LOCUS       NM_001304762             980 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens eva-1 homolog B (EVA1B), transcript variant 2, mRNA.
ACCESSION   NM_001304762 XM_005270998
VERSION     NM_001304762.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 980)
  AUTHORS   Qu,S., Liu,J. and Wang,H.
  TITLE     EVA1B to Evaluate the Tumor Immune Microenvironment and Clinical
            Prognosis in Glioma
  JOURNAL   Front Immunol 12, 648416 (2021)
   PUBMED   33889156
  REMARK    GeneRIF: EVA1B to Evaluate the Tumor Immune Microenvironment and
            Clinical Prognosis in Glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 980)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 980)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 980)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI193341.1, AL591845.27, BC006241.2 and BU625845.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001304762.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.252075.1,
                                           ERR279836.10873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000490466.2/ ENSP00000507013.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BI193341.1         5-54
            51-51               AL591845.27        59831-59831         c
            52-416              BI193341.1         55-419
            417-976             BC006241.2         204-763
            977-980             BU625845.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..980
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /note="eva-1 homolog B"
                     /db_xref="GeneID:55194"
                     /db_xref="HGNC:HGNC:25558"
     exon            1..187
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /inference="alignment:Splign:2.1.0"
     exon            188..284
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..715
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /note="protein FAM176B; family with sequence similarity
                     176, member B"
                     /codon_start=1
                     /product="protein eva-1 homolog B"
                     /protein_id="NP_001291691.1"
                     /db_xref="CCDS:CCDS406.1"
                     /db_xref="GeneID:55194"
                     /db_xref="HGNC:HGNC:25558"
                     /translation="MDAPRRDMELLSNSLAAYAHIRANPESFGLYFVLGVCFGLLLTL
                     CLLVISISWAPRPRPRGPAQRRDPRSSTLEPEDDDEDEEDTVTRLGPDDTLPGPELSA
                     EPDGPLNVNVFTSAEELERAQRLEERERILREIWRTGQPDLLGTGTLGPSPTATGTLG
                     RMHYY"
     exon            285..980
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      959..964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /note="hexamer: AAGAAA"
     polyA_site      980
                     /gene="EVA1B"
                     /gene_synonym="C1orf78; FAM176B"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcctc ggaggaaact ttccgccggc tggtccctcg gtccgtgtcc cgcccgtgct
       61 gccgcggcct gggagcccag cggggccgga ggggcggcgg gacccgagcg ggcgggggcg
      121 gccggaccca gtgtatgcgg ccgcgggacg cgctggggcc gggcagccgg gaagcggggc
      181 gctgacggct ggtaggggag ctgcccccca gagcagcatg gatgccccgc gaagggacat
      241 ggagttgctc agcaacagcc tggctgccta cgcgcacatc cgcgccaacc ccgagagctt
      301 cggcctctac ttcgtgctgg gcgtctgctt cggcctgctg ctcaccctct gcctgctcgt
      361 catcagcatc tcgtgggcgc cccgcccgcg gccccggggc ccggctcagc gccgggaccc
      421 ccgcagcagc accctggagc ccgaggacga cgacgaggac gaggaggaca cggtgactcg
      481 gctgggcccc gacgacacgc tgccgggccc cgagctgtcc gcagagccgg acgggcccct
      541 caacgtcaac gtcttcacgt cggcggagga gctggagcgg gcgcagcggc tggaggagcg
      601 cgaacggatc ctgcgggaga tctggcgcac cgggcagccg gacctgctgg gcacaggcac
      661 gctggggccc agccccacgg ccacgggcac cctgggccgc atgcactatt actgatgggc
      721 cccggctccc gctgcaaggc gctcggggta ccggacctgc acatgagctc agagctaccc
      781 cacaccttcg gactgcctcg gcccccacag ctcccaggtg ctactgggcg tggaccgcca
      841 ccccctgaga ggctcccttc cccagtcctg ccagaagacc ccgggggcgg ggagggggca
      901 gcatgcaggg tccccactcc ctctctgggg tcgatgaaga ggtgaagtga ccaaatgaaa
      961 gaaagctgca ttctcagtga
//
