagactgc acaggccaga
       61 aagtctgcgg agcgggccgc gcccctggcc cgcccgggct ccaagtcccg cgtcgccgcc
      121 ctggcgggga cggtgcagca ggcggcggga tgcggcgggg cggcagcctg agcgccccgg
      181 atggcccgcg gcggggcggc ctgcaagagc gacgcgcggc tgctgctggg gcgggacgcg
      241 ctgcggccgg cgcccgccct gctggccccc gccgtgctgc tgggcgccgc gctcggcctc
      301 ggcctcggcc tttggcttgg ctgccgcgcg ggccgccagc gcacgcgaca ccagaaagac
      361 gacactcaaa atctgctcaa gaatttggag tctaatgcgc agaccccctc ggaaactggc
      421 tccccatcaa ggaggaggaa gagagaagtg cagatgtcga aggacaagga agctgttgat
      481 gaatgtgagc cgccttccaa cagcaatatc acagcattcg ccctgaaggc caaagtcatc
      541 taccccatca atcagaagtt ccggcctctg gccgatggct cctccaaccc gtctctgcat
      601 gaaaacttaa agcaggctgt tttgccacac cagccggtag aggcctctcc ttccagcagt
      661 ctggggagcc tgagccaggg tgagaaggac gactgcagct cctcatccag cgtccactcg
      721 gccaccagcg atgacaggtt tctcagccgc accttcctcc gggtgaacgc cttccctgaa
      781 gtgctggcct gcgagagtgt agacgttgac ctgtgtatct acagccttca cttaaaagac
      841 ctgctgcatt tggacacggc actgaggcag gaaaagcata tgatgtttat tcagattttt
      901 aaaatgtgcc tccttgacct tcttcctaaa aagaagtcag atgatgaact ataccagaag
      961 atcctttcaa aacaagaaaa agatttggag gaactagaaa agggacttca ggtcaaactg
     1021 tcaaacacag aaatgtcggg ggctggtgac tctgagtaca tcaccctggc tgatgtggaa
     1081 aagaaggaga gagaatactc tgaacagcta atcgataata tggaagcttt ctggaaacag
     1141 atggcaaata tccagcactt tcttgtggac cagtttaagt gttccagctc caaagcccga
     1201 cagctgatga tgactctgac ggaaagaatg attgcagccg aagggctatt gtgcgattct
     1261 caggagctgc aggctctgga cgccctggag aggacgatgg ggcgggcgca catggcaaaa
     1321 gtgattgagt ttctgaagct gcaagtccag gaggagacca ggtgccggct ggctgccatc
     1381 tcccacggcc tggagctgct ggctggtgag gggaagctgt ccgggcggca gaaggaggag
     1441 ctgctcacgc agcagcacaa ggccttctgg caggaggcag agcgcttcag ccgggagttt
     1501 gtccagcgag gcaaagacct ggtcacggcg tctctggctc accaggtgga gggaacggca
     1561 aaactcacgc tggcccaaga ggaggaacag agaagcttcc tggctgaggc ccagccgact
     1621 gctgacccgg aaaagtttct cgaggctttt catgaggtcc tggagaggca gaggctgatg
     1681 cagtgtgacc tggaggaaga ggagaatgtc agagccaccg aggctgtggt tgcactctgc
     1741 caggagctgt acttcagcac cgtggacact ttccagaagt tcgtggatgc cctgttcctt
     1801 cagacgctcc ctggcatgac tggcctcccc ccggaagagt gtgactactt gaggcaggaa
     1861 gtccaggaga acgctgcctg gcagctgggg aagtcaaatc gcttccggag gcagcagtgg
     1921 aaactcttcc aggagctcct agagcaagac cagcaggtgt ggatggagga gtgtgcgctg
     1981 tccagcgtgc tgcagacaca cctgcgggag gaccacgagg gcaccatccg cggcgtcttg
     2041 ggccgactgg gcggcctcac tgaagagtcc acgcggtgtg tcctgcaggg gcatgacctg
     2101 ctgttgcgct cagccctccg gaggctggca ctccgcggca acgccctggc caccctgacg
     2161 cagatgcggc tatcggggaa gaagcacctc ctgcaggagc tgcgggaaca gcgtgcactg
     2221 gagcaggggt cctcccagtg cctggacgag catcagtggc agctgctcag ggccctggag
     2281 gcgcgtgtgc tggaggaggc cagccggcta gaggaggaag cacagcagac acggctgcag
     2341 ctccagcagc ggctcctggc cgaggcccag gaggtggggc agcttctgca gcagcacatg
     2401 gagtgcgcca ttgggcaggc gctgctggtg catgcacgga atgcagccac caagagccgg
     2461 gccaaggaca gggatgactt caagaggaca ctgatggagg cggcagtgga gagcgtctac
     2521 gtgaccagcg ctggtgtcag ccgcctggtg caggcgtatt accagcaaat cggaaggatc
     2581 atggaggacc acgaggagag aaaactgcag cacctgaaga ccctgcaggg tgagaggatg
     2641 gaaaattaca aactgcggaa aaagcaagaa ctcagcaacc cttcgtcggg cagcaggacg
     2701 gcaggtggcg ctcatgagac ctcccaggcg gtccaccaga ggatgctgtc ccagcagaag
     2761 aggttcctgg cccagttccc agtgcaccag cagatgcgtc tgcacgccca gcagcagcag
     2821 gcaggagtca tggaccttct ggaagcccag ctggagaccc agctacagga agctgaacag
     2881 aacttcatct ccgagctggc agccttggcc cgagtgcccc ttgctgaaag caaactgttg
     2941 cctgctaagc gtgggctgct agagaagccc ctaaggacta aaaggaagaa gcccctgccc
     3001 caggaaagag gggacctggg ggtgcccaac aatgaggacc ttgcctccgg ggaccagacc
     3061 tcaggctcac tcagcagcaa aaggctgagt cagcaagaaa gtgaagctgg ggacagtggg
     3121 aactcaaaga agatgctaaa gagaagaagc aacttgtagt ttaagaccag tcggtgggac
     3181 aagacctgaa gccctgggtc tgggtgtgaa ttccaccttc cctcctgcag tgctgagagg
     3241 cagcgaggac ggagaggaca gcggcatctc taggctcttc tgagagggac agagaaagaa
     3301 tagaaatgtg ccctaaaagc ataaatgagt atcacctgag aaaattaggc attcccgtct
     3361 tggaaacacg tctctgtgag tttgcatttc atttggcttg gagccctggc tcgatgcctc
     3421 atggatcttt ctccccaagg agggacgtct tgaggggtcc gagcctcagg ccaaggaccc
     3481 ctgatgcaga ctctggaatc cctggcccaa aggcctgtct gggcccatct ggggctgagg
     3541 acacacagat acataatgac acctgcagaa atgtattctc tgaggacact tagaatatga
     3601 ggaagagggt gtggcccaac cctcacttca cctggggagg ggcttcttcc ggacagtaga
     3661 caccctgccc gtgcagagag atgtcatggg ggcacctgct ctccctgata gatgctgaga
     3721 gcatccagaa acttccagac cagccctctc accacaccca gaagaggcct ttcccatctg
     3781 gagagaagct tccagaccag cccttcacac accacagcca ggaggggcct ttcccacctg
     3841 gagagaaact tccagaccag cccctcatac cacagccaag aggggccttt ctcacctgga
     3901 gagaaatttc cagaccatcc cctctcacca cagccaggag aggcctttcc caccggtaga
     3961 gaaacttcca gaccagcccc tcacaccaca gccaagagaa gcctttccag cctggagaga
     4021 aacttccaga ccagccctct cactacagcc aggagaggcc tttcccgcct ggaaacttcc
     4081 ggacaagcct ctcacacacc acagccagga gaggcctttc ccacctggac agaaacttcc
     4141 agaccagccc ctctcaccac agccaggaga ggcctttacc acctggagag aagcttccag
     4201 accagcccct cacaccacag ccaggagagg cctttcccac ctggagagaa acttccagac
     4261 cagcccctca taccacagcc aagaggggcc tttctcacct ggagagaaac ttccagacca
     4321 gcccctcaca ccaccgccag gagaggcctt tcccaccggg agagaaactt ccagaccagc
     4381 ccctcacacc acagccagga gaggcctttc ccaccgggag agaaacttcc agaccagccc
     4441 tctcactaca gccagaagag gcctttccca ccgggagagg aacttccaga ccagcccctc
     4501 acaccacagc caggagaggc ctttcccgcc tggagagaag cttcaggcca gctcctcaca
     4561 ccacagccag gagagacctt ttctgcctgg agagaaactt tcagaccagc cccacacacc
     4621 acagccagga gaggccgttc ctgcctggag agaagcttcc agaccagccc ttcacaccac
     4681 agccaggaga ggcctttccc acctggagag aaacttccag accagcccct ctcaccacag
     4741 ccaggagagg ccgttcccac ctggagggaa aattgctcct ttgatggagg ttagggactg
     4801 tcaccctcag cactgtgaac ataccgggcg agatcattct tcaggggaag gagctgccca
     4861 gagcatcaca ggatgttcca gtgtccctgg tctctgccca ccagatgcca gcactcccac
     4921 cattcgtggc aaccaaggat gtctccagac actgccccgt gtccatgggg ttatcaccca
     4981 ctgtgctgag tcaaagggtg ccttgccctg gtctaatcca ggacatagcc gtggatacgt
     5041 ccaaaaatcc ccagaaccta gtgagccctc tggctctggg agcccctatc tcaggaattt
     5101 tcagggtcat ttgtgacttt tcatttctta aaacctgaaa tagactctct tagaaacaag
     5161 tgactccttc ccagtggcca aaacttaatc atcagagcgc ttccttcagt tcctcaccca
     5221 tcagccagtg ggctctccaa agttaaccaa cagctccctc ttgtggttca ctaaaaaact
     5281 tggttattcc atggagttgt gcaaagctat ggcttccttg gtgcaatatt cttaaaacct
     5341 gctttgcata gaaatcactt ttgcccaggc tggagtgcag tggcgtgatc tcggctcatg
     5401 gcaatctcca tctcccgggt tcaagcgatt ttcctgcctc agcctcccca gtagctggga
     5461 ctacagacgt gtgccaccac gcctggctaa atcttttttg tattttattt tagtagagac
     5521 ggggtttcac catactggcc aggctgctct cgaactcctg acctcatcgt ccacctgcct
     5581 cggcctcccc aaagtgctga gattaggcgt tagccaccgc gcccggccag aaatcacttt
     5641 tatattgtca catgggccct ctgcacagag tccgatggct cctcccgggg aagcctgatt
     5701 ttgtgacgtg tgtatagtaa atgcaggccc tctggcagca ccataattgg tcggttaccc
     5761 tgagcccaga gctctgaaag catctgtgga atgatcacgg gacccttctc ctctgagaag
     5821 gctcccggct gcctccccgc caccgagctt gtagcctgaa tgcctggctg tcgcatggag
     5881 cattttgctt ctggggtgtc ttccttagcc aaagggaacg tgtcatttgc tcgaccctgg
     5941 cccacccttg ccgcccagct gttgtgctgg gcacagtctg gggcacaggc ctccatgatg
     6001 aagacgcgtg ggctgtcggt gctttcatcc gtcacaaact ggcacctgta cctgccagca
     6061 ggagcatgat ggggacttcc atgctggaat tgctccctga ttaaaatgag atatggctat
     6121 ttggaagaca ctgcatttta gccagtgtac ctgggcacag actcggggct gccctgaagc
     6181 tgatgaaggc ttgaaggacg gaagggctga gccacatgaa ggcagcactc agggccaggg
     6241 gagagagaag aggatcagca gtgcagcccc aggatgcctc gcaggtaccc tgcctccatt
     6301 ttggttacca tccccactta ttatgggctg tgggctgtta tggtgatgga tggatgtgga
     6361 tttggaaggg gaccatgaga gatgatgtat tatgatgaac tcatgattta attctttggt
     6421 gaaaata
//
