LOCUS       NM_001135032            1828 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens eva-1 homolog A, regulator of programmed cell death
            (EVA1A), transcript variant 1, mRNA.
ACCESSION   NM_001135032
VERSION     NM_001135032.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Chen,Y., Wang,D., Yin,J., Krafft,P.R., Luo,X., Hao,D., Li,C.,
            Liu,Y., Li,L., Zhang,Y. and Zhu,C.
  TITLE     Increased TMEM166 Level in Patients with Postoperative Stroke after
            Carotid Endarterectomy
  JOURNAL   Neuroscience 549, 138-144 (2024)
   PUBMED   38734302
  REMARK    GeneRIF: Increased TMEM166 Level in Patients with Postoperative
            Stroke after Carotid Endarterectomy.
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Canham,L., Sendac,S., Diagbouga,M.R., Wolodimeroff,E., Pirri,D.,
            Tardajos Ayllon,B., Feng,S., Souilhol,C., Chico,T.J.A., Evans,P.C.
            and Serbanovic-Canic,J.
  TITLE     EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and
            Inflammatory Activation Under Disturbed Flow Via Regulation of
            Autophagy
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (4), 547-561 (2023)
   PUBMED   36794585
  REMARK    GeneRIF: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and
            Inflammatory Activation Under Disturbed Flow Via Regulation of
            Autophagy.
            Erratum:[Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):e230. doi:
            10.1161/ATV.0000000000000163.. PMID: 37224275]
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   Xu,Q., Liao,Z., Gong,Z., Liu,X., Yang,Y., Wang,Z., Yang,W., Hou,L.,
            Yang,J., Song,J., Liu,W., Wang,B., Hua,J., Pu,M. and Li,N.
  TITLE     Down-regulation of EVA1A by miR-103a-3p promotes hepatocellular
            carcinoma cells proliferation and migration
  JOURNAL   Cell Mol Biol Lett 27 (1), 93 (2022)
   PUBMED   36273122
  REMARK    GeneRIF: Down-regulation of EVA1A by miR-103a-3p promotes
            hepatocellular carcinoma cells proliferation and migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Liao,Z., Gong,Z., Wang,Z., Yang,W., Liu,W., Hou,L., Liu,X., Hua,J.,
            Wang,B. and Li,N.
  TITLE     The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to
            Protect SH-SY5Y Cells Exposed to MPP
  JOURNAL   Cells 11 (17), 2706 (2022)
   PUBMED   36078115
  REMARK    GeneRIF: The Degradation of TMEM166 by Autophagy Promotes AMPK
            Activation to Protect SH-SY5Y Cells Exposed to MPP().
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Wang,Z., Han,S., Chen,X., Li,X., Xia,N. and Pu,L.
  TITLE     Eva1a inhibits NLRP3 activation to reduce liver
            ischemia-reperfusion injury via inducing autophagy in kupffer cells
  JOURNAL   Mol Immunol 132, 82-92 (2021)
   PUBMED   33556710
  REMARK    GeneRIF: Eva1a inhibits NLRP3 activation to reduce liver
            ischemia-reperfusion injury via inducing autophagy in kupffer
            cells.
REFERENCE   6  (bases 1 to 1828)
  AUTHORS   Xu,D., Yang,F., He,H., Hu,J., Lv,X., Ma,D. and Chen,Y.Y.
  TITLE     Expression of TMEM166 protein in human normal and tumor tissues
  JOURNAL   Appl Immunohistochem Mol Morphol 21 (6), 543-552 (2013)
   PUBMED   22495369
  REMARK    GeneRIF: TMEM166 expression was widely down-regulated in the cancer
            tissues.
REFERENCE   7  (bases 1 to 1828)
  AUTHORS   Li,L., Khatibi,N.H., Hu,Q., Yan,J., Chen,C., Han,J., Ma,D., Chen,Y.
            and Zhou,C.
  TITLE     Transmembrane protein 166 regulates autophagic and apoptotic
            activities following focal cerebral ischemic injury in rats
  JOURNAL   Exp Neurol 234 (1), 181-190 (2012)
   PUBMED   22227058
REFERENCE   8  (bases 1 to 1828)
  AUTHORS   Sun,W., Ma,X.M., Bai,J.P., Zhang,G.Q., Zhu,Y.J., Ma,H.M., Guo,H.,
            Chen,Y.Y. and Ding,J.B.
  TITLE     Transmembrane protein 166 expression in esophageal squamous cell
            carcinoma in Xinjiang, China
  JOURNAL   Asian Pac J Cancer Prev 13 (8), 3713-3716 (2012)
   PUBMED   23098460
  REMARK    GeneRIF: Low TMEM166 mRNA and protein expression is associated with
            esophageal squamous cell carcinoma.
REFERENCE   9  (bases 1 to 1828)
  AUTHORS   Wang,L., Yu,C., Lu,Y., He,P., Guo,J., Zhang,C., Song,Q., Ma,D.,
            Shi,T. and Chen,Y.
  TITLE     TMEM166, a novel transmembrane protein, regulates cell autophagy
            and apoptosis
  JOURNAL   Apoptosis 12 (8), 1489-1502 (2007)
   PUBMED   17492404
  REMARK    GeneRIF: TMEM166 is a novel regulator involved in both autophagy
            and apoptosis.
REFERENCE   10 (bases 1 to 1828)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP276065.1, BE892427.1, BC016157.1 and AW016395.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001135032.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016157.1, BU526860.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393913.8/ ENSP00000377490.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               BP276065.1         28-150
            124-329             BE892427.1         103-308
            330-1676            BC016157.1         293-1639
            1677-1828           AW016395.1         18-169              c
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..1828
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="eva-1 homolog A, regulator of programmed cell
                     death"
                     /db_xref="GeneID:84141"
                     /db_xref="HGNC:HGNC:25816"
                     /db_xref="MIM:618990"
     exon            1..260
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:2.1.0"
     exon            261..383
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:2.1.0"
     exon            384..536
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..910
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="transmembrane protein 166; protein FAM176A; family
                     with sequence similarity 176, member A"
                     /codon_start=1
                     /product="protein eva-1 homolog A"
                     /protein_id="NP_001128504.1"
                     /db_xref="CCDS:CCDS1959.1"
                     /db_xref="GeneID:84141"
                     /db_xref="HGNC:HGNC:25816"
                     /db_xref="MIM:618990"
                     /translation="MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCI
                     GLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRR
                     FERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY"
     exon            537..1828
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="hexamer: AATAAA"
     polyA_site      1828
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="major polyA site"
ORIGIN      
        1 actgactcgg gctcctgcag cttctgcggg gcttggcgcc gccgtccgtg agcacccagg
       61 ccgggacccc acatccccag gccagccctg accccggcgg cccctccgcc gggattcctt
      121 tccgaggtac tggtgccggc ccaagacccg ggcagcgctt tgtcgtgtcc gcccctcagt
      181 gatcagctcc gggtccccct gctcggcccc gcgcgcccca agcgcagtcc ccggaagtgc
      241 gcgccggggc cccagcaaag agtctgagaa gccaactggg gccaaacaag ttttagaacc
      301 tctactggct gatgccaaca tcatcagaga tgaactgttc ttaccagaaa cttctctgct
      361 cctgacaccc cacctctccc cagaagagaa gaaggagagt ggccacgttg attcagccaa
      421 gcacctccag gaggtcccct ctggatgtcc catgaggctg cccctcagcc acagcccaga
      481 gcacgtggag atggctttgc tcagcaacat cctagcggcc tattcctttg tctcagaaaa
      541 tcctgagcga gcagctctgt actttgtttc tggcgtgtgc atcgggctgg tgctgaccct
      601 ggctgctctg gtgataagga tctcttgcca cacagactgc aggcggcgtc ccgggaagaa
      661 gttcctgcag gacagagaga gcagcagcga cagcagcgac agcgaggatg gcagtgagga
      721 caccgtgtcc gatctctccg tgcggagaca ccgccgcttc gagaggactt tgaacaagaa
      781 tgtgttcacc tctgcggagg agctggagcg cgcccagcgg ctggaggagc gcgagcgcat
      841 catcagggag atctggatga atggccagcc tgaggtgccc gggaccagga gcctgaatcg
      901 ctactattag ggagcagcag gaccccggaa accactggag gccgcctgga aaggagagcg
      961 tctgcaggga cagtgggcac aaggaactga acccagctct gctaatattg tgatttcaga
     1021 gaaaaagcag gacatgcccc ttttctagcc aggaggattg ctcctttttg gccaaatgta
     1081 tggagaagta gaaaaatcaa agcagttcat caccctttcc aggtctcgga atggtgctga
     1141 aaaatcctct ccaacactgt ggatggagat cggagaaacg cgactgtggt ttctcttgat
     1201 ttctgaggat ctcagaagtt tcagcagact tccttgctct gtgttattcc tttgcaaaag
     1261 gaaagatcat tatagcatga gggctgggaa tagcagggtg aacttaaccc aataaatgca
     1321 atttcctaaa tgacttcatg ctatggaggt gattctgatt caaatagcat gatccatgct
     1381 tattatttaa ggctgatttt taaaatcttg tgttgcaagg gcaacctcgt ccattttaac
     1441 tggcacctca gggattaaaa tcctactttt tagtgtagtt cccacctcat tcatgaaaat
     1501 gaatagaact attgtattat gggagatgtg tcagtgaact agaaaatgtc aataacctca
     1561 aaggatgaag ggtttttatt ttaaatagtt tataaaatat atattgacat gcatatttga
     1621 aaatgctgca taaaaataaa agtggtgtgt tttccccctc tttggagaca agaaaatttt
     1681 attatgactc tagataattg tgattttaaa cactttgttt tttttttttt ttttaattgg
     1741 atttcaaaga aaagaatgga aatgagaggt aaggattaaa gccaaagtta ggatgggaat
     1801 taaaaaaata aacattacat aaaatctt
//
