LOCUS       NM_016135               1605 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ETS variant transcription factor 7 (ETV7), transcript
            variant 1, mRNA.
ACCESSION   NM_016135
VERSION     NM_016135.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Zhan,J., Harwood,F., Have,S.T., Lamond,A., Phillips,A.H.,
            Kriwacki,R.W., Halder,P., Cardone,M. and Grosveld,G.C.
  TITLE     Assembly of mTORC3 Involves Binding of ETV7 to Two Separate
            Sequences in the mTOR Kinase Domain
  JOURNAL   Int J Mol Sci 25 (18), 10042 (2024)
   PUBMED   39337528
  REMARK    GeneRIF: Assembly of mTORC3 Involves Binding of ETV7 to Two
            Separate Sequences in the mTOR Kinase Domain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Li,Y., Fan,L., Yan,A., Ren,X., Zhao,Y. and Hua,B.
  TITLE     Exosomal miR-361-3p promotes the viability of breast cancer cells
            by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway
  JOURNAL   J Transl Med 22 (1), 112 (2024)
   PUBMED   38282047
  REMARK    GeneRIF: Exosomal miR-361-3p promotes the viability of breast
            cancer cells by targeting ETV7 and BATF2 to upregulate the
            PAI-1/ERK pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Chai,B., Li,Y., Guo,Y., Zhang,Z., Jia,K., Chai,X. and Suo,Y.
  TITLE     ETV7 promotes colorectal cancer progression through upregulation of
            IFIT3
  JOURNAL   Funct Integr Genomics 24 (1), 8 (2024)
   PUBMED   38200280
  REMARK    GeneRIF: ETV7 promotes colorectal cancer progression through
            upregulation of IFIT3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Li,H., Zhang,Y. and Zheng,S.
  TITLE     Comprehensive Analysis Identified ETV7 as a Potential Prognostic
            Biomarker in Bladder Cancer
  JOURNAL   Biomed Res Int 2021, 8530186 (2021)
   PUBMED   34926692
  REMARK    GeneRIF: Comprehensive Analysis Identified ETV7 as a Potential
            Prognostic Biomarker in Bladder Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Pezze,L., Meskyte,E.M., Forcato,M., Pontalti,S., Badowska,K.A.,
            Rizzotto,D., Skvortsova,I.I., Bicciato,S. and Ciribilli,Y.
  TITLE     ETV7 regulates breast cancer stem-like cell features by repressing
            IFN-response genes
  JOURNAL   Cell Death Dis 12 (8), 742 (2021)
   PUBMED   34315857
  REMARK    GeneRIF: ETV7 regulates breast cancer stem-like cell features by
            repressing IFN-response genes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Cardone,M., Kandilci,A., Carella,C., Nilsson,J.A., Brennan,J.A.,
            Sirma,S., Ozbek,U., Boyd,K., Cleveland,J.L. and Grosveld,G.C.
  TITLE     The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis
  JOURNAL   Mol Cell Biol 25 (6), 2395-2405 (2005)
   PUBMED   15743832
  REMARK    GeneRIF: Human TEL2 augments the proliferation and survival of
            normal mouse B cells and dramatically accelerates lymphoma
            development in Emu-Myc transgenic mice.
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Boccuni,P., MacGrogan,D., Scandura,J.M. and Nimer,S.D.
  TITLE     The human L(3)MBT polycomb group protein is a transcriptional
            repressor and interacts physically and functionally with TEL (ETV6)
  JOURNAL   J Biol Chem 278 (17), 15412-15420 (2003)
   PUBMED   12588862
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Gu,X., Shin,B.H., Akbarali,Y., Weiss,A., Boltax,J., Oettgen,P. and
            Libermann,T.A.
  TITLE     Tel-2 is a novel transcriptional repressor related to the Ets
            factor Tel/ETV-6
  JOURNAL   J Biol Chem 276 (12), 9421-9436 (2001)
   PUBMED   11108721
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Poirel,H., Lopez,R.G., Lacronique,V., Della Valle,V.,
            Mauchauffe,M., Berger,R., Ghysdael,J. and Bernard,O.A.
  TITLE     Characterization of a novel ETS gene, TELB, encoding a protein
            structurally and functionally related to TEL
  JOURNAL   Oncogene 19 (41), 4802-4806 (2000)
   PUBMED   11032031
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Potter,M.D., Buijs,A., Kreider,B., van Rompaey,L. and Grosveld,G.C.
  TITLE     Identification and characterization of a new human ETS-family
            transcription factor, TEL2, that is expressed in hematopoietic
            tissues and can associate with TEL1/ETV6
  JOURNAL   Blood 95 (11), 3341-3348 (2000)
   PUBMED   10828014
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF147782.1 and AF116509.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016135.3.
            
            Summary: The protein encoded by this gene belongs to the ETS family
            of transcription factors, which is a large group of evolutionarily
            conserved transcriptional regulators that play an important role in
            a variety of cellular processes throughout development and
            differentiation, and are involved in oncogenesis as well. This
            protein is predominantly expressed in hematopoietic tissues.
            Several alternatively spliced transcript variants encoding
            different isoforms have been described for this gene
            (PMID:11108721).[provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as Tel-2b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035853.1, AJ276205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2161836
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340181.9/ ENSP00000341843.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AF147782.1         49-122
            75-1604             AF116509.1         22-1551
            1605-1605           AF147782.1         1422-1422
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..1605
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /note="ETS variant transcription factor 7"
                     /db_xref="GeneID:51513"
                     /db_xref="HGNC:HGNC:18160"
                     /db_xref="MIM:605255"
     exon            1..134
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1154
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /note="isoform 1 is encoded by transcript variant 1; ets
                     variant gene 7 (TEL2 oncogene); Ets transcription factor
                     TEL-2b; transcription factor ETV7; tel-related Ets factor;
                     ETS-related protein Tel2"
                     /codon_start=1
                     /product="transcription factor ETV7 isoform 1"
                     /protein_id="NP_057219.1"
                     /db_xref="CCDS:CCDS4819.1"
                     /db_xref="GeneID:51513"
                     /db_xref="HGNC:HGNC:18160"
                     /db_xref="MIM:605255"
                     /translation="MQEGELAISPISPVAAMPPLGTHVQARCEAQINLLGEGGICKLP
                     GRLRIQPALWSREDVLHWLRWAEQEYSLPCTAEHGFEMNGRALCILTKDDFRHRAPSS
                     GDVLYELLQYIKTQRRALVCGPFFGGIFRLKTPTQHSPVPPEEVTGPSQMDTRRGHLL
                     QPPDPGLTSNFGHLDDPGLARWTPGKEESLNLCHCAELGCRTQGVCSFPAMPQAPIDG
                     RIADCRLLWDYVYQLLLDTRYEPYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTY
                     EKMSRALRHYYKLNIIKKEPGQKLLFRFLKTPGKMVQDKHSHLEPLESQEQDRIEFKD
                     KRPEISP"
     exon            135..270
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     exon            271..435
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     exon            436..561
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     exon            562..792
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     exon            793..935
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1036
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1605
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /note="hexamer: AATAAA"
     polyA_site      1605
                     /gene="ETV7"
                     /gene_synonym="TEL-2; TEL2; TELB"
                     /note="major polyA site"
ORIGIN      
        1 ccagttctcg gagccaggtt aggggtttgg cggaggagga ctgcggggcg cgggcctagg
       61 gccccagcag ccacagccag gggagcgctc aagacagaaa gccggtggct tcctcacctc
      121 cacctgtaat gcaggaggga gaattggcta tttctcctat aagccctgtg gcagccatgc
      181 ctcccctagg cacccacgtg caagccagat gtgaagctca aattaacctg ctgggtgaag
      241 gggggatctg caagctgcca ggaagactcc gcatccagcc cgcactgtgg agcagggagg
      301 acgtgctgca ctggctgcgc tgggcagagc aggagtactc tctgccatgc accgcggagc
      361 acgggttcga gatgaacgga cgcgccctct gcatcctcac caaggacgac ttccggcacc
      421 gtgcgcccag ctcaggtgac gtcctgtatg agctgctcca gtacatcaag acccagcggc
      481 gagccctggt gtgtgggccc ttttttggag ggatcttcag gctgaagacg cccacccagc
      541 actctccagt ccccccggaa gaggtgactg gcccctctca gatggacacc cgaaggggcc
      601 acctgctgca gccaccagac ccagggctta ccagcaactt cggccacctg gatgaccctg
      661 gcctggcaag gtggacccct ggcaaggagg agtccctcaa cttatgtcac tgtgcagagc
      721 tcggctgcag gacccagggg gtctgttcct tccccgcgat gccgcaggcc cccattgacg
      781 gcaggatcgc tgactgccgc ctgctgtggg attacgtgta tcagctgctc cttgataccc
      841 gatatgagcc ctacatcaag tgggaagaca aggacgccaa gatcttccga gttgtggatc
      901 caaatgggct cgccagactc tggggaaatc acaagaaccg ggtgaacatg acctacgaga
      961 agatgtctcg tgccctgcgc cactattata agcttaatat cattaagaag gaaccggggc
     1021 agaaactcct gttcagattt ctaaagactc cgggaaagat ggtccaggac aagcacagcc
     1081 acctggagcc gctggagagc caggagcagg acagaataga gttcaaggac aagaggccag
     1141 aaatctctcc gtgaggggca ggtggactcc aggcacccgg taccgatggg gcagggaccg
     1201 agtctcccat gaaggcagac tcctcctccc agcagagcag caggatcccc agccagactc
     1261 tgtacccaca ggattacagc cattgcttgg gaaggctggg aggcctccca tccaggacac
     1321 tgggggcagg agtgtcatct tttgggcagg gcaatcctgg ggctaaatga ggtacagggg
     1381 aatggactct cccctactgc acccctggga gaggaagcca ggcaccgata gagcacccag
     1441 ccccacccct gtaaatggaa tttaccagat gaagggaatg aagtccctca ctgagcctca
     1501 gatttcctca cctgtgaaat gggctgaggc aggaaatggg aaaaagtgtt agtgcttcca
     1561 ggcggcactg acagcctcag taacaataaa aacaatggta gctga
//
