LOCUS       NM_001306090            6424 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens EvC ciliary complex subunit 1 (EVC), transcript
            variant 2, mRNA.
ACCESSION   NM_001306090
VERSION     NM_001306090.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6424)
  AUTHORS   Zaka,A., Shahzad,S., Rao,H.Z., Kanwal,S., Gul,A. and Basit,S.
  TITLE     An intrafamilial phenotypic variability in Ellis-Van Creveld
            syndrome due to a novel 27 bps deletion mutation
  JOURNAL   Am J Med Genet A 185 (10), 2888-2894 (2021)
   PUBMED   34037314
  REMARK    GeneRIF: An intrafamilial phenotypic variability in Ellis-Van
            Creveld syndrome due to a novel 27 bps deletion mutation.
REFERENCE   2  (bases 1 to 6424)
  AUTHORS   Liu,F., Liu,X., Xu,Z., Yuan,P., Zhou,Q., Jin,J., Yan,X., Xu,Z.,
            Cao,Q., Yu,J., Cheng,Y., Wan,R. and Hong,K.
  TITLE     Molecular mechanisms of Ellis-van Creveld gene variations in
            ventricular septal defect
  JOURNAL   Mol Med Rep 17 (1), 1527-1536 (2018)
   PUBMED   29257216
  REMARK    GeneRIF: The molecular mechanism underlying the development of
            ventricular septal defect induced by the EVC c.343C>G mutation may
            be due to a reduction in the anti-apoptotic and proliferative
            abilities of cardiomyocytes via downregulation of Hh pathway
            activity.
REFERENCE   3  (bases 1 to 6424)
  AUTHORS   Ibarra-Ramirez,M., Campos-Acevedo,L.D., Lugo-Trampe,J.,
            Martinez-Garza,L.E., Martinez-Glez,V., Valencia-Benitez,M.,
            Lapunzina,P. and Ruiz-Perez,V.
  TITLE     Phenotypic Variation in Patients with Homozygous c.1678G>T Mutation
            in EVC Gene: Report of Two Mexican Families with Ellis-van Creveld
            Syndrome
  JOURNAL   Am J Case Rep 18, 1325-1329 (2017)
   PUBMED   29229899
  REMARK    GeneRIF: Here, we report on two Mexican families with patients
            diagnosed with Ellis-van Creveld syndrome. In all cases, molecular
            analysis by Sanger sequencing identified the same homozygous
            mutation in exon 12 of EVC, c.1678G>T, which leads to a premature
            stop codon.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6424)
  AUTHORS   Umair,M., Seidel,H., Ahmed,I., Ullah,A., Haack,T.B., Alhaddad,B.,
            Jan,A., Rafique,A., Strom,T.M., Ahmad,F., Meitinger,T. and Ahmad,W.
  TITLE     Ellis-van Creveld syndrome and profound deafness resulted by
            sequence variants in the EVC/EVC2 and TMC1 genes
  JOURNAL   J Genet 96 (6), 1005-1014 (2017)
   PUBMED   29321360
  REMARK    GeneRIF: the whole exome sequencing (WES) in this family revealed
            two homozygous variants in EVC2 (c.30dupC; p.Thr11Hisfs*45) and
            TMC1 (c.1696-1G>A) genes. In family B, WES revealed novel compound
            heterozygous variants (p.Ser307Pro, c.2894+3A>G) in the EVC gene.
REFERENCE   5  (bases 1 to 6424)
  AUTHORS   Ruiz-Perez,V.L., Tompson,S.W., Blair,H.J., Espinoza-Valdez,C.,
            Lapunzina,P., Silva,E.O., Hamel,B., Gibbs,J.L., Young,I.D.,
            Wright,M.J. and Goodship,J.A.
  TITLE     Mutations in two nonhomologous genes in a head-to-head
            configuration cause Ellis-van Creveld syndrome
  JOURNAL   Am J Hum Genet 72 (3), 728-732 (2003)
   PUBMED   12571802
REFERENCE   6  (bases 1 to 6424)
  AUTHORS   .
  TITLE     Correction to 'NPHS2, encoding the glomerular protein podocin, is
            mutated in autosomal recessive steroid-resistant nephrotic
            syndrome'
  JOURNAL   Nat Genet 25 (1), 125 (2000)
   PUBMED   10802674
REFERENCE   7  (bases 1 to 6424)
  AUTHORS   Ruiz-Perez,V.L., Ide,S.E., Strom,T.M., Lorenz,B., Wilson,D.,
            Woods,K., King,L., Francomano,C., Freisinger,P., Spranger,S.,
            Marino,B., Dallapiccola,B., Wright,M., Meitinger,T.,
            Polymeropoulos,M.H. and Goodship,J.
  TITLE     Mutations in a new gene in Ellis-van Creveld syndrome and Weyers
            acrodental dysostosis
  JOURNAL   Nat Genet 24 (3), 283-286 (2000)
   PUBMED   10700184
  REMARK    Erratum:[Nat Genet 2000 May;25(1):125]
REFERENCE   8  (bases 1 to 6424)
  AUTHORS   Polymeropoulos,M.H., Ide,S.E., Wright,M., Goodship,J.,
            Weissenbach,J., Pyeritz,R.E., Da Silva,E.O., Ortiz De Luna,R.I. and
            Francomano,C.A.
  TITLE     The gene for the Ellis-van Creveld syndrome is located on
            chromosome 4p16
  JOURNAL   Genomics 35 (1), 1-5 (1996)
   PUBMED   8661097
REFERENCE   9  (bases 1 to 6424)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   10 (bases 1 to 6424)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF216185.1, AF239742.1 and
            AC105915.5.
            
            On May 31, 2019 this sequence version replaced NM_001306090.1.
            
            Summary: This gene encodes a protein containing a leucine zipper
            and a transmembrane domain. This gene has been implicated in both
            Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF239742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AF216185.1         5-184
            181-948             AF239742.1         1-768
            949-949             AC105915.5         11459-11459
            950-1525            AF239742.1         770-1345
            1526-1526           AF216185.1         1530-1530
            1527-3156           AF239742.1         1347-2976
            3157-6423           AF216185.1         3164-6430
            6424-6424           AC105915.5         83982-83982
FEATURES             Location/Qualifiers
     source          1..6424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2"
     gene            1..6424
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /note="EvC ciliary complex subunit 1"
                     /db_xref="GeneID:2121"
                     /db_xref="HGNC:HGNC:3497"
                     /db_xref="MIM:604831"
     exon            1..354
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3156
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ellis-van Creveld syndrome protein; Ellis van Creveld
                     syndrome; Ellis van Creveld protein; evC complex member
                     EVC"
                     /codon_start=1
                     /product="evC complex member EVC isoform 2"
                     /protein_id="NP_001293019.1"
                     /db_xref="GeneID:2121"
                     /db_xref="HGNC:HGNC:3497"
                     /db_xref="MIM:604831"
                     /translation="MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGL
                     WLGCRAGRQRTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDEC
                     EPPSNSNITAFALKAKVIYPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSS
                     LGSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHL
                     KDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGL
                     QVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKC
                     SSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEE
                     TRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTA
                     SLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEE
                     NVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAA
                     WQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLG
                     GLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQ
                     GSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHM
                     ECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIG
                     RIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRML
                     SQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPL
                     AESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSKRLSQQE
                     SEAGDSGNSKKMLKRRSNL"
     exon            355..480
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            481..564
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            565..797
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            798..882
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            883..981
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1119
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1278
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1495
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1644
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1743
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1956
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2066
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2277
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2484
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2629
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2741
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2868
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2962
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3074
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..6424
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6396
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
     polyA_site      6424
                     /gene="EVC"
                     /gene_synonym="DWF-1; EVC1; EVCL"
                     /note="major polyA site"
ORIGIN      
        1 ccggctcggc gaagcaggga aggggagaga agcaggagtc gggagactgc acaggccaga
       61 aagtctgcgg agcgggccgc gcccctggcc cgcccgggct ccaagtcccg cgtcgccgcc
      121 ctggcgggga cggtgcagca ggcggcggga tgcggcgggg cggcagcctg agcgccccgg
      181 atggcccgcg gcggggcggc ctgcaagagc gacgcgcggc tgctgctggg gcgggacgcg
      241 ctgcggccgg cgcccgccct gctggccccc gccgtgctgc tgggcgccgc gctcggcctc
      301 ggcctcggcc tttggcttgg ctgccgcgcg ggccgccagc gcacgcgaca ccagaaagac
      361 gacactcaaa atctgctcaa gaatttggag tctaatgcgc agaccccctc ggaaactggc
      421 tccccatcaa ggaggaggaa gagagaagtg cagatgtcga aggacaagga agctgttgat
      481 gaatgtgagc cgccttccaa cagcaatatc acagcattcg ccctgaaggc caaagtcatc
      541 taccccatca atcagaagtt ccggcctctg gccgatggct cctccaaccc gtctctgcat
      601 gaaaacttaa agcaggctgt tttgccacac cagccggtag aggcctctcc ttccagcagt
      661 ctggggagcc tgagccaggg tgagaaggac gactgcagct cctcatccag cgtccactcg
      721 gccaccagcg atgacaggtt tctcagccgc accttcctcc gggtgaacgc cttccctgaa
      781 gtgctggcct gcgagagtgt agacgttgac ctgtgtatct acagccttca cttaaaagac
      841 ctgctgcatt tggacacggc actgaggcag gaaaagcata tgatgtttat tcagattttt
      901 aaaatgtgcc tccttgacct tcttcctaaa aagaagtcag atgatgaact ataccagaag
      961 atcctttcaa aacaagaaaa agatttggag gaactagaaa agggacttca ggtcaaactg
     1021 tcaaacacag aaatgtcggg ggctggtgac tctgagtaca tcaccctggc tgatgtggaa
     1081 aagaaggaga gagaatactc tgaacagcta atcgataata tggaagcttt ctggaaacag
     1141 atggcaaata tccagcactt tcttgtggac cagtttaagt gttccagctc caaagcccga
     1201 cagctgatga tgactctgac ggaaagaatg attgcagccg aagggctatt gtgcgattct
     1261 caggagctgc aggctctgga cgccctggag aggacgatgg ggcgggcgca catggcaaaa
     1321 gtgattgagt ttctgaagct gcaagtccag gaggagacca ggtgccggct ggctgccatc
     1381 tcccacggcc tggagctgct ggctggtgag gggaagctgt ccgggcggca gaaggaggag
     1441 ctgctcacgc agcagcacaa ggccttctgg caggaggcag agcgcttcag ccgggagttt
     1501 gtccagcgag gcaaagacct ggtcacggcg tctctggctc accaggtgga gggaacggca
     1561 aaactcacgc tggcccaaga ggaggaacag agaagcttcc tggctgaggc ccagccgact
     1621 gctgacccgg aaaagtttct cgaggctttt catgaggtcc tggagaggca gaggctgatg
     1681 cagtgtgacc tggaggaaga ggagaatgtc agagccaccg aggctgtggt tgcactctgc
     1741 caggagctgt acttcagcac cgtggacact ttccagaagt tcgtggatgc cctgttcctt
     1801 cagacgctcc ctggcatgac tggcctcccc ccggaagagt gtgactactt gaggcaggaa
     1861 gtccaggaga acgctgcctg gcagctgggg aagtcaaatc gcttccggag gcagcagtgg
     1921 aaactcttcc aggagctcct agagcaagac cagcaggtgt ggatggagga gtgtgcgctg
     1981 tccagcgtgc tgcagacaca cctgcgggag gaccacgagg gcaccatccg cggcgtcttg
     2041 ggccgactgg gcggcctcac tgaagagtcc acgcggtgtg tcctgcaggg gcatgacctg
     2101 ctgttgcgct cagccctccg gaggctggca ctccgcggca acgccctggc caccctgacg
     2161 cagatgcggc tatcggggaa gaagcacctc ctgcaggagc tgcgggaaca gcgtgcactg
     2221 gagcaggggt cctcccagtg cctggacgag catcagtggc agctgctcag ggccctggag
     2281 gcgcgtgtgc tggaggaggc cagccggcta gaggaggaag cacagcagac acggctgcag
     2341 ctccagcagc ggctcctggc cgaggcccag gaggtggggc agcttctgca gcagcacatg
     2401 gagtgcgcca ttgggcaggc gctgctggtg catgcacgga atgcagccac caagagccgg
     2461 gccaaggaca gggatgactt caagaggaca ctgatggagg cggcagtgga gagcgtctac
     2521 gtgaccagcg ctggtgtcag ccgcctggtg caggcgtatt accagcaaat cggaaggatc
     2581 atggaggacc acgaggagag aaaactgcag cacctgaaga ccctgcaggg tgagaggatg
     2641 gaaaattaca aactgcggaa aaagcaagaa ctcagcaacc cttcgtcggg cagcaggacg
     2701 gcaggtggcg ctcatgagac ctcccaggcg gtccaccaga ggatgctgtc ccagcagaag
     2761 aggttcctgg cccagttccc agtgcaccag cagatgcgtc tgcacgccca gcagcagcag
     2821 gcaggagtca tggaccttct ggaagcccag ctggagaccc agctacagga agctgaacag
     2881 aacttcatct ccgagctggc agccttggcc cgagtgcccc ttgctgaaag caaactgttg
     2941 cctgctaagc gtgggctgct agagaagccc ctaaggacta aaaggaagaa gcccctgccc
     3001 caggaaagag gggacctggg ggtgcccaac aatgaggacc ttgcctccgg ggaccagacc
     3061 tcaggctcac tcagcaaaag gctgagtcag caagaaagtg aagctgggga cagtgggaac
     3121 tcaaagaaga tgctaaagag aagaagcaac ttgtagttta agaccagtcg gtgggacaag
     3181 acctgaagcc ctgggtctgg gtgtgaattc caccttccct cctgcagtgc tgagaggcag
     3241 cgaggacgga gaggacagcg gcatctctag gctcttctga gagggacaga gaaagaatag
     3301 aaatgtgccc taaaagcata aatgagtatc acctgagaaa attaggcatt cccgtcttgg
     3361 aaacacgtct ctgtgagttt gcatttcatt tggcttggag ccctggctcg atgcctcatg
     3421 gatctttctc cccaaggagg gacgtcttga ggggtccgag cctcaggcca aggacccctg
     3481 atgcagactc tggaatccct ggcccaaagg cctgtctggg cccatctggg gctgaggaca
     3541 cacagataca taatgacacc tgcagaaatg tattctctga ggacacttag aatatgagga
     3601 agagggtgtg gcccaaccct cacttcacct ggggaggggc ttcttccgga cagtagacac
     3661 cctgcccgtg cagagagatg tcatgggggc acctgctctc cctgatagat gctgagagca
     3721 tccagaaact tccagaccag ccctctcacc acacccagaa gaggcctttc ccatctggag
     3781 agaagcttcc agaccagccc ttcacacacc acagccagga ggggcctttc ccacctggag
     3841 agaaacttcc agaccagccc ctcataccac agccaagagg ggcctttctc acctggagag
     3901 aaatttccag accatcccct ctcaccacag ccaggagagg cctttcccac cggtagagaa
     3961 acttccagac cagcccctca caccacagcc aagagaagcc tttccagcct ggagagaaac
     4021 ttccagacca gccctctcac tacagccagg agaggccttt cccgcctgga aacttccgga
     4081 caagcctctc acacaccaca gccaggagag gcctttccca cctggacaga aacttccaga
     4141 ccagcccctc tcaccacagc caggagaggc ctttaccacc tggagagaag cttccagacc
     4201 agcccctcac accacagcca ggagaggcct ttcccacctg gagagaaact tccagaccag
     4261 cccctcatac cacagccaag aggggccttt ctcacctgga gagaaacttc cagaccagcc
     4321 cctcacacca ccgccaggag aggcctttcc caccgggaga gaaacttcca gaccagcccc
     4381 tcacaccaca gccaggagag gcctttccca ccgggagaga aacttccaga ccagccctct
     4441 cactacagcc agaagaggcc tttcccaccg ggagaggaac ttccagacca gcccctcaca
     4501 ccacagccag gagaggcctt tcccgcctgg agagaagctt caggccagct cctcacacca
     4561 cagccaggag agaccttttc tgcctggaga gaaactttca gaccagcccc acacaccaca
     4621 gccaggagag gccgttcctg cctggagaga agcttccaga ccagcccttc acaccacagc
     4681 caggagaggc ctttcccacc tggagagaaa cttccagacc agcccctctc accacagcca
     4741 ggagaggccg ttcccacctg gagggaaaat tgctcctttg atggaggtta gggactgtca
     4801 ccctcagcac tgtgaacata ccgggcgaga tcattcttca ggggaaggag ctgcccagag
     4861 catcacagga tgttccagtg tccctggtct ctgcccacca gatgccagca ctcccaccat
     4921 tcgtggcaac caaggatgtc tccagacact gccccgtgtc catggggtta tcacccactg
     4981 tgctgagtca aagggtgcct tgccctggtc taatccagga catagccgtg gatacgtcca
     5041 aaaatcccca gaacctagtg agccctctgg ctctgggagc ccctatctca ggaattttca
     5101 gggtcatttg tgacttttca tttcttaaaa cctgaaatag actctcttag aaacaagtga
     5161 ctccttccca gtggccaaaa cttaatcatc agagcgcttc cttcagttcc tcacccatca
     5221 gccagtgggc tctccaaagt taaccaacag ctccctcttg tggttcacta aaaaacttgg
     5281 ttattccatg gagttgtgca aagctatggc ttccttggtg caatattctt aaaacctgct
     5341 ttgcatagaa atcacttttg cccaggctgg agtgcagtgg cgtgatctcg gctcatggca
     5401 atctccatct cccgggttca agcgattttc ctgcctcagc ctccccagta gctgggacta
     5461 cagacgtgtg ccaccacgcc tggctaaatc ttttttgtat tttattttag tagagacggg
     5521 gtttcaccat actggccagg ctgctctcga actcctgacc tcatcgtcca cctgcctcgg
     5581 cctccccaaa gtgctgagat taggcgttag ccaccgcgcc cggccagaaa tcacttttat
     5641 attgtcacat gggccctctg cacagagtcc gatggctcct cccggggaag cctgattttg
     5701 tgacgtgtgt atagtaaatg caggccctct ggcagcacca taattggtcg gttaccctga
     5761 gcccagagct ctgaaagcat ctgtggaatg atcacgggac ccttctcctc tgagaaggct
     5821 cccggctgcc tccccgccac cgagcttgta gcctgaatgc ctggctgtcg catggagcat
     5881 tttgcttctg gggtgtcttc cttagccaaa gggaacgtgt catttgctcg accctggccc
     5941 acccttgccg cccagctgtt gtgctgggca cagtctgggg cacaggcctc catgatgaag
     6001 acgcgtgggc tgtcggtgct ttcatccgtc acaaactggc acctgtacct gccagcagga
     6061 gcatgatggg gacttccatg ctggaattgc tccctgatta aaatgagata tggctatttg
     6121 gaagacactg cattttagcc agtgtacctg ggcacagact cggggctgcc ctgaagctga
     6181 tgaaggcttg aaggacggaa gggctgagcc acatgaaggc agcactcagg gccaggggag
     6241 agagaagagg atcagcagtg cagccccagg atgcctcgca ggtaccctgc ctccattttg
     6301 gttaccatcc ccacttatta tgggctgtgg gctgttatgg tgatggatgg atgtggattt
     6361 ggaaggggac catgagagat gatgtattat gatgaactca tgatttaatt ctttggtgaa
     6421 aata
//
